CAZyme Information: MGYG000000924_00579

Basic Information

• Species: An172 sp002160515
• Lineage: Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Acutalibacteraceae; An172; An172 sp002160515
• CAZyme ID: MGYG000000924_00579
• CAZy Family: GH29
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1318	MGYG000000924_6|CGC1	143897.07	4.1938

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000000924	2081481	MAG	China	Asia

• Gene Location: Start: 14817; End: 18773 Strand: +

Full Sequence      

MKKKKMLSVLMCGCMLMGSIVPLAGASAAETYAYDGYVDDSAATGAAADIPVWGVTPNDA
QLKYHKDGFAVFCHFGPNTFNNIEWGENYGDKSPNEIFTLTEDFDAETLVKTAKEAGADR
LMITAKHHDGFCIWDSETTDYDIAETDYYKTHKELGGGQGDILKEISDACTKYNLDMGLY
LSPWDIHEQNYGCYGDGNNNPSSNGAYDDYNELYQAQIREICTAQNEDGTYKYGNNNPNR
SGDRFVEWWMDGATGSGAYFQTYDWEGIFSAIRDTNPDCQIFGTHKAGAELGGTGGIHWI
GNEAGIAAVETWAKVNKGENFENYPRGEGNAIIGKAEGNQWSVPEADAKLLNAGWFWSQS
KQSSLLSMEKLGNMYFNTIGRGAVLLLNMSPNSSGTIDENQKNRLLEFGAAVKEIYENDL
TEAEGVKVYADSIYKNSETYKPSNLIDEYTLNTSVTKEERVYDETCWAPEDGAKEGSVII
DLGSEQTFDTIKIEEYIQKGQRISEFTIEYMNERGQWKEFYSGKTIGSQSVTRHAPVTSS
QIRITVKSDYATPILNDVGIYKGPETFELEADDNIEFIVDESELDYKSIKDATRTGSWQT
SDNTHYWSAGTNSSVTFKFTGTAFYVKAIEDPNHSSFEVVVDGKSMGTVNLNNSTRIENK
IVYYSDDIGYGEHTVELKTLNSSGKTCIDVYGIYGLNIEEGIFEVGNLTYDIAETDTVQL
EVVRKHGSKGAATVNFSTTTGSAQQNMNYEYKDGTLEFADGETSKVIDVKIYAHKDTTSM
LNFYLDINTAEGARLGLNTRAVINIHPADKTATLESLNALIAEAKALLDNPAVTEEAKAY
LNEKIAFAEKAAAQPDAEQSVYGGATTALQMAIDNAGVDSSVLNLAVSGTVAFEAEDAKL
EQAVAGDKNIHIVEGDNYSGGKKVGWVKAGDKIIIPFYAEAAGTYTMDMYAQSGRVEGSS
YTSNKFDISGTNVEETSVEFYGSVDAPIKKYTCEIVVTKSGAGELVLTAAADHDGPDVDK
FEFTCKEISQEGLLVLPTDGSEVSFEAEDAQLVPTVEDNEHLHTKESSKASGGVMLDWYM
AGDKVIIPFYAEKAGTYNVDIYAECGRVEGTKKPNRLLLTGKKIEEDELDFYGSSATAPQ
IEKRSYQIVVTESGIGELVFTAAEGYDGPNLDKLVFSLDVPVTVDKTALDAKIKEAEAIE
NVYTANSFKALTDVIAAGKTILDKDDAQQTEVDNAVTAITEAIEALAYNSGDTDHDGALS
IIDVTAIQSHIVDKAVENFDEKLADANKDGIINIIDATIVQLVVSGKYTLDGDGNIVY

Enzyme Prediction     

No EC number prediction in MGYG000000924_00579.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH29	58	413	2.3e-57	0.8641618497109826

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG3669	AfuC	2.06e-53	53	561	2	430	Alpha-L-fucosidase [Carbohydrate transport and metabolism].
pfam01120	Alpha_L_fucos	2.73e-27	69	410	27	326	Alpha-L-fucosidase.
smart00812	Alpha_L_fucos	4.14e-27	69	434	28	338	Alpha-L-fucosidase. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 29 encompasses alpha-L-fucosidases, which is a lysosomal enzyme responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of alpha-L-fucosidase results in the lysosomal storage disease fucosidosis.
pfam03160	Calx-beta	1.84e-09	701	771	2	74	Calx-beta domain.
smart00237	Calx_beta	2.52e-09	701	771	2	73	Domains in Na-Ca exchangers and integrin-beta4. Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QRT29448.1	1.97e-188	4	1227	15	1299
QHB23055.1	2.69e-188	4	1227	15	1299
QEI30547.1	2.69e-188	4	1227	15	1299
PLT74914.1	1.80e-175	4	1199	15	1264
SLK22631.1	6.11e-161	53	1099	50	1078

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
6TR3_A	1.04e-147	37	606	8	549	Ruminococcusgnavus GH29 fucosidase E1_10125 in complex with fucose [[Ruminococcus] gnavus E1]
6TR4_A	1.53e-146	37	606	8	549	Ruminococcusgnavus GH29 fucosidase E1_10125 D221A mutant in complex with fucose [[Ruminococcus] gnavus E1],6TR4_B Ruminococcus gnavus GH29 fucosidase E1_10125 D221A mutant in complex with fucose [[Ruminococcus] gnavus E1]
6ORG_A	1.16e-80	54	564	8	451	Crystalstructure of SpGH29 [Streptococcus pneumoniae TIGR4],6ORG_B Crystal structure of SpGH29 [Streptococcus pneumoniae TIGR4]
6OR4_A	1.38e-79	54	564	8	451	Crystalstructure of SpGH29 [Streptococcus pneumoniae TIGR4],6OR4_B Crystal structure of SpGH29 [Streptococcus pneumoniae TIGR4],6ORH_A Crystal structure of SpGH29 [Streptococcus pneumoniae TIGR4],6ORH_B Crystal structure of SpGH29 [Streptococcus pneumoniae TIGR4]
6ORF_A	1.42e-79	54	564	8	451	Crystalstructure of SpGH29 [Streptococcus pneumoniae TIGR4],6ORF_B Crystal structure of SpGH29 [Streptococcus pneumoniae TIGR4]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q8GW72	2.57e-69	57	561	38	477	Alpha-L-fucosidase 1 OS=Arabidopsis thaliana OX=3702 GN=FUC1 PE=1 SV=2
Q7XUR3	3.63e-62	44	561	24	476	Putative alpha-L-fucosidase 1 OS=Oryza sativa subsp. japonica OX=39947 GN=Os04g0560400 PE=3 SV=2
P10901	4.52e-07	51	472	23	397	Alpha-L-fucosidase OS=Dictyostelium discoideum OX=44689 GN=alfA PE=3 SV=1
P49713	1.42e-06	51	185	20	169	Putative alpha-L-fucosidase OS=Caenorhabditis elegans OX=6239 GN=W03G11.3 PE=3 SV=2

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000344	0.998758	0.000336	0.000224	0.000174	0.000157

TMHMM  Annotations     

start	end
7	29