Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000304216 |
Family | GT47 |
Protein Properties | Length: 713 Molecular Weight: 83003.7 Isoelectric Point: 8.2523 |
Chromosome | Chromosome/Scaffold: 017710278 Start: 7438 End: 16396 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 25 | 307 | 0 |
KRFKIWSYKEGDLPMVHNGPTTYIYSIEGQFIFEXESGPSPFVAQHPDEAHAFFLPXSVSKITDFLYRPHHETFFHRLDRTFTDYIFVVADKYPYWNRSG GADHFFVSCHDWAPIISRDDPRPYKNLIKVLCNANTSEGFKPTRDVSLPEYNLKAFDLGPPRFGEPPDKRPLLAFFAGAAHGDIRSILFEHWKEKDDEVR VYEKLPKDLNYHKLMGQTKFCLCPSGSEVASPXVVEAMYAGCVPVLISDYYAVPFDDVLDWSKFSIQIPPKRISEIKTILKAV | |||
GT47 | 380 | 664 | 0 |
KRFKIWAYKEGEIPMFHNGPMSYIYSIEGHFIDELDSSGKSPFLARHHDEAHSFFVPVSVKRIADFLYDRPNPYTFHGRLVRIVTDYINVVAQKYPYWNR SXGADHFMLSCHDWAPEIIDDDRDFYKNFIRVLCNSNTSEGFQPKRDVSLPEYNIPEHTLGPSLLDXHPDKRPILAFFAGGAHGDIRKFLFEHWRDKDDE IQVHEYLPKGQNYHEIMGRTKFCLCPSGSEVASPRVVEAMYAGCVPVLISDYYSLPFADVLDWSKFTVEIPPKRIPEIKTILKAV |
Full Sequence |
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Protein Sequence Length: 713 Download |
MRLPQLPPPP NSVXLLPKSH VEMMKRFKIW SYKEGDLPMV HNGPTTYIYS IEGQFIFEXE 60 SGPSPFVAQH PDEAHAFFLP XSVSKITDFL YRPHHETFFH RLDRTFTDYI FVVADKYPYW 120 NRSGGADHFF VSCHDWAPII SRDDPRPYKN LIKVLCNANT SEGFKPTRDV SLPEYNLKAF 180 DLGPPRFGEP PDKRPLLAFF AGAAHGDIRS ILFEHWKEKD DEVRVYEKLP KDLNYHKLMG 240 QTKFCLCPSG SEVASPXVVE AMYAGCVPVL ISDYYAVPFD DVLDWSKFSI QIPPKRISEI 300 KTILKAVPYS KYLKLQKRVI QEKSSTSSKI EEELARARAA IREAIRTKNY TSDRQEIYIP 360 RGSIYRNPYA FHQSHIEMVK RFKIWAYKEG EIPMFHNGPM SYIYSIEGHF IDELDSSGKS 420 PFLARHHDEA HSFFVPVSVK RIADFLYDRP NPYTFHGRLV RIVTDYINVV AQKYPYWNRS 480 XGADHFMLSC HDWAPEIIDD DRDFYKNFIR VLCNSNTSEG FQPKRDVSLP EYNIPEHTLG 540 PSLLDXHPDK RPILAFFAGG AHGDIRKFLF EHWRDKDDEI QVHEYLPKGQ NYHEIMGRTK 600 FCLCPSGSEV ASPRVVEAMY AGCVPVLISD YYSLPFADVL DWSKFTVEIP PKRIPEIKTI 660 LKAVPHSEFL KLQKRVMQVR RHFMLNRPAK PYDVFHMVLH SIWLRRLDIR LPN 720 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 4.0e-54 | 23 | 307 | 306 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
pfam03016 | Exostosin | 1.0e-56 | 378 | 664 | 305 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI21065.1 | 0 | 322 | 712 | 10 | 401 | unnamed protein product [Vitis vinifera] |
EMBL | CBI25537.1 | 0 | 18 | 321 | 134 | 442 | unnamed protein product [Vitis vinifera] |
EMBL | CBI25537.1 | 0 | 318 | 712 | 79 | 476 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002263848.1 | 0 | 18 | 321 | 53 | 361 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002263848.1 | 0 | 325 | 713 | 5 | 396 | PREDICTED: hypothetical protein [Vitis vinifera] |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
GO540152 | 212 | 45 | 256 | 0 |
GO540152 | 213 | 402 | 614 | 0 |
CN916657 | 212 | 27 | 238 | 0 |
CN916657 | 214 | 382 | 595 | 0 |
EC939466 | 270 | 347 | 612 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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