y
Basic Information | |
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Species | Oryza sativa |
Cazyme ID | LOC_Os08g10320.1 |
Family | CBM57 |
Protein Properties | Length: 1016 Molecular Weight: 111502 Isoelectric Point: 6.9605 |
Chromosome | Chromosome/Scaffold: 8 Start: 6032171 End: 6039181 |
Description | Leucine-rich repeat transmembrane protein kinase |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
CBM57 | 422 | 592 | 5.7e-24 |
FAVDCGSNRSIRGSDNTMYELDFTDLGSSSYYVTSETRWGVSNVGKYFQSPNDSKIIYSNEKIQNAVVSELLQTARMSPSSLRYFGLGLENGNYTVLLQF AELGYPDSPTWKSLGRRVFDIYIQGDLKEKDFDIRKMAGGKSFTAVYKSYTATVSKNFLEIHLFWAGKGTC |
Full Sequence |
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Protein Sequence Length: 1016 Download |
MGGHVIVWIL LSVCSWRISA AQAQQPPRTD PVEVAALEAI LGRWNKTNSP VWSMSGEPCR 60 GVPVDGVTGL DGNPKNNPGI KCDCSYINGT VCHITQLKVY ALNVVGQIPA ELQNLTYLNY 120 LDLDQNYLSG PIPSFIGQLT ALTELHVGFN ALSGPIPKEL GNLTNLNLLG ISLTNFTGQL 180 PEELGNLTKL QRLYTDSAGL SGPFPSTFSK LKNLKLLRAS DNDFTGKIPD YIGSLTNLED 240 LAFQGNSFEG PIPESLSNLT KLTTLRIGDI VSGSSSFAFV SSLTSLNILV LRNCRISGDL 300 GAVDFSKFTK LAFLDLSFNN ISGKVPQSIL NLQMLTDLFL GNNSLTGGLP DGISPSLKNL 360 DFSYNQLTGS FPSWATQNNL QLNLVANNFD LGSTNNGILP PGLNCLQKDT PCLRGSPEYY 420 SFAVDCGSNR SIRGSDNTMY ELDFTDLGSS SYYVTSETRW GVSNVGKYFQ SPNDSKIIYS 480 NEKIQNAVVS ELLQTARMSP SSLRYFGLGL ENGNYTVLLQ FAELGYPDSP TWKSLGRRVF 540 DIYIQGDLKE KDFDIRKMAG GKSFTAVYKS YTATVSKNFL EIHLFWAGKG TCCIPIQGYY 600 GPLISALSIT PNFTPTVRNG VPKRKSKVGA IAGISIGASV VGLAALFGIF MFIKKRRRLA 660 QQQGELYNLV GRPDVFSNAE LKLATNNYSS QNILGEGGYG PVYKGMLPDG RVIAVKQLSQ 720 SSHQGKNQFV TEVATISSVQ HRNLVKLHGC CIDSNTPLLV YEYLENGSLD QALFRKNSLK 780 LDWATRFEII LGIARGLTYL HEESSVRIVH RDIKASNVLL DTDLTPKISD FGLARLYDEK 840 KTHVSTGIAG TFGYLAPEYA MRRHLTEKVD VYAFGVVALE TVAGRSNTNN SIEESKIYLL 900 EWAWDLYEKE QAQRIVDPRL EDFNKDEVLR VIHVALLCTQ GSPNQRPPMS RVMAVLTGDA 960 EVVEMVTKPS YITEWQYRDG NSTNSESTTS EFSRQKEIDP LTMSPTITGS SHDGR* 1020 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
smart00221 | STYKc | 3.0e-47 | 693 | 877 | 192 | + Protein kinase; unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. | ||
pfam00069 | Pkinase | 2.0e-47 | 693 | 930 | 250 | + Protein kinase domain. | ||
smart00219 | TyrKc | 3.0e-49 | 693 | 877 | 191 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
cd00180 | PKc | 1.0e-50 | 694 | 880 | 191 | + Catalytic domain of Protein Kinases. Protein Kinases (PKs), catalytic (c) domain. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase. PKs make up a large family of serine/threonine kinases, protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation, about 95%, occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and 550 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. | ||
pfam11721 | Malectin | 3.0e-57 | 420 | 607 | 190 | + Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan. |
Gene Ontology | |
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GO Term | Description |
GO:0000166 | nucleotide binding |
GO:0004672 | protein kinase activity |
GO:0005515 | protein binding |
GO:0005524 | ATP binding |
GO:0005886 | plasma membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAY67902.1 | 0 | 3 | 1015 | 14 | 1027 | SHR5-receptor-like kinase [Saccharum hybrid cultivar SP70-1143] |
GenBank | EEC78858.1 | 0 | 15 | 1007 | 24 | 1018 | hypothetical protein OsI_19210 [Oryza sativa Indica Group] |
GenBank | EEE68222.1 | 0 | 1 | 1015 | 1 | 938 | hypothetical protein OsJ_26394 [Oryza sativa Japonica Group] |
RefSeq | NP_001061223.1 | 0 | 1 | 1013 | 1 | 1020 | Os08g0203400 [Oryza sativa (japonica cultivar-group)] |
RefSeq | XP_002444009.1 | 0 | 3 | 1015 | 18 | 1009 | hypothetical protein SORBIDRAFT_07g005820 [Sorghum bicolor] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3ulz_A | 0 | 660 | 960 | 6 | 310 | A Chain A, Barley Alpha-Amylase Isozyme 1 (Amy1) H395a Mutant |
PDB | 3uim_A | 0 | 660 | 960 | 6 | 310 | A Chain A, Structural Basis For The Impact Of Phosphorylation On Plant Receptor- Like Kinase Bak1 Activation |
PDB | 3tl8_H | 0 | 660 | 959 | 14 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_G | 0 | 660 | 959 | 14 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_D | 0 | 660 | 959 | 14 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |