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CAZyme Information: MGYG000002341_01971
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Acinetobacter ursingii | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; Acinetobacter ursingii | |||||||||||
| CAZyme ID | MGYG000002341_01971 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Acetyl-coenzyme A synthetase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 116679; End: 118622 Strand: + | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd05968 | AACS_like | 0.0 | 21 | 633 | 8 | 610 | Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase. This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms. |
| PRK10524 | prpE | 0.0 | 21 | 637 | 3 | 621 | propionyl-CoA synthetase; Provisional |
| cd17634 | ACS-like | 0.0 | 22 | 609 | 1 | 587 | acetate-CoA ligase. This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain. |
| COG0365 | Acs | 0.0 | 66 | 622 | 1 | 525 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]. |
| cd05967 | PrpE | 0.0 | 22 | 639 | 1 | 617 | Propionyl-CoA synthetase (PrpE). EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| CAE6201330.1 | 1.39e-245 | 4 | 641 | 564 | 1211 |
| CAE6201338.1 | 1.90e-245 | 4 | 641 | 575 | 1222 |
| AFZ04852.1 | 8.20e-20 | 65 | 613 | 571 | 1074 |
| CAE6256584.1 | 1.06e-17 | 251 | 616 | 1706 | 2058 |
| AFY93865.1 | 8.61e-16 | 77 | 613 | 330 | 842 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2P2F_A | 5.67e-319 | 22 | 640 | 24 | 642 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2F_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 5JRH_A | 8.41e-319 | 22 | 640 | 24 | 642 | Crystalstructure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2],5JRH_B Crystal structure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
| 2P2M_A | 1.70e-318 | 22 | 640 | 24 | 642 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2M_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 2P2B_A | 2.55e-318 | 22 | 640 | 24 | 642 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2B_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 2P2Q_A | 3.40e-318 | 22 | 640 | 24 | 642 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2Q_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q4UP35 | 0.0 | 1 | 640 | 1 | 641 | Acetyl-coenzyme A synthetase OS=Xanthomonas campestris pv. campestris (strain 8004) OX=314565 GN=acsA PE=3 SV=1 |
| Q885K7 | 0.0 | 4 | 642 | 6 | 644 | Acetyl-coenzyme A synthetase OS=Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) OX=223283 GN=acsA PE=3 SV=1 |
| Q7MGU3 | 0.0 | 4 | 641 | 6 | 644 | Acetyl-coenzyme A synthetase OS=Vibrio vulnificus (strain YJ016) OX=196600 GN=acsA PE=3 SV=2 |
| Q6LLZ1 | 0.0 | 4 | 641 | 6 | 643 | Acetyl-coenzyme A synthetase OS=Photobacterium profundum (strain SS9) OX=298386 GN=acsA PE=3 SV=1 |
| Q88EH6 | 0.0 | 4 | 642 | 6 | 644 | Acetyl-coenzyme A synthetase 1 OS=Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) OX=160488 GN=acsA1 PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000064 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |