LOCUS       CR626927                8827 bp    DNA     linear   BCT 06-FEB-2015
DEFINITION  Bacteroides fragilis NCTC 9343, complete genome.
ACCESSION   CR626927
VERSION     CR626927.1
DBLINK      BioProject: PRJNA46
            BioSample: SAMEA1705957
KEYWORDS    complete genome.
SOURCE      Bacteroides fragilis NCTC 9343
  ORGANISM  Bacteroides fragilis NCTC 9343
            Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
            Bacteroides.
REFERENCE   1  (bases 1 to 8827)
  AUTHORS   Cerdeno-Tarraga,A.M., Patrick,S., Crossman,L.C., Blakely,G.,
            Abratt,V., Lennard,N., Poxton,I., Duerden,B., Harris,B., Quail,M.A.,
            Barron,A., Clark,L., Corton,C., Doggett,J., Holden,M.T., Larke,N.,
            Line,A., Lord,A., Norbertczak,H., Ormond,D., Price,C.,
            Rabbinowitsch,E., Woodward,J., Barrell,B. and Parkhill,J.
  TITLE     Extensive DNA inversions in the B. fragilis genome control variable
            gene expression
  JOURNAL   Science 307 (5714), 1463-1465 (2005)
   PUBMED   15746427
REFERENCE   2  (bases 1 to 8827)
  AUTHORS   Cerdeno-Tarraga,A.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2004) Cerdeno-Tarraga A.M., submitted on behalf of
            the Pathogen Sequencing Unit, Sanger Institute, Wellcome Trust
            Genome Campus, Hinxton, Cambridge CB10 1SA E-mail: amct@sanger.ac.uk
COMMENT     Accession number for plasmid pBF9343 in this genome project:
            CR626928.
FEATURES             Location/Qualifiers
     source          1..8827
                     /organism="Bacteroides fragilis NCTC 9343"
                     /mol_type="genomic DNA"
                     /culture_collection="ATCC:25285"
                     /culture_collection="NCTC:9343"
                     /type_material="type strain of Bacteroides fragilis"
                     /db_xref="taxon:272559"
     misc_feature    <1..8824
                     /note="short region involved with PS synthesis"
     gene            <1..126
                     /locus_tag="BF9343_4184"
     CDS             <1..126
                     /locus_tag="BF9343_4184"
                     /old_locus_tag="BF4298"
                     /note="Similar to Escherichia coli O-antigen repeat unit
                     transporter Wzx SWALL:Q9RP63 (EMBL:AF172324) (473 aa) fasta
                     scores: E(): 8.4e-40, 27.96% id in 472 aa, and to
                     Bacteroides thetaiotaomicron putative transmembrane
                     transport protein, putative lipopolysaccharide biosynthesis
                     protein BT2934 SWALL:Q8A3M0 (EMBL:AE016938) (482 aa) fasta
                     scores: E(): 4.7e-108, 54.41% id in 476 aa, and to
                     Bacteroides thetaiotaomicron putative lipopolysaccharide
                     biosynthesis protein BT1717 SWALL:Q8A708 (EMBL:AE016933)
                     (494 aa) fasta scores: E(): 1.9e-47, 31.94% id in 479 aa"
                     /codon_start=1
                     /transl_table=11
                     /product="putative O-antigen repeat unit transporter"
                     /protein_id="CAH09965.1"
                     /db_xref="EnsemblGenomes-Gn:BF9343_4184"
                     /db_xref="EnsemblGenomes-Tr:CAH09965"
                     /db_xref="GOA:Q5L7I7"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q5L7I7"
                     /translation="MAEQSLKEKTAKGLFWGGFSNGIQQLLNLLFGIIITRMLDSTDYG
                     MIGMLAIFTAVANSIQESGFTAALANKQTFRHEDYNAVFWFSFLMGASLYLLLFFCAPF
                     IAAFYKTPQLIPLSRFLFLGFLISSCGTAHNAVLFKKLMVKEKAKATITALLCSGTIGI
                     VMAYNGMAFWGLAVQQITYIFIANALLWYFSPWRPTFSFNFKPIREMLPFSSKLLITNV
                     FHYINDNIFSVLLGRFYTSQDVGYYTQANKWTNMGFSLISNMINGVSQPVLVETSSDAM
                     RQKNIFRKMLRFTAFISFPAMFGLALIANEFIVIAVTAKWQACVPIMQILCIWGAFVPI
                     TYMYSNLLISKGKSNLFMWNTIAQSLVQLTMLLCTISQGILVMAVIYTVINIGWLLIWH
                     YFVNKQIHITLWEVMKDITPYLLISGGVIGTSYFLTIGFHNLYVLLILKIGIAVSLYVF
                     IMWIGKSVIFFESVQFIRKKLLK"
     misc_feature    1..69
                     /locus_tag="BF9343_4184"
                     /note="11 probable transmembrane helices predicted for
                     BF4298 by TMHMM2.0 at aa 39-61, 71-90, 110-132, 142-164,
                     177-199, 204-221, 320-342, 352-374, 405-427, 442-461 and
                     466-488"
     gene            130..1317
                     /locus_tag="BF9343_4185"
     CDS             130..1317
                     /locus_tag="BF9343_4185"
                     /old_locus_tag="BF4299"
                     /note="Similar to Yersinia enterocolitica LPS biosynthesis
                     WbcM protein SWALL:Q56916 (EMBL:Z47767) (358 aa) fasta
                     scores: E(): 2.8e-10, 27.47% id in 222 aa, and to
                     Bacteroides thetaiotaomicron putative glycosyltransferase
                     hi1698 BT1352 SWALL:AAO76459 (EMBL:AE016931) (389 aa) fasta
                     scores: E(): 7.6e-24, 28.77% id in 351 aa, and to
                     Bacteroides thetaiotaomicron putative glycosyltransferase
                     BT1180 SWALL:AAO76287 (EMBL:AE016930) (384 aa) fasta
                     scores: E(): 1.4e-15, 27.92% id in 333 aa"
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="CAH09966.1"
                     /db_xref="EnsemblGenomes-Gn:BF9343_4185"
                     /db_xref="EnsemblGenomes-Tr:CAH09966"
                     /db_xref="GOA:Q5L7I6"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q5L7I6"
                     /translation="MNILIQQTKAFPHRANSFYWFYAQLTEWLTAHGVDSKLYFSYLEL
                     ADSEFENGLLLPDHYSQFYTPRNIEAICRFIIDKQIDVILDYSHVITGDTRKYYLEIKK
                     RNPGIKICTMIHNCPSHTTQLKQYELSTLRFKDVHGPKKLFQWMLPQLYISLLKKVVSH
                     QNRSAYDTLDEVVLLSPAYIPEFKKLIGKKDAWKLSAIPNAIKPVHSNIPIEEKDKEII
                     FVGRMATEKALPKLLKIWGMVQDKLPDWKLTLVGDGPQFGTCRQIIAEKKLKRVCLTGH
                     QMSIPYIDRARILCLTSVIEGLPTVFTEAMSLGVIPIGFDSFNAIYDMIDDGIDGFIIP
                     DNNYEQYAETILRLAQNDTLRCRIAYKAQKRKNRYDIEQVGPLWMETFRKHGLIK"
     misc_feature    739..1242
                     /locus_tag="BF9343_4185"
                     /note="Pfam match to entry PF00534 Glycos_transf_1,
                     Glycosyl transferases group 1, score 112.1, E-value
                     9.2e-31"
     gene            1327..2337
                     /locus_tag="BF9343_4186"
     CDS             1327..2337
                     /locus_tag="BF9343_4186"
                     /old_locus_tag="BF4300"
                     /note="Similar to Methylobacillus sp. 12S exopolysaccharide
                     biosynthesis protein EpsR SWALL:BAC55146 (EMBL:AB062506)
                     (312 aa) fasta scores: E(): 3.6e-05, 21.51% id in 237 aa"
                     /codon_start=1
                     /transl_table=11
                     /product="GT0|GT94"
                     /protein_id="CAH09967.1"
                     /db_xref="EnsemblGenomes-Gn:BF9343_4186"
                     /db_xref="EnsemblGenomes-Tr:CAH09967"
                     /db_xref="UniProtKB/TrEMBL:Q5L7I5"
                     /translation="MKVTIYPYSINKGDIRVNPYISDFIHALQQNGITIANPPHKNPLF
                     SLIPRKADSDAYIFHWPENVPDYKYGMLQTLAAIWLLFKIKCHHKKIIWFLHNKQPHVM
                     KHRWSKKLLIHLLLRKADLIVTHATEGIKVVQDQYPKAVAKTVFLHHPTKNRIEEYIPQ
                     PPETDLLIWGNISRYKGVPEFVRFATQHSLKLKTKIIGKCSSQELLEELRKESNEMISI
                     EDRSIPFEELKQEIRRSRFVLVPYAAESILSSGILMDSLSFGAKVIGPAVGSFRDYAAE
                     PLLNVYTFHTFDDIQELVDKANEATDIAGYNRFLNVHSWNEFGKKFQNLLQKIIQ"
     gene            2337..3536
                     /locus_tag="BF9343_4187"
     CDS             2337..3536
                     /locus_tag="BF9343_4187"
                     /old_locus_tag="BF4301"
                     /note="Similar to Shigella dysenteriae
                     galactosyltransferase RfpB SWALL:Q53452 (EMBL:S73325) (377
                     aa) fasta scores: E(): 2.6e-07, 25.11% id in 223 aa, and to
                     Bacteroides thetaiotaomicron putative glycosyltransferase
                     BT2938 SWALL:AAO78044 (EMBL:AE016938) (408 aa) fasta
                     scores: E(): 4e-125, 75.43% id in 399 aa, and to
                     Clostridium perfringens probable hexosyltransferase CPE0499
                     SWALL:Q8XN39 (EMBL:AP003187) (375 aa) fasta scores: E():
                     5.4e-14, 27.77% id in 252 aa"
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="CAH09968.1"
                     /db_xref="EnsemblGenomes-Gn:BF9343_4187"
                     /db_xref="EnsemblGenomes-Tr:CAH09968"
                     /db_xref="GOA:Q5L7I4"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q5L7I4"
                     /translation="MKVLYTFGGMPHYLNAMLNKLHNKGVEITVITPQKGNATIGKGVK
                     MVKGGTYRHLTAIEKKAFYGKSAYPSLPEIVREEKPDILIMGWPYFLQVFFQPRLRKAM
                     KECRTRLVIREIPFQTPPYGKIKEYFHENPMYDENMRLVSTGTGFYLKQWLTAKIRKYC
                     YARITGTLNYSTAAYDILPSYGVKQEQIHVTYNSTDTDALLKEKEAVLTSPPLLPPSSK
                     RALHIGRLVKWKRVDLLIDAFTKVIASHPDAELVVVGDGPELDNLKKQAADLNLTEQVR
                     FIGAVYSPKELGAYMNESTVYVLAGMGGLSINDAMTYGLPVVCSVCDSTERDLVTDGVN
                     GLFFKEGNADSLSDKLNKLFASPERCASMGRESERIIREKINIETVSKRYLQAFRTFMQ
                     "
     misc_feature    2958..3464
                     /locus_tag="BF9343_4187"
                     /note="Pfam match to entry PF00534 Glycos_transf_1,
                     Glycosyl transferases group 1, score 138.2, E-value
                     1.3e-38"
     gene            3605..4252
                     /locus_tag="BF9343_4188"
     CDS             3605..4252
                     /locus_tag="BF9343_4188"
                     /old_locus_tag="BF4302"
                     /note="no significant database matches"
                     /codon_start=1
                     /transl_table=11
                     /product="putative transmembrane protein"
                     /protein_id="CAH09969.1"
                     /db_xref="EnsemblGenomes-Gn:BF9343_4188"
                     /db_xref="EnsemblGenomes-Tr:CAH09969"
                     /db_xref="GOA:Q5L7I3"
                     /db_xref="UniProtKB/TrEMBL:Q5L7I3"
                     /translation="MTDLTILIAVIALALWPIVFLISRILHERNKRAKPSGDTASAETE
                     EVTEEMTTSALIMSILQQLGCQPEVNEENHISFKYQGDDFLVAAEDGLRLIIVWNPWWA
                     SISIDNQALPYLKEIINAVNMNSLVTTVYALDEDEKTFGIHSKCHMLFAPEEEEPEKSF
                     TDLLDSFFTTHNTIKENLKQLGNGMPDMEKKERVRIKGFAAYKDNSTELKGE"
     misc_feature    3614..3682
                     /locus_tag="BF9343_4188"
                     /note="1 probable transmembrane helix predicted for BF4302
                     by TMHMM2.0 at aa 4-26"
     gene            complement(4304..5434)
                     /locus_tag="BF9343_4189"
     CDS             complement(4304..5434)
                     /locus_tag="BF9343_4189"
                     /old_locus_tag="BF4303"
                     /EC_number="5.1.3.14"
                     /note="Similar to Salmonella typhimurium
                     UDP-N-acetylglucosamine 2-epimerase WecB or RffE or STM3920
                     or STMd1.70 SWALL:WECB_SALTY (SWALL:Q9L6R5) (376 aa) fasta
                     scores: E(): 2.4e-85, 61.29% id in 372 aa, and to
                     Bacteroides thetaiotaomicron putative
                     UDP-N-acetylglucosamine 2-epimerase BT2944 SWALL:AAO78050
                     (EMBL:AE016938) (376 aa) fasta scores: E(): 1.8e-125,
                     88.77% id in 374 aa, and to Acinetobacter lwoffii putative
                     UDP-N-acetylglucosamine 2-epimerase WeeA SWALL:Q9RMD6
                     (EMBL:AJ243431) (376 aa) fasta scores: E(): 2.6e-86, 60.9%
                     id in 376 aa"
                     /codon_start=1
                     /transl_table=11
                     /product="putative UDP-N-acetylglucosamine 2-epimerase"
                     /protein_id="CAH09970.1"
                     /db_xref="EnsemblGenomes-Gn:BF9343_4189"
                     /db_xref="EnsemblGenomes-Tr:CAH09970"
                     /db_xref="GOA:Q5L7I2"
                     /db_xref="InterPro:IPR003331"
                     /db_xref="InterPro:IPR029767"
                     /db_xref="UniProtKB/TrEMBL:Q5L7I2"
                     /translation="MKKILLVFGTRPEAIKMAPLVKALQRDTEHFETKVCVTAQHRQML
                     DQVLEVFDIIPDYDLNIMAPNQDLYDITTKVLLGLRDVLKDFCPDTVLVHGDTTTSMAA
                     SLAAFYRQVAVGHVEAGLRTYDMLSPWPEEMNRQVTDRICTYYFAPTGKSKQNLLQENI
                     DAKKIFVTGNTVIDALLMAVDIISKKPGIKEKLHQELRDKGYEVGQREYILVTGHRREN
                     FGEGFLHICKAIRELAALHPEMDIVYPVHLNPNVQKPVYELLSGVDNVYLISPLDYLPF
                     IYAMQHSTLLLTDSGGVQEEAPSLGKPVLVMRNTTERPEAVEAGTVKLVGTDAEAIVSN
                     VTELLRNKELYRRMSETHNPYGDGHACERILSVLTR"
     misc_feature    complement(4310..5371)
                     /locus_tag="BF9343_4189"
                     /note="Pfam match to entry PF02350 Epimerase_2,
                     UDP-N-acetylglucosamine 2-epimerase, score 567.3, E-value
                     8.3e-168"
     gene            complement(5489..6691)
                     /locus_tag="BF9343_4190"
     CDS             complement(5489..6691)
                     /locus_tag="BF9343_4190"
                     /old_locus_tag="BF4304"
                     /note="Similar to Escherichia coli
                     UDP-N-acetyl-D-mannosamine dehydrogenase WecC or RffD or
                     b3787 SWALL:WECC_ECOLI (SWALL:P27829) (420 aa) fasta
                     scores: E(): 2.6e-75, 54.56% id in 394 aa, and to
                     Bacteroides thetaiotaomicron UDP-N-acetyl-D-mannosamine
                     dehydrogenase BT2945 SWALL:AAO78051 (EMBL:AE016938) (400
                     aa) fasta scores: E(): 1.3e-139, 89% id in 400 aa, and to
                     Bacteroides fragilis UDP-ManNAc dehydrogenase MnaB
                     SWALL:Q9RGJ9 (EMBL:AF125164) (408 aa) fasta scores: E():
                     7.1e-101, 65.65% id in 396 aa"
                     /codon_start=1
                     /transl_table=11
                     /product="putative UDP-N-acetyl-D-mannosamine
                     dehydrogenase"
                     /protein_id="CAH09971.1"
                     /db_xref="EnsemblGenomes-Gn:BF9343_4190"
                     /db_xref="EnsemblGenomes-Tr:CAH09971"
                     /db_xref="GOA:Q5L7I1"
                     /db_xref="InterPro:IPR001732"
                     /db_xref="InterPro:IPR008927"
                     /db_xref="InterPro:IPR014026"
                     /db_xref="InterPro:IPR014027"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR017476"
                     /db_xref="InterPro:IPR028359"
                     /db_xref="UniProtKB/TrEMBL:Q5L7I1"
                     /translation="MKKVVFLGLGYIGLPTAAVAAGHGYEVVGVDVNPSVVETINQGKI
                     HIVEPELDQIVKEVVRTGNLRAVSKPEQADAFFVVVPTPFKQNHRADITYVESATRSVI
                     PYLREGNLFVIESTSPVFTTERMAEVIYKERPELKDKIYIAYCPERVLPGNTLYELVHN
                     DRVIGGVNPESTAKAIEFYSAFVQGKLHPTNARTAEMCKLTENSSRDSQIAFANELSMI
                     CDKAGINVWELIELANKHPRVNILQPGCGVGGHCIAVDPWFIVSDYPEQAQIIKRARET
                     NDYKADWCANKVMEACQQFVEKNDREPVVACMGLAFKPNIDDLRESPAKYIASRIVSES
                     RAEVLIVEPNVASHASFHLTDYREAYQKADIVVWLVRHTPFVELPREESKLELDFCGVR
                     K"
     misc_feature    complement(5507..5761)
                     /locus_tag="BF9343_4190"
                     /note="Pfam match to entry PF03720 UDPG_MGDP_dh_C,
                     UDP-glucose/GDP-mannose dehydrogenase family, UDP binding
                     domain, score 59.3, E-value 7.3e-15"
     misc_feature    complement(5837..6109)
                     /locus_tag="BF9343_4190"
                     /note="Pfam match to entry PF00984 UDPG_MGDP_dh,
                     UDP-glucose/GDP-mannose dehydrogenase family, central
                     domain, score 130.2, E-value 3.1e-36"
     misc_feature    complement(6131..6688)
                     /locus_tag="BF9343_4190"
                     /note="Pfam match to entry PF03721 UDPG_MGDP_dh_N,
                     UDP-glucose/GDP-mannose dehydrogenase family, NAD binding
                     domain, score 236.4, E-value 3.5e-68"
     misc_feature    complement(6632..6691)
                     /locus_tag="BF9343_4190"
                     /note="Signal peptide predicted for BF4304 by SignalP 2.0
                     HMM (Signal peptide probability 0.989) with cleavage site
                     probability 0.925 between residues 20 and 21"
     gene            6796..8061
                     /locus_tag="BF9343_4191"
     CDS             6796..8061
                     /locus_tag="BF9343_4191"
                     /old_locus_tag="BF4305"
                     /note="Similar to Vibrio cholerae O37 glysosyl-transferase
                     SWALL:Q8L354 (EMBL:AF390573) (409 aa) fasta scores: E():
                     3.5e-21, 24.1% id in 419 aa, and to Bacteroides
                     thetaiotaomicron putative glycosyltransferase BT2946
                     SWALL:Q8A3K8 (EMBL:AE016938) (421 aa) fasta scores: E():
                     7.5e-143, 80.99% id in 421 aa, and to Anabaena sp.
                     hypothetical protein ALL4426 SWALL:Q8YNY3 (EMBL:AP003596)
                     (417 aa) fasta scores: E(): 3.8e-43, 34.98% id in 423 aa"
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="CAH09972.1"
                     /db_xref="EnsemblGenomes-Gn:BF9343_4191"
                     /db_xref="EnsemblGenomes-Tr:CAH09972"
                     /db_xref="GOA:Q5L7I0"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q5L7I0"
                     /translation="MRVLIINTSERLGGAAVAASRLMESLKNNGIKAKMLVRDKQTDQI
                     SVVGLQRNWWQVWRFVWERIVIWKANRFKKNNLFAVDIANTGTDITSLPEFQQADVIHL
                     HWVNQGMLSLNDIRKILKSGKPVVWTMHDMWPCTGICHHARECTNYHQECNHCPYLYGG
                     GSKKDLSNRIFRKKQQLYKEAPITFVTCSQWLKGQAEKSALLTGETVISIPNPINTNLF
                     KPRNKKEARSKCHLPQNGKLILFGSAKITDKRKGIDYLIESCKLLAEKHPELKDSLSVV
                     VFGKQSEQLKPLLPFKVYPLNYVSNEHELVDVYNAVDLFVTPSLEENLPNTIMEAMACG
                     VPCIGFNVGGIPEMIDHLHNGYVAQYKSSEDFANGIYWALTDPDYPSLSEQANRKVIAN
                     YSEGIIAKRYIDVYNKITGRYA"
     misc_feature    7474..7983
                     /locus_tag="BF9343_4191"
                     /note="Pfam match to entry PF00534 Glycos_transf_1,
                     Glycosyl transferases group 1, score 113.0, E-value 5e-31"
     gene            8054..8827
                     /locus_tag="BF9343_4192"
     CDS             8054..8827
                     /locus_tag="BF9343_4192"
                     /old_locus_tag="BF4306"
                     /note="Similar to Methanosarcina mazei glycosyltransferase
                     involved in cell wall biogenesis MM0653 SWALL:Q8PZ41
                     (EMBL:AE013290) (248 aa) fasta scores: E(): 1.6e-22, 32.52%
                     id in 246 aa, and to Bacteroides thetaiotaomicron putative
                     glycosyltransferase BT2947 SWALL:AAO78053 (EMBL:AE016938)
                     (251 aa) fasta scores: E(): 8.1e-83, 81.14% id in 244 aa,
                     and to Helicobacter pylori J99 putative jhp0094
                     SWALL:Q9ZMX1 (EMBL:AE001448) (260 aa) fasta scores: E():
                     7.5e-22, 37.03% id in 216 aa. CDS overlapping 20 amino
                     acids with the downstream CDS"
                     /codon_start=1
                     /transl_table=11
                     /product="GT2|GT2_Glycos_transf_2"
                     /protein_id="CAH09973.1"
                     /db_xref="EnsemblGenomes-Gn:BF9343_4192"
                     /db_xref="EnsemblGenomes-Tr:CAH09973"
                     /db_xref="GOA:Q5L7H9"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="InterPro:IPR029044"
                     /db_xref="UniProtKB/TrEMBL:Q5L7H9"
                     /translation="MHSHPSPKFSVITVTYNAEKVLEDTVQSVISQTYHHVEYIIIDGA
                     SKDGTLEIVNRYRNRINQLVSEPDKGLYDAMNKGIALATGDYLCFLNAGDSFHEDDTLQ
                     KMVHSINGNELPDILYGETALVDAERHFLRMRRLSAPETLNWKSFKQGMLVCHQAFFPR
                     HTLIEPYDLQYRFSADFDWCIHIMKKARTFHNTHLILIDYLAEGMTTQNHKASLLERFR
                     IMTRHYGLLSTLAHHAWFVVRSFSRNSATPSDAPF"
     misc_feature    8081..8566
                     /locus_tag="BF9343_4192"
                     /note="Pfam match to entry PF00535 Glycos_transf_2,
                     Glycosyl transferase, score 107.5, E-value 2.2e-29"
     gene            complement(8761..>8827)
                     /gene="cobB"
                     /locus_tag="BF9343_4193"
     CDS             complement(8761..>8827)
                     /gene="cobB"
                     /locus_tag="BF9343_4193"
                     /old_locus_tag="BF4307"
                     /note="Similar to Salmonella typhimurium, and Salmonella
                     typhi CobB protein or STM1221 or STY1261 or t1699
                     SWALL:COBB_SALTY (SWALL:P97013) (273 aa) fasta scores: E():
                     1.4e-27, 44.62% id in 242 aa, and to Bacteroides
                     thetaiotaomicron putative nicotinate
                     mononucleotide:5,6-dimethylbenzimidazole
                     phosphoribosyltransferase BT2975 SWALL:Q8A3H9
                     (EMBL:AE016938) (234 aa) fasta scores: E(): 6.5e-78, 83.55%
                     id in 231 aa, and to Helicobacter pylori J99 putative
                     Jhp1180 SWALL:Q9ZJW8 (EMBL:AE001545) (234 aa) fasta scores:
                     E(): 1.1e-42, 51.08% id in 231 aa. CDS overlapping 20 amino
                     acids with the upstream CDS."
                     /codon_start=3
                     /transl_table=11
                     /product="putative nicotinate
                     mononucleotide:5,6-dimethylbenzimidazole
                     phosphoribosyltransferase"
                     /protein_id="CAH09974.1"
                     /db_xref="EnsemblGenomes-Gn:BF9343_4193"
                     /db_xref="EnsemblGenomes-Tr:CAH09974"
                     /db_xref="GOA:Q5L7H8"
                     /db_xref="InterPro:IPR003000"
                     /db_xref="InterPro:IPR026590"
                     /db_xref="InterPro:IPR026591"
                     /db_xref="InterPro:IPR027546"
                     /db_xref="InterPro:IPR029035"
                     /db_xref="UniProtKB/TrEMBL:Q5L7H8"
                     /translation="MKNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARD
                     PELVTHFYNERRKQLLEVEPNRGHELLAELEKDFQVTIVTQNIDNLHERAGSSHIIHLH
                     GELTKVCSSRDPNNPHYIKELKPEEFEVKIGDLAGDGSQLRPFIVWFGESVPEIETAID
                     WVEKADVFVIIGTSMNVYPAAGLLNYVPRNAEIYLIDPKPVDVHSSRPIHVIQKGASEG
                     VAELREKLLTTNHA"
ORIGIN
        1 ctatatgtat tgctgattct taaaatagga atagccgtaa gcctttatgt gttcatcatg
       61 tggatcggca aatcggtgat cttttttgaa agtgtacaat ttatccggaa aaaactcttg
      121 aaataagtca tgaacatcct gatccaacaa accaaagcat ttcctcatcg tgccaatagc
      181 ttttattggt tctatgcgca actgaccgaa tggctgactg cacacggagt ggacagtaag
      241 ctttactttt cgtacctgga actggctgac agcgaatttg agaacggcct cctgttgccc
      301 gatcattatt ctcaattcta tacaccccgc aacatcgaag caatctgtcg cttcattatc
      361 gacaaacaga tagacgtgat tctcgattac tcccatgtca tcaccggaga tacacgcaaa
      421 tattacctcg aaatcaaaaa aagaaatccc ggaatcaaaa tatgcacgat gatccacaac
      481 tgtcccagcc atacgacaca gttaaaacaa tacgagttat ctacactccg gttcaaagac
      541 gtgcatggac ccaagaaact ttttcagtgg atgctaccac aactctacat cagcttatta
      601 aaaaaagtgg tcagccatca aaaccgttcg gcatacgaca cgctcgacga agtggtactg
      661 ctgtcacccg cttatatacc cgaattcaag aaacttatag gcaaaaaaga cgcatggaag
      721 ttatctgcca tccctaatgc cataaaacct gtgcatagta acatcccgat tgaggagaag
      781 gacaaagaaa tcatctttgt tggcagaatg gcaaccgaaa aggcattacc caaattacta
      841 aagatatggg gtatggttca ggataaactg ccggactgga aactcaccct tgtaggagat
      901 ggtccccaat tcggcacgtg ccggcaaatt attgccgaga aaaaattgaa gcgggtctgc
      961 ctgaccggcc atcagatgtc gatcccctat atagaccgtg cccggattct ttgtctgact
     1021 tccgtcatag aaggactacc caccgtattt acagaagcaa tgtcactggg ggtgattcct
     1081 atcggattcg attctttcaa tgcgatctat gacatgatag atgacggcat agacggattc
     1141 attattcccg acaacaatta tgaacaatat gcagaaacca ttctacggtt ggcacaaaat
     1201 gacacactcc gctgccggat agcctacaaa gctcaaaagc ggaaaaacag atatgacata
     1261 gaacaggtag gaccactgtg gatggaaact ttccgtaaac atggattaat taaataggag
     1321 aacacaatga aggtcacgat atatccatac tctatcaaca aaggtgatat acgcgttaat
     1381 ccgtatatca gcgacttcat ccatgcactg caacagaacg gaatcacaat tgccaatccc
     1441 ccgcacaaga atccgttatt cagcctcatc ccaagaaaag cagatagcga tgcttatatc
     1501 tttcattggc cggagaatgt acccgactac aaatatggaa tgttgcagac tcttgctgct
     1561 atctggcttc ttttcaaaat taaatgccac cataagaaga tcatctggtt cttgcacaat
     1621 aagcagcccc atgtgatgaa acaccgatgg tcgaaaaagt tattgataca tctgctcctc
     1681 cgcaaagccg atttgatagt gacacatgct acagaaggta tcaaagtggt tcaggatcaa
     1741 tatccgaagg ctgtagccaa aacggtattc ttgcatcacc ctactaaaaa ccggatagaa
     1801 gaatacatcc cccaaccacc ggaaaccgac ctgctgatct ggggaaatat ctcccgatac
     1861 aaaggggtac cggaattcgt acgttttgct actcagcatt cattaaaact gaagactaaa
     1921 atcatcggga aatgcagttc gcaggaactc ctggaagaac tacgcaaaga aagtaatgag
     1981 atgatcagca tagaggaccg tagtattcct ttcgaagagc taaaacaaga gatccgcaga
     2041 tcacgtttcg tactggtacc ttatgctgcc gagtctatct taagttccgg catactgatg
     2101 gactctctct cattcggagc caaagtcatc ggaccggctg taggctcttt cagggactac
     2161 gccgccgaac ccttgcttaa tgtatatact ttccatacgt tcgatgatat acaggaactc
     2221 gttgacaagg caaacgaagc aacagatata gccggttaca accggttcct caatgtacat
     2281 agctggaacg aattcggcaa aaagtttcaa aatttacttc agaaaataat acagtaatga
     2341 aagtactcta tacattcggc ggcatgcccc attatctgaa tgccatgctc aacaaacttc
     2401 ataacaaagg agtggaaatc accgttatca ctcctcaaaa aggaaatgcc actatcggta
     2461 aaggtgtaaa aatggtaaag ggaggaacat acaggcacct caccgccatt gagaagaaag
     2521 cattctacgg aaaaagcgcc tatccctccc taccggaaat agtacgtgaa gagaaaccgg
     2581 atattctgat aatgggatgg ccctatttcc tgcaagtgtt ctttcaaccc cgattgagaa
     2641 aggctatgaa agagtgccgg acacggttgg ttatccgtga aattcccttc cagacccctc
     2701 cctacgggaa aataaaagaa tatttccatg aaaacccgat gtatgatgaa aacatgcggc
     2761 tggtcagtac cggaaccggc ttttatctta aacaatggct gacagcgaaa atacgtaaat
     2821 actgctacgc acgcattacc ggaacgctga attactcgac cgctgcatac gatattcttc
     2881 cttcctatgg agtgaagcag gagcaaatac atgtcactta caactctacg gacacagatg
     2941 ccttactgaa ggagaaagaa gccgtactca cctcgccccc gcttcttcct ccttcctcca
     3001 aaagagcgct acacatcggc cgattagtga aatggaaaag ggtggatctg ctgatcgatg
     3061 catttacaaa ggttattgcc agtcatccgg acgcggaact ggtagtggta ggcgatggac
     3121 cggagctgga taacctgaaa aaacaggcag ccgacctgaa tctgacagaa caggttcgat
     3181 tcatcggtgc agtatacagt cccaaagaac tgggagccta tatgaatgaa tcgactgtct
     3241 atgtactcgc gggcatggga ggattatcca tcaatgatgc catgacctac ggactgcccg
     3301 tggtttgttc ggtatgcgac agcaccgaac gtgacctggt aacggacgga gtgaacggac
     3361 ttttcttcaa agaaggcaat gccgacagct tgagcgacaa gctcaacaaa ctgtttgcct
     3421 ctcccgaacg ttgtgcctct atgggacgtg agtcagaacg aatcatccgc gagaaaatca
     3481 acattgaaac ggtcagcaaa cgttatttgc aagctttccg aacttttatg cagtaaaaat
     3541 ggagtacgac caaaaagaat gattatcttt aggcagacat taatcattta atagctctac
     3601 tactatgacc gatcttacca ttctcatcgc agtcatcgca ttggcgttat ggccaattgt
     3661 attcctgata tcacgtatcc tgcacgagcg gaacaaacgt gcgaagccat cgggtgacac
     3721 tgcctctgcc gaaacggaag aagtgacaga ggaaatgact acctccgcac tgatcatgag
     3781 catccttcaa cagctcggtt gccaaccgga agtgaatgaa gaaaatcata tcagcttcaa
     3841 gtatcaggga gacgatttcc ttgtcgcagc cgaagacggt ctccggttaa tcattgtatg
     3901 gaatccttgg tgggcgtcca tcagtatcga caatcaggca ttaccctatc tgaaagaaat
     3961 tatcaatgca gtcaatatga actcattagt gaccactgtc tatgcgctgg acgaggatga
     4021 aaaaacattt ggtatccaca gtaaatgcca tatgctcttc gctcccgaag aagaggagcc
     4081 ggaaaaaagt ttcaccgacc tgctggacag ttttttcact acccacaata ctattaaaga
     4141 aaacctgaaa caattgggta acggaatgcc ggatatggaa aagaaagaac gagtaagaat
     4201 caaaggattt gctgcctaca aggacaacag cacggaactg aaaggggaat aaacttcccc
     4261 tcttcctctt gcccgtacag cctataaacg aatcatgtga gctttaacgg gttaataccg
     4321 acaggatgcg ttcacaagca tgcccgtcac cataaggatt atgtgtttcg gacatacgac
     4381 ggtataactc cttattacgg agcagctcag tcacattact gacaatcgcc tcagcatccg
     4441 tccccaccag ttttacagtt cccgcctcta ctgcttccgg acgttccgtg gtatttcgca
     4501 tcaccaacac cggcttgcca agtgaaggag cctcctcttg tactccaccg ctatcggtca
     4561 gcagcaaagt ggagtgctgc atagcgtaaa taaacggcag ataatccaac ggcgaaataa
     4621 gatatacatt gtctactcct gacagaagtt cgtatacggg tttctgtaca ttcgggttca
     4681 gatgtaccgg atatacaata tccatctcgg gatgcaacgc ggctaattct ctaatcgctt
     4741 tacaaatatg taaaaatcct tccccaaagt tctcacgacg atgcccggta accagaatat
     4801 attcacgttg tcccacttcg taacctttgt cacgaagttc ctgatgcaac ttttctttga
     4861 ttcccggctt cttcgaaata atgtcaacag ccatcaacaa agcatcgata accgtattac
     4921 cggtaacaaa tatcttcttt gcatcgatgt tttcctgtaa cagattctgt ttcgatttcc
     4981 cggtaggagc aaaatagtag gtacaaatac ggtcggtcac ctgacgattc atctcttccg
     5041 gccagggaga cagcatatca taggtacgca aaccggcctc aacatgtccc acggcaacct
     5101 gccgatagaa tgcagccagt gaagcggcca tcgacgtagt ggtatctccg tgtaccagca
     5161 ccgtatccgg acagaaatct ttcagcacat cgcgcaggcc cagaagaact ttagtggtga
     5221 tgtcgtacaa gtcctggttg ggtgccataa tattcagatc gtagtcagga atgatgtcga
     5281 acacttcaag tacctggtcc aacatctgac gatgttgtgc cgtcacacac actttcgttt
     5341 caaagtgttc agtatctctt tgcaaggctt tcaccaacgg ggccatctta atggcctcag
     5401 gacgggtacc gaaaacaagt aatatctttt tcattatacg atcagactat ttacgatggt
     5461 tcattaagac gatatgccag ttctctttct actttcttac tccgcagaag tccaactcca
     5521 atttactttc ttcacggggc aactccacaa acggagtgtg acgtaccagc cataccacga
     5581 tatccgcttt ctgataagcc tcccgatagt cagtcagatg gaaactggca tgtgaagcga
     5641 cattgggttc tacaatcagc acctctgcac gcgactcaga tacaatgcgg gaagcaatat
     5701 atttagcagg agattcacgc aaatcatcaa tattgggttt aaaggcaagt cccatgcaag
     5761 ccactaccgg ttcacgatcg ttcttctcga caaattgctg acaagcttcc attactttgt
     5821 tggcacacca atcagcttta taatcgttcg tctcacgggc acgtttgatg atttgtgcct
     5881 gttcgggata gtccgaaaca ataaaccagg gatctacggc tatacagtgt cctcccactc
     5941 cgcagccggg ttgcaggatg ttcacacgcg gatgtttgtt agccaattct atcagttccc
     6001 agacgttgat acccgctttg tcacaaatca tggacaattc gttggcaaac gcaatctgag
     6061 agtcgcgcga agagttctcg gtcaacttac acatttctgc cgtacgagca ttcgtcgggt
     6121 ggagtttacc ctgtacaaag gcagaataaa actctatggc tttagcggtc gactcgggat
     6181 tgacgccacc gatcacccga tcgttatgaa ctagttcata aagcgtatta cccggcaata
     6241 cacgttcggg acaataggct atgtatattt tgtctttcag ttccgggcgc tctttataaa
     6301 tgacttcagc catacgttcg gtcgtaaata ccggtgaagt ggactcgata acaaacaggt
     6361 ttccttctct cagataagga attacggagc gggtagccga ttccacatag gtgatatctg
     6421 cacggtggtt ttgtttgaaa ggggtaggta ctaccacaaa aaaagcatct gcctgctcag
     6481 gtttcgaaac ggcacggaga ttacctgttc gcaccacctc ttttacaatc tgatccagtt
     6541 ccggctccac aatatgtatt ttaccctgat tgatggtttc tactaccgaa ggattaacat
     6601 ccacacctac aacttcataa ccatgtccgg cggccacggc agcagtagga agtccgatat
     6661 agcctaatcc taaaaaaaca acctttttca tacgtatatc tccttatcta taagtgccgc
     6721 aaaagtacaa ataatatgtg actttgtacg gtttctcacc gaaaaccact acttttgcca
     6781 aaacatttcg atcgaatgag agttttaata atcaatactt ccgaacgttt gggcggagcg
     6841 gccgtcgcag caagccgctt gatggaatcg ttgaaaaaca acggtatcaa agccaaaatg
     6901 ttggtgcgcg acaagcaaac cgaccagatc agcgtagtag gtctgcaacg taactggtgg
     6961 caagtatgga ggtttgtgtg ggaacgcatt gtcatctgga aagccaaccg ctttaagaag
     7021 aacaatcttt tcgcagtcga tatagccaat acaggcacag acattacaag cctgccggag
     7081 tttcagcagg cagatgtcat ccacctgcat tgggtgaatc aaggaatgtt gtcactgaac
     7141 gatatccgga agattctgaa atccggtaaa ccggtagtgt ggaccatgca cgatatgtgg
     7201 ccctgtacag gcatctgcca tcacgcccgt gagtgtacca actaccatca ggagtgtaac
     7261 cactgtccat acctgtatgg agggggaagt aagaaagatc tgtccaaccg tatcttccgt
     7321 aaaaaacaac aactctacaa agaagcaccc attaccttcg tcacttgtag ccaatggctg
     7381 aagggacaag ctgaaaagag tgctttgctg acaggagaaa cggtaatcag tatacctaac
     7441 cccattaaca ccaatctatt taaacccaga aacaagaaag aggcacgtag caaatgccat
     7501 ttaccccaaa acggaaaact gattcttttc ggttcggcca aaatcacgga taaacggaaa
     7561 ggcatcgatt atctgattga atcgtgtaaa ttactggctg agaagcatcc tgaactgaaa
     7621 gattctctaa gtgtagtcgt ttttggcaag caatcggaac aactcaagcc gttgcttcct
     7681 tttaaagtat atccactcaa ctacgtgagt aacgagcatg aactggtaga tgtttacaat
     7741 gcggtcgacc ttttcgttac tccctcactg gaagagaacc tgcccaatac catcatggaa
     7801 gctatggcat gcggagtgcc ttgtatcggc ttcaatgtcg gcggcatccc ggaaatgata
     7861 gaccatctgc acaacgggta tgtggcacaa tacaaatcat ccgaagattt tgccaacggc
     7921 atctattggg cactgaccga cccggattat ccgtctctct cggaacaggc caaccgaaaa
     7981 gtaatcgcca actactcgga aggcattatt gccaaaagat acattgatgt ctacaataaa
     8041 ataacaggaa gatatgcata gccatcccag tcccaaattc tccgtgatca cagtgaccta
     8101 caatgccgaa aaggtattgg aagatactgt gcaaagcgta atttcgcaga cctatcatca
     8161 tgtagagtat atcatcatcg acggtgcatc gaaagacggg actttagaga ttgtcaaccg
     8221 ataccgcaac cgcatcaacc aattggtgag cgaaccggac aaaggacttt atgacgcaat
     8281 gaacaaagga atcgccctgg caacgggcga ctatctctgc tttctgaatg ccggagacag
     8341 tttccacgaa gacgacactt tgcaaaagat ggttcactcc atcaatggaa atgagttgcc
     8401 cgacatactg tatggcgaaa cagccttagt ggatgccgag aggcatttcc tccgtatgcg
     8461 tcggttatcg gcaccggaga cactgaactg gaaaagtttc aagcagggaa tgcttgtgtg
     8521 ccatcaggct tttttccccc gccatacact tatcgagcct tatgatctgc aatatcgttt
     8581 ctcggcggat ttcgattggt gtatccacat catgaaaaaa gcacgtactt ttcacaatac
     8641 tcaccttatc ctgattgatt atctggcaga aggcatgacg acacaaaatc ataaggcatc
     8701 gcttttggaa cgattccgca tcatgacccg ccactatggc ctgctaagta ccctcgcaca
     8761 tcacgcatgg tttgtggtaa gaagtttctc ccgcaactca gctactcctt ccgatgcacc
     8821 cttctga
//
