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CAZyme Information: MGYG000003819_00857

You are here: Home > Sequence: MGYG000003819_00857

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species UMGS1872 sp900555795
Lineage Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Oscillospiraceae; UMGS1872; UMGS1872 sp900555795
CAZyme ID MGYG000003819_00857
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
377 MGYG000003819_9|CGC1 40509.66 8.6177
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003819 2286303 MAG United States North America
Gene Location Start: 46945;  End: 48078  Strand: -

Full Sequence      Download help

MRVIFTCGGT  AGHVNPALAL  AGLLRERRPD  SQVLFVGANR  GMERALIEGA  GWPFQAVEIS60
SFHRSLAPGE  LRHNLISLKN  LLRSPGQARR  VLDGFPADLV  VGTGGYASYP  MVREAARRGI120
PTAIHESNAI  PGLTTRLLEN  SADLIMVGFE  ECRKNYRHPG  KVAVTGTPVR  GDFFRLTKKE180
AKVRLGMDDG  RPLIVSFWGS  LGAAAMNRQM  ARFMALEAAE  QPFHHIHGAG  TVGCAHMAEY240
LAAAGVELKD  APALEVRPYI  DNMGTLMRAA  DLVLCRAGAS  TISELTALGV  PAIIVPSPNV300
AHNHQEYNAR  VLADAGAAVL  LREEESTGDK  LYAAAREILE  DPDRRRRMSA  SMAALGTIDA360
AEKIYAALMA  LCRSAAQ377

Enzyme Prediction      help

No EC number prediction in MGYG000003819_00857.

CAZyme Signature Domains help

Created with Snap1837567594113131150169188207226245263282301320339358196359GT28
Family Start End Evalue family coverage
GT28 196 359 4e-44 0.9681528662420382

CDD Domains      download full data without filtering help

Created with Snap18375675941131311501691882072262452632823013203393581374murG2366GT28_MurG1371MurG1368murG193364Glyco_tran_28_C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00726 murG 1.40e-119 1 374 2 357
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 2.22e-115 2 366 1 349
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
COG0707 MurG 3.19e-94 1 371 1 354
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
TIGR01133 murG 7.42e-88 1 368 1 348
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam04101 Glyco_tran_28_C 3.24e-36 193 364 1 166
Glycosyltransferase family 28 C-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.

CAZyme Hits      help

Created with Snap18375675941131311501691882072262452632823013203393582373QUO37394.1|GT282373QCI58785.1|GT282371BAK98610.1|GT281371QNL43650.1|GT282365BCK83092.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
QUO37394.1 7.34e-172 2 373 7 378
QCI58785.1 1.88e-167 2 373 7 378
BAK98610.1 9.79e-160 2 371 7 375
QNL43650.1 3.57e-159 1 371 1 371
BCK83092.1 8.07e-157 2 365 7 370

PDB Hits      download full data without filtering help

Created with Snap183756759411313115016918820722624526328230132033935823733S2U_A23317D1I_A23291F0K_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
3S2U_A 2.05e-44 2 373 4 356
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]
7D1I_A 4.58e-40 2 331 11 326
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]
1F0K_A 1.24e-32 2 329 8 313
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]

Swiss-Prot Hits      download full data without filtering help

Created with Snap18375675941131311501691882072262452632823013203393581365sp|A3DE27|MURG_ACET21364sp|B1I4C4|MURG_DESAP1365sp|B0K3H0|MURG_THEPX1365sp|B0K8K7|MURG_THEP31364sp|A4J2B1|MURG_DESRM
Hit ID E-Value Query Start Query End Hit Start Hit End Description
A3DE27 5.96e-86 1 365 1 356
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) OX=203119 GN=murG PE=3 SV=1
B1I4C4 1.20e-80 1 364 1 360
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Desulforudis audaxviator (strain MP104C) OX=477974 GN=murG PE=3 SV=1
B0K3H0 1.30e-80 1 365 1 357
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter sp. (strain X514) OX=399726 GN=murG PE=3 SV=1
B0K8K7 1.30e-80 1 365 1 357
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) OX=340099 GN=murG PE=3 SV=1
A4J2B1 1.65e-80 1 364 1 360
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Desulfotomaculum reducens (strain MI-1) OX=349161 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000061 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000003819_00857.