CAZyme Information: MGYG000001093_00907

Basic Information

• Species: Flavobacterium lindanitolerans
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Flavobacteriales; Flavobacteriaceae; Flavobacterium; Flavobacterium lindanitolerans
• CAZyme ID: MGYG000001093_00907
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1C

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
777		88712.41	9.1127

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000001093	3659018	MAG	Sweden	Europe

• Gene Location: Start: 1268; End: 3601 Strand: -

Full Sequence      

MIKRNPKKSVFFGLLFIAYYFCLPRTLFEQPYSTVIESEEGELLGAKIARDGQWRFPAQD
SIPEKFKKCIVYFEDEHFYQHPGFNPIAMVKAAKQNHDAGRVVRGGSTLTQQVIRLSRGE
KKRNYFEKLVELVLATRLEFRYSKEKILELYAAHAPYGGNVVGLEMASWRYFGVQPHQLS
WAETATLAVLPNAPSLIYPGKNQQKLLNKRNGLLKKLYQEKIIDKTTYQLSVLEELPQKP
YDLPQIAPHLLQNVARRQEGTRVKTTVKFALQNRVNQIATQYYNQYRQSEIYNLAIIVVD
VETRNILSYVGNSPTDKDHQKDVDIITAPRSTGSILKPLLYASMLDAGEILPNTLVPDIP
TQIAGYSPKNFDLTYDGAVPAHRALSRSLNIPSVLMLKDHGVYRFYDQLQQFKLRDINKH
PNHYGLSLILGGAESNLWDLTKTYAGLTSTLNYFTTHSAKYRTDEFKELNWLHGAKLDFG
KESYDKKNLGAASIWLTYNAMKEVNRPEGDEAWKFYDSSLEVAWKTGTSFGNRDGWAIGT
NSRYVVGVWVGNASGEGRPSLTGVGSAAPVLFDVFNLLPRKKWFTTPYDDLEEAEVCQLS
GHIAGEYCPKIKQWIPLKSKQTTVCPYHKLIHLDASGEYQVNSNCEEVDRMVAKPWFVLP
PVMELYYKTKHINYVPLPPFRPDCLGASSYSMDFIYPKENGKVYLTKNFNGEIQPFIIKV
AHSDQKAKLFWYLNDKFLGTTQTFHEMSVEAKTGKYYITVTDEAGNEISRRIEIVKE

Enzyme Prediction     

No EC number prediction in MGYG000001093_00907.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	59	217	2.3e-48	0.8926553672316384

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02073	PBP_1c	0.0	24	775	2	727	penicillin-binding protein 1C. This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG4953	PbpC	1.17e-176	14	774	17	731	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
PRK11240	PRK11240	2.16e-108	51	578	58	562	penicillin-binding protein 1C; Provisional
COG0744	MrcB	1.72e-91	10	594	28	613	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	2.77e-82	55	570	2	520	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QEE48424.1	0.0	3	777	15	788
ALM49541.1	0.0	2	777	27	802
AOE53159.1	0.0	2	777	27	802
AWH84705.1	0.0	2	777	7	782
AXG75248.1	0.0	15	777	5	767

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5FGZ_A	2.70e-34	34	556	146	672	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	2.93e-34	34	556	167	693	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]
3FWL_A	2.48e-31	34	556	150	676	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli]
2OQO_A	5.76e-29	60	232	26	198	Crystalstructure of a peptidoglycan glycosyltransferase from a class A PBP: insight into bacterial cell wall synthesis [Aquifex aeolicus VF5],3D3H_A Crystal structure of a complex of the peptidoglycan glycosyltransferase domain from Aquifex aeolicus and neryl moenomycin A [Aquifex aeolicus],3NB7_A Crystal structure of Aquifex Aeolicus Peptidoglycan Glycosyltransferase in complex with Decarboxylated Neryl Moenomycin [Aquifex aeolicus]
3NB6_A	1.98e-28	60	232	26	198	Crystalstructure of Aquifex aeolicus peptidoglycan glycosyltransferase in complex with Methylphosphoryl Neryl Moenomycin [Aquifex aeolicus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P76577	2.92e-86	24	765	33	760	Penicillin-binding protein 1C OS=Escherichia coli (strain K12) OX=83333 GN=pbpC PE=1 SV=1
Q9KUC0	1.65e-41	56	570	182	706	Penicillin-binding protein 1B OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=mrcB PE=3 SV=1
P45345	5.42e-41	34	587	147	713	Penicillin-binding protein 1B OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) OX=71421 GN=mrcB PE=3 SV=1
Q89AR2	1.96e-37	56	551	159	666	Penicillin-binding protein 1B OS=Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) OX=224915 GN=mrcB PE=3 SV=1
P02919	2.02e-33	34	556	203	729	Penicillin-binding protein 1B OS=Escherichia coli (strain K12) OX=83333 GN=mrcB PE=1 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.845116	0.151521	0.002228	0.000326	0.000237	0.000580

TMHMM  Annotations     

start	end
9	28