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CAZyme Information: MGYG000002359_03770
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Mycobacterium tuberculosis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Actinobacteriota; Actinomycetia; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis | |||||||||||
| CAZyme ID | MGYG000002359_03770 | |||||||||||
| CAZy Family | GT53 | |||||||||||
| CAZyme Description | putative arabinosyltransferase A | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 293513; End: 296797 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GT53 | 10 | 1091 | 0 | 0.998093422306959 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam14896 | Arabino_trans_C | 0.0 | 703 | 1091 | 1 | 384 | EmbC C-terminal domain. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol. This domain represents the C-terminal extracellular domain that is likely to bind to carbohydrate. |
| pfam04602 | Arabinose_trans | 1.35e-177 | 198 | 667 | 1 | 459 | Mycobacterial cell wall arabinan synthesis protein. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol. |
| pfam17689 | Arabino_trans_N | 2.33e-61 | 37 | 194 | 1 | 155 | Arabinosyltransferase concanavalin like domain. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| AMC92290.1 | 0.0 | 1 | 1094 | 1 | 1094 |
| CCG13711.1 | 0.0 | 1 | 1094 | 1 | 1094 |
| AHJ57111.1 | 0.0 | 1 | 1094 | 1 | 1094 |
| AJF45931.1 | 0.0 | 1 | 1094 | 1 | 1094 |
| AKO26966.1 | 0.0 | 1 | 1094 | 1 | 1094 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 7BVC_A | 0.0 | 11 | 1094 | 14 | 1088 | Cryo-EMstructure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155],7BVG_A Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with di-arabinose. [Mycolicibacterium smegmatis MC2 155] |
| 7BVF_A | 0.0 | 1 | 1094 | 9 | 1102 | Cryo-EMstructure of Mycobacterium tuberculosis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol [Mycobacterium tuberculosis H37Rv] |
| 7BWR_A | 1.55e-266 | 11 | 1094 | 24 | 1082 | Mycobacteriumsmegmatis arabinosyltransferase complex EmbB2-AcpM2 in substrate DPA bound asymmetric 'active state' [Mycolicibacterium smegmatis MC2 155],7BWR_B Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in substrate DPA bound asymmetric 'active state' [Mycolicibacterium smegmatis MC2 155],7BX8_A Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in symmetric 'resting state' [Mycolicibacterium smegmatis MC2 155],7BX8_B Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in symmetric 'resting state' [Mycolicibacterium smegmatis MC2 155] |
| 6X0O_A | 2.56e-266 | 11 | 1094 | 24 | 1082 | Single-ParticleCryo-EM Structure of Arabinosyltransferase EmbB from Mycobacterium smegmatis [Mycolicibacterium smegmatis MC2 155] |
| 7BVC_B | 2.72e-266 | 11 | 1094 | 24 | 1082 | Cryo-EMstructure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155],7BVG_B Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with di-arabinose. [Mycolicibacterium smegmatis MC2 155] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q50394 | 0.0 | 4 | 1094 | 13 | 1092 | Probable arabinosyltransferase A OS=Mycolicibacterium smegmatis OX=1772 GN=embA PE=3 SV=2 |
| P9WNL8 | 0.0 | 1 | 1094 | 1 | 1094 | Probable arabinosyltransferase A OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=embA PE=3 SV=1 |
| P9WNL9 | 0.0 | 1 | 1094 | 1 | 1094 | Probable arabinosyltransferase A OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=embA PE=1 SV=1 |
| P71485 | 0.0 | 1 | 1094 | 1 | 1108 | Probable arabinosyltransferase A OS=Mycobacterium avium OX=1764 GN=embA PE=3 SV=1 |
| Q9CDA8 | 0.0 | 1 | 1094 | 1 | 1111 | Probable arabinosyltransferase A OS=Mycobacterium leprae (strain TN) OX=272631 GN=embA PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.998431 | 0.001480 | 0.000042 | 0.000007 | 0.000005 | 0.000087 |
TMHMM Annotations download full data without filtering help
| start | end |
|---|---|
| 12 | 34 |
| 205 | 224 |
| 247 | 269 |
| 322 | 344 |
| 356 | 375 |
| 408 | 430 |
| 451 | 470 |
| 519 | 536 |
| 543 | 565 |
| 575 | 597 |
| 604 | 626 |
| 641 | 663 |
| 684 | 706 |