LOCUS       NC_016776              10147 bp    DNA     linear   CON 17-FEB-2020
DEFINITION  Bacteroides fragilis 638R, complete sequence.
ACCESSION   NC_016776
VERSION     NC_016776.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMEA3138381
            Assembly: GCF_000210835.1
KEYWORDS    RefSeq.
SOURCE      Bacteroides fragilis 638R
  ORGANISM  Bacteroides fragilis 638R
            Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
            Bacteroides.
REFERENCE   1
  AUTHORS   Patrick,S., Blakely,G.W., Houston,S., Moore,J., Abratt,V.R.,
            Bertalan,M., Cerdeno-Tarraga,A.M., Quail,M.A., Corton,N., Corton,C.,
            Bignell,A., Barron,A., Clark,L., Bentley,S.D. and Parkhill,J.
  TITLE     Twenty-eight divergent polysaccharide loci specifying within- and
            amongst-strain capsule diversity in three strains of Bacteroides
            fragilis
  JOURNAL   Microbiology (Reading, Engl.) 156 (Pt 11), 3255-3269 (2010)
   PUBMED   20829291
REFERENCE   2
  AUTHORS   Aslett,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JUL-2010) Sanger Institute, Wellcome Trust Genome
            Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/17/2020 18:16:11
            Annotation Pipeline               :: NCBI Prokaryotic Genome
            Annotation Method                 :: Best-placed reference protein
            Annotation Software revision      :: 4.11
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
            Genes (total)                     :: 4,439
            CDSs (total)                      :: 4,346
            Genes (coding)                    :: 4,241
            CDSs (with protein)               :: 4,241
            Genes (RNA)                       :: 93
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 105
            CDSs (without protein)            :: 105
            Pseudo Genes (ambiguous residues) :: 0 of 105
            Pseudo Genes (frameshifted)       :: 50 of 105
            Pseudo Genes (incomplete)         :: 48 of 105
            Pseudo Genes (internal stop)      :: 34 of 105
            Pseudo Genes (multiple problems)  :: 24 of 105
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence was derived from
            FQ312004.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Data release policy http://www.sanger.ac.uk/legal/#t_2 DNA source:
            unknown.
            Annotation Pipeline (PGAP)
            set; GeneMarkS-2+
            repeat_region
FEATURES             Location/Qualifiers
     source          1..10147
                     /organism="Bacteroides fragilis 638R"
                     /mol_type="genomic DNA"
                     /strain="638R"
                     /db_xref="taxon:862962"
     gene            1..1446
                     /locus_tag="BF638R_RS21575"
                     /old_locus_tag="BF638R_4457"
     CDS             1..1446
                     /locus_tag="BF638R_RS21575"
                     /old_locus_tag="BF638R_4457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005803862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipopolysaccharide biosynthesis protein"
                     /protein_id="WP_014299635.1"
                     /translation="MAEQSLKEKTAKGLFWGGFSNGIQQLLNLLFGIIITHMLDSTDYG
                     MIGMLAIFTAVANSIQESGFTAALANKQTFRHEDYNAVFWFSFLMGASLYLLLFFCAPF
                     IAAFYKTPQLIPLSRFLFLGFLISSCGTAHNAVLFKKLMVKEKAKATITALLCSGTIGI
                     VMAYNGMAFWGLAVQQITYIFIANALLWYFSPWRPTFSFNFKPIREMLPFSSKLLITNV
                     FHYINDNIFSVLLGRFYTSQDVGYYTQANKWTNMGFSLISNMINGVSQPVLVETSSDAM
                     RQKNIFRKMLRFTAFISFPAMFGLALIANEFIVIAVTAKWQACVPIMQILCIWGAFVPI
                     TYMYSNLLISKGKSNLFMWNTIAQSLVQLTMLLCTISQGILVMAVIYTVINIGWLLIWH
                     YFVNKQIHITLWEVMKDITPYLLISGGVIGTSYFLTIGFHNLYVLLILKIGIAVSLYVF
                     IMWIGKSVIFFESVQFIRKKLLK"
     gene            1450..2637
                     /locus_tag="BF638R_RS21580"
                     /old_locus_tag="BF638R_4458"
     CDS             1450..2637
                     /locus_tag="BF638R_RS21580"
                     /old_locus_tag="BF638R_4458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005803861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="WP_008661647.1"
                     /translation="MNILIQQTKAFPHRANSFYWFYAQLTEWLTAHGVDSKLYFSYLEL
                     ADSEFENGLLLPDHYSQFYTPRNIEAICRFIIDKQIDVILDYSHVITGDTRKYYLEIKK
                     RNPGIKICTMIHNCPSHTTQLKQYELSTLRFKDVHGPKKLFQWMLPQLYISLLKKVVSH
                     QNRSAYDTLDEVVLLSPAYIPEFKKLIGKKDAWKLSAIPNAIKPVHSNIPIEEKDKEII
                     FVGRMATEKALPKLLKIWGMVQDKLPDWKLTLVGDGPQFGTCRQIIAEKKLKRVCLTGH
                     QMSIPYIDRARILCLTSVIEGLPTVFTEAMSLGVIPIGFDSFNAIYDMIDDGIDGFIIP
                     DNNYEQYAETILRLAQNDTLRCRIAYKAQKRKNRYDIEQVGPLWMETFRKHGLIK"
     gene            2647..3657
                     /locus_tag="BF638R_RS21585"
                     /old_locus_tag="BF638R_4459"
     CDS             2647..3657
                     /locus_tag="BF638R_RS21585"
                     /old_locus_tag="BF638R_4459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005797203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT0|GT94"
                     /protein_id="WP_008661648.1"
                     /translation="MKVTIYPYSINKGDIRVNPYISDFIHALQQNGITIANPPHKNPLF
                     SLIPRKADSDAYIFHWPENVPDYKYGMLQTLAAIWLLFKIKCHHKKIIWFLHNKQPHVM
                     KHRWSKKLLIHLLLRKADLIVTHATEGIKVVQDQYPKAVAKTVFLHHPTKNRIEEYIPQ
                     PPETDLLIWGNISRYKGVPEFVRFATQHSLKLKTKIIGKCSSQELLEELHKESNEMISI
                     EDRSIPFEELKQEIRRSRFVLVPYAAESILSSGILMDSLSFGAKVIGPAVGSFRDYATE
                     PLLNVYTFHTFDDIQELVDKANEATDIAGYNRFLNAHSWNEFGKKFQNLLQKIIQ"
     gene            3657..4856
                     /locus_tag="BF638R_RS21590"
                     /old_locus_tag="BF638R_4460"
     CDS             3657..4856
                     /locus_tag="BF638R_RS21590"
                     /old_locus_tag="BF638R_4460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005811820.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="WP_008661650.1"
                     /translation="MKVLYTFGGMPHYLNAMLNKLHNKGVEITVITPQKGNATIGKGVK
                     MVEGGTYRHLTAIEKKAFYGKSSYPSLPEIVREEKPDILIMGWPYFLQVFFQPRLRKAM
                     KECRTRLVIREIPFQTPPYGKIKEYFHENPMYDENMRLVSTGTGFYLKQWLTAKIRKYC
                     YARITGTLNYSTAAYDILPSYGVKQEQIHVTYNSTDTDALLKEKEAVLTSPPLLPPSSK
                     RALHIGRLVKWKRVDLLIDAFTKVIASHPDAELVVVGDGPELDNLKKQAADLNLTEQVR
                     FIGAVYSPKELGAYMNESTVYVLAGMGGLSINDAMTYGLPVVCSVCDSTERDLVTDGVN
                     GLFFKEGNADSLSDKLNKLFASPERCASMGRESERIIREKINIETVSERYLQAFRTFMQ
                     "
     gene            4925..5572
                     /locus_tag="BF638R_RS21595"
                     /old_locus_tag="BF638R_4461"
     CDS             4925..5572
                     /locus_tag="BF638R_RS21595"
                     /old_locus_tag="BF638R_4461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005797199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_005791920.1"
                     /translation="MTDLTILIAVIALALWPIVFLISRILHERNKRAKPSGDTASAETE
                     EVTEEMTTSALIMSILQQLGCQPEVNEENHISFKYQGDDFLVAAEDGLRLIIVWNPWWA
                     SISIDNQALPYLKEIINAVNMNSLVTTVYALDEDEKTFGIHSKCHMLFAPEEEEPEKSF
                     TDLLDSFFTTHNTIKENLKQLGNGMPDMEKKERVRIKGFAAYKDNSTELKGE"
     gene            complement(5624..6754)
                     /gene="wecB"
                     /locus_tag="BF638R_RS21600"
                     /old_locus_tag="BF638R_4462"
     CDS             complement(5624..6754)
                     /gene="wecB"
                     /locus_tag="BF638R_RS21600"
                     /old_locus_tag="BF638R_4462"
                     /EC_number="5.1.3.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005791919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine 2-epimerase
                     (non-hydrolyzing)"
                     /protein_id="WP_005791919.1"
                     /translation="MKKILLVFGTRPEAIKMAPLVKALQRDTEHFETKVCVTAQHRQML
                     DQVLEVFDIIPDYDLNIMAPNQDLYDITTKVLLGLRDVLKDFCPDTVLVHGDTTTSMAA
                     SLAAFYRQVAVGHVEAGLRTYDMLSPWPEEMNRQVTDRICTYYFAPTGKSKQNLLQENI
                     DAKKIFVTGNTVIDALLMAVDIISKKPGIKEKLHQELRDKGYEVGQREYILVTGHRREN
                     FGEGFLHICKAIRELAALHPEMDIVYPVHLNPNVQKPVYELLSGVDNVYLISPLDYLPF
                     IYAMQHSTLLLTDSGGVQEEAPSLGKPVLVMRNTTERPEAVEAGTVKLVGTDAEAIVSN
                     VTELLRNKELYRRMSETHNPYGDGHACERILSALTR"
     gene            complement(6809..8011)
                     /gene="wecC"
                     /locus_tag="BF638R_RS21605"
                     /old_locus_tag="BF638R_4463"
     CDS             complement(6809..8011)
                     /gene="wecC"
                     /locus_tag="BF638R_RS21605"
                     /old_locus_tag="BF638R_4463"
                     /EC_number="1.1.1.336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005791918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetyl-D-mannosamine dehydrogenase"
                     /protein_id="WP_008661652.1"
                     /translation="MKKVVFLGLGYIGLPTAAVVAGHGYEVVGVDVNPSVVETINQGKI
                     HIVEPELDQIVKEVVRTGNLRAVSKPEQADAFFVVVPTPFKQNHRADITYVESATRSVI
                     PYLREGNLFVIESTSPVFTTERMAEVIYKERPELKDKIYIAYCPERVLPGNTLYELVHN
                     DRVIGGVNPESTAKAIEFYSAFVQGKLHPTNARTAEMCKLTENSSRDSQIAFANELSMI
                     CDKAGINVWELIELANKHPRVNILQPGCGVGGHCIAVDPWFIVSDYPEQAQIIKRARET
                     NDYKADWCANKVMEACQQFVEKNDREPVVACMGLAFKPNIDDLRESPAKYIASRIVSES
                     RAEVLIVEPNVASHASFHLTDYREAYQKADIVVWLVRHTPFVELPREESKLELDFCGVR
                     K"
     gene            8116..9381
                     /locus_tag="BF638R_RS21610"
                     /old_locus_tag="BF638R_4464"
     CDS             8116..9381
                     /locus_tag="BF638R_RS21610"
                     /old_locus_tag="BF638R_4464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005797195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="WP_008661654.1"
                     /translation="MRVLIINTSERLGGAAVAASRLMESLKNNGIKAKMLVRDKQTDQI
                     SVVGLQRNWWQVWRFVWERIVIWKANRFKKNNLFAVDIANTGTDITSLPEFQQADVIHL
                     HWVNQGMLSLNDIRKILKSGKPVVWTMHDMWPCTGICHHARECTNYHQECNHCPYLYGG
                     GSKKDLSNRIFRKKQQLYKEAPITFVTCSQWLKGQAEKSALLTGETVISIPNPINTNLF
                     KPRNKKEARSKCHLPQNGKLILFGSAKITDKRKGIDYLIESCKLLAEKHPELKDSLSVV
                     VLGKQSEQLKPLLPFKVYPLNYVSNEHELVDVYNAVDLFVTPSLEENLPNTIMEAMACG
                     VPCIGFNVGGIPEMIDHLHNGYVAQYKSSEDFANGIYWALTDPDYPSLSEQANRKVIAN
                     YSEGIIAKRYIDVYNKITGRYA"
     gene            9374..10147
                     /locus_tag="BF638R_RS21615"
                     /old_locus_tag="BF638R_4465"
     CDS             9374..10147
                     /locus_tag="BF638R_RS21615"
                     /old_locus_tag="BF638R_4465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010993801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT2|GT2_Glycos_transf_2"
                     /protein_id="WP_005803856.1"
                     /translation="MHSHPSPKFSVITVTYNAEKVLEDTVQSVISQTYHHVEYIIIDGA
                     SKDGTLEIVNRYRDRIHQLVSEPDKGLYDAMNKGIALATGDYLCFLNAGDSFHEDDTLQ
                     KMVHSINGNELPDILYGETALVDAERHFLRMRRLSAPETLNWKSFKQGMLVCHQAFFPR
                     HTLIEPYDLQYRFSADFDWCIRIMKKARTFHNTHLILIDYLAEGMTTQNHKASLLERFR
                     IMTRHYGLLSTLAHHAWFVVRSFSRNSATPSDAPF"
ORIGIN
        1 atggcagaac agtcgctaaa agaaaaaaca gccaaaggat tattctgggg tggattcagc
       61 aatggcatcc agcaattact gaacctgctg ttcggaatta tcatcaccca tatgctggat
      121 tcgacagact acggtatgat tggtatgctg gctatattta ccgccgtagc caactctata
      181 caagagagcg gatttacggc cgctctggcc aataaacaga cgttccgtca tgaagactac
      241 aatgcggtgt tctggttcag ttttctaatg ggtgcatcgc tttacctgct gctctttttt
      301 tgtgccccgt ttatcgcagc attctataag actccacagc ttattcctct atcccgcttc
      361 cttttcctgg gttttctgat ttcaagttgc ggaactgccc ataatgcggt attatttaaa
      421 aaactaatgg tgaaagaaaa agcgaaagca accattaccg cactattgtg ttcaggcacc
      481 ataggaattg tcatggcata caatggaatg gctttctggg ggctggccgt acagcaaatc
      541 acctatattt tcatcgctaa tgcgctgtta tggtactttt ctccgtggcg tcctactttt
      601 tcgttcaatt tcaaacctat cagggagatg cttccgttca gcagtaaact gcttatcacc
      661 aatgtatttc attacatcaa tgataacata ttttctgttc tgctggggcg cttttatacc
      721 agtcaggatg taggttacta tactcaggcc aacaaatgga ccaatatggg cttctcactg
      781 atcagtaaca tgatcaacgg agtatctcag cctgtcctgg tcgaaacctc ttccgacgcc
      841 atgcgacaga aaaatatatt tcggaagatg ttgcgcttca ccgcctttat ctctttcccg
      901 gccatgttcg gactggcatt gatagccaac gagttcatcg taattgccgt caccgccaaa
      961 tggcaggcat gtgtacccat catgcagatt ctttgcatct ggggagcatt tgtccccatt
     1021 acttatatgt actccaatct tctgatcagt aaaggaaagt cgaatctttt tatgtggaat
     1081 accattgcac agagcctggt tcaactcaca atgcttcttt gtactatctc acaaggcata
     1141 ctcgtcatgg ccgtgattta tacggttatc aacatcggtt ggctactgat atggcattat
     1201 ttcgtaaaca agcagattca catcacccta tgggaagtca tgaaagatat cactccgtac
     1261 ctactgatct ccggaggagt cataggaacc agctatttcc tcacgatcgg cttccataac
     1321 ctatatgtat tgctgattct taaaatagga atagccgtaa gcctttatgt gttcatcatg
     1381 tggatcggca aatcggtgat cttttttgaa agtgtacaat ttatccggaa aaaactcttg
     1441 aaataagtca tgaacatcct gatccaacaa accaaagcat ttcctcatcg tgccaatagc
     1501 ttttattggt tctatgcgca actgaccgaa tggctgactg cacacggagt ggacagtaag
     1561 ctttactttt cgtacctgga actggctgac agcgaatttg agaacggcct cctgttgccc
     1621 gatcattatt ctcaattcta tactccccgc aacatcgaag caatctgtcg cttcattatc
     1681 gacaaacaga tagacgtgat tctcgattac tcccatgtca tcaccggaga tacacgcaaa
     1741 tattacctcg aaatcaaaaa aagaaatccc ggaatcaaaa tatgcacgat gatccacaac
     1801 tgtcccagcc atacgacaca gttaaaacaa tacgagttat ctacactccg gttcaaagac
     1861 gtgcatggac ccaagaaact ttttcagtgg atgctgccac aactctacat cagcttatta
     1921 aaaaaagtgg tcagccatca aaaccgttcg gcatacgaca cgctcgacga agtggtactg
     1981 ctgtcacccg cttatatacc cgaattcaag aaacttatag gcaaaaaaga cgcatggaag
     2041 ttatctgcca tccctaatgc cataaaacct gtgcatagta acatcccgat tgaggagaag
     2101 gacaaagaaa ttatctttgt tggcagaatg gcaaccgaaa aggcattacc caaattacta
     2161 aagatatggg gcatggttca ggataaacta ccggactgga aactcaccct tgtaggagat
     2221 ggtccccaat tcggcacgtg ccggcaaatt attgccgaga aaaaattgaa acgggtctgc
     2281 ctgaccggcc atcagatgtc gatcccctat atagaccgtg cccggattct ttgtctgact
     2341 tccgtcatag aaggactacc caccgtattt acagaagcaa tgtcactggg ggtgattcct
     2401 atcggattcg attctttcaa tgcgatctat gacatgatag atgacggcat agacggattc
     2461 attattcccg acaacaatta tgaacaatat gcagaaacca ttctacggtt ggcacaaaat
     2521 gacacactcc gctgccggat agcctacaaa gctcaaaagc ggaaaaacag atatgacata
     2581 gaacaggtag gaccactgtg gatggaaact ttccgtaaac atggattaat taaataggag
     2641 aacacaatga aggtcacgat atatccatac tctatcaaca aaggtgatat acgcgttaat
     2701 ccgtatatca gcgacttcat ccatgcactg caacagaacg gaatcacaat tgccaatccc
     2761 ccgcacaaga atccgttatt cagcctcatc ccaagaaaag cagatagcga tgcttatatc
     2821 tttcattggc cggagaatgt acccgactac aaatatggaa tgttgcagac tcttgctgct
     2881 atctggcttc ttttcaaaat taaatgccac cataagaaga tcatctggtt cttgcacaat
     2941 aagcagcccc atgtgatgaa acaccgatgg tcgaaaaagt tattgataca tctgctcctc
     3001 cgcaaagccg atttgatagt gacacatgct acagaaggta tcaaagtggt tcaggatcaa
     3061 tatccgaagg ctgtagccaa aacggtattc ttgcatcacc ctactaaaaa ccggatagaa
     3121 gaatacatcc cccaaccacc ggaaaccgac ctgctgatct ggggaaatat ctcccgatac
     3181 aaaggggtac cggaattcgt acgttttgct actcagcatt cattaaaact gaagactaaa
     3241 atcatcggga aatgcagttc gcaggaactc ctggaagaac tacacaaaga aagtaatgag
     3301 atgatcagca tagaggaccg tagtattcct ttcgaagagc taaaacaaga gatccgcaga
     3361 tcacgtttcg tactggtacc ttatgctgcc gagtctatct taagttccgg catactgatg
     3421 gactctctct cattcggagc caaagtcatc ggaccggctg taggctcttt cagggactac
     3481 gccaccgaac ccttgcttaa cgtatatact ttccatacgt tcgatgatat acaggaactc
     3541 gttgacaagg caaacgaagc aacagatata gccggttaca accggttcct caatgcacat
     3601 agctggaacg aattcggcaa aaagtttcaa aatttacttc agaaaataat acagtaatga
     3661 aagtactcta tacattcggc ggcatgcccc attatctgaa tgccatgctc aacaaacttc
     3721 ataacaaagg agtggaaatc accgttatca ctcctcaaaa aggaaatgcc actatcggta
     3781 aaggtgtaaa aatggtagag ggaggaacat acaggcacct caccgccatt gagaagaaag
     3841 cattctacgg aaaaagctcc tatccctccc taccggaaat agtacgtgaa gagaaaccgg
     3901 atattctgat aatgggatgg ccctatttcc tgcaagtgtt ctttcaaccc cgattgagaa
     3961 aggctatgaa agagtgccgg acacggttgg ttatccgtga aattcccttc cagacccctc
     4021 cctacgggaa aataaaagaa tatttccatg aaaacccgat gtatgatgaa aacatgcggc
     4081 tggtcagtac cggaaccggc ttttatctta aacaatggct gacagcgaaa atacgtaaat
     4141 actgctacgc acgcattacc ggaacgctga attactcgac cgctgcatac gatattcttc
     4201 cttcctatgg agtgaagcag gagcaaatac atgtcactta caactctacg gacacagatg
     4261 ccttactgaa ggagaaagaa gccgtactca cctcgccccc gcttcttcct ccttcctcca
     4321 aaagagcgct acacatcggc cgattagtga aatggaaaag ggtggatctg ctgatcgatg
     4381 cgtttacaaa ggttattgcc agtcatccgg acgcggaact ggtagtggta ggcgatggac
     4441 cggagctgga taacctgaaa aaacaggcag ccgacctgaa tctgacagaa caggttcgat
     4501 tcatcggtgc agtatacagt cccaaagaac tgggagccta tatgaatgaa tcgactgtct
     4561 atgtactcgc gggcatggga ggattatcca tcaatgatgc catgacctac ggactgcccg
     4621 tggtttgttc ggtatgcgac agcaccgaac gtgacctggt gacggacgga gtgaacggac
     4681 ttttcttcaa agaaggcaat gccgacagct tgagcgacaa gctcaacaaa ctgtttgcct
     4741 ctcccgaacg ttgtgcctct atgggacgtg agtcggaacg aatcatccgc gagaaaatca
     4801 acattgaaac ggttagcgaa cgttatttgc aagctttccg aacttttatg cagtaaaaat
     4861 ggagtacgac caaaaagaat gattatcttt aggcagacat taatcattta atagctctac
     4921 tactatgacc gatcttacca ttctcatcgc agtcatcgca ttggcgttat ggccaattgt
     4981 attcctgata tcgcgtatcc tgcacgagcg gaacaaacgt gcgaagccat cgggtgacac
     5041 tgcctctgcc gaaacggaag aagtgacaga ggaaatgact acctccgcac tgatcatgag
     5101 catccttcaa cagctcggtt gccaaccgga agtgaatgaa gaaaatcata tcagcttcaa
     5161 gtatcaggga gacgatttcc ttgtcgcagc cgaagacggt ctccggttaa tcattgtatg
     5221 gaatccttgg tgggcgtcca tcagcatcga caatcaggca ttaccctatc tgaaagaaat
     5281 tatcaatgca gtcaatatga actcattagt gactactgtc tatgcgctgg acgaggatga
     5341 aaaaacattt ggtatccaca gtaaatgtca tatgctcttc gctcccgaag aagaggagcc
     5401 ggaaaaaagt ttcaccgacc tgctggacag ttttttcact acccacaata ctattaaaga
     5461 aaacctgaaa caattgggta acggaatgcc ggatatggaa aagaaagaac gagtaagaat
     5521 caaaggattt gctgcctaca aggacaacag cacggaactg aaaggggaat gaacttcccc
     5581 tcttcctctt gcccgtacag cctataaacg aatcatgtga gctttaacgg gttaatgccg
     5641 acaggatgcg ttcacaagca tgcccgtcac cataaggatt atgtgtttcg gacatacgac
     5701 ggtataactc cttattacgg agcagctcag tcacattact gacaatcgcc tcagcatccg
     5761 tccccaccag ttttacagtt cccgcctcta ctgcttcagg acgttccgtg gtatttcgca
     5821 tcaccaacac cggcttgcca agtgaaggag cctcctcttg tactccaccg ctatcggtca
     5881 gcagcaaagt ggagtgctgc atagcgtaaa taaacggcag ataatccaac ggcgaaataa
     5941 gatatacatt gtctactcct gacagaagtt cgtatacggg tttctgtaca ttcgggttca
     6001 gatgtaccgg atatacaata tccatctcgg gatgcaacgc ggctaattct ctaatcgctt
     6061 tacaaatatg taaaaatcct tccccaaagt tctcacgacg atgcccggta accagaatat
     6121 attcacgttg tcccacttcg taacctttgt cacgaagttc ctgatgcaac ttttctttga
     6181 ttcccggctt cttcgaaata atgtcaacag ccatcaacaa agcatcgata accgtattac
     6241 cggtaacaaa tatcttcttt gcgtcgatgt tttcctgtaa cagattctgt ttcgatttcc
     6301 cggtaggagc aaaatagtag gtacaaatac ggtcggtcac ctgacgattc atctcttccg
     6361 gccagggaga cagcatatca taggtacgca aaccggcctc aacatgtccc acggcaacct
     6421 gccgatagaa tgcagccagt gaagcggcca tcgacgtagt ggtatctccg tgtaccagca
     6481 ccgtatccgg acagaaatct ttcagcacat cgcgcaggcc cagaagaact ttagtggtga
     6541 tgtcgtacaa gtcctggttg ggtgccataa tattcagatc gtagtcagga atgatgtcga
     6601 acacttcaag tacctggtcc aacatctgac gatgttgtgc cgtcacacac actttcgttt
     6661 caaagtgttc agtatctctt tgcaaggctt tcaccaacgg ggccatctta atggcctcag
     6721 gacgggtacc gaaaacaagt aatatctttt tcattatacg atcagactat ttacgatggt
     6781 tcattaagac gatatgccag ttctctttct actttcttac tccgcagaag tccaactcca
     6841 atttactttc ttcacggggc aactccacaa acggagtgtg acgtaccagc cataccacga
     6901 tatccgcttt ctgataagcc tcccgatagt cagtcagatg gaaactggca tgtgaagcga
     6961 cattgggttc tacaatcagc acctctgcac gcgactcaga tacaatgcgg gaagcaatat
     7021 atttagcagg agattcacgc aaatcatcaa tattgggttt aaaggcaagt cccatgcaag
     7081 ccactaccgg ttcacgatcg ttcttctcga caaattgctg acaagcttcc attactttgt
     7141 tggcacacca atcagcttta taatcgttcg tctcacgggc acgtttgatg atttgtgcct
     7201 gttcgggata gtccgaaaca ataaaccaag gatctacggc tatacagtgt cctcccactc
     7261 cgcagccggg ttgtaggatg ttcacacgcg gatgtttgtt agccaattct atcagttccc
     7321 agacgttgat acccgctttg tcacaaatca tggacaattc gttggcaaac gcaatctgag
     7381 agtcgcgcga agagttctcg gtcaacttac acatttctgc cgtacgagca ttcgtcgggt
     7441 ggagtttacc ctgtacaaag gcagaataaa actctatggc tttagcggtc gactcgggat
     7501 tgacgccacc gatcacccga tcgttatgaa ccagttcata aagcgtatta cccggcaata
     7561 cacgttcggg acaataggct atgtatattt tgtctttcag ttccgggcgc tctttataaa
     7621 tgacttcagc catacgttcg gtcgtaaata ccggtgaagt ggactcgata acaaacaagt
     7681 ttccttctct cagataagga attacggagc gggtagccga ttccacatag gtgatatctg
     7741 cacggtggtt ttgtttgaaa ggggtaggca ctaccacaaa aaaagcatct gcctgctcag
     7801 gtttcgaaac ggcacggaga ttacctgttc gcaccacctc ttttacaatc tgatccagtt
     7861 ccggttccac aatatgtatt ttaccctgat tgatggtttc tacgaccgaa ggattaacat
     7921 ccacacctac aacttcataa ccatgtccgg cgaccacggc agcagtagga agtccgatat
     7981 agcctaatcc taaaaaaaca acctttttca tacgtatatc tccttatcta taagtgccgc
     8041 aaaagtacaa ataatatgtg actttgtacg gtttctcacc gaaaaccact acttttgcca
     8101 aaacatttcg atcgaatgag agttttaata atcaatactt ccgaacgttt gggcggagcg
     8161 gccgtcgcag caagccgctt gatggaatcg ttgaaaaaca acggtatcaa agccaaaatg
     8221 ttggtgcgcg acaagcaaac cgaccagatc agcgtagtag gtctgcaacg taactggtgg
     8281 caagtatgga ggtttgtgtg ggaacgcatt gtcatctgga aagccaaccg ctttaagaag
     8341 aacaatcttt tcgcagtcga tatagccaat acaggcacag acattacaag cctgccggag
     8401 tttcagcagg cagatgtcat ccacctgcat tgggtgaatc agggaatgtt gtcactgaac
     8461 gatatccgga agattctgaa atccggtaaa ccggtagtgt ggaccatgca cgatatgtgg
     8521 ccctgtacag gcatctgcca tcacgcccgt gagtgtacca actaccatca ggagtgtaac
     8581 cactgtccat acctgtatgg agggggaagt aagaaagatc tgtccaaccg tatcttccgt
     8641 aaaaaacaac aactctacaa agaagcaccc attaccttcg tcacttgtag ccaatggctg
     8701 aagggacaag ctgaaaagag tgctttgctg acaggagaaa cggtaatcag tatacctaac
     8761 cccattaaca ccaatctatt taaacccaga aacaagaaag aggcacgcag caaatgccat
     8821 ttaccccaaa acggaaaact gattcttttc ggttcggcca aaatcacgga taagcggaaa
     8881 ggcatcgatt atctgattga atcgtgtaaa ttactggctg agaagcatcc tgaactgaaa
     8941 gattctctaa gtgtagtcgt tttgggcaag caatcggaac aactcaagcc gttgcttcct
     9001 tttaaagtat atccactcaa ctacgtgagt aacgagcatg aactggtaga tgtttacaat
     9061 gcggtcgacc ttttcgttac tccctcactg gaagagaacc tgcccaatac tatcatggaa
     9121 gctatggcat gcggagtgcc ttgtatcggc ttcaatgtcg gcggcatccc ggaaatgata
     9181 gaccatctgc acaacgggta tgtggcacaa tacaaatcat ccgaagattt tgccaacggc
     9241 atctattggg cactgaccga cccggattat ccgtctctct cggaacaggc caaccgaaaa
     9301 gtaatcgcca actactcgga aggcattatt gccaaaagat acattgatgt ctacaataaa
     9361 ataacaggaa gatatgcata gccatcccag tcccaaattc tccgtgatca cagtgaccta
     9421 caatgccgaa aaggtattgg aagatactgt gcaaagcgta atttcgcaga cctatcatca
     9481 tgtagagtat atcatcatcg acggtgcatc gaaagacggg actttagaga ttgtcaaccg
     9541 ataccgcgac cgcatccacc aattggtgag cgaaccggac aaaggacttt atgacgcaat
     9601 gaacaaagga atcgccctgg caacgggcga ctatctctgc tttctgaatg ccggagacag
     9661 tttccacgaa gacgacactt tgcaaaagat ggttcactcc atcaatggaa atgagttgcc
     9721 cgacatactg tatggcgaaa cagccttagt ggatgccgag aggcatttcc tccgtatgcg
     9781 tcggttatcg gcaccagaga cactgaactg gaaaagtttc aagcagggaa tgcttgtgtg
     9841 ccatcaggct tttttccccc gccatacact tatcgagcct tatgatctgc aatatcgttt
     9901 ctcggcggat ttcgattggt gtatccgcat catgaaaaaa gcacgtactt ttcacaatac
     9961 tcaccttatc ctgattgatt atctggcaga aggcatgacg acacaaaatc ataaggcatc
    10021 gcttttggaa cgattccgca tcatgacccg ccactatggc ctgctaagta ccctcgcaca
    10081 tcacgcatgg tttgtggtaa gaagtttctc ccgcaactca gctactcctt ccgatgcacc
    10141 cttctga
//
