| Basic Information | |
|---|---|
| Species | Carica papaya |
| Cazyme ID | evm.model.supercontig_182.15 |
| Family | CE1 |
| Protein Properties | Length: 335 Molecular Weight: 36784.4 Isoelectric Point: 5.6359 |
| Chromosome | Chromosome/Scaffold: 182 Start: 195089 End: 199421 |
| Description | S-formylglutathione hydrolase |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| CE1 | 111 | 333 | 0 |
| SPTLGCSMTFHIYFPPSPSSSHKFPVLYWLSGLTCTDENFIIKSGAQRTASAEGVALVAPDTSPRGLNVEGEADSWDFGVGAGFYLNATQEKWKNWRMYD YVVKELPTVLSENFPQLDTSKASISGHSMGGHGALTIYLKNLDKYKSVSAFAPICNPINCPWGQKAFTNYLGDNKGDWEEYDAASLISKFNDLAATILID QGENDTFLHNQLLPQKFEEACRK | |||
| Full Sequence |
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| Protein Sequence Length: 335 Download |
| MGSAPGSACI AFLVELEGRP AQEAYGNILL CTAQSVTSRV PSRFPPDNAD TSQSSAPENT 60 PPLLEAHSLF INFLDRDLNP NSARTKMETK PVEIGSSKMF GGYNKRFKHF SPTLGCSMTF 120 HIYFPPSPSS SHKFPVLYWL SGLTCTDENF IIKSGAQRTA SAEGVALVAP DTSPRGLNVE 180 GEADSWDFGV GAGFYLNATQ EKWKNWRMYD YVVKELPTVL SENFPQLDTS KASISGHSMG 240 GHGALTIYLK NLDKYKSVSA FAPICNPINC PWGQKAFTNY LGDNKGDWEE YDAASLISKF 300 NDLAATILID QGENDTFLHN QLLPQKFEEA CRKY* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam00756 | Esterase | 7.0e-48 | 111 | 332 | 225 | + Putative esterase. This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family. | ||
| COG0627 | COG0627 | 7.0e-62 | 82 | 333 | 281 | + Predicted esterase [General function prediction only] | ||
| TIGR02821 | fghA_ester_D | 7.0e-106 | 94 | 333 | 241 | + S-formylglutathione hydrolase. This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well [Cellular processes, Detoxification]. | ||
| PLN02442 | PLN02442 | 3.0e-180 | 87 | 333 | 247 | + S-formylglutathione hydrolase | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004091 | carboxylesterase activity |
| GO:0016023 | cytoplasmic membrane-bounded vesicle |
| GO:0018738 | S-formylglutathione hydrolase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACJ11734.1 | 0 | 87 | 332 | 1 | 246 | S-formylglutathione hydrolase [Gossypium hirsutum] |
| GenBank | ACU18661.1 | 0 | 87 | 333 | 1 | 247 | unknown [Glycine max] |
| RefSeq | NP_181684.1 | 0 | 87 | 333 | 1 | 247 | SFGH (S-FORMYLGLUTATHIONE HYDROLASE); S-formylglutathione hydrolase/ hydrolase, acting on ester bonds [Arabidopsis thaliana] |
| RefSeq | XP_002284489.1 | 0 | 87 | 332 | 1 | 246 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
| RefSeq | XP_002308013.1 | 0 | 87 | 332 | 1 | 246 | esterase d, s-formylglutathione hydrolase [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3fcx_B | 0 | 93 | 331 | 5 | 243 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3fcx_A | 0 | 93 | 331 | 5 | 243 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3s8y_A | 0 | 94 | 331 | 7 | 241 | A Chain A, Bromide Soaked Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_B | 0 | 94 | 331 | 7 | 241 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_A | 0 | 94 | 331 | 7 | 241 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| formaldehyde oxidation II (glutathione-dependent) | S-FORMYLGLUTATHIONE-HYDROLASE-RXN | EC-3.1.2.12 | S-formylglutathione hydrolase |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| EX262580 | 284 | 50 | 333 | 0 |
| EX279970 | 271 | 63 | 333 | 0 |
| EX281945 | 272 | 63 | 333 | 0 |
| EX259402 | 253 | 33 | 285 | 0 |
| FQ425222 | 247 | 86 | 332 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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