CAZyme Information: MGYG000002783_00108

Basic Information

• Species: Prevotellamassilia sp900541335
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Prevotellamassilia; Prevotellamassilia sp900541335
• CAZyme ID: MGYG000002783_00108
• CAZy Family: GH33
• CAZyme Description: Sialidase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
401	MGYG000002783_1|CGC3	44577.45	8.7583

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002783	2416856	MAG	United States	North America

• Gene Location: Start: 133918; End: 135123 Strand: +

Full Sequence      

MYRFFSIFFLALSTLCASAQTVLFHTGDSTGYPYRIPAIAKARNGELIALSDLRPCGGDI
GYGRVDIVGRISRDNGANWNPAFKLLEGTGKGKDTGYGDACLVADRKRNELLLVCVSGDV
PYWKSSPQNRQRMVTLHATYDKKGKQWNWDKQVTDITSQVYDELLKGKINGLFMGSGRIC
QSSRVKVGKYYRLYAALCTHKGNYVIYSDDFGRNWGLLGTPEVSCAPKGDEPKCEELPDG
SVLLSSRKHGGRFFNIYKYTDVRTAAGQWAEAVDSRQAPGGISNEGTPCNGEILIIPVRR
TADGKKTILALQSIPAGPNRSNVSIYYKELTTPDTYQSPLAFASNWSEAYQVSDKGSAYS
TMIQQADGRIAFFYEEEPQYYQMVYRALNIQDITKGKFEAL

Enzyme Prediction     

No EC number prediction in MGYG000002783_00108.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH33	20	386	2.2e-47	0.9707602339181286

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd15482	Sialidase_non-viral	1.08e-62	21	389	1	339	Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.
COG4409	NanH	2.12e-04	18	127	258	387	Neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QFQ12979.1	1.43e-184	12	398	12	397
EFC70822.1	1.76e-159	1	398	1	402
ALO48969.1	4.90e-118	23	398	29	399
QYR10380.1	2.12e-112	10	398	13	395
QFQ13500.1	2.10e-88	28	401	632	1010

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7LBU_A	3.56e-13	31	247	91	303	ChainA, Exo-alpha-sialidase [Cutibacterium acnes],7LBV_A Chain A, Exo-alpha-sialidase [Cutibacterium acnes]
2BF6_A	1.95e-11	23	396	12	449	AtomicResolution Structure of the bacterial sialidase NanI from Clostridium perfringens in complex with alpha-Sialic Acid (Neu5Ac). [Clostridium perfringens]
2VK5_A	1.97e-11	23	396	12	449	TheStructure Of Clostridium Perfringens Nani Sialidase And Its Catalytic Intermediates [Clostridium perfringens],2VK6_A The Structure Of Clostridium Perfringens Nani Sialidase And Its Catalytic Intermediates [Clostridium perfringens],2VK7_A The Structure Of Clostridium Perfringens Nani Sialidase And Its Catalytic Intermediates [Clostridium perfringens],2VK7_B The Structure Of Clostridium Perfringens Nani Sialidase And Its Catalytic Intermediates [Clostridium perfringens]
5TSP_A	1.12e-10	23	396	13	450	Crystalstructure of the catalytic domain of Clostridium perfringens neuraminidase (NanI) in complex with a CHES [Clostridium perfringens ATCC 13124],5TSP_B Crystal structure of the catalytic domain of Clostridium perfringens neuraminidase (NanI) in complex with a CHES [Clostridium perfringens ATCC 13124]
7MHU_A	9.80e-10	17	252	33	266	ChainA, Exo-alpha-sialidase [Bacteroides acidifaciens],7MHU_B Chain B, Exo-alpha-sialidase [Bacteroides acidifaciens]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q02834	1.32e-08	31	375	63	386	Sialidase OS=Micromonospora viridifaciens OX=1881 GN=nedA PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.002743	0.938671	0.057690	0.000330	0.000275	0.000278

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002783_00108.