| Basic Information | |
|---|---|
| Species | Phaseolus vulgaris |
| Cazyme ID | Phvul.009G182100.1 |
| Family | GH89 |
| Protein Properties | Length: 778 Molecular Weight: 89762.4 Isoelectric Point: 5.6559 |
| Chromosome | Chromosome/Scaffold: 09 Start: 26831907 End: 26845064 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 92 | 435 | 0 |
| PQILIEGTTGVDIVSGLHWYLKHWCGSHISWDKTGGSQLFSLPNVGFLPRIPHSAGISVQRPIPWSYYQNAVTSSYSFAWWDWERWEKEIDWMALQGVNL PLAFTGQEAIWQKVFQEKFNMSMSDLDDFFGGPAFLAWSRMGNLHGWGGPLPQSWFDKQLILQKKILARMYELGMTPVLPAFSGNVPAALKYIFPSAKIT RLGNWFSVKNDLKWCCTYLLDATDPLFIEIGKAFIEKQLQEYGRTGHIYNCDTFDENTPPIDDPEYISSLGAATFKGMQSGDDDAVWLMQGWLFSYDPFW RPPQMKALLHSVPLGKLVVLDLFAEVKPIWVTSEQFYGVPYIWK | |||
| GH89 | 436 | 760 | 0 |
| VGVGMSMEGIEQNPIVYDLMSEMAFQQKKIDVKAWVDMYSTRRYGKSLPLIQEGWNVLYHTIYNCTDGAYDKNRDVIVAFPDVDPSLISVQYDQSHHYYR PSGTVIKEITDPFDRPHLWYSTSEVIYALELFITIGDELSRSKTYRYDLVDLTRQVLAKYANELFFKVIEAYKSHDVHGMTLLSQRFLDLVEDLDTLLAC HDGFLLGPWLESAKQLAQNEEQERQFEWNARTQITMWFDNTKEEASLLRDYGNKYWSGLLHDYYGPRAAIYFKYLRESLERGEDFKLIEWRREWIKLTNE WQKSRNTFPVESKGDALNTSRWLFN | |||
| Full Sequence |
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| Protein Sequence Length: 778 Download |
| MNLPFPAIFL IFIFSIPSSS TAATGVNAIS RLIEIQDRER APPSVQEAAA RGVLLRLLPS 60 QSSSFQFRIK QCGGEYCFVI KNHPSFATPG DPQILIEGTT GVDIVSGLHW YLKHWCGSHI 120 SWDKTGGSQL FSLPNVGFLP RIPHSAGISV QRPIPWSYYQ NAVTSSYSFA WWDWERWEKE 180 IDWMALQGVN LPLAFTGQEA IWQKVFQEKF NMSMSDLDDF FGGPAFLAWS RMGNLHGWGG 240 PLPQSWFDKQ LILQKKILAR MYELGMTPVL PAFSGNVPAA LKYIFPSAKI TRLGNWFSVK 300 NDLKWCCTYL LDATDPLFIE IGKAFIEKQL QEYGRTGHIY NCDTFDENTP PIDDPEYISS 360 LGAATFKGMQ SGDDDAVWLM QGWLFSYDPF WRPPQMKALL HSVPLGKLVV LDLFAEVKPI 420 WVTSEQFYGV PYIWKVGVGM SMEGIEQNPI VYDLMSEMAF QQKKIDVKAW VDMYSTRRYG 480 KSLPLIQEGW NVLYHTIYNC TDGAYDKNRD VIVAFPDVDP SLISVQYDQS HHYYRPSGTV 540 IKEITDPFDR PHLWYSTSEV IYALELFITI GDELSRSKTY RYDLVDLTRQ VLAKYANELF 600 FKVIEAYKSH DVHGMTLLSQ RFLDLVEDLD TLLACHDGFL LGPWLESAKQ LAQNEEQERQ 660 FEWNARTQIT MWFDNTKEEA SLLRDYGNKY WSGLLHDYYG PRAAIYFKYL RESLERGEDF 720 KLIEWRREWI KLTNEWQKSR NTFPVESKGD ALNTSRWLFN KYLNLTNTET KLIEVQR* 780 |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 1.0e-20 | 46 | 142 | 98 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 7.0e-97 | 469 | 762 | 294 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 6.0e-160 | 158 | 461 | 337 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | EEC78143.1 | 0 | 29 | 764 | 33 | 808 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| GenBank | EEE61812.1 | 0 | 19 | 764 | 323 | 1108 | hypothetical protein OsJ_16433 [Oryza sativa Japonica Group] |
| RefSeq | XP_002280399.1 | 0 | 19 | 763 | 21 | 805 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 21 | 768 | 26 | 809 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 3 | 768 | 5 | 805 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 65 | 774 | 190 | 888 | B Chain B, Reassembly And Co-Crystallization Of A Family 9 Processive Endoglucanase From Separately Expressed Gh9 And Cbm3c Modules |
| PDB | 2vcb_A | 0 | 65 | 774 | 190 | 888 | B Chain B, Reassembly And Co-Crystallization Of A Family 9 Processive Endoglucanase From Separately Expressed Gh9 And Cbm3c Modules |
| PDB | 2vca_A | 0 | 65 | 774 | 190 | 888 | B Chain B, Reassembly And Co-Crystallization Of A Family 9 Processive Endoglucanase From Separately Expressed Gh9 And Cbm3c Modules |
| PDB | 2vc9_A | 0 | 65 | 774 | 190 | 888 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 65 | 774 | 213 | 911 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
