| Basic Information | |
|---|---|
| Species | Zea mays |
| Cazyme ID | GRMZM2G393002_T01 |
| Family | GH51 |
| Protein Properties | Length: 1861 Molecular Weight: 208279 Isoelectric Point: 6.6874 |
| Chromosome | Chromosome/Scaffold: 4 Start: 11060491 End: 11085316 |
| Description | alpha-L-arabinofuranosidase 1 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH51 | 752 | 1199 | 0 |
| AGDSKWIKVEKKLVAKGTNRTSRLQITSKKKGTVWLDQVSLMPADTYKGHGFRKGLVSMLMDLKPRFLRFPGGCFVEGGWLRNAFRWRQSIGPWEERPGH FGDCWQYWTDDGLGYYEFLLLSEDIGAAPIWVFNNGISYNDEVNTATIAPFVKNLLEAVRIRHGALLEPKWGIPKPFPVKYVAIGNEDCERKFYRGNYLK FYNAIREVYPDIQLISNCDGSSGPLDHPADIYDFHVYADAKTLFSMKSTFDKSPRSGPKAFVSEYAVWKTDAGRGTLLAALAEAAFLTGLEKNSDAVEMA CHAPLFVNDDIEKKWNPDVIVFNTWQHYGTPSYWMQKLFRESSGAMVHPTTTISSGSSADSLAASAITWKDSENNDSFLRVKARLRSVLIPEALVQIVNF GSDAIRVAISTAGLQATIDVLRSTATVLTSTAVMDENSFSNPNKPEAV | |||
| Full Sequence |
|---|
| Protein Sequence Length: 1861 Download |
| MAADRAWMYN GWSRNGRHSD DWVAKTKEFV DHVFALSLTG TVRCPCRHHE NSIFLNKERV 60 SLDLCQFGFM PGYEVWEHHG EVVPNRNVEE EENNDWAGDD AMHEMLDSLR PEFNLSSEDP 120 ATPEEEEDDE EEVQHHEEED EQAHEEDDEE EVQHHEEEDE QAHEGIDAEA DDDTTEAPVV 180 RRRGTRKGHF VLPPSAPAQS EARVLIIPVG DSQWEDTSFD GRGHHRQVNQ VLGKRRYRVE 240 PEAQEHADRV LEKNAKKVCR DAFSNARLQV GNAYMKRRGH SINNFRQYSD VYLTVDEYME 300 VTLPWMEHRP QAYKALCEIW ASPEWIEKSN RNRHRQRHQQ DEDDDEVVVN HTYGADGHIR 360 LAKRMEAQTG VVPSPIDVYR RGHRAKNNEI SDELCSQAVV ERMETYGQEM VKKYGEDYDW 420 RGAPTIDAEV VHSLGGKAHG RYSMFTGVID STELRSRGGS SSQAGCGSSR HSRRSVSSME 480 EAMREQQEKF REELRQQQMA FLQQQSEYMV AYNAQAQQAM NSWFPQQAQQ QPFVFPQFQL 540 SMPQWGLHAP TPPPPHQGSR VIGHNTPSLV ISAPGGAYAG EGAYAGEDPN PSHGFVNQFL 600 ASEASKCLGG ASGLNSTQMV TLKVDASPKL ARKIPDTFLG VFFEEMGHGG AGGIWAELVS 660 NRGFEAGGPN TPSNIDPWLI VGDDSSVYVE TDRSSCFSRN IVALRMEVLC NDCPAGGVGI 720 YNPGFWGMPY VWTRRGSLII QALLKYWFCR VAGDSKWIKV EKKLVAKGTN RTSRLQITSK 780 KKGTVWLDQV SLMPADTYKG HGFRKGLVSM LMDLKPRFLR FPGGCFVEGG WLRNAFRWRQ 840 SIGPWEERPG HFGDCWQYWT DDGLGYYEFL LLSEDIGAAP IWVFNNGISY NDEVNTATIA 900 PFVKNLLEAV RIRHGALLEP KWGIPKPFPV KYVAIGNEDC ERKFYRGNYL KFYNAIREVY 960 PDIQLISNCD GSSGPLDHPA DIYDFHVYAD AKTLFSMKST FDKSPRSGPK AFVSEYAVWK 1020 TDAGRGTLLA ALAEAAFLTG LEKNSDAVEM ACHAPLFVND DIEKKWNPDV IVFNTWQHYG 1080 TPSYWMQKLF RESSGAMVHP TTTISSGSSA DSLAASAITW KDSENNDSFL RVKARLRSVL 1140 IPEALVQIVN FGSDAIRVAI STAGLQATID VLRSTATVLT STAVMDENSF SNPNKPEAVA 1200 CCSLCTGAAE ARVKARADVA GARGRLCTGL SLKAKEKKRK KSSSEAQALE VESTWLHALN 1260 FYGNEDIHQE SSAKFNRDQM HSVKWKGINV LLSHLCPKCS KKHDDTTSGS QTTGCTCWQW 1320 FFTPSTSNDT ANVASANGGN TSQVEEKVLA PSYKLDNAET SVSAVGHHTK SSMHHRLKIW 1380 ISSGHNGIMG KYGNKLELGM PHEARPLLLD EHAKPGWPDW LINVAPEAVR GWFPRRQDSF 1440 EKLDKVGQGT YSSVYKARDL KTDKFVALKK VRFVNVDPES VRFMAREILI LRKLNHPNII 1500 KLEGIVTSSV SRSLYLVFEY MEHDLVGLAA TPGLKFTEPQ VKCLFQQLLS GLDHCHSNGV 1560 LHRDLKCSNL LIDNNGVLKI ADFGLATSFD PDNQQPLTSR VATLWYRPPE LLLGATKYGP 1620 SVDLWSTGCI FAELLAGKPI LPGRTEVEQL HKIFKLCGSP PDDYWSKLEV PQAGMFKPSR 1680 QYSGCIAETF KDFPNSVVLL DNLLALQPYA RGTAAETLRS DFFRQKPLAC SPSSLPKCPP 1740 SKEYDARLRM EEARRKRKAA ESVSGFGSIE TEDVNPLASG NTKVAMIRPE SADARNAILG 1800 SQNNNLGLKG PAVNKGKSRI YQHSGSMITA KGNVEQMLKE HEKNIQEAVR KARLSKHREL 1860 * 1920 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd07841 | STKc_CDK7 | 1.0e-92 | 1440 | 1724 | 297 | + Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7. Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase 7 (CDK7) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK7 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDK7 plays essential roles in the cell cycle and in transcription. It associates with cyclin H and MAT1 and acts as a CDK-Activating Kinase (CAK) by phosphorylating and activating cell cycle CDKs (CDK1/2/4/6). In the brain, it activates CDK5. CDK7 is also a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of RNA polymerase II when it is bound with unphosphorylated DNA, as present in the pre-initiation complex. Following phosphorylation, the CTD dissociates from the DNA which allows transcription initiation. | ||
| cd07864 | STKc_CDK12 | 5.0e-96 | 1432 | 1722 | 302 | + Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12. Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase 12 (CDK12) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK12 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDK12 is also called Cdc2-related protein kinase 7 (CRK7) or Cdc2-related kinase arginine/serine-rich (CrkRS). It is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 is widely expressed in tissues. It interacts with cyclins L1 and L2, and plays roles in regulating transcription and alternative splicing. | ||
| cd07843 | STKc_CDC2L1 | 4.0e-100 | 1435 | 1723 | 296 | + Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1. Serine/Threonine Kinases (STKs), Cell Division Cycle 2-like 1 (CDC2L1) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDC2L1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDC2L1, also called PITSLRE, exists in different isoforms which are named using the alias CDK11(p). The CDC2L1 gene produces two protein products, CDK11(p110) and CDK11(p58). CDC2L1 is also represented by the caspase-processed CDK11(p46). CDK11(p110), the major isoform, associates with cyclin L and is expressed throughout the cell cycle. It is involved in RNA processing and the regulation of transcription. CDK11(p58) associates with cyclin D3 and is expressed during the G2/M phase of the cell cycle. It plays roles in spindle morphogenesis, centrosome maturation, sister chromatid cohesion, and the completion of mitosis. CDK11(p46) is formed from the larger isoforms by caspases during TNFalpha- and Fas-induced apoptosis. It functions as a downstream effector kinase in apoptotic signaling pathways and interacts with eukaryotic initiation factor 3f (eIF3f), p21-activated kinase (PAK1), and Ran-binding protein (RanBPM). | ||
| cd07829 | STKc_CDK_like | 4.0e-106 | 1440 | 1723 | 291 | + Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase (CDK)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDKs are partly regulated by their subcellular localization, which defines substrate phosphorylation and the resulting specific function. CDK1, CDK2, CDK4, and CDK6 have well-defined functions in the cell cycle, such as the regulation of the early G1 phase by CDK4 or CDK6, the G1/S phase transition by CDK2, or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes, showing that some CDKs can compensate for each other. For example, CDK4 can compensate for the loss of CDK6, however, double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH. | ||
| cd07840 | STKc_CDK9_like | 2.0e-142 | 1440 | 1723 | 287 | + Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs), Cyclin-Dependent protein Kinase 9 (CDK9)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes, yeast BUR1, C-type plant CDKs (CdkC), and similar proteins. CDK9, BUR1, and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2, and participates in regulating transcription and alternative splicing. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004672 | protein kinase activity |
| GO:0005524 | ATP binding |
| GO:0006468 | protein phosphorylation |
| GO:0046373 | L-arabinose metabolic process |
| GO:0046556 | alpha-N-arabinofuranosidase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACN33779.1 | 0 | 599 | 1195 | 40 | 640 | unknown [Zea mays] |
| GenBank | EEC67598.1 | 0 | 606 | 1210 | 23 | 631 | hypothetical protein OsI_34967 [Oryza sativa Indica Group] |
| RefSeq | NP_001065660.1 | 0 | 606 | 1210 | 23 | 631 | Os11g0131900 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_001148977.1 | 0 | 599 | 1195 | 40 | 640 | alpha-N-arabinofuranosidase A [Zea mays] |
| RefSeq | XP_002450568.1 | 0 | 646 | 1195 | 1 | 551 | hypothetical protein SORBIDRAFT_05g007100 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 4bcf_A | 0 | 1440 | 1735 | 20 | 325 | A Chain A, Structure Of Cdk9 In Complex With Cyclin T And A 2-amino-4- Heteroaryl-pyrimidine Inhibitor |
| PDB | 4imy_E | 0 | 1440 | 1735 | 21 | 326 | G Chain G, The Aff4 Scaffold Binds Human P-tefb Adjacent To Hiv Tat |
| PDB | 4imy_C | 0 | 1440 | 1735 | 21 | 326 | G Chain G, The Aff4 Scaffold Binds Human P-tefb Adjacent To Hiv Tat |
| PDB | 4imy_A | 0 | 1440 | 1735 | 21 | 326 | G Chain G, The Aff4 Scaffold Binds Human P-tefb Adjacent To Hiv Tat |
| PDB | 4bcj_A | 0 | 1440 | 1735 | 20 | 325 | G Chain G, The Aff4 Scaffold Binds Human P-tefb Adjacent To Hiv Tat |
| Hydropathy |
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