Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000216342 |
Family | GT47 |
Protein Properties | Length: 836 Molecular Weight: 96767 Isoelectric Point: 9.2996 |
Chromosome | Chromosome/Scaffold: 020559133 Start: 15851 End: 22499 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 175 | 289 | 1.6e-29 |
KRFKVWSYKEGEHPLIHFGPVNDIYGIEGQFIDEIEREESPFRATHPDEAHTFFLPFSVANVVRYVHMPITRKQDYHRDRLQRVVTDYISVVADKYPYWN RSNGADHFMASCHDW | |||
GT47 | 292 | 407 | 3.36312e-44 |
KSRPILAFFAGRVHGPVRPILLDHWKDKDDEVQVYEKLPKGLNYTKFMGQSKFCLCPSGFEVASPRIVEAIYAGCVPVLISDNYTLLFSDVLDWSKFSVQ IPVDKIPEIKTILQAI | |||
GT47 | 504 | 787 | 0 |
EKRLKVWVYREGEHPLVHTGPLNDIYAIEGQFIDEMESGKSRFMARHPDEAHLFLIPISVANIINTLYKPLVTYNRDQLQRVVMDYIGVIAEKYPHWNRS RGADHFLVSCHDWAPDISQVNPKLYRXFIRVLCNANISEGFKPQRDVSIPEINIPYGKFGPTPQNTSLDKRSILAFFAGGSHGXIRKILLEHWKDKDNEV QVHEYLKNKKDYFKLMGKAKFCLCPSGYEVASARVVTAISVGCVPVLISDDYVLPFSDVLDWSKFSVYIPSKKIPEIKTILRGI |
Full Sequence |
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Protein Sequence Length: 836 Download |
MAMTSAFRCR TLFWLIIFFF LVFFVLTFSP LLRENNVIIP FVSSFNSTTT PFNLTKSNCT 60 SLPQVSYFDE LLTSSMYQRR HKANLTKGKT SLDTIEEGLA KARAAILEAI QFKKYASQKN 120 ETFIPRGTIY KNPYAFHQLN YDCQTSAVQL QSSTAPVHPI HCHSCILKSH VEMMKRFKVW 180 SYKEGEHPLI HFGPVNDIYG IEGQFIDEIE REESPFRATH PDEAHTFFLP FSVANVVRYV 240 HMPITRKQDY HRDRLQRVVT DYISVVADKY PYWNRSNGAD HFMASCHDWA PKSRPILAFF 300 AGRVHGPVRP ILLDHWKDKD DEVQVYEKLP KGLNYTKFMG QSKFCLCPSG FEVASPRIVE 360 AIYAGCVPVL ISDNYTLLFS DVLDWSKFSV QIPVDKIPEI KTILQAIPFD KYLKMQKRVY 420 RKMSNLERIE ADLGRAREAI RKAVHEKNQT SNYKGNDDVI IPKGSVYRNA QSFHQLSSKH 480 NYLSMIQTYN QKWNPSNMSY VEMEKRLKVW VYREGEHPLV HTGPLNDIYA IEGQFIDEME 540 SGKSRFMARH PDEAHLFLIP ISVANIINTL YKPLVTYNRD QLQRVVMDYI GVIAEKYPHW 600 NRSRGADHFL VSCHDWAPDI SQVNPKLYRX FIRVLCNANI SEGFKPQRDV SIPEINIPYG 660 KFGPTPQNTS LDKRSILAFF AGGSHGXIRK ILLEHWKDKD NEVQVHEYLK NKKDYFKLMG 720 KAKFCLCPSG YEVASARVVT AISVGCVPVL ISDDYVLPFS DVLDWSKFSV YIPSKKIPEI 780 KTILRGISPS RYLELQKSVM EVHRHFTIHR PAQPYDMLHM VLHSVWLRRL DVSLLS 840 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 1.0e-42 | 173 | 407 | 306 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
pfam03016 | Exostosin | 2.0e-64 | 503 | 787 | 303 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | NP_197526.4 | 0 | 93 | 419 | 25 | 372 | catalytic [Arabidopsis thaliana] |
RefSeq | NP_197526.4 | 0 | 429 | 834 | 27 | 407 | catalytic [Arabidopsis thaliana] |
Swiss-Prot | Q3E9A4 | 0 | 429 | 834 | 85 | 465 | GLYT5_ARATH RecName: Full=Probable glycosyltransferase At5g20260 |
RefSeq | XP_002531945.1 | 0 | 87 | 419 | 71 | 415 | catalytic, putative [Ricinus communis] |
RefSeq | XP_002531945.1 | 0 | 421 | 834 | 71 | 450 | catalytic, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 2jhp_A | 0.0005 | 669 | 763 | 362 | 457 | A Chain A, Crystal Structure Of Udp-Glucosyltransferase Gtfb |
PDB | 2jhc_A | 0.0005 | 669 | 763 | 362 | 457 | A Chain A, Crystal Structure Of Udp-Glucosyltransferase Gtfb |
PDB | 2jha_A | 0.0005 | 669 | 763 | 362 | 457 | A Chain A, Crystal Structure Of Udp-Glucosyltransferase Gtfb |
PDB | 2jh9_A | 0.0005 | 669 | 763 | 362 | 457 | A Chain A, Crystal Structure Of Udp-Glucosyltransferase Gtfb |
PDB | 2jh8_A | 0.0005 | 669 | 763 | 362 | 457 | A Chain A, The Structure Of Bluetongue Virus Vp4 Reveals A Multifunctional Rna-capping Production-line |