y
Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000425449 |
Family | GT47 |
Protein Properties | Length: 1274 Molecular Weight: 146390 Isoelectric Point: 9.543 |
Chromosome | Chromosome/Scaffold: 008863369 Start: 3145 End: 15344 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 504 | 789 | 0 |
KRFKVWTYKEGELPLLHIGPMKNIYGIEGHFIDEMERMDNPFRATHPDEAHTFFLPFSVANIIEYVYLPITGKQDYRRDRLQRVVIDYIGIVANKYRYWN RSNGADHFMASCHDWAPEISAGQPKLFKNFIRXLCNANTSEGFRPKIDVSLPEVYVPPRELGPPDLGQAPNNRRILAFFAGRVHGPIRPILLDYWKGKDD EVQVHEKLLQDQNYTKLMGQSKYCLCPSGYEVASPRAVEAIHAGCVPVLISDNYTLPFSDALDWSQFSVQIPVAKIPDIKTILRAI | |||
GT47 | 939 | 1224 | 0 |
KRFKVWSYKEGEHPLIHFGPLNDIYGIEGQFIDEIEREESPFRATHPDKAHTFFLPLSVANVVRFVYMPITRRQDYHRDRLQRVVTDYIGVVAGKYPYWN RSNGADHFMASCHDWAPEVSVGNQELFKNFIRVLCNANTSEGFKPKRDVSLPEIYLYKGNLGSSNLCQAXKSRPILAFFAGRVHGPVRPILLDHWKDKDD EVQVYEKLPKGLNYTKFMVQSKFCLCPSGFEVASPRIVEAIYAGCVPVLISDSYTLPFSDVLDWSKFSVQIPVAKIPEIKTILQAI |
Full Sequence |
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Protein Sequence Length: 1274 Download |
MSPKEGGALA RMRYSSKQTT PASAKQVEDE MKNQQTLIRN ISSVDNIKNK RRRKKKKKQN 60 KANPKXYGLM SYWELPEYMK DNEFILNYYR XDWSLPEALF SVFRWHNETL NVWTHLIGFV 120 LFLGLTMANL LEVPPVADLL GFFARSTPIS GVXNVSRNFI SGMTTNLIXL KQMTSQDMEF 180 ASSAPSAEMG VIYWPFYVFL AGSMFCLLSS TICHLFSCHS HPLNLMLLRI DYAGITTMII 240 TSFFPPIYYI FQCDSRWQFI YLGGITVMGI FTIVTLLSPX LSSSEFRKFR ALLFASMGLF 300 GIVPAIHGSV VNWGNPKRNL TLVYEAXMAF FYLTGTGFYV TRIPERWRPG WFDLAGHSHQ 360 IFHVLVVLGA LAHYGAILVL LDWRNSFGWL LKINFDGSVI NXKXAADFVA GARSLGENSI 420 FVAEALALRD AFWLGKGKGF KKACVKNKTS VERIEEDLSE ARAAIRKAIQ SRNYSSEREE 480 TFIPRGSVYK NPYAFHQSHI EMRKRFKVWT YKEGELPLLH IGPMKNIYGI EGHFIDEMER 540 MDNPFRATHP DEAHTFFLPF SVANIIEYVY LPITGKQDYR RDRLQRVVID YIGIVANKYR 600 YWNRSNGADH FMASCHDWAP EISAGQPKLF KNFIRXLCNA NTSEGFRPKI DVSLPEVYVP 660 PRELGPPDLG QAPNNRRILA FFAGRVHGPI RPILLDYWKG KDDEVQVHEK LLQDQNYTKL 720 MGQSKYCLCP SGYEVASPRA VEAIHAGCVP VLISDNYTLP FSDALDWSQF SVQIPVAKIP 780 DIKTILRAIP YENYLKMQKR VSQVKRHFVL NRPSEPFDLI HMILHSSNYT ALPQVSYFDE 840 PTTTPFNLTK SNHTALPQVS YFDELLTSSM YQRRHKANLT KGKTSLDRIE EDLAKARAAI 900 LEAIXYKKYT SQKIETFIPR GTIYKNPYAF HQSHIEMVKR FKVWSYKEGE HPLIHFGPLN 960 DIYGIEGQFI DEIEREESPF RATHPDKAHT FFLPLSVANV VRFVYMPITR RQDYHRDRLQ 1020 RVVTDYIGVV AGKYPYWNRS NGADHFMASC HDWAPEVSVG NQELFKNFIR VLCNANTSEG 1080 FKPKRDVSLP EIYLYKGNLG SSNLCQAXKS RPILAFFAGR VHGPVRPILL DHWKDKDDEV 1140 QVYEKLPKGL NYTKFMVQSK FCLCPSGFEV ASPRIVEAIY AGCVPVLISD SYTLPFSDVL 1200 DWSKFSVQIP VAKIPEIKTI LQAIPFDKYL KMQKRVCRVR PHFVINRPAX PFDVIHMILH 1260 SVWLRRLDFK LEA* 1320 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
TIGR01065 | hlyIII | 1.0e-7 | 193 | 381 | 193 | + channel protein, hemolysin III family. This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role. | ||
COG1272 | COG1272 | 3.0e-28 | 79 | 384 | 310 | + Predicted membrane protein, hemolysin III homolog [General function prediction only] | ||
pfam03006 | HlyIII | 2.0e-50 | 103 | 374 | 273 | + Haemolysin-III related. Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. | ||
pfam03016 | Exostosin | 1.0e-58 | 937 | 1224 | 306 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
pfam03016 | Exostosin | 1.0e-58 | 502 | 789 | 307 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016021 | integral to membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI21065.1 | 0 | 445 | 826 | 9 | 390 | unnamed protein product [Vitis vinifera] |
EMBL | CBI25537.1 | 0 | 420 | 826 | 56 | 465 | unnamed protein product [Vitis vinifera] |
EMBL | CBI25537.1 | 0 | 842 | 1271 | 39 | 475 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002263848.1 | 0 | 445 | 826 | 1 | 384 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002263848.1 | 0 | 881 | 1271 | 2 | 394 | PREDICTED: hypothetical protein [Vitis vinifera] |