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Browse anti-prokaryotic immune system families by Host order

AD families AD genes Defense system CLAN ID Phages/MGEs References Description
APIS104 narp2_nampt NAD+ reconstitution pathway (NARP) CLAN043 Vibrio phage KVP40 Osterman et al., 2024 Nicotinamide phosphoribosyltransferase activity (Nampt), capable of producing NMN from PRPP and nicotinamide.
APIS113 antiDnd_p0020 Dnd CLAN048 Vibrio phage 44E38.1 PMID:35760840 Two genes (p0020 and p0021) provide resistance to the Dnd system (anti-Dnd), p0020 encodes a protein with a phosphoadenosine phosphosulphate reductase (PAPS) domain and a DNA N-6-adenine-methyltransferase (Dam) domain.
APIS131 vcrx091 CRISPR-Cas evasion by DNA repair CLAN055 Vibrio cholerae PMID:32556263 CRISPR–Cas evasion by repairing double-strand DNA breaks via recombination between short sequence repeats
APIS133 vcrx092 CRISPR-Cas evasion by DNA repair CLAN056 Vibrio cholerae PMID:32556263 CRISPR–Cas evasion by repairing double-strand DNA breaks via recombination between short sequence repeats
APIS148 OrbA bacteriophage exclusion (BREX) CLAN058 Vibrio phage ICP1 PMID:34326207 Clinical phage ICP1 overcomes cocirculating SXT ICEs through acquisition of epigenetic RM as well as an anti-BREX protein, OrbA.
APIS153 antiDnd_p0021 Dnd CLAN059 Vibrio phage 44E38.1 PMID:35760840 Two genes (p0020 and p0021) provide resistance to the Dnd system (anti-Dnd), p0021 encodes a protein of unknown function.
APIS166 vcrx089 restriction-modification (RM) CLAN039 Vibrio cholerae PMID:32556263 vcrx089 and vcrx090 promote resistance against type I restriction-modification.
APIS170 narp2_nmnat NAD+ reconstitution pathway (NARP) CLAN049 Vibrio phage KVP40 Osterman et al., 2024 Nicotinamide mononucleotide adenylyltransferase (Nmnat), capable of generating NAD+ by conjugating AMP to NMN.
APIS176 CLAN003
APIS185 vcrx093 CRISPR-Cas evasion by DNA repair CLAN038 Vibrio cholerae PMID:32556263 CRISPR–Cas evasion by repairing double-strand DNA breaks via recombination between short sequence repeats
vcrx090 vcrx090 restriction-modification (RM) CLAN073 Vibrio cholerae PMID:32556263 vcrx089 and vcrx090 promote resistance against type I restriction-modification.