| Basic Information | |
|---|---|
| Species | Populus trichocarpa |
| Cazyme ID | Potri.012G075900.1 |
| Family | GH89 |
| Protein Properties | Length: 763 Molecular Weight: 87162.2 Isoelectric Point: 6.0494 |
| Chromosome | Chromosome/Scaffold: 12 Start: 10100312 End: 10109835 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 100 | 435 | 0 |
| PQILISGVTGVEVLAGLHWYLKYWCGSHISWDKTGGVQLNSIPKLGSLPRLQDDSILVQRPVPWNYYQNAVTSSYSFAWWDWKRWEKEIDWMALQGINLP LAFTGQEAIWQKVFQKFNISKEDLDDFFGGPAFLAWSRMANLHRWGGPLPQSWFDQQLVLQKKILARMYELGMTPVLPAFSGNVPAALRNIFPSAKITRL GNWFSVRSDVRWCCTYLLDATDPLFIEIGRAFIEQQLTEYGSTSHIYNCDTFDENTPPVDDPEYISSLGGSIFEGMQSGDSNAVWLMQGWLFSYDPFWRP PQTKALLHSVPIGRLVVLDLFAEVKPIWNTSEQFYG | |||
| GH89 | 436 | 751 | 0 |
| VGVGMSMEGIEQNPVVYDLMSEMAFQKNKVDVKVMEIPTIQNAWNILYHTVYNCTDGAYDKNRDVIVAFPDVNPNLVSMLQGRHHTDVKLVSRRAALIKN TDSYEHPHLWYSTTEVVRALELFIAGGDELSGSSTYSYDLVDLTRQVLAKYANELFLKVIEAYRLKDSHGVAHQSQMFLDLVEDIDTLLACHEGFLLGPW LESAKQLAQDEEQQIQFEWNARTQITMWYDNTEVEASLLRDYGNKYWSGLLKDYYGPRAAIYFNFLTQSLENGHGFQLKAWRREWIKLTNKWQKSRKIFP VESNGNALNISRWLYH | |||
| Full Sequence |
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| Protein Sequence Length: 763 Download |
| MDSPPVAAVS LVLLASFLLF FSFAQSSTIG VGYISKILEI QDRERALPSV QVAAARGVLQ 60 RLLPSHSSSF EFRIVSKEQC GGESCFIIKN HPSFTRRGAP QILISGVTGV EVLAGLHWYL 120 KYWCGSHISW DKTGGVQLNS IPKLGSLPRL QDDSILVQRP VPWNYYQNAV TSSYSFAWWD 180 WKRWEKEIDW MALQGINLPL AFTGQEAIWQ KVFQKFNISK EDLDDFFGGP AFLAWSRMAN 240 LHRWGGPLPQ SWFDQQLVLQ KKILARMYEL GMTPVLPAFS GNVPAALRNI FPSAKITRLG 300 NWFSVRSDVR WCCTYLLDAT DPLFIEIGRA FIEQQLTEYG STSHIYNCDT FDENTPPVDD 360 PEYISSLGGS IFEGMQSGDS NAVWLMQGWL FSYDPFWRPP QTKALLHSVP IGRLVVLDLF 420 AEVKPIWNTS EQFYGVGVGM SMEGIEQNPV VYDLMSEMAF QKNKVDVKVM EIPTIQNAWN 480 ILYHTVYNCT DGAYDKNRDV IVAFPDVNPN LVSMLQGRHH TDVKLVSRRA ALIKNTDSYE 540 HPHLWYSTTE VVRALELFIA GGDELSGSST YSYDLVDLTR QVLAKYANEL FLKVIEAYRL 600 KDSHGVAHQS QMFLDLVEDI DTLLACHEGF LLGPWLESAK QLAQDEEQQI QFEWNARTQI 660 TMWYDNTEVE ASLLRDYGNK YWSGLLKDYY GPRAAIYFNF LTQSLENGHG FQLKAWRREW 720 IKLTNKWQKS RKIFPVESNG NALNISRWLY HKYLGNPDTY DH* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 9.0e-23 | 51 | 150 | 100 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 1.0e-88 | 473 | 753 | 281 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 3.0e-157 | 165 | 464 | 339 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | EEC78143.1 | 0 | 27 | 758 | 19 | 811 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| GenBank | EEE61812.1 | 0 | 28 | 758 | 327 | 1111 | hypothetical protein OsJ_16433 [Oryza sativa Japonica Group] |
| RefSeq | XP_002280399.1 | 0 | 24 | 761 | 21 | 812 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 1 | 762 | 1 | 812 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 11 | 762 | 5 | 809 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 44 | 743 | 168 | 866 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
| PDB | 2vcb_A | 0 | 44 | 743 | 168 | 866 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
| PDB | 2vca_A | 0 | 44 | 743 | 168 | 866 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
| PDB | 2vc9_A | 0 | 44 | 743 | 168 | 866 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 44 | 743 | 191 | 889 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
