CAZyme Information: MGYG000004172_01198

Basic Information

• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae
• CAZyme ID: MGYG000004172_01198
• CAZy Family: GT19
• CAZyme Description: Lipid-A-disaccharide synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
388		43253.2	8.8102

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000004172	3050906	MAG	United Kingdom	Europe

• Gene Location: Start: 248631; End: 249797 Strand: +

Full Sequence      

MRYYLIAGEASGDLHGANLMKGLLRHDPQAQFRFWGGDKMAAVGGAGNLARHYKTASFMG
FVEVVMNLPTILGQLRECKADVAAYAPDVLILIDYPGFNFKMAKFAHLAGIPTFYYISPK
VWAWKESRVKLIRKYVDRLFIIFPFEVEYFRRRGIEAIYEGNPIEDVLVEQKRSIPSREA
FLAENGLDDRPIVALLAGSRKTEIRYNLPFMAKLAAEFPGYQFVVGGVSWLDRSLYDAVL
GGESPVKYVCDKTYPLLAHAEAAVVTSGTATLETALLGTPEFVCYRAGSVTIAIGRLLIR
SIRYISLVNLIMDREVVREMIQGDMEVRHAAEELRAVLPGGAKHEKMLADYAALRERVGG
PGASDRFAARMVTLLRERLASSETPKTE

Enzyme Prediction     

No EC number prediction in MGYG000004172_01198.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT19	4	357	2.3e-106	0.9858757062146892

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK00025	lpxB	7.18e-100	1	378	2	378	lipid-A-disaccharide synthase; Reviewed
COG0763	LpxB	2.41e-99	1	377	2	381	Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis].
pfam02684	LpxB	7.87e-76	4	366	2	366	Lipid-A-disaccharide synthetase. This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
TIGR00215	lpxB	2.79e-67	5	369	10	380	lipid-A-disaccharide synthase. Lipid-A precursor biosynthesis producing lipid A disaccharide in a condensation reaction. transcribed as part of an operon including lpxA [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
PRK14089	PRK14089	2.14e-46	57	328	49	307	lipid-A-disaccharide synthase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QGA24435.1	3.47e-187	1	377	1	375
BCG53033.1	6.73e-171	1	387	1	385
AFL77950.1	9.75e-166	1	375	1	373
BBL11605.1	4.31e-162	1	376	1	374
BBL08813.1	4.31e-162	1	376	1	374

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5W8N_A	4.02e-32	5	358	11	365	LipidA Disaccharide Synthase (LpxB)-6 solubilizing mutations [Escherichia coli BL21(DE3)]
5W8S_A	5.56e-32	5	358	11	365	LipidA Disaccharide Synthase (LpxB)-7 solubilizing mutations [Escherichia coli BL21(DE3)],5W8X_A Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations-Bound to UDP [Escherichia coli BL21(DE3)]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q1D393	3.11e-74	2	375	6	378	Lipid-A-disaccharide synthase OS=Myxococcus xanthus (strain DK1622) OX=246197 GN=lpxB PE=3 SV=1
Q2LVL8	6.86e-73	5	377	8	380	Lipid-A-disaccharide synthase OS=Syntrophus aciditrophicus (strain SB) OX=56780 GN=lpxB PE=3 SV=1
Q39T49	3.56e-66	2	378	8	383	Lipid-A-disaccharide synthase OS=Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15) OX=269799 GN=lpxB PE=3 SV=1
Q1INL4	4.75e-66	1	370	2	369	Lipid-A-disaccharide synthase OS=Koribacter versatilis (strain Ellin345) OX=204669 GN=lpxB PE=3 SV=1
Q74AT9	3.90e-65	2	379	8	384	Lipid-A-disaccharide synthase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) OX=243231 GN=lpxB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000059	0.000003	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000004172_01198.