| Basic Information | |
|---|---|
| Species | Populus trichocarpa |
| Cazyme ID | Potri.007G117800.1 |
| Family | GT47 |
| Protein Properties | Length: 401 Molecular Weight: 46827 Isoelectric Point: 7.0723 |
| Chromosome | Chromosome/Scaffold: 07 Start: 13789882 End: 13792710 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT47 | 100 | 351 | 0 |
| ERSEGYFYHNLNHSRFLTKDPEKAHLFFIPIYCHSMSPEEKSKKERAIAVQDFVKFLISKYPYWNRTLGADHFFVSCSEVDVAATARIADRLKNSIGLMC SPSYNSKYVPHKDVSLPQSVQPYAYTEARNIEKNRTMLGFWSGVEDSYIRERLYLTWEYDSELYIEARDWPTSIEQGHWQAREDFYNSKFCICPGGPQLD GFIAFAIHYGCIPVILSDYYDLPFNDILDWRKFSVILKENDVYSLKKILQDI | |||
| Full Sequence |
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| Protein Sequence Length: 401 Download |
| CCYVQGKSED ERATAVEDFV KSIISQYPYR NRSLGADHFF ISCADIDVTA TARIANLMKN 60 SIRLVCSPTY NHEYVPHKDV SLPQNVQPFD VSSAGNKSSE RSEGYFYHNL NHSRFLTKDP 120 EKAHLFFIPI YCHSMSPEEK SKKERAIAVQ DFVKFLISKY PYWNRTLGAD HFFVSCSEVD 180 VAATARIADR LKNSIGLMCS PSYNSKYVPH KDVSLPQSVQ PYAYTEARNI EKNRTMLGFW 240 SGVEDSYIRE RLYLTWEYDS ELYIEARDWP TSIEQGHWQA REDFYNSKFC ICPGGPQLDG 300 FIAFAIHYGC IPVILSDYYD LPFNDILDWR KFSVILKEND VYSLKKILQD IPKQTYESLQ 360 NHTFMVQKHF QWNLSPVKYD AFHMVMYDLW LRHHVTKYRY * |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 8.0e-8 | 20 | 88 | 71 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| pfam03016 | Exostosin | 5.0e-43 | 102 | 351 | 268 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI38234.1 | 5e-25 | 5 | 114 | 67 | 176 | unnamed protein product [Vitis vinifera] |
| EMBL | CBI38234.1 | 0 | 102 | 398 | 31 | 326 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002268836.1 | 0 | 102 | 398 | 122 | 417 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002309856.1 | 9.99967e-42 | 4 | 113 | 65 | 174 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002309856.1 | 0 | 90 | 398 | 20 | 325 | predicted protein [Populus trichocarpa] |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| xylogalacturonan biosynthesis | RXN-9589 | EC-2.4.2.41 | xylogalacturonan β-1,3-xylosyltransferase |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| EG459159 | 265 | 135 | 398 | 0 |
| EX317869 | 273 | 102 | 373 | 0 |
| GT006581 | 251 | 149 | 398 | 0 |
| EX317869 | 111 | 5 | 115 | 1e-24 |
| EG459159 | 111 | 5 | 115 | 7e-24 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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