| Basic Information | |
|---|---|
| Species | Glycine max |
| Cazyme ID | Glyma06g19791.1 |
| Family | GH89 |
| Protein Properties | Length: 777 Molecular Weight: 89661.2 Isoelectric Point: 6.0524 |
| Chromosome | Chromosome/Scaffold: 06 Start: 16130306 End: 16155239 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH89 | 94 | 437 | 0 |
| PQILIEGTTGVDIVAGLHWYLKHWCGSHISWDKTGGSQLFSVPNVGLLLPRVHHAGVSVQRPVPWSYYQNAVTSSYSFAWWDWERWEREIDWMVLHGVNL PLAFTGQEAIWQKVFQEKFNMTTSDLDDFFGGPAFLAWSRMGNLHGWGGPLPQSWFDQQLILQKKILARMFELGMTPVLPAFSGNVPAALKHIFPSAKIT RLGNWFSVKNDLKWCCTYLLDATDSLFVEIGKAFIEKQLQEYGRTSHIYNCDTFDENTPPVDDPEYISSLGAATFKGMQSGDDDAVWLMQGWLFSYDPFW RPPQMKALLHSVPVGKLVVLDLFAEVKPIWVTSEQFYGVPYIWK | |||
| GH89 | 438 | 763 | 0 |
| VGVGMSMEGIEQNPIVYDLMSEMAFQHKKVDVKAWVDMYSTRRYGQTLPLIQEGWNVLYHTIYNCTDGAYDKNRDVIVAFPDVDPSLISVQHEQSHHNDK PYSGTIIKEITDSFDRPHLWYPTSEVIYALELFITSGDELSRCNTYRYDLVDLTRQVLAKYANELFFKVIEAYQSHDIHGMTLLSQRFLDLVEDLDTLLA CHDGFLLGPWLESAKQLALNEEQERQFEWNARTQITMWFDNSDEEASLLRDYGNKYWNGLLHDYYGPRAAIYFKYLRESLESGEDFKLRGWRREWIKLTN EWQKRRNIFPVESSGDALNTSRWLFN | |||
| Full Sequence |
|---|
| Protein Sequence Length: 777 Download |
| MKLPFPAIFL IFIFFLPSST TGAGIDTIFR LIRIQDRERA PPSVQEAAAR GVLLRLLPSH 60 SSSFEFRILS KKQCGGEYCF KIKNHPSFTK AGDPQILIEG TTGVDIVAGL HWYLKHWCGS 120 HISWDKTGGS QLFSVPNVGL LLPRVHHAGV SVQRPVPWSY YQNAVTSSYS FAWWDWERWE 180 REIDWMVLHG VNLPLAFTGQ EAIWQKVFQE KFNMTTSDLD DFFGGPAFLA WSRMGNLHGW 240 GGPLPQSWFD QQLILQKKIL ARMFELGMTP VLPAFSGNVP AALKHIFPSA KITRLGNWFS 300 VKNDLKWCCT YLLDATDSLF VEIGKAFIEK QLQEYGRTSH IYNCDTFDEN TPPVDDPEYI 360 SSLGAATFKG MQSGDDDAVW LMQGWLFSYD PFWRPPQMKA LLHSVPVGKL VVLDLFAEVK 420 PIWVTSEQFY GVPYIWKVGV GMSMEGIEQN PIVYDLMSEM AFQHKKVDVK AWVDMYSTRR 480 YGQTLPLIQE GWNVLYHTIY NCTDGAYDKN RDVIVAFPDV DPSLISVQHE QSHHNDKPYS 540 GTIIKEITDS FDRPHLWYPT SEVIYALELF ITSGDELSRC NTYRYDLVDL TRQVLAKYAN 600 ELFFKVIEAY QSHDIHGMTL LSQRFLDLVE DLDTLLACHD GFLLGPWLES AKQLALNEEQ 660 ERQFEWNART QITMWFDNSD EEASLLRDYG NKYWNGLLHD YYGPRAAIYF KYLRESLESG 720 EDFKLRGWRR EWIKLTNEWQ KRRNIFPVES SGDALNTSRW LFNKYLNLSN PETKKL* 780 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 6.0e-21 | 45 | 132 | 88 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 3.0e-95 | 471 | 765 | 295 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 5.0e-145 | 160 | 464 | 338 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | EEC78143.1 | 0 | 19 | 772 | 19 | 816 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| GenBank | EEE61812.1 | 0 | 17 | 772 | 317 | 1116 | hypothetical protein OsJ_16433 [Oryza sativa Japonica Group] |
| RefSeq | XP_002280399.1 | 0 | 18 | 776 | 21 | 813 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 18 | 773 | 26 | 809 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 3 | 773 | 5 | 805 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 64 | 755 | 190 | 866 | B Chain B, Crystal Structure Of Yeast AlphaBETAPRIME-Cop Subcomplex Of The Copi Vesicular Coat |
| PDB | 2vcb_A | 0 | 64 | 755 | 190 | 866 | B Chain B, Crystal Structure Of Yeast AlphaBETAPRIME-Cop Subcomplex Of The Copi Vesicular Coat |
| PDB | 2vca_A | 0 | 64 | 755 | 190 | 866 | B Chain B, Crystal Structure Of Yeast AlphaBETAPRIME-Cop Subcomplex Of The Copi Vesicular Coat |
| PDB | 2vc9_A | 0 | 64 | 755 | 190 | 866 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 64 | 755 | 213 | 889 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
