| Basic Information | |
|---|---|
| Species | Medicago truncatula |
| Cazyme ID | Medtr3g032980.1 |
| Family | GH89 |
| Protein Properties | Length: 833 Molecular Weight: 94895.7 Isoelectric Point: 6.7645 |
| Chromosome | Chromosome/Scaffold: 3 Start: 10415659 End: 10429640 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 95 | 333 | 0 |
| GPEIIIRGTTGVEIASGLHWYLKYWCGAHVSWDKTGGIQTTSIPKPGSLPLLKDGGVKIKRPVPWNYYQNVVTSSYSFVWWDWERWEKEVDWMALQGVNL PLAFTGQEAIWQKVFKDFNISSEDLNSFFGGPAFLAWARMGNLHGWGGPLSQNWLDQQLVLQKQIISRMLELGMTPVLPSFSGNVPAALTKIFPSAKITR LGDWNTVDADPRWCCTYLLDPSDPLFVEIGEAFIRKQIK | |||
| GH89 | 357 | 829 | 0 |
| LDDEYGDVTDIYNCDTFNENSPPTSDPAYISTLGAAVYQGISKGDKDAVWLMQGWLFYSDSSFWKPPQMKALLQSVPSGKMIVLDLFADVKPIWKTSFQF YGTPYIWCMLHNFGGNIEMYGVLDAIASGPVDARVSENSTMVGVGMCMEGIEHNPIVYELMSEMAFRDEKVKINEWLKSYSHRRYGKAIHEVDAAWEILY HTIYNSTDGIADHNHDYIVMLPDWDPSAAVKSGMSNHQKKIYFLPPGNRRYLFQQTPAGMPQAHLWYPPEDVIKALQLFLAGGKNLKGSLTYRYDLVDLT RQVLSKFANQVYIKAITSFQKKNIDALQLNSHMFLELIKDIDLLLASDDNFLLGTWLQSAKKLAVNPSELKQYEWNARTQVTMWFDTNETTQSKLHDYAN KFWSGILENYYLPRASTYFSHLSESLKQNEKFNLTEWRKEWIPMSNKWQEGSELYPVKAKGDALTISQALYKK | |||
| Full Sequence |
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| Protein Sequence Length: 833 Download |
| MLKLKLLLFQ LLILILTFSF PLALCNHHEA IQSLLHRLDS KRALPSVQES AAKGVLKRLL 60 PTHFSSFEFI IVSKDACGGD SCFIINNYNK SSQKGPEIII RGTTGVEIAS GLHWYLKYWC 120 GAHVSWDKTG GIQTTSIPKP GSLPLLKDGG VKIKRPVPWN YYQNVVTSSY SFVWWDWERW 180 EKEVDWMALQ GVNLPLAFTG QEAIWQKVFK DFNISSEDLN SFFGGPAFLA WARMGNLHGW 240 GGPLSQNWLD QQLVLQKQII SRMLELGMTP VLPSFSGNVP AALTKIFPSA KITRLGDWNT 300 VDADPRWCCT YLLDPSDPLF VEIGEAFIRK QIKATETIHQ ESEDLGSLII MDRAVRLDDE 360 YGDVTDIYNC DTFNENSPPT SDPAYISTLG AAVYQGISKG DKDAVWLMQG WLFYSDSSFW 420 KPPQMKALLQ SVPSGKMIVL DLFADVKPIW KTSFQFYGTP YIWCMLHNFG GNIEMYGVLD 480 AIASGPVDAR VSENSTMVGV GMCMEGIEHN PIVYELMSEM AFRDEKVKIN EWLKSYSHRR 540 YGKAIHEVDA AWEILYHTIY NSTDGIADHN HDYIVMLPDW DPSAAVKSGM SNHQKKIYFL 600 PPGNRRYLFQ QTPAGMPQAH LWYPPEDVIK ALQLFLAGGK NLKGSLTYRY DLVDLTRQVL 660 SKFANQVYIK AITSFQKKNI DALQLNSHMF LELIKDIDLL LASDDNFLLG TWLQSAKKLA 720 VNPSELKQYE WNARTQVTMW FDTNETTQSK LHDYANKFWS GILENYYLPR ASTYFSHLSE 780 SLKQNEKFNL TEWRKEWIPM SNKWQEGSEL YPVKAKGDAL TISQALYKKY FS* 840 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 1.0e-24 | 48 | 146 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 1.0e-99 | 531 | 830 | 300 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 161 | 526 | 366 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAA77084.1 | 0 | 7 | 832 | 4 | 811 | alpha-N-acetylglucosaminidase [Nicotiana tabacum] |
| EMBL | CBI24942.1 | 0 | 9 | 832 | 69 | 868 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_196873.1 | 0 | 23 | 831 | 20 | 805 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 9 | 832 | 4 | 803 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 29 | 831 | 27 | 805 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 53 | 820 | 175 | 866 | A Chain A, Crystal Structure Of A Beta-Galactosidase From Bacteroides Thetaiotaomicron |
| PDB | 2vcb_A | 0 | 53 | 820 | 175 | 866 | A Chain A, Crystal Structure Of A Beta-Galactosidase From Bacteroides Thetaiotaomicron |
| PDB | 2vca_A | 0 | 53 | 820 | 175 | 866 | A Chain A, Crystal Structure Of A Beta-Galactosidase From Bacteroides Thetaiotaomicron |
| PDB | 2vc9_A | 0 | 53 | 820 | 175 | 866 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 53 | 820 | 198 | 889 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
