LOCUS       NC_006347              14280 bp    DNA     linear   CON 04-APR-2020
DEFINITION  Bacteroides fragilis YCH46, complete genome.
ACCESSION   NC_006347
VERSION     NC_006347.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMD00061068
            Assembly: GCF_000009925.1
KEYWORDS    RefSeq.
SOURCE      Bacteroides fragilis YCH46
  ORGANISM  Bacteroides fragilis YCH46
            Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
            Bacteroides.
REFERENCE   1
  AUTHORS   Kuwahara,T., Yamashita,A., Hirakawa,H., Nakayama,H., Toh,H.,
            Okada,N., Kuhara,S., Hattori,M., Hayashi,T. and Ohnishi,Y.
  TITLE     Genomic analysis of Bacteroides fragilis reveals extensive DNA
            inversions regulating cell surface adaptation
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (41), 14919-14924 (2004)
   PUBMED   15466707
REFERENCE   2  (bases 1 to 14280)
  AUTHORS   Hattori,M., Yamashita,A., Toh,H., Oshima,K. and Shiba,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2004) Contact:Masahira Hattori Graduate School of
            Frontier Sciences, University of Tokyo; 5-1-5 Kashiwanoha, Kashiwa,
            Chiba 277-8561, Japan
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 04/04/2020 09:42:13
            Annotation Pipeline               :: NCBI Prokaryotic Genome
            Annotation Method                 :: Best-placed reference protein
            Annotation Software revision      :: 4.11
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
            Genes (total)                     :: 4,454
            CDSs (total)                      :: 4,360
            Genes (coding)                    :: 4,278
            CDSs (with protein)               :: 4,278
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 82
            CDSs (without protein)            :: 82
            Pseudo Genes (ambiguous residues) :: 0 of 82
            Pseudo Genes (frameshifted)       :: 42 of 82
            Pseudo Genes (incomplete)         :: 34 of 82
            Pseudo Genes (internal stop)      :: 28 of 82
            Pseudo Genes (multiple problems)  :: 17 of 82
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence was derived from
            AP006841.
            This work was done in collaboration with Tomomi Kuwahara, Haruyuki
            Nakayama, Natsumi Okada, Yoshinari Ohnishi (University of
            Tokushima), Hideki Hirakawa, Satoru Kuhara (Kyushu University),
            Tetsuya Hayashi (Miyazaki Medical College), and supported by the
            Research for the Future Program of the Japan Society for the
            Promotion of Science.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotation Pipeline (PGAP)
            set; GeneMarkS-2+
            repeat_region
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..14280
                     /organism="Bacteroides fragilis YCH46"
                     /mol_type="genomic DNA"
                     /strain="YCH46"
                     /db_xref="taxon:295405"
     gene            complement(1..588)
                     /locus_tag="BF_RS18570"
                     /old_locus_tag="BF3911"
     CDS             complement(1..588)
                     /locus_tag="BF_RS18570"
                     /old_locus_tag="BF3911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011203508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|H8E4X1|9.B.18.1.2"
                     /protein_id="WP_011203508.1"
                     /translation="MIRFFDIVFSLLGILLLSPVFLFLYIAICLESKGGGFYKQLRVGQ
                     YGRDFYVYKFRSMRVGADKKGLITVGGRDPRITHTGYFIRKYKLDELPQLFNVLKGDMS
                     LVGPRPEVRKYVDLYTDDQKRVLSVRPGITDYASIEYVDENTILGKASDPDKAYIEQIM
                     PDKIRYNMKYICNRSVKEYLKIIFLTFWSIIR"
     gene            complement(620..1843)
                     /locus_tag="BF_RS18575"
                     /old_locus_tag="BF3912"
     CDS             complement(620..1843)
                     /locus_tag="BF_RS18575"
                     /old_locus_tag="BF3912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005786175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="WP_011203509.1"
                     /translation="MKIPFSPPYIDEAVINEVVDSLRSGWITSGPKVKALEKEIKSFSG
                     AKEVLCVNSWTSGAIMMLRWLGVKEGDEVIVPAYTYSATALAVLHAGAKPVMVDSGMDF
                     NISVEAVRKAITAKTKAIIPVDIAGFPCDYEKIMALVQEPGMIKLFRAESPVQEKLGRI
                     LVMNDAAHSLGARYSNRQRTGCETDVAIFSLHAVKNVTTAEGGAICLNLPKPFDNAELY
                     KELRMMSLNCQTKDAFSKSKAGGWRYDIVGFGMKINMADVNAAIGLAQIREYPELLKER
                     KRVFNTYNDAFSTCDWAIVPPSVDGEKESSYHIYALRVKDFTEEQRDRMIGEIAKREVA
                     VNVHFIPMPMLSFFKSMGYAMNDYPQAYQNFKGEISLPIYPQLDSEKLNFIIDTVKAAY
                     TTVIAENR"
     gene            complement(1851..2456)
                     /locus_tag="BF_RS18580"
                     /old_locus_tag="BF3913"
     CDS             complement(1851..2456)
                     /locus_tag="BF_RS18580"
                     /old_locus_tag="BF3913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005816580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_011203510.1"
                     /translation="MYQVRIVDFIEIDSIVAIHNNAFPGFFLTLLGNRFLRLYYRSVLR
                     HKDGILLGCYDETEKLSGFCAATISAKGFNTKLIKTAFFSFCSVGIYLLFTDANALKRL
                     YLNWSKKDNMQEDTKDYAELLSIGVNSSSQGKGLGKFMLSELENMVSKKGGGRISLTTD
                     CHDNTKTIKFYKSMGYEVYYEFITYPDRKMYRMIKLLK"
     gene            complement(2444..3658)
                     /locus_tag="BF_RS18585"
                     /old_locus_tag="BF3914"
     CDS             complement(2444..3658)
                     /locus_tag="BF_RS18585"
                     /old_locus_tag="BF3914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004569940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_011203511.1"
                     /translation="MNSTVLIISAVFPPEPVVSAKLSSDIVNDLVAFGIHVTVLHPKPT
                     RPFGFYFNREKRAGLNFQEVLLPSYTCPKSNVFGRLFESYSFGCKCRNYIQSHHLELAC
                     IYVNSWPLFSQAIIVKTASKYGIPCIMHVQDIYPESFINKMSSGLWAMLFQRALLPIDK
                     YILSHADYIFAISANMKEYLVKTRKIDSTKISIIENWQNEDEFIAYHNKLQMKKENRPL
                     TFMYLGNNGPIAGVEFLIHCFVKANIQGARLVIAGSGSRKVACMELAKTYSNVEIEFWD
                     VPDGKVPEIQDQADVMLLPIKKGAAMSSIPSKLPAYMFSKKTILGSMDMESDTARAIED
                     AGCGIVVRPENEEELVRAWKEMAQWSKDAMEQKGYNGFIYAMNRFSKKSNLPIITDIIK
                     EICIK"
     gene            complement(3665..4879)
                     /locus_tag="BF_RS18590"
                     /old_locus_tag="BF3915"
     CDS             complement(3665..4879)
                     /locus_tag="BF_RS18590"
                     /old_locus_tag="BF3915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005781529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="WP_032588990.1"
                     /translation="MPVLLQINVVVNSGSTGRIVEEIGQKAISLGWDSYIAYGRNKCPS
                     QSNLIKIGTNWDLRFHGLQTRLFDRHGLGSKRATERLIKKIGEIHPDIIHLHVIHGYYL
                     NYKVLFKFLSESNIPVVWTMHDCWAYTGHCVYYTSVNCEKWKTECSHCPVSTSYPQSVL
                     WDRSKHNFRNKNEAFTSLDRKKLVIVPVSKWLADEVEGSFLKKYPIVPIYNGVNTDVFV
                     HSSINKKKYGVDGKFMILGVATQWTERKGIQDFIKLSKFISEDVAIVLVGLTHKQIVGL
                     PSSIIGISKTDNVQQMVELYSSADLYISFSMEETFGLTIAESLSCGTPALVYNTTATPE
                     IVSEETGFIVTPGDFNAVIDVINTVKLHGKTNYSEKCHQRALTFFSKKSKSSDYISLYK
                     SLLGI"
     gene            complement(4912..5862)
                     /locus_tag="BF_RS18595"
                     /old_locus_tag="BF3916"
     CDS             complement(4912..5862)
                     /locus_tag="BF_RS18595"
                     /old_locus_tag="BF3916"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_011203513.1"
                     /translation="MFFDRLFKNRIWELWCLRKYSFITLGHIVTEQSVIAVSDNSVPKC
                     GGLVDRLKGIISLFHFSIVTDKRFYINCTFPFDLNKYLIPNEYNWEIILDRYPIYQFRT
                     LYLIGEMDGERLFSYKGKRSLLIYSNFNLISQLNACYKTDFSFGELFKILFKPSEMVKG
                     KIEYVKNLFCLDNYVAVHFRFQQLLGDFRDVNGNVLDQNGQKKMISDCLSMLNQIQNKH
                     QDMKFLIFSDSSKFIEKCGECGYTIIPGTIGHIDFCETDDVFLKTFVDFFLISEAKYTY
                     SVILDQMYPSAFPEYASLLNNVPFQRVYSLESETI"
     gene            complement(5876..6940)
                     /locus_tag="BF_RS18600"
                     /old_locus_tag="BF3917"
     CDS             complement(5876..6940)
                     /locus_tag="BF_RS18600"
                     /old_locus_tag="BF3917"
                     /inference="COORDINATES: protein
                     motif:HMM:NF012744.1,HMM:NF024831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="WP_011203514.1"
                     /translation="MQKKIMFFTPSLQIGGIEKVFTTYANCLAISGYKVYYVFGNDHFD
                     YSLFNSYVVKISLGNIRLRASLWRLMKNVIKYSPDVLVTGGDYPNIYCIISSLLTFKRS
                     KILISHHSYFNVEVNHTLSRILIKYFYNMADGVLSVSNGITAHLESLGVRKSLCTTIYN
                     PVDINYVINSSNEPCNNLDHPYIIFVGRLSKVKNLKLLIDAFGILRERLKDTNLVIVGD
                     GEEKEDLVNYVESLGLDKEILFTGPLANPYSLMAKSMLITLTSISEALPTVIIEAFALG
                     KTVVSTPTCGAIDLLSGGEYGYLTKRFDNPIEFAELMEKAVALPIDQKKLVDRANFFAV
                     ENQSTELIHLLNHL"
     gene            complement(6864..8264)
                     /locus_tag="BF_RS18605"
                     /old_locus_tag="BF3918"
     CDS             complement(6864..8264)
                     /locus_tag="BF_RS18605"
                     /old_locus_tag="BF3918"
                     /inference="COORDINATES: protein motif:HMM:NF025654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|F3PUJ6|9.B.67.3.3"
                     /protein_id="WP_011203515.1"
                     /translation="MFRKNLIKKLFLFFSLLSFIQYLYCPNYYSFGYILFLFLLFCVDV
                     YLYFKIKKKKNYFDFDTLFLFVFSLAAFAYPVFLYEPSFPFIYFFGFSFNVDTISHAVS
                     ISLIAINCYLLGSVSLTKKEETASRVIYVNNRLLIFLSCLLFVLFICSGGVSYYQAMYG
                     KSANAELSGPINQLQSLLQATLIATIGTEFYNLRACRKKPNKLFLLVCVTLSFLMLYAG
                     NRTFAMQILLPTSFFLFYFYYQISFSRFILLAIIGFFSMWFIQINRTGKTIDENIIINS
                     ASVISDIVIPSRSNFLVFEVVDKTGFTYGYSMSGGVIGVIPSLERFLNLVGLDSKNTGS
                     ATLFTRYTLGDNPSVGLGTMLQADIYLSFGLVGILLFFWGLGKFVNRIQMQLQLNVYYS
                     YIIYSALMAHAVFWVRAEATYPLRIIIWSLIIAYLNKLYWNCYAKKDNVFYSKSANRRN
                     RESVHHLC"
     gene            complement(8296..9315)
                     /locus_tag="BF_RS18610"
                     /old_locus_tag="BF3919"
     CDS             complement(8296..9315)
                     /locus_tag="BF_RS18610"
                     /old_locus_tag="BF3919"
                     /inference="COORDINATES: protein motif:HMM:NF012745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT2_Glycos_transf_2|GT2"
                     /protein_id="WP_011203516.1"
                     /translation="MGEENVDVSVLMSIYEEPIAWIKDSVYSILQQTFTNFEFIILIDH
                     PNRTDVRLFFKELIKQDRRIRLIQNETNIGLTKSLNRGLSVAKGRYVARMDADDISDVR
                     RLEIQYNFLNQHPSVDVCGSFAKLFGDVHFYSKKFISFPVSNRGILINSLFENPIVHPS
                     VMMKHTIQGQSVCYNEEMKKSQDFFLWGDLLIRGAVFSNIPKYLLSYRISKQQISCKNK
                     KEQVKVADLVRKQLLLSLVPNITIGEISIHNMICENKKGEVCLLNQKLSWLEKIHHILA
                     DLFPESIADVDEILFKYRFSAYLNADKPSLIFHDRYFKLILFLKNKYWIDLIRHLLKK"
     gene            complement(9321..10634)
                     /locus_tag="BF_RS18615"
                     /old_locus_tag="BF3920"
     CDS             complement(9321..10634)
                     /locus_tag="BF_RS18615"
                     /old_locus_tag="BF3920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002561433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose/GDP-mannose dehydrogenase family
                     protein"
                     /protein_id="WP_011203517.1"
                     /translation="MKIAIVGTGYVGLVTGTCFSEMGVDVICVDIQDRKIENLKKGIIP
                     IYEPGLEDMVSRNYKAGRLKFSVDLKTCLEDVEVVFCAVGTPPEEDGSADLQYVLEVAR
                     TIGRNMNKYILVVTKSTVPVGTAQKVKDTIQRELDRRKVQIEFDVASNPEFLKEGDAVN
                     DFMKPDRVVVGVESERAKEIMERLYKPFMMNNYRLIFTDIPSAEMIKYAANSMLATRIS
                     FMNDIANLCELVGADVNMVRKGIGADTRIGSKFLYPGCGYGGSCFPKDVKALIKTAEKN
                     GYSMRVLKAVEEVNEFQKCILYEKLLKYFSGDIAGKQVAVWGLSFKPETDDLREAPALV
                     LINMLIKADAMVKVYDPIAMDGCKLIIGNKVKYATDMYDAILDADALLLVTEWKEFRVP
                     SWGVLKKTMKQAVVIDGRNIYDEKELVALGITYYCIGK"
     gene            complement(10649..11701)
                     /locus_tag="BF_RS18620"
                     /old_locus_tag="BF3921"
     CDS             complement(10649..11701)
                     /locus_tag="BF_RS18620"
                     /old_locus_tag="BF3921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005923251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent epimerase"
                     /protein_id="WP_011203518.1"
                     /translation="MRVLVTGAAGFIGSFVCRELLLRGDEVVGLDNINTYYEVDLKYDR
                     LATLTINRESVDWYKFVQSDTYQNFRFIRMNLEDRQAMQMLFANEHFDRVVNLAAQAGV
                     RYSIENPYAYVESNVNGFLNVLEGCRHNGVKHLVYASSSSVYGLNGKVPFSEKDGIAHP
                     VSLYAATKKSDELMAHTYSYLYGIPTTGLRFFTVYGPWGRPDMSPFLFADAMLHNRSIK
                     VFNNGDMLRDFTYIDDIVEGVLRVIDHIPMPDPRWCAEYPNPSSSTAPYKIYNIGNSYP
                     VKLTDFIQAIEDMIGYSAEKIYLPMQSGDIYQTNADTTSLQEELGFKPNKSIKEGVKET
                     IEWYRSYYKL"
     gene            complement(11706..12863)
                     /locus_tag="BF_RS18625"
                     /old_locus_tag="BF3922"
     CDS             complement(11706..12863)
                     /locus_tag="BF_RS18625"
                     /old_locus_tag="BF3922"
                     /inference="COORDINATES: protein motif:HMM:NF012744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="WP_011203519.1"
                     /translation="MNKILFDGIATQSSDKVKYHGGSEYAKFILKYALENNYRNFDFVY
                     SADMLLHDDVREMVEKFNIKTICLKKTSELQRFILGSEYTCFYSALPYGYGDFELGDIL
                     FIFTIHGCRALELPSDSYRHYYTDSVYSSLIMRILNPVFRLFTYYVSMKSFRHLLNVKN
                     KKIITVSNHSKYSLMSFFSNVNFDDLIVSYSPIDFSIKEYTDKVDIEGDFFLLISSNRF
                     EKNAYRAILALDCLFSENRLEKKKVLVLGCVNCSLITKVANKDRFVFMGYVPKNKLVSY
                     FKSAFAFVYPTLNEGFGYPPVMAMQYGVPVICSAVTSIPEICADGACYFNPYDINEIKN
                     RILYVSEDADYRQRLINNGYRRSSELQNLQKLNMDYLMECIFVKN"
     gene            complement(12856..14280)
                     /locus_tag="BF_RS18630"
                     /old_locus_tag="BF3923"
     CDS             complement(12856..14280)
                     /locus_tag="BF_RS18630"
                     /old_locus_tag="BF3923"
                     /inference="COORDINATES: protein
                     motif:HMM:NF024832.1,HMM:NF026018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|O32273|2.A.66.2.6"
                     /protein_id="WP_011203520.1"
                     /translation="MKMIMVKSKVFIDSIWSFIERFSVQGLQFLFSIILARLLSPSDYG
                     LIAMLSIFLALSQTLLDCGFSNALIRKIDRTDIDKSTVFFYNILSGVLLYFALFFLSPY
                     IALFYEMPILELLLRYMSIIIPINAISLTHRTLLQIQCDYKLQVKISLLSIFASGTVGV
                     IFAFYGFGVWGLVVQALLNSLFATIMYWVFVKWQPKLLFSMTSLKELFLFGNNILLSGL
                     LRTFYVNIYSLVIGKFFTPLDLGFYSRADSLSQFTSTNLTMALIRVFYPSLCECQNDRV
                     MLINMYYKYMKILCLVIFPIVTLLIGLASPLVIVLLGDKWVPSIYLLQILLIGYIFYPI
                     YNLNNAFWQSINRPDMVLKAEFMYKVIGFSLLLITLPFGLKCLAWGTVCTSIITFIISF
                     IYTMNSLKISVSEVLLQILKILLLSIFMFVVVCVVVSLFCLEIYQLFFGAIIGISSFFL
                     FDYLTFRVVFKTLKNE"
ORIGIN
        1 ctaacgaatg atgctccaaa atgtcagaaa tataattttt aaatattcct tcaccgaacg
       61 attacatata tatttcatat tataccgtat tttatcgggc ataatctgtt ctatatatgc
      121 cttgtcggga tccgaagcct ttccaagaat cgtattttca tccacatatt caatagaagc
      181 ataatccgta attccgggac gtacactcaa tacccttttc tggtcatcag tatacaaatc
      241 cacatactta cgaacctcag gccgtggtcc caccagactc atatcacctt tcagtacatt
      301 gaacaactgg ggtaattcat ctaatttata cttccggata aaatacccgg tatgggttat
      361 tctgggatct ctccccccca ccgttatcaa tcccttctta tcagccccca cacgcattga
      421 acggaattta tagacataaa agtcccgccc gtattgtccc acacgaagtt gtttatagaa
      481 accgcctcct ttactttcaa ggcagatggc tatataaaga aagagaaaaa cgggagaaag
      541 cagaaggatt cccaaaaggg aaaaaacaat atcaaaaaaa cgaatcaaga agcttatcta
      601 tttagtattt gtaaatatac tatctgtttt ctgcgattac ggtcgtatag gccgccttta
      661 cagtatcaat aatgaaattc aatttttcac tatccagttg aggatatatc ggtaatgata
      721 tctccccctt aaaattctga taagcctgtg gataatcatt catagcatat cccatcgatt
      781 tgaagaacga caacatcggc atcggtataa aatgtacatt cacagccact tcacgtttag
      841 caatctcgcc aatcatccgg tcgcgttgct cttctgtaaa gtctttcaca cgcaaagcat
      901 aaatatgata agagctttcc ttttctccat ctacagaagg cggcacaata gcccagtcac
      961 aagtcgaaaa agcatcattg taggtattga acaccctttt tcgctccttt agtaactccg
     1021 gatattcccg tatttgcgcc agtccgatgg cagcattcac atcggccata ttgattttca
     1081 ttccgaaacc gacaatatca taacgccatc ctccggcttt cgatttcgaa aaagcatcct
     1141 tagtctggca gttcaagctc atcatccgga gttctttata cagctctgca ttatcgaacg
     1201 gcttgggcaa gttcaaacaa atggctccgc cttcggcagt agtcacgttc ttcacggcat
     1261 ggagtgaaaa gatagccaca tcagtttcgc aaccggtacg ctgccggtta ctgtaacgtg
     1321 cccccaaaga atgggcagca tcattcatca ccaagatacg tcctaatttt tcttgcacgg
     1381 gagattccgc acggaacaat tttatcattc caggttcctg caccagtgcc atgatctttt
     1441 cataatcgca aggaaaaccg gcaatgtcta ctgggataat tgcctttgtt ttagcagtaa
     1501 tagctttacg aacagcctct accgagatat taaaatccat tccggaatcc accatcaccg
     1561 gtttagcccc ggcatgaagc acggccaatg ccgttgcgct ataagtataa gcaggaacaa
     1621 ttacttcatc tccctccttc actcccagcc aacgcaacat cataatagct cctgatgtcc
     1681 aggaattgac acaaagtact tcttttgctc ccgagaaaga ttttatttct ttctccaaag
     1741 ccttcacttt cggaccggat gtgatccaac cggaacgtaa cgaatcaacg acttcattga
     1801 tgaccgcctc gtcaatataa ggtggtgaaa atggtatttt cataagctaa tcattttaat
     1861 aattttatca tgcgatacat tttccgatcg ggatacgtaa taaactcata atatacttca
     1921 tagcccattg atttataaaa ttttatagtt ttagtgttat catgacaatc tgttgttaag
     1981 gaaattcttc cacccccctt cttagaaacc atattttcta attcagacaa cataaatttc
     2041 cccaatcctt taccttgact ggaggaatta actccaattg aaagtaattc ggcatagtct
     2101 tttgtatcct cctgcatatt atcttttttg gaccaattaa gatacaaacg tttcaaagca
     2161 ttagcatctg taaataagag atagatcccc acactacaaa aagagaaaaa ggccgtcttt
     2221 atcaatttag tattaaatcc tttagcagag attgttgcgg cacaaaaacc agatagtttt
     2281 tcagtctcgt cgtaacaccc caatagaata ccatctttat gcctcaatac agaacggtaa
     2341 tatagtctca aaaaacgatt ccctaatagc gtaagaaaga aaccgggaaa agcattgtta
     2401 tgaattgcaa caatagagtc aatttctata aaatcaacga ttcttacttg atacatattt
     2461 ctttaatgat atccgttatt atcggtaaat tagatttttt agaaaagcga ttcatggcat
     2521 atataaaacc attataccct ttctgttcca tcgcatcttt actccattgc gccatctctt
     2581 tccatgcccg tactaactcc tcttcatttt ccggacgaac tactattcca cacccagcat
     2641 cctctatagc tcttgcagta tcgctctcca tgtccataga tcccagaatc gtctttttag
     2701 aaaacatata tgcaggtaat ttagaaggaa ttgagctcat cgctgcccct tttttgatcg
     2761 gaagcaacat cacatccgcc tgatcttgaa tttccggtac tttcccatct ggaacatccc
     2821 aaaactcaat ttccacattt gaataagttt tagccaattc catgcatgct acttttcttg
     2881 atccactccc agcgatcact aaacgtgctc cctgaatatt cgcctttaca aaacaatgta
     2941 tcaaaaactc tactcctgct attggaccat tgttccctaa atacataaaa gtcagaggcc
     3001 tgttctcttt tttcatctgt agcttattat ggtaagctat aaattcatct tcattctgcc
     3061 aattttcaat aattgaaatt tttgttgaat caatctttct tgtcttcact aaatactcct
     3121 tcatattggc agatattgca aaaatgtaat ctgcatgaga caatatatat ttatcaatag
     3181 gaagtaaggc tctttgaaat aacatagccc acaatccgga cgacatttta ttaataaacg
     3241 attcagggta gatgtcttgt acatgcataa tacaaggtat accgtatttt gaagccgttt
     3301 ttacgataat agcttgtgag aaaagaggcc aagaattaac ataaatacaa gctaattcca
     3361 aatgatgaga ttgtatgtaa ttccggcatt tacatccaaa actataactt tcaaataatc
     3421 taccaaaaac attcgatttc ggacatgtat aagaaggcaa cagcacttct tgaaagttaa
     3481 gaccagcacg tttttcccga ttaaaataaa aaccaaacgg acgagtcggt ttagggtgca
     3541 gaactgtcac atgtatgcca aatgccacca agtcattaac tatatctgac gacaatttag
     3601 ccgaaacaac aggttcggga ggaaaaactg cagaaataat cagaacagta gaattcatat
     3661 ttttttatat tcccagaaga gatttataaa gagaaatata atcactagat ttactctttt
     3721 ttgaaaaaaa agtaagagca cgttgatgac atttttcaga ataatttgtt tttccatgta
     3781 atttaactgt atttatcaca tctataacag cattaaaatc cccaggagta acaataaaac
     3841 cagtttcttc agagactatt tcaggagtag cagtcgtatt gtaaactaat gcaggagtac
     3901 cacaagataa actttcagca atagtcaaac caaatgtttc ctccatagaa aaacttatat
     3961 aaagatctgc ggaagaatac aattctacca tttgttgtac attatcagtc ttagaaatac
     4021 ctattatgga agaaggcaaa cctactattt gtttgtgagt aagtcctact aatacaatcg
     4081 caacatcctc agaaataaat ttcgaaagct ttataaaatc ttgaattcct tttctttccg
     4141 tccattgagt tgcgactcct aaaatcataa acttcccatc aactccatat ttctttttat
     4201 ttatagatga atgaacaaaa acatccgtat tcactccatt gtatatagga actatcggat
     4261 atttcttaag aaaagaacct tccacttcat ccgctaacca ctttgaaaca ggtacaataa
     4321 ccaacttttt tctatccaaa gaagtaaatg cttcattttt attcctaaaa ttatgttttg
     4381 acctatccca taaaacactc tgtggatagg aagtagaaac aggacaatgg ctacattcag
     4441 tcttccattt ttcacaattt acagatgtat aatagacaca atgtccagta tatgcccaac
     4501 aatcatgcat tgtccatact acaggaatat tcgattctga caggaattta aacaacactt
     4561 tataattcaa ataataacca tgaattacat gaagatgaat aatgtccgga tgtatttcac
     4621 ctattttctt aattaacctc tctgtagctc ttttcgatcc tagaccatgt ctatcgaaca
     4681 atcgagtttg caaaccatga aatctcaaat cccaattggt ccctattttt atcaaatttg
     4741 attgacttgg acatttatta cgtccataag caatatagct gtcccaacct aatgaaattg
     4801 ctttttgacc aatctcctca acaatacgac cggtcgaacc actattcacc acaacattta
     4861 tttgtaaaag aacaggcata ttcatttttt taggttagta atcgtttctt tttaaatcgt
     4921 ttcggattcc aaagagtata ctctttgaaa agggacatta ttcaataaag aggcatattc
     4981 cggaaaagca gacggataca tctgatccaa aataacagaa taggtatact tagcttcact
     5041 tattaaaaag aaatcaacaa atgtttttaa gaacacatca tctgtttcac agaaatcaat
     5101 atgtccgatt gtcccaggaa ttatcgtata accacattct ccacattttt ctataaattt
     5161 agatgaatct gaaaagataa gaaacttcat gtcctgatgt ttgttttgta tctgatttag
     5221 catagacaag caatcactta tcatcttttt ctgtccattc tgatctaaaa cattgccatt
     5281 tacatcccta aaatcaccca ataattgttg aaatctaaaa tgtacagcaa cataattatc
     5341 aagacaaaaa agatttttta catattcaat ttttccctta accatttccg aaggtttaaa
     5401 taatatctta aataattccc caaatgaaaa atcagtttta taacaagcat ttagctgaga
     5461 aattaaatta aaatttgaat agatcaacaa agagcgtttc cctttatagc tgaataatcg
     5521 ttctccatcc atttcaccga ttaaatagag tgttctgaac tgataaatag gatatctatc
     5581 taaaataatt tcccaattgt attcattagg aatcaagtat ttgttgagat caaacgggaa
     5641 tgtacaatta atataaaaac gtttgtcggt tacgattgaa aaatgaaaca aagaaataat
     5701 ccctttcaat cgatccacca gtcctccaca tttcggtaca gagttatcag atacggctat
     5761 aacagattgt tctgtaacaa tatgaccaag agttatgaat gaatattttc ttaagcacca
     5821 taattcccat attctatttt taaacaaacg gtcaaaaaac ataacagctt aaaaattata
     5881 aatgatttaa taagtgaatc aactcggttg attggttctc tacagcaaaa aaattagccc
     5941 tatctaccag ttttttttga tcaataggta gtgctactgc tttttccatt aactcagcaa
     6001 attcaatagg attatcaaac cgctttgtta aatatccata ttctccacca gacaatagat
     6061 caatagctcc acaagtaggc gttgaaacca ccgtctttcc caaagcaaaa gcttcaatga
     6121 tcacagtggg taatgcctct gaaatagaag ttaacgtaat aagcatagat ttagccatta
     6181 aagagtacgg attagccaat ggacctgtaa atagaatttc tttgtccaat ccaagactct
     6241 ctacgtaatt caccaaatcc tctttttctt ctccgtcacc aacaatcact aaatttgtat
     6301 cctttaatcg ttctcgtaaa atcccaaaag catctattaa cagtttcaag tttttcacct
     6361 tgcttaatct tcctacaaat attatatagg gatgatccag attattacac ggttcattag
     6421 aagaatttat cacataatta atatctaccg gattatagat ggtagtacac aaacttttcc
     6481 tgactcctaa agattccaaa tgcgctgtaa taccatttga tacagataat acaccatccg
     6541 ccatgttata aaaatatttt attagtattc gagaaagagt atgatttact tcaacattaa
     6601 agtaactatg atgagaaatt aatattttac tacgtttaaa agtaagcaaa gaggaaatta
     6661 tgcaatatat attaggataa tctcctccag tcaccaacac gtcaggagaa tattttatta
     6721 catttttcat caacctccat aaggaagctc ttaacctgat attaccaaga gaaattttta
     6781 ctacatatga attaaataaa ctataatcaa agtgatcatt cccgaagaca taatacactt
     6841 tatatccact tattgccaag caattagcat aagtggtgaa cactttctct attcctccta
     6901 tttgcagact tggagtaaaa aacattatct ttttttgcat aacaattcca atatagttta
     6961 tttaaataag caataatcaa actccaaatt ataatcctta aaggataagt agcctctgca
     7021 cgcacccaga aaacagcatg tgccatcaat gccgagtaga taatatacga ataatatacg
     7081 tttagttgaa gctgcatttg gatacgattt acaaattttc ctaaacccca aaagaatagg
     7141 agaataccta ccaaaccaaa agaaagatat atatcagctt ggagcatagt tcccaaccca
     7201 accgagggat tatcccctaa tgtatatctg gtaaatagag tggcagaacc ggtattttta
     7261 gaatcaagcc ccactaaatt taaaaagcgt tctagagacg ggatcactcc tataacccct
     7321 ccagacatac tatatccata tgtaaatccg gttttatcga ccacctcaaa aaccaaaaaa
     7381 ttactccttg aaggtatgac aatatcacta attacagacg cagaattaat gataatattt
     7441 tcatcaatag tttttcccgt tctattaatt tgtataaacc acatagaaaa aaatcctatg
     7501 attgccaaca gaataaaacg agaaaaacta atttgataat aaaaataaaa aaggaaaaaa
     7561 gaagtcggca ataaaatttg catggcaaat gttcgattcc cggcataaag cattaagaag
     7621 gaaagcgtaa cacaaaccaa caagaatagt ttgttcggtt ttttcctaca agcccgtaga
     7681 ttataaaatt ctgtaccaat ggtagcgata agggtcgctt ggagcaaaga ttgtaattga
     7741 ttgataggtc cactcaattc cgcattggca gatttaccgt acatagcttg ataataagaa
     7801 acccctccag aacaaataaa tagtacaaac agtaggcaag ataaaaaaat caggagtcga
     7861 ttatttacat atattactcg gcttgccgtt tcctcttttt tcgtcaaaga gacactacct
     7921 aataaataac aattaatagc aatcaatgaa attgaaacag catgcgaaat cgtatctaca
     7981 ttaaaagaaa atccaaaaaa atatatgaat gggaaagaag gttcatacaa aaagacagga
     8041 taagcaaaag ctgccaaact gaaaacaaat aaaaacaagg tatcaaaatc aaaataattt
     8101 tttttctttt taatcttaaa atacaaatat acatccacac aaaagagaag aaataaaaaa
     8161 agaatatagc caaaagaata gtaattagga caatataaat actgaataaa agacagtagt
     8221 gaaaagaata aaaaaagttt ttttattaag ttctttctaa acatttttat ataatataag
     8281 gattaaacca atatcctatt ttttcaacaa gtgccttatt aaatcaatcc aatacttatt
     8341 tttcaagaaa agaatcagtt taaagtaacg atcatgaaaa ataagagatg gcttatcagc
     8401 attcagatat gctgaaaacc gatatttaaa tagaatttca tctacatccg ctatcgattc
     8461 tggaaacaga tcagccaata tatggtgtat tttttcaagc caagaaagtt tctgattaag
     8521 caagcatact tctccctttt tgttttcaca gatcatatta tggatcgaaa tttctcctat
     8581 agttatgtta ggtactaatg ataacagcag ttgctttctt accaaatcag cgaccttaac
     8641 ttgttctttt ttattcttac aacttatttg ttgtttggag atacgataac tcaataaata
     8701 cttaggaata ttactaaaaa cagccccccg gatgagcaga tctccccaca ggaaaaaatc
     8761 ttgggatttt ttcatttctt cattatagca tacagattga ccctggatcg tatgcttcat
     8821 cattaccgaa ggatgaacta ttggattctc aaacaaagaa ttgatgagga taccacgatt
     8881 agaaacagga aaagagataa acttctttga ataaaaatgg acatctccaa acaatttcgc
     8941 aaatgatccg caaacatcta cagatggatg ttgatttaaa aagttatact gaatttccaa
     9001 gcgcctaaca tcacttatat catcagcatc catccgagct acatatcgtc cttttgcgac
     9061 ggaaagtcct ctattcaaag actttgtcaa gcctatattg gtttcatttt gaataaggcg
     9121 aattcttctg tcttgcttga tcaattcttt aaaaaataat ctgacatccg ttctattagg
     9181 atggtctata aggatgataa actcaaaatt tgtaaaagtt tgctgaagaa tagaataaac
     9241 agaatcctta atccaagcta tcggttcttc atatatactc atcaaaacag aaacatccac
     9301 attctcttcg cccataacct ctattttcca atgcaataat aagtgatgcc caaagctact
     9361 aattcttttt catcatagat atttcgtccg tcaattacaa cagcctgctt catcgtcttt
     9421 ttcagtactc cccaactcgg cacacggaat tctttccatt ccgttacaag taataaggca
     9481 tccgcatcta atatggcatc atacatatct gtagcatatt tcactttatt acctatgatc
     9541 aatttacatc cgtccatcgc aatcggatca taaactttca ccattgcatc tgccttaatc
     9601 agcatattaa tcagcaccaa ggcaggagct tcacgcagat catccgtctc cggcttaaaa
     9661 gacaatcccc atacagccac ttgttttcca gctatatcac cactaaaata ttttaataat
     9721 ttctcataaa ggatacactt ctgaaattca ttcacctctt caacagcctt taaaacacgc
     9781 atcgaataac cattcttctc agcagtcttt atcaaagctt ttacatcttt tggaaaacaa
     9841 gatccaccat atccacaacc cggataaagg aatttactac caatacgagt atcagcacct
     9901 atccccttac gaaccatatt cacatcagct cccacaagtt cacacaggtt ggctatatcg
     9961 ttcataaaac taatacgggt agctagcata gaattggcag catattttat catctcagca
    10021 ctggggatat ccgtaaatat caatcgataa ttattcatca taaaaggctt ataaagacgt
    10081 tccattattt ccttagccct ttctgattca acccccacca ctacacggtc aggtttcata
    10141 aagtcattta ccgcatcacc ttcttttaaa aattcaggat tggacgctac atcaaactct
    10201 atctggactt ttcgtcgatc aagctccctt tgaattgtat ctttcacctt ttgggccgtt
    10261 ccgaccggaa cagtgctttt agttaccacc aatatatatt tattcatatt acgaccaatc
    10321 gtacgcgcca cttctaatac atattgtaaa tcggcactac catcctcttc tggcggagtt
    10381 cctacagcgc agaatactac ttcaacatcc tccaaacacg tttttaaatc aaccgaaaac
    10441 ttcagccgcc cggctttata attgcgagat accatatctt ctaatcccgg ttcataaata
    10501 ggaataatac ctttcttcag attctcaatc ttgcgatctt gtatatctac acaaataaca
    10561 tctacaccca tctcagaaaa acaagtgcca gttaccaaac cgacataacc ggtaccaacg
    10621 attgctattt tcattttatt taattgcatt acagtttata ataagagcga taccattcga
    10681 tggtttcttt cactccctct tttattgact tattaggctt aaatcccaac tcttcttgca
    10741 aagaagtagt atctgcattg gtttgataaa tatctcccga ttgcatgggt agataaatct
    10801 tctctgctga atatccaatc atatcctcta tcgcctgaat gaaatccgtc aattttaccg
    10861 gatacgaatt acctatatta taaattttgt aaggagcagt agaagaactt ggattgggat
    10921 actctgcaca ccaacgagga tcaggcattg gaatgtgatc tatcacgcga aggactcctt
    10981 caacaatatc atcgatatag gtaaaatcac gaagcatatc tccattattg aaaactttta
    11041 tcgaacggtt gtgcaacatc gcatccgcaa aaaggaaagg agacatatcc ggacgccccc
    11101 aaggaccata aacggtgaaa aagcgtaatc cggtagtagg gataccatat aaataactat
    11161 acgtatgcgc cattaattca tccgactttt tcgttgcggc atacagactg accggatggg
    11221 caatgccatc cttttccgaa aaaggtactt taccgtttaa gccatacaca ctgctcgaac
    11281 tggcataaac caagtgtttc accccattat gtcggcaacc ttccaagaca tttaaaaagc
    11341 cgtttacatt actttcgaca tatgcataag gattttcgat agaataacgt acccctgcct
    11401 gtgcagctag atttacaacc ctatcaaaat gctcattagc gaagagcatc tgcatagcct
    11461 gcctgtcttc cagattcatc cgaataaaac gaaagttttg ataagtatca ctttgtacga
    11521 atttatacca atcaacactt tcacgattta tagttaaagt agccaagcgg tcatacttta
    11581 aatctacctc ataataggtg ttgatattat ctaatcctac tacttcatca ccacgcaata
    11641 aaagttccct acatacaaaa gaaccaataa atccagcagc tcctgttact aatactctca
    11701 tatttttagt ttttaacaaa aatacattcc attaaataat ccatattcaa cttctgtaaa
    11761 ttttgcagtt cagatgaacg cctataacca ttgttaatca aacgttgtct ataatcagca
    11821 tcttcagata cgtataatat tctatttttg atttcattaa tatcatatgg attaaaataa
    11881 caagctccat ctgcacaaat ctcaggaata ctggttaccg ctgaacaaat gacaggtaca
    11941 ccatattgca tagccattac cggcgggtac ccaaatccct catttagtgt aggatataca
    12001 aaagcaaaag cactcttaaa atacgatacc aatttgtttt tcggcacata acccataaaa
    12061 acaaagcgat ctttattagc aactttagtt attaatgagc aattaacaca tcccaaaaca
    12121 agcacttttt tcttttctaa tcgattttct gaaaacaagc agtccaatgc aagaatggcc
    12181 ctatatgcat ttttttcaaa acgattacta ctaatcagta aaaagaagtc accttcaata
    12241 tccaccttat ccgtatactc ttttatgcta aaatctatgg gcgaatagct tacgatcaag
    12301 tcatcaaaat tgacattaga aaaaaaagac attaaagaat acttagaatg atttgaaacg
    12361 gttataatct tcttattttt cacgttcaac aaatgtctaa atgatttcat tgaaacgtaa
    12421 tatgtaaaca atctaaaaac aggatttaga atcctcatta tcaatgacga ataaacacta
    12481 tctgtataat aatgcctata agaatcagag ggtaattcga gagcacggca tccgtgaatt
    12541 gtaaatataa acaaaatatc acccaattca aagtccccat acccatatgg caaagctgag
    12601 tagaaacaag tatactcgct acctaatata aaccgttgaa gctcactagt cttttttaaa
    12661 caaatcgttt ttatattaaa tttttccacc atttctctta catcatcatg caaaagcata
    12721 tcagcagaat aaacaaagtc aaaattacga taattatttt ctaaagcata tttcaatata
    12781 aactttgcat actcactccc tccatgatat ttaaccttat cagaactttg agttgcaatt
    12841 ccatcaaata atattttatt catttttcaa tgttttaaaa acaacacgaa atgttagata
    12901 atcaaataaa aagaatgaag atattccaat aattgcccca aaaaacaatt gatatatttc
    12961 caaacaaaaa agagaaacaa cgacacacac tactacaaac ataaaaattg acaataacaa
    13021 aattttcaat atctgaagaa gcacttcaga tacagatatt tttaaactat tcatcgtata
    13081 aataaaacta ataataaaag taatgataga agtgcatact gttccccaag ccaaacattt
    13141 cagaccaaaa ggcagagtta tcaagagaag cgaaaagcct ataaccttat acataaactc
    13201 tgccttcaac accatatccg gccgatttat agattgccaa aatgcattat tcagattata
    13261 tataggataa aatatataac caatcagcaa aatctgtaac aaataaattg atggcaccca
    13321 cttgtcaccc aaaagtacga ttaccaaagg tgatgccaaa cctataagca aagtcacaat
    13381 aggaaaaatg acaagacaca atatcttcat gtatttataa tacatattta ttagcattac
    13441 tctatcattt tgacattcac atagagacgg ataaaaaacc cttatcaatg ccattgttag
    13501 attggttgaa gtaaattgag acaaggaatc cgctcttgag taaaagccta gatcaagtgg
    13561 agtaaaaaat ttgcctataa ccaaggagta tatattcaca taaaaagttc ttaaaagtcc
    13621 actaagaaga atattattgc caaataaaaa aagttctttc agagaagtca tcgagaacaa
    13681 gagtttgggc tgccatttta caaataccca atacataatt gtcgcaaata ggctatttaa
    13741 caaagcttgc accaccaatc cccaaactcc aaacccgtaa aaagcaaata ttacccccac
    13801 tgtaccactt gcaaaaatag atagaagaga tattttaacc tgcaatttgt aatcacattg
    13861 gatttgtaat aaagtacgat gagttaaaga aatagcattt attggaatta taatcgacat
    13921 atagcgtaat aacaattcca aaattggcat ctcataaaat aatgcgatat aaggagacaa
    13981 aaagaataat gcaaaatata gtaaaacccc agataatata ttataaaaaa agacggttga
    14041 cttatcaata tccgttctat ctattttacg aattaatgca ttcgagaacc cacaatccaa
    14101 taatgtttgt gaaagagcca aaaaaataga tagcatggca attaaaccat aatcggaagg
    14161 ggataataat cttgccaaaa taatagagaa caaaaattgg agcccttgaa ctgagaatcg
    14221 ttcaataaaa ctccaaatag aatcaataaa aactttgctt ttaaccatta tcattttcat
//
