CAZyme Information: MGYG000003338_01266

Basic Information

• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae; Dysgonomonas
• CAZyme ID: MGYG000003338_01266
• CAZy Family: GT19
• CAZyme Description: Lipid-A-disaccharide synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
380		43772.84	6.8376

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003338	3210940	MAG	United States	North America

• Gene Location: Start: 1737; End: 2879 Strand: +

Full Sequence      

MKYFLVAGEASGDLHGSNLMAALKEQDKNAEFCFFGGDLMQAQGGRLIKHYREMAFMGFI
PVLLNLRTILRNMKMCREEIIKYQPDVLILIDYPGFNLKIAKYIKTHTQIPVYYYISPKV
WAWKEYRVKSFKKYVDEMLAILPFEVEFYKKHNYHIDYVGNPVVDAVAKFREENENDSLE
KFVAENNLENKPIIALLAGSRQQEIKDNLPAMLESIKEFSDYQPVIAGAPGIEPEYYTKY
IGSSPCKIVFGQTYRLLEYAHAALVTSGTATLETALFRVPQVVCYETPIPSIVYWVFKNI
LHTKYISLVNLIADKVVVQELFAKFFSVESIREEVNKLVNDNIYRNMMLDEYDNIINILG
KPGASERAANIIIEKLKENK

Enzyme Prediction     

No EC number prediction in MGYG000003338_01266.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT19	4	357	1.4e-116	0.9830508474576272

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK00025	lpxB	1.66e-114	1	380	2	379	lipid-A-disaccharide synthase; Reviewed
COG0763	LpxB	1.75e-100	1	378	2	381	Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis].
pfam02684	LpxB	4.20e-74	4	321	2	321	Lipid-A-disaccharide synthetase. This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
TIGR00215	lpxB	1.67e-65	5	374	10	384	lipid-A-disaccharide synthase. Lipid-A precursor biosynthesis producing lipid A disaccharide in a condensation reaction. transcribed as part of an operon including lpxA [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
PRK14089	PRK14089	1.51e-50	1	372	1	344	lipid-A-disaccharide synthase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QIK59046.1	5.26e-213	1	376	1	376
QIK53577.1	2.14e-212	1	376	1	376
ABR44355.1	3.80e-177	1	376	1	375
QRO15504.1	3.80e-177	1	376	1	375
QCY57761.1	3.80e-177	1	376	1	375

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5W8S_A	1.36e-34	5	374	11	379	LipidA Disaccharide Synthase (LpxB)-7 solubilizing mutations [Escherichia coli BL21(DE3)],5W8X_A Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations-Bound to UDP [Escherichia coli BL21(DE3)]
5W8N_A	2.61e-34	5	374	11	379	LipidA Disaccharide Synthase (LpxB)-6 solubilizing mutations [Escherichia coli BL21(DE3)]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q1D393	2.73e-66	2	376	6	378	Lipid-A-disaccharide synthase OS=Myxococcus xanthus (strain DK1622) OX=246197 GN=lpxB PE=3 SV=1
B6J161	1.08e-59	5	372	8	370	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain CbuG_Q212) OX=434923 GN=lpxB PE=3 SV=1
A9KC41	1.52e-59	5	372	8	370	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain Dugway 5J108-111) OX=434922 GN=lpxB PE=3 SV=1
B6J9H1	1.52e-59	5	372	8	370	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain CbuK_Q154) OX=434924 GN=lpxB PE=3 SV=1
Q83DS5	3.01e-59	5	372	8	370	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain RSA 493 / Nine Mile phase I) OX=227377 GN=lpxB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000045	0.000012	0.000001	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000003338_01266.