| Basic Information | |
|---|---|
| Species | Malus domestica |
| Cazyme ID | MDP0000150270 |
| Family | CE10 |
| Protein Properties | Length: 391 Molecular Weight: 43323.6 Isoelectric Point: 6.2369 |
| Chromosome | Chromosome/Scaffold: 009554412 Start: 11383 End: 14748 |
| Description | alpha/beta-Hydrolases superfamily protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| CE10 | 153 | 299 | 2.7e-33 |
| RLDLYLPKNSDGPKPVIAFVTGGAWIIGYKAWGSLLGQQLSERDIIVACIDYRNFPQGTISDMVKDASQGISFVCNHIADYGGDPNRVYVMGQSAGAHIG ACTLVDQAIKEAXEGESSSWSLSQIKAYFGLSGGYNLLNLVDHFHRR | |||
| Full Sequence |
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| Protein Sequence Length: 391 Download |
| MPSQQILPIT YHPPSEKSLR KEAEDDPTTG LLLYSNFEDE EKNTPXKPLL PRVSSYTTTS 60 AAAANNHQQR RRRTASDSSL SSHSDEGSRH SLAGDVEHAA AETFLVTRLS LKLLKYLGVG 120 YRWITRFLAL GCYSFLLMPG FIQELIPEVL FCRLDLYLPK NSDGPKPVIA FVTGGAWIIG 180 YKAWGSLLGQ QLSERDIIVA CIDYRNFPQG TISDMVKDAS QGISFVCNHI ADYGGDPNRV 240 YVMGQSAGAH IGACTLVDQA IKEAXEGESS SWSLSQIKAY FGLSGGYNLL NLVDHFHRRD 300 YSIPSDASKN FAETLQRLGV TAESILYEGK THTDLFLQDP MRGGRDDMFE DLVAIIHEGD 360 LEALAKDAVA PPRRRLVPEC MLKLAHRVSP F |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam07859 | Abhydrolase_3 | 3.0e-6 | 174 | 257 | 85 | + alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes. | ||
| cd00312 | Esterase_lipase | 1.0e-7 | 154 | 249 | 109 | + Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate. | ||
| pfam00135 | COesterase | 4.0e-9 | 156 | 251 | 117 | + Carboxylesterase family. | ||
| COG2272 | PnbA | 2.0e-10 | 154 | 256 | 117 | + Carboxylesterase type B [Lipid metabolism] | ||
| COG0657 | Aes | 1.0e-14 | 153 | 251 | 101 | + Esterase/lipase [Lipid metabolism] | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0008152 | metabolic process |
| GO:0016787 | hydrolase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAG50528.1 | 0 | 1 | 391 | 1 | 472 | AC084221_10 hypothetical protein [Arabidopsis thaliana] |
| RefSeq | NP_173937.2 | 0 | 1 | 391 | 1 | 476 | esterase-related [Arabidopsis thaliana] |
| RefSeq | XP_002277990.1 | 0 | 6 | 391 | 5 | 458 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002315969.1 | 0 | 1 | 391 | 1 | 517 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002514516.1 | 0 | 25 | 391 | 49 | 445 | catalytic, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 1lzl_A | 0.000000006 | 147 | 257 | 63 | 171 | A Chain A, Bacterial Heroin Esterase |
| PDB | 1lzk_A | 0.000000006 | 147 | 257 | 63 | 171 | A Chain A, Bacterial Heroin Esterase Complex With Transition State Analog Dimethylarsenic Acid |
| PDB | 2hm7_A | 0.00000001 | 152 | 257 | 60 | 166 | A Chain A, Crystal Structure Analysis Of The G84s Est2 Mutant |
| PDB | 1u4n_A | 0.00000002 | 152 | 257 | 60 | 166 | A Chain A, Crystal Structure Analysis Of The G84s Est2 Mutant |
| PDB | 1qz3_A | 0.00000002 | 152 | 257 | 60 | 166 | A Chain A, Crystal Structure Of Mutant M211sR215L OF CARBOXYLESTERASE Est2 Complexed With Hexadecanesulfonate |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| DT491083 | 264 | 176 | 391 | 0 |
| ES827954 | 274 | 154 | 379 | 0 |
| DY277968 | 351 | 95 | 382 | 0 |
| FC901726 | 219 | 95 | 299 | 0 |
| GE479256 | 299 | 121 | 356 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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