LOCUS       SEU43366                4500 bp    DNA     linear   BCT 19-MAR-1998
DEFINITION  Staphylococcus epidermidis operon mediating intercellular adhesion:
            IcaR, IcaA, IcaD, IcaB, and IcaC genes, complete cds.
ACCESSION   U43366
VERSION     U43366.1
KEYWORDS    .
SOURCE      Staphylococcus epidermidis RP62A
  ORGANISM  Staphylococcus epidermidis RP62A
            Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 4500)
  AUTHORS   Heilmann,C., Schweitzer,O., Gerke,C., Vanittanakom,N., Mack,D. and
            Gotz,F.
  TITLE     Molecular basis of intercellular adhesion in the biofilm-forming
            Staphylococcus epidermidis
  JOURNAL   Mol. Microbiol. 20 (5), 1083-1091 (1996)
   PUBMED   8809760
REFERENCE   2  (bases 1 to 4500)
  AUTHORS   Schweitzer,O., Heilmann,C., Gerke,C. and Goetz,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-1995) Biologie, Mikrobielle Genetik, Universitaet
            Tuebingen, Waldhaeuserstr. 70/8, Tuebingen 72076, Germany
REFERENCE   3  (bases 1 to 4500)
  AUTHORS   Gerke,C., Schweitzer,O. and Goetz,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-MAR-1998) Biologie, Mikrobielle Genetik, Universitaet
            Tuebingen, Waldhaeuserstr. 70/8, Tuebingen 72076, Germany
  REMARK    Sequence update by submitter
COMMENT     On Mar 19, 1998 this sequence version replaced gi:1161379.
FEATURES             Location/Qualifiers
     source          1..4500
                     /organism="Staphylococcus epidermidis RP62A"
                     /mol_type="genomic DNA"
                     /strain="RP62A"
                     /db_xref="taxon:176279"
     gene            complement(39..596)
                     /gene="icaR"
     CDS             complement(39..596)
                     /gene="icaR"
                     /codon_start=1
                     /transl_table=11
                     /product="STP|TetR_N"
                     /protein_id="AAC06121.1"
                     /translation="MKDKIIDNAITLFSEKGYDGTTLDDISKSVNIKKASLYYHYDNKE
                     EIYRKSVENCFNYFIDFLLRNHDDNYSIDGLYQFLFKFIFDVDERYIKLYVQLSSAPEA
                     LNSEIKHHLQEINTTLHDELIKYYDPTHIALDKEDFINLILLFLETWYFRASFSQKFGI
                     IEDSKNRFKDQVYSLLNVFLKK"
     gene            761..1999
                     /gene="icaA"
     CDS             761..1999
                     /gene="icaA"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q54066|4.D.1.1.2"
                     /protein_id="AAC06117.1"
                     /translation="MHVFNFLLFYPIFMSIYWIVGSIYYFFIKEKPFNRSLLVKSEHQQ
                     VEGISFLLACYNESETVQDTLSSVLSLEYPEKEIIIINDGSSDNTAEIIYDFKKNHDFK
                     FVDLEVNRGKANALNEGIKQASYEYVMCLDADTVIDDDAPFYMIEDFKKNPKLGAVTGN
                     PRIRNKSSILGKIQTIEYASIIGCIKRSQSLAGAINTISGVFTLFKKSALKDVGYWDTD
                     MITEDIAVSWKLHLFDYEIKYEPRALCWMLVPETIGGLWKQRVRWAQGGHEVLLRDFWP
                     TIKTKKLSLYILMFEQIASITWVYIVLCYLSFLVITANILDYTYLKYSFSIFFFSSFTM
                     TFINIIQFTVALFIDSRYEKKNIVGLIFLSWYPTLYWVINAAVVIMAFPKALKRKKGGY
                     ATWSSPDRGNIQR"
     gene            1963..2268
                     /gene="icaD"
     CDS             1963..2268
                     /gene="icaD"
                     /codon_start=1
                     /transl_table=11
                     /product="IcaD"
                     /protein_id="AAC06120.1"
                     /translation="MVKPRQRQYPTVTSYLNIVRESLFITISGVFWMYCIVVMIVYIGT
                     LINSQMESVITIRIALNVENTEIYKLFGWMSLFVLIIFIFFTFSLAFQKYKKGRDI"
     gene            2265..3134
                     /gene="icaB"
     CDS             2265..3134
                     /gene="icaB"
                     /codon_start=1
                     /transl_table=11
                     /product="CE4"
                     /protein_id="AAC06118.1"
                     /translation="MKPFKLIFISALMILIMTNATPISHLNAQANEENKKLKYEKNSAL
                     ALNYHRVRKKDPLNDFISLLSGSKEIKNYSVTDQEFKSQIQWLKAHDAKFLTLKEFIKY
                     KEKGKFPKRSVWINFDDMDQTIYDNAFPVLKKYHIPATGFLITNHIGSTNFHNLNLLSK
                     KQLDEMYETGLWDFESHTHDLHALKKGNKSKFLDSSQSVASKDIKKSEHYLNKNYPKNE
                     RALAYPYGLINDDKIKAMKKNGIQYGFTLQEKAVTPDADNYRIPRILVSNDAFETLIKE
                     WDGFDEEK"
     gene            3121..4188
                     /gene="icaC"
     CDS             3121..4188
                     /gene="icaC"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|A6QKF8|9.B.97.1.7"
                     /protein_id="AAC06119.1"
                     /translation="MKKNKLELVYLRAFICVIIIVTHLLTQITLENEQMSDSSLILQYY
                     IRNIFIFGTPSFIILSQLLTTLNYESVTINYLFSRFKYIFIPYLLIGLFYSYSESLITA
                     SSFKKQFIENVVLGQWYGYFIIIIMQFFVLSYIIYKINFRLFNSKILLLLAFIVQQSYL
                     HYFLNNDTFHQFMTHYYPLSENTMILGWIFYFFLGGYIGYNYEKILSFLEKYLIIVIML
                     TLGAYVLFIAVSGSDYWNVTSFTYTLTLYNSVMFFLLLGVCMHFKTMLLNTIKAISAFS
                     FFIYLLHPIILDSLFAYTNIFEDNTIVFLAISLLMILGICIGVGMMLREFYIFRFVIGK
                     QPYKLQFDQYQPNWN"
ORIGIN
        1 tttgaaatct cgaatttgtt acatactagt tacaaaaatt atttttttaa aaatacattt
       61 aacagtgaat atacttggtc tttaaaacgg tttttactgt cctcaataat cccgaatttt
      121 tgtgaaaagg aggctctaaa ataccaagtc tcaagaaaaa gaagaattaa gtttataaag
      181 tcctctttat ccaaagcgat gtgcgtagga tcataatact ttatcaattc atcatgtaag
      241 gtagtattaa tttcttgaag atggtgtttg atttctgaat tcagtgcttc tggagcacta
      301 gataattgaa catataattt aatatatctc tcatcaacgt cgaatataaa tttgaataaa
      361 aactggtaaa gtccgtcaat ggaataatta tcatcatggt tcctaagcaa aaaatctata
      421 aagtaattga aacaattctc aacacttttt cgatatattt cttccttatt atcgtaatga
      481 taatatagac tagccttttt tatatttaca cttttagaaa tatcatcaag tgtagtacca
      541 tcgtacccct tttcggaaaa taaggttatt gcgttatcaa taatcttatc tttcaattct
      601 aaaatctccc ccttattcaa ttttctaaaa atatattaca gaaaaattaa gttaaaatta
      661 caaatattac tgtttcagta taacaacatt ctattgcaaa ttgaaatact ttcgattagc
      721 atatgcttta caacctaact aacgaaaggt aggtgaaaaa atgcatgtat ttaacttttt
      781 acttttctat ccaattttta tgtcaattta ctggatagta ggatcgattt actatttttt
      841 tattaaagaa aaacccttta atcgatcatt gttagtaaaa tctgaacatc aacaagttga
      901 aggcatctcc tttttattag cttgctacaa tgaaagtgaa acagttcaag acacgctttc
      961 tagtgtttta tctctagaat atcctgaaaa agaaattatc attatcaatg atggaagttc
     1021 tgataatact gctgaaatca tctatgactt caagaaaaat catgatttta aatttgttga
     1081 cctcgaagtc aatagaggta aagctaatgc actcaatgag ggaatcaaac aagcatctta
     1141 cgaatatgtt atgtgtttag atgctgacac tgtcattgat gacgatgcgc ctttttatat
     1201 gattgaagac tttaaaaaga atccaaaatt aggcgcagtt acaggtaatc cacgtattcg
     1261 taataaaagt tctattttag gaaaaataca gaccattgaa tatgcaagta ttattggttg
     1321 tatcaagcga agtcaatctc ttgcaggagc aatcaatact atttcaggtg ttttcacact
     1381 atttaaaaaa agtgcactca aagatgtagg ttattgggat actgacatga ttactgagga
     1441 tattgctgtt tcatggaaac tccatctttt tgattacgaa attaagtacg aaccacgtgc
     1501 tctatgctgg atgttagtgc ctgaaactat aggtggttta tggaaacaaa gggttcgatg
     1561 ggctcaaggc gggcatgaag tacttttaag agacttttgg ccaacaatta aaactaagaa
     1621 attatcacta tatattttaa tgtttgaaca aatcgcatcg attacatggg tctacatcgt
     1681 actatgttat ttatcttttt tagtaatcac agccaacatc ttagattaca catatttaaa
     1741 atatagtttt tcaatctttt tcttttcatc ctttacgatg acctttatca atatcatcca
     1801 atttacagtt gccttattta ttgacagtcg ctacgaaaag aaaaatatag ttggcctgat
     1861 atttttaagt tggtatccaa cgttatactg ggttatcaat gccgcagttg tcattatggc
     1921 atttcctaaa gcattaaaaa gaaagaaagg tggctatgct acatggtcaa gcccagacag
     1981 aggcaatatc caacggtaac ctcttattta aatatagtta gggagagctt atttattact
     2041 atatccggag tattttggat gtattgtatc gttgtgatga ttgtttatat aggaactctt
     2101 atcaattctc aaatggaaag tgttataaca atacgtattg cattaaatgt tgaaaacacg
     2161 gaaatttaca aattattcgg atggatgagt ttgtttgtac ttattatatt tatctttttt
     2221 acatttagtc tcgcgtttca aaaatataag aaaggtcgtg acatatgaaa cctttcaaat
     2281 taatctttat tagcgcattg atgatattaa taatgacgaa tgcaacacca atatcacacc
     2341 tgaatgctca agctaatgaa gaaaacaaga agttaaagta cgaaaaaaat agcgcactcg
     2401 cgttaaacta tcacagagta agaaaaaagg atcctttgaa tgactttata tcattactat
     2461 ctgggagtaa ggaaattaaa aattatagtg tcactgatca agaatttaaa tcacaaattc
     2521 aatggcttaa agcacacgac gcaaagtttt taactttgaa agaatttatt aaatataaag
     2581 aaaaaggtaa atttcctaaa agaagtgttt ggattaactt tgatgatatg gatcaaacga
     2641 tttatgacaa tgcctttcct gttttgaaaa aatatcatat tccagcaaca ggttttctta
     2701 ttacgaacca cattggttct accaattttc ataatttaaa tttactttca aaaaagcaat
     2761 tagatgaaat gtatgaaaca ggcttatggg actttgaatc tcatactcat gatttacacg
     2821 ctcttaagaa aggcaataaa tcgaagtttt tagattcgtc tcaatctgtt gctagtaaag
     2881 atattaaaaa aagcgaacac tatttaaata aaaactaccc aaaaaatgaa cgcgcacttg
     2941 cttacccata cggattaatt aatgacgaca aaataaaagc tatgaaaaaa aatggaattc
     3001 aatatgggtt tacacttcag gaaaaagctg tcacaccaga tgccgataac tatagaattc
     3061 cacgtatttt agtaagtaat gatgcatttg aaacgctaat aaaggaatgg gacggattcg
     3121 atgaagaaaa ataaacttga attagtgtat ttacgtgcgt ttatttgtgt cataatcatc
     3181 gtgacacact tactaacgca aatcacttta gaaaatgaac agatgtctga tagttcactc
     3241 atattgcaat attatatacg caatattttt attttcggca cccctagttt tataatattg
     3301 tctcaattat taacaacatt aaattacgaa tcagtaacta taaattatct tttttcaaga
     3361 tttaagtata tttttattcc atatctttta atcggcttgt tctatagtta tagtgaatca
     3421 cttatcaccg cttcttcttt taaaaagcag tttatcgaaa atgttgtttt aggacaatgg
     3481 tatggctatt tcattatcat aattatgcag ttctttgttc tatcttatat catttacaaa
     3541 attaatttta gattgttcaa tagtaaaatt ttgctgcttt tagcatttat agtccaacaa
     3601 tcttatctac attatttttt gaataatgac acttttcatc aattcatgac tcattattat
     3661 ccattaagcg aaaatacaat gatattagga tggatattct actttttctt aggtggttac
     3721 attggctata attatgaaaa aatattatct ttcttagaaa aatatttaat tatagttatt
     3781 atgttaactt taggcgcata tgttttattt atcgctgttt ccggtagtga ttattggaat
     3841 gtcacaagct ttacttatac gttaacatta tataatagtg tcatgttctt cttattacta
     3901 ggagtctgta tgcactttaa aactatgtta ttaaatacta ttaaagctat tagtgcattt
     3961 tcctttttca tttatttgtt gcacccaatt atcttagatt ctctttttgc ttacaccaac
     4021 atatttgaag ataatacaat tgttttcttg gcgatttcac ttttaatgat tctaggaatt
     4081 tgtataggcg tcggaatgat gttaagagag ttttatatat tcagatttgt aattggaaaa
     4141 caaccgtaca agttacaatt tgaccaatac cagcctaact ggaattaata aaaaaagtcc
     4201 cttattcaag ctatggctta tgtatgtgct tgaataaggg attttatctt actatagttt
     4261 cacattatga aaataaattt tttaatattc tgtataaaga gcctaataat tgaaagaaat
     4321 cacctgtcat gtatctcact cctatctata taagattacg ttaggtttat accctatatc
     4381 attttattta tttgttgatg ttaattgttc actttgtact aaatcatcag caagaccatg
     4441 ccaaaactgt tgcaattcat ctctagtacg ttttgtatct gtactgtctt gtcctacaaa
//
