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CAZyme Information: MGYG000003949_01191

You are here: Home > Sequence: MGYG000003949_01191

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Eubacterium_F sp900539115
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Eubacterium_F; Eubacterium_F sp900539115
CAZyme ID MGYG000003949_01191
CAZy Family CBM36
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
1185 127740.91 9.3924
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003949 2807569 MAG United Kingdom Europe
Gene Location Start: 42344;  End: 45901  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

EC 3.2.1.8 3.2.1.4 3.2.1.-

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH8 635 948 5e-82 0.940625
CBM36 277 390 8.5e-18 0.9565217391304348
CBM36 449 563 1.3e-17 0.9652173913043478

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3405 BcsZ 8.70e-51 584 956 1 351
Endo-1,4-beta-D-glucanase Y [Carbohydrate transport and metabolism].
pfam03442 CBM_X2 2.96e-24 970 1053 1 83
Carbohydrate binding domain X2. This domain binds to cellulose and to bacterial cell walls. It is found in glycosyl hydrolases and in scaffolding proteins of cellulosomes (multiprotein glycosyl hydrolase complexes). In the cellulosome it may aid cellulose degradation by anchoring the cellulosome to the bacterial cell wall and by binding it to its substrate. This domain has an Ig-like fold.
pfam01270 Glyco_hydro_8 4.97e-24 638 947 25 317
Glycosyl hydrolases family 8.
cd04078 CBM36_xylanase-like 5.31e-21 276 388 5 113
Carbohydrate Binding Module family 36 (CBM36); appended mainly to glycoside hydrolase family 11 (GH11) domains; xylan binding. This family includes carbohydrate binding module family 36 (CBM36) most of which appear appended to glycoside hydrolase family 11 (GH11) domains. These CBMs are non-catalytic carbohydrate binding domains that facilitate the strong binding of the GH11 catalytic modules with their dedicated, insoluble substrates. GH11 domains have xylanase (endo-1,4-beta-xylanase) activity which catalyzes the hydrolysis of beta-1,4 bonds of xylan, the major component of hemicelluloses, to generate xylooligosaccharides and xylose. This family includes XynB from Dictyoglomus thermophilum Rt46B.1 and Xyn11A from Pseudobutyrivibrio xylanivorans Mz5T. Xyn11A is a multicatalytic enzyme with an N-terminal GH11 domain, a CBM36 domain, and a C-terminal putative NodB-like polysaccharide deacetylase which is predicted to be an acetyl esterase involved in debranching activity in the xylan backbone. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold. Consistent with its structural and sequence similarity to CBM6, CBM36 binds xylan, but only at binding site I, and in a calcium-dependent manner; the latter suggests its potential application in affinity labeling.
cd04078 CBM36_xylanase-like 4.24e-20 448 565 5 118
Carbohydrate Binding Module family 36 (CBM36); appended mainly to glycoside hydrolase family 11 (GH11) domains; xylan binding. This family includes carbohydrate binding module family 36 (CBM36) most of which appear appended to glycoside hydrolase family 11 (GH11) domains. These CBMs are non-catalytic carbohydrate binding domains that facilitate the strong binding of the GH11 catalytic modules with their dedicated, insoluble substrates. GH11 domains have xylanase (endo-1,4-beta-xylanase) activity which catalyzes the hydrolysis of beta-1,4 bonds of xylan, the major component of hemicelluloses, to generate xylooligosaccharides and xylose. This family includes XynB from Dictyoglomus thermophilum Rt46B.1 and Xyn11A from Pseudobutyrivibrio xylanivorans Mz5T. Xyn11A is a multicatalytic enzyme with an N-terminal GH11 domain, a CBM36 domain, and a C-terminal putative NodB-like polysaccharide deacetylase which is predicted to be an acetyl esterase involved in debranching activity in the xylan backbone. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold. Consistent with its structural and sequence similarity to CBM6, CBM36 binds xylan, but only at binding site I, and in a calcium-dependent manner; the latter suggests its potential application in affinity labeling.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
QUL54973.1 4.98e-188 440 990 28 578
ALQ07930.1 1.59e-163 440 1150 22 759
AAS85781.1 7.23e-159 580 1173 651 1296
QNU67295.1 2.16e-155 575 963 22 413
QWG04463.1 1.48e-147 448 1097 51 697

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
6G00_A 2.54e-114 584 957 5 395
CrystalStructure of a GH8 xylanase from Teredinibacter turnerae [Teredinibacter turnerae T7901],6G09_A Crystal Structure of a GH8 xylobiose complex from Teredinibacter turnerae [Teredinibacter turnerae T7901],6G0B_A Crystal Structure of a GH8 xylotriose complex from Teredinibacter Turnerae [Teredinibacter turnerae T7901]
6G0N_A 1.34e-113 584 957 5 395
CrystalStructure of a GH8 catalytic mutant xylohexaose complex xylanase from Teredinibacter turnerae [Teredinibacter turnerae T7901]
5YXT_A 1.52e-112 583 957 5 377
Glycosidehydrolase family 8 Xylanase [Paenibacillus barengoltzii G22],5YXT_B Glycoside hydrolase family 8 Xylanase [Paenibacillus barengoltzii G22],5YXT_C Glycoside hydrolase family 8 Xylanase [Paenibacillus barengoltzii G22],5YXT_D Glycoside hydrolase family 8 Xylanase [Paenibacillus barengoltzii G22]
6SHY_A 2.11e-112 583 956 6 380
Structureof L320A/H321S double mutant of Rex8A from Paenibacillus barcinonensis [Paenibacillus barcinonensis],6SHY_B Structure of L320A/H321S double mutant of Rex8A from Paenibacillus barcinonensis [Paenibacillus barcinonensis]
6SUD_A 2.95e-112 583 956 6 380
Structureof L320A mutant of Rex8A from Paenibacillus barcinonensis complexed with xylose. [Paenibacillus barcinonensis],6SUD_B Structure of L320A mutant of Rex8A from Paenibacillus barcinonensis complexed with xylose. [Paenibacillus barcinonensis]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
A0A0S2UQQ5 2.93e-111 583 956 6 380
Reducing-end xylose-releasing exo-oligoxylanase Rex8A OS=Paenibacillus barcinonensis OX=198119 GN=rex8A PE=1 SV=1
Q9KB30 8.04e-104 582 963 5 386
Reducing end xylose-releasing exo-oligoxylanase OS=Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) OX=272558 GN=BH2105 PE=1 SV=1
A1A048 4.27e-76 593 954 14 377
Reducing end xylose-releasing exo-oligoxylanase OS=Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) OX=367928 GN=xylA PE=1 SV=1
Q3MUH7 1.17e-13 917 1059 725 871
Xyloglucanase OS=Paenibacillus sp. OX=58172 GN=xeg74 PE=1 SV=1
P45796 6.66e-12 444 564 516 632
Arabinoxylan arabinofuranohydrolase OS=Paenibacillus polymyxa OX=1406 GN=xynD PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as LIPO

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.003276 0.141978 0.853371 0.000681 0.000404 0.000261

TMHMM  Annotations      download full data without filtering help

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12 31