LOCUS       CR931683               21475 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain 1196/45 (serotype 23a).
ACCESSION   CR931683
VERSION     CR931683.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 21475)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 21475)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..21475
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="1196/45"
                     /db_xref="taxon:1313"
     gene            1204..2649
                     /gene="wzg"
                     /locus_tag="SPC23A_0004"
     CDS             1204..2649
                     /gene="wzg"
                     /locus_tag="SPC23A_0004"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI33811.1"
                     /db_xref="GOA:Q4K0K5"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4K0K5"
                     /translation="MSRRFKKSGSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAFR
                     YLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNRLN
                     ATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLTVNQ
                     SSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAPKTSK
                     NQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADGGNNQK
                     DKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKLIDLLGGIDVYNDQEFTAHT
                     NGKYYPAGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNYS
                     TIINSLQDSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRTDLPSYAMPDSNLY
                     VMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1204..1320
                     /gene="wzg"
                     /locus_tag="SPC23A_0004"
                     /note="Signal peptide predicted for SPC1162 by SignalP 2.0
                     HMM (Signal peptide probability 0.993) with cleavage site
                     probability 0.538 between residues 39 and 40"
     misc_feature    1408..1755
                     /gene="wzg"
                     /locus_tag="SPC23A_0004"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 1.6e-64"
     misc_feature    1933..2376
                     /gene="wzg"
                     /locus_tag="SPC23A_0004"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 2.5e-69"
     gene            2651..3382
                     /gene="wzh"
                     /locus_tag="SPC23A_0005"
     CDS             2651..3382
                     /gene="wzh"
                     /locus_tag="SPC23A_0005"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI33812.1"
                     /db_xref="GOA:Q4K0K4"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4K0K4"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLTESYRQGVRTIVSTSHRRK
                     GMFETPEEKIAENFLQVREIAKEVADDLVIAYGAEIYYTLDALEKLEKKEIPTLNDSRY
                     ALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNGKRVRELIDMGCYTQIN
                     SYHVSKPKFFGEKYKFMKKRARYFLERDLVHVVASDMHNLDSRPPYMQQAYDIIAKKYG
                     AKKAKELFVDNPRKIIMDQLI"
     misc_feature    2654..3262
                     /gene="wzh"
                     /locus_tag="SPC23A_0005"
                     /note="HMMPfam hit to PF02811, PHP domain, score 4.9e-37"
     gene            3391..4083
                     /gene="wzd"
                     /locus_tag="SPC23A_0006"
     CDS             3391..4083
                     /gene="wzd"
                     /locus_tag="SPC23A_0006"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q93E03|8.A.3.2.3"
                     /protein_id="CAI33813.1"
                     /db_xref="GOA:Q4K0K3"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4K0K3"
                     /translation="MKEQNTLEIDVLQLFRALWKRKLVILLVAIITSSVAFTYSTFVIK
                     PEFTSTTRIYVVNRNQGEKSGLTNQDLQAGTYLVKDYREIILSQDVLEEVVSDLKLDLT
                     PKGLANKIKVTVPVDTRIVSVSVNDRVPEEASRIANSLREVAAQKIISITRVSDVTTLE
                     EARPAISPSSPNIKRNILIGFLAGVIGTSVIVLLLELLDTRVKRPEDIEDTLQMTLLGV
                     VPNLNKLK"
     misc_feature    3409..3825
                     /gene="wzd"
                     /locus_tag="SPC23A_0006"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 1.9e-52"
     misc_feature    3931..4008
                     /gene="wzd"
                     /locus_tag="SPC23A_0006"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            4093..4776
                     /gene="wze"
                     /locus_tag="SPC23A_0007"
     CDS             4093..4776
                     /gene="wze"
                     /locus_tag="SPC23A_0007"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q93NW3|8.A.3.2.2"
                     /protein_id="CAI33814.1"
                     /db_xref="GOA:Q4K0K2"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4K0K2"
                     /translation="MPTLEIAQKKLEFIKKAEEYYNALCTNIQLSGDKLKVISVTSVSP
                     GEGKTTTSVNIAWSFARAGYKTLLIDGDTRNSVISGFFKSREKITGLTEFLSGTADLSH
                     GLCDTNIENLFVVQSGSVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTAPIGIVIDAA
                     IITQKCDASILVTATGEANKRDVQKAKQQLKQTGKLFLGVVLNKLDISVDKYGVYGFYG
                     NYGKK"
     gene            4792..6159
                     /gene="wchA"
                     /locus_tag="SPC23A_0008"
     CDS             4792..6159
                     /gene="wchA"
                     /locus_tag="SPC23A_0008"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|H8E4X1|9.B.18.1.2"
                     /protein_id="CAI33815.1"
                     /db_xref="GOA:Q4K0K1"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4K0K1"
                     /translation="MDEKGLKIFMAVLQSIIVILLVYFLSFVRETELERSSMVILYLLH
                     FFVFYVSSYGNNFFKRGYLVEFNSTIRYIFFFAIAISVLNFFIAERFSISRRGMVYFLT
                     LEGISLYLLNFLVKKYWKHVFFNLKNSKKILLLTVTKNMEKVLDKLLESDELSWKLVAV
                     SVLNKSDFQHDKIPVIEKEKIIEFATHEVVDEVFVNLPGESYDIGEIISRFETMGIDVT
                     VNLKAFDKNLGRNKQIHEMVGLNVVTFSTNFYKTSHVISKRILDICGATIGLILFAIAS
                     LVLVPLIRKDGGPAIFAQTRIGKNGRHFTFYKFRSMRIDAEAIKEQLMDQNTMQGGMFK
                     IDNDPRVTKIGRFIRKTSLDELPQFWNVFIGDMSLVGTRPPTVDEYDQYTPEQKRRLSF
                     KPGITGLWQVSGRSKITDFDDVVKLDVSYIDNWTIWKDIEILLKTVKVVFMRDGAK"
     misc_feature    5575..6156
                     /gene="wchA"
                     /locus_tag="SPC23A_0008"
                     /note="HMMPfam hit to PF02397, Bacterial sugar transferase,
                     score 4.9e-146"
     gene            6190..7368
                     /gene="wchF"
                     /locus_tag="SPC23A_0009"
     CDS             6190..7368
                     /gene="wchF"
                     /locus_tag="SPC23A_0009"
                     /note="member of homology group 15"
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="CAI33816.1"
                     /db_xref="GOA:Q4K0K0"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="InterPro:IPR015393"
                     /db_xref="UniProtKB/TrEMBL:Q4K0K0"
                     /translation="MKKSVYIIGSKGIPAKYGGFETFVEKLTAFQQDKAIQYYVACMRE
                     NSAKSGTTEDVFEHNGAICYNVDVPNIGPARAIVYDIAAINRAIEIAKENKDEDPIFYI
                     LACRIGPFIHGIKKKIQAIGGTLLVNPDGHEWLRAKWSTPVRRYWKISEGLMVKHADLL
                     VCDSKNIEQYIQEDYKQFQPKTTYIAYGTDTTRSILKSSDEKVRSWFKEKNVSENEYYL
                     VVGRFVPENNYESMILGFLASNSKKDFVLITNVEQNKFYNQLLAKTGFDKDPRVKFVGT
                     VYNQELLKYIRENAFAYFHGHEVGGTNPSLLEALASTKLNLLLDVGFNREVAEDGADYW
                     EKDNLHKVIEASEQKTQEEINEKNILSTKQVTERFSWDLIVNEYEKLFTRKN"
     misc_feature    6805..7302
                     /gene="wchF"
                     /locus_tag="SPC23A_0009"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases group,
                     score 0.0028"
     gene            7578..8984
                     /gene="wzy"
                     /locus_tag="SPC23A_0010"
     CDS             7578..8984
                     /gene="wzy"
                     /locus_tag="SPC23A_0010"
                     /note="member of homology group 243"
                     /codon_start=1
                     /transl_table=11
                     /product="oligosaccharide repeat unit polymerase Wzy"
                     /protein_id="CAI33817.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K0J9"
                     /translation="MRYGIMRISFSKKTMLCGLLYIGLILSVVTIPTIVTFLYSLLFIG
                     IVTVLNYNSILASDEDANSFFVALPIILSSFQNVYLGFGADRLNSVTLQVLLSISIAII
                     TITVFLGIILNRFKSKEFSWLVLSILVIIIQSVILLIFFPTTLPAYLSSMRNILAPLLI
                     FYFSIYGFKNINLQKFYKYMFIIILVVLIFGFIEYIYGNSLWTRLNIKKLWALKGLAIE
                     NRVVPGNWHSSELIGGKQLRRMVSTFADPVNLGSYLFAAFMLAWYKNKKLLQVLLLASF
                     VLSVSKAAFLSMLVYIIIYTWVVDKNKILSIFGIIISTVLGLYFYNFSQVSSYGSINAH
                     IDGFFSALSTPLHYPFGMGVGSVGVLASKLGSQTALSSEVLETGIGMIIAQLGFVGVII
                     YLIFFVKLSVIGKNINNKRDKILWFTLIYSFLANAFFNEVALSPNSCTLYFLILGLLYN
                     KNKIRSTEFS"
     misc_feature    7578..7748
                     /gene="wzy"
                     /locus_tag="SPC23A_0010"
                     /note="Signal peptide predicted for SPC1168 by SignalP 2.0
                     HMM (Signal peptide probability 0.974) with cleavage site
                     probability 0.336 between residues 57 and 58"
     gene            8984..9955
                     /gene="wchV"
                     /locus_tag="SPC23A_0011"
     CDS             8984..9955
                     /gene="wchV"
                     /locus_tag="SPC23A_0011"
                     /note="member of homology group 109"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|P75905|4.D.1.1.3"
                     /protein_id="CAI33818.1"
                     /db_xref="GOA:Q4K0J8"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4K0J8"
                     /translation="MEKLVSIILPVYNVEQYIKNCLESIQQQTYPNLEVIIVNDGSTDK
                     SVEYCEQICKIDSRFSITHKENGGLSDARNVGIDKAKGDYLIFVDSDDFVSQDMVSYLV
                     SCMENNEADIAICDPVHYYSDRQNNDLNIFSPASSVKVYETTEALCEMFYQKSFLVSAW
                     AKIFKRELFDDIRFPVGKLFEDSAIMYLLLEKCETIAYSDAKLYAYVHRDNSITTKKFS
                     DRDLDILEITNTIINHYGDNLRVYTAAVSYKVSACFRILLNSPSEEKYKKVQKECLSYI
                     LQNWRNILFNNNVRLKNKLALISITIFNPFVKLIYSKVNRWE"
     misc_feature    8999..9511
                     /gene="wchV"
                     /locus_tag="SPC23A_0011"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase family,
                     score 1e-49"
     gene            9962..11194
                     /gene="wchW"
                     /locus_tag="SPC23A_0012"
     CDS             9962..11194
                     /gene="wchW"
                     /locus_tag="SPC23A_0012"
                     /note="member of homology group 110"
                     /codon_start=1
                     /transl_table=11
                     /product="putative transferase"
                     /protein_id="CAI33819.1"
                     /db_xref="GOA:Q9R924"
                     /db_xref="UniProtKB/TrEMBL:Q9R924"
                     /translation="MNKYEERYQENLSKNDFYKLINKSYLSDKELQVQQVKAGIVLPPK
                     AFETKLSNKLGLQKSLHGKGGVVDSNGNYIELSAQKAVGMRNRVYGPYKINYDNLPIRN
                     EKVIYLNYFIKQWGHFLLDVVGRLWYPLLQDNDTKLVYTCYAGTETKIEGNYLEFLKLL
                     GIDQSRLIMINCPTQFSEVIIPESSILPGGYYTKEYKQLFSSVVENIKLDKYDVNAKMI
                     YCSRSKLGIAKSKEFGEDGIEGIFKQNGYTSVYMETMSLEEQIKTLLSAKTIVLTSGSL
                     AHNLLFVNKDIDVFILNKTYRVNLHQFLINEISDATVRFVDIYRSPLPILYGYGPFLMD
                     LTKPLANFLDDNEFVYEKGTVLSKKDYFKYYLKWLWSYRFFLFRLNGIKEGNSEFEKSF
                     KIIRRYYKTGR"
     gene            11196..12581
                     /gene="wzx"
                     /locus_tag="SPC23A_0013"
     CDS             11196..12581
                     /gene="wzx"
                     /locus_tag="SPC23A_0013"
                     /note="member of homology group 111"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase Wzx"
                     /protein_id="CAI33820.1"
                     /db_xref="GOA:Q4K0J6"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4K0J6"
                     /translation="MSKYKELAKNTGIFALANFSSKILIFLLVPIYTRVLTTTEYGFYD
                     LVYTTIQLFVPILTLNISEAVMRFLMKDGVSKKSVFSIAVLDIFIGSIAFALLLLVNNL
                     FSLSDLISQYSIYIFVIFVFYTLNNFLIQFSKGIDKIGVTAISGVISTAVMLAMNVILL
                     VVFDWGLLGFFIANVCGYVIPCIYIVSRLRLWELFEIKIDKKLQWEMVYYALPLVLNIL
                     SWWVNNTSDRYIVTAIVGIQASAIISVAYKIPQILSTISAIFIQSWQISAIKIQEDKSG
                     TTFVSNMLLYYNALLLIIASGIILFVKPISNILFGISFYSAWELVPFLIISSLFNAISG
                     CIGAIMGAKMDTHNIAKSALVGMIANIILNIVLTFLMGPQGITISTLIASFLIFYMRKD
                     SVKEINSETYRAIYLSWILLVVEACLLIYMDFIIGALIAMVINLFLLKDVIKPLYLKIF
                     KRN"
     misc_feature    11214..12023
                     /gene="wzx"
                     /locus_tag="SPC23A_0013"
                     /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis
                     protein, score 6.3e-67"
     gene            12589..13737
                     /gene="wchX"
                     /locus_tag="SPC23A_0014"
     CDS             12589..13737
                     /gene="wchX"
                     /locus_tag="SPC23A_0014"
                     /note="member of homology group 53"
                     /codon_start=1
                     /transl_table=11
                     /product="putative glycerol phosphotransferase"
                     /protein_id="CAI33821.1"
                     /db_xref="GOA:Q9R922"
                     /db_xref="InterPro:IPR007554"
                     /db_xref="UniProtKB/TrEMBL:Q9R922"
                     /translation="MIVLQYFKILARFVFMFLISAVLLPFKIKPNKIVFINFNGKGYGD
                     NPKSICEYLRTTYPDLDLVWLARDNEGFPDGVRVVKYGTFQAFYEQASSKVWVYNVRAF
                     ARILKKRGQIYIQTWHGASSFKLIEKQADLPINYVLEAKYDARVTDIMISDSRKQTEEF
                     QKYFWYSGEIFEVGMPRNDALFHYKEDYDKLNNIRKELSIHSDDYVILYAPTFRDDGDA
                     SYLDINFERLLQCVEHGIKKKCKFLIRLHPNHSHLCNNISFNKNIINATFYSDMQELTL
                     LADVLVTDYSSSIFDFMLLNKPYVRYVNDLEKYAELRGVSDTYYELPDSIIKTAEELYD
                     LLPKKIENFDYDSIKKYRNEILCPIFNGTASENVGRRIIQEL"
     misc_feature    13177..13728
                     /gene="wchX"
                     /locus_tag="SPC23A_0014"
                     /note="HMMPfam hit to PF04464,
                     CDP-Glycerol:Poly(glycerophosphate) gl, score 4.3e-73"
     gene            13773..14801
                     /gene="gtp1"
                     /locus_tag="SPC23A_0015"
     CDS             13773..14801
                     /gene="gtp1"
                     /locus_tag="SPC23A_0015"
                     /note="member of homology group 40"
                     /codon_start=1
                     /transl_table=11
                     /product="putative glycerol-2-phosphate dehydrogenase"
                     /protein_id="CAI33822.1"
                     /db_xref="GOA:Q9R921"
                     /db_xref="InterPro:IPR002658"
                     /db_xref="InterPro:IPR016205"
                     /db_xref="UniProtKB/TrEMBL:Q9R921"
                     /translation="MKNNDLKIGSGAIHQISATLSQNSISGKILYCADPVVDDLYGSIV
                     RSQIEEIGRVKEESCNYNTIAYAMNIAERAIATDIDCIVGMGGGRVLDVCKYASFISKR
                     PYLSIPTTAANDGIASPVAVLKRQDDRPKSLGAAIPSMTLIDIDVIASGPIQNIKAGIG
                     DTISNYTALKDWELAVERGKDEMHGFAYLMSQNSLDALMKTKYNSITPDFIEVLVNSLV
                     LSGIAMDFAGSSRPVSGSEHLFSHALDYYGSTRNLHGIQVALGTVAVLKLIENSVDTVV
                     DYLQRFEVHINPKLLGIDEELFIYCMQHATKMRSNRYTYLHEVDLSTDRLKQIYKELIS
                     EL"
     misc_feature    13794..14714
                     /gene="gtp1"
                     /locus_tag="SPC23A_0015"
                     /note="HMMPfam hit to PF01761, 3-dehydroquinate synthase,
                     score 2.9e-70"
     gene            14817..15521
                     /gene="gtp2"
                     /locus_tag="SPC23A_0016"
     CDS             14817..15521
                     /gene="gtp2"
                     /locus_tag="SPC23A_0016"
                     /note="member of homology group 41"
                     /codon_start=1
                     /transl_table=11
                     /product="putative nucleotidyl transferase"
                     /protein_id="CAI33823.1"
                     /db_xref="GOA:O85005"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="UniProtKB/TrEMBL:O85005"
                     /translation="MKALILAAGLGTRLAPITNEVPKSLVPVNGKPILMKQIENLYQNN
                     ITDITIIAGYKSSVLTDAVTEKYPEINIIDNVDFKTTNNMYSAYLGKAAMGDSDFLMMN
                     ADVFYDASVIKSLLLHKAPNAIVTDLGIYIEESMKVVEKNGRLVEISKQISPEETLGAS
                     IDVYKFSYEAGARFFEKCKEFIEDKRELQMWSEVALNAILSEVEFVACPLEGRWLEIDN
                     HEDLVAAEKLFA"
     misc_feature    14820..15518
                     /gene="gtp2"
                     /locus_tag="SPC23A_0016"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 1e-07"
     gene            15536..16369
                     /gene="gtp3"
                     /locus_tag="SPC23A_0017"
     CDS             15536..16369
                     /gene="gtp3"
                     /locus_tag="SPC23A_0017"
                     /note="member of homology group 42"
                     /codon_start=1
                     /transl_table=11
                     /product="putative phosphotransferase"
                     /protein_id="CAI33824.1"
                     /db_xref="GOA:Q4K0F2"
                     /db_xref="InterPro:IPR005834"
                     /db_xref="InterPro:IPR006357"
                     /db_xref="UniProtKB/TrEMBL:Q4K0F2"
                     /translation="MKLTNRVDYFGADISELQNKKLFLFDMDGTIYEEDRLFEGTLELL
                     DYIHNIGGEYIFITNNSSKSVVDYVEKVNRLGIKAERDNFFTSAQATIVYIKENYPKSK
                     VYCQGTKSLIKELSDAGIDVTEQVSADIDVVLVGFDTELTSDKIRNTCEILSTKDVPFI
                     ATNPDIRCPVSFGFIPDCGSICDMISKSVDRKPVYIGKPEPTMVDIVRKKLNYSLFETV
                     VIGDRLYTDIMTGINAGVTSVCVLTGEATVNDIQQDSIKPTYTFKNVKEMWKGIV"
     misc_feature    15593..16279
                     /gene="gtp3"
                     /locus_tag="SPC23A_0017"
                     /note="HMMPfam hit to PF00702, haloacid dehalogenase-like
                     hydrolase, score 5.9e-25"
     gene            16529..17398
                     /gene="rmlA"
                     /locus_tag="SPC23A_0018"
     CDS             16529..17398
                     /gene="rmlA"
                     /locus_tag="SPC23A_0018"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI33825.1"
                     /db_xref="GOA:Q4K0F1"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:Q4K0F1"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLAG
                     IRDILIISTPQDLPRFKELLQDGSEFGIKLSYAEQPSPDGLAQAFIIGEEFIGDDSVAL
                     ILGDNIYHGPGLSTMLQKAAKKEKGATVFGYHVKDPERFGVVEFDENMNAISIEEKPEY
                     PRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRGFAWL
                     DTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRRGYISREDVLALAQSLKKNEYGQY
                     LLRLIGEA"
     misc_feature    16532..17248
                     /gene="rmlA"
                     /locus_tag="SPC23A_0018"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 3.7e-121"
     gene            17399..17992
                     /gene="rmlC"
                     /locus_tag="SPC23A_0019"
     CDS             17399..17992
                     /gene="rmlC"
                     /locus_tag="SPC23A_0019"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase RmlC"
                     /protein_id="CAI33826.1"
                     /db_xref="GOA:Q9AHA9"
                     /db_xref="HSSP:1NXM"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q9AHA9"
                     /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEKM
                     LPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREGET
                     FGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYADPS
                     LGIEWENIAEAEVSEADKNHPLLKDVKPLKKEDL"
     misc_feature    17435..17965
                     /gene="rmlC"
                     /locus_tag="SPC23A_0019"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 4.5e-16"
     gene            18005..19054
                     /gene="rmlB"
                     /locus_tag="SPC23A_0020"
     CDS             18005..19054
                     /gene="rmlB"
                     /locus_tag="SPC23A_0020"
                     /EC_number="4.2.1.46"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI33827.1"
                     /db_xref="GOA:Q9AHA8"
                     /db_xref="HSSP:1KEP"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q9AHA8"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNR
                     ANIEEILGNRVELVVGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTNFI
                     GTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSPYSS
                     TKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGK
                     NVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQAVDAYDHV
                     TDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKEAVEANY
                     AKTQEIITV"
     misc_feature    18020..18976
                     /gene="rmlB"
                     /locus_tag="SPC23A_0020"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 9.7e-05"
     misc_feature    18023..18763
                     /gene="rmlB"
                     /locus_tag="SPC23A_0020"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 5.4e-77"
     misc_feature    18026..18838
                     /gene="rmlB"
                     /locus_tag="SPC23A_0020"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 1.6e-05"
     gene            19120..19971
                     /gene="rmlD"
                     /locus_tag="SPC23A_0021"
     CDS             19120..19971
                     /gene="rmlD"
                     /locus_tag="SPC23A_0021"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI33828.1"
                     /db_xref="GOA:Q4K0E8"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K0E8"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDITDAEMVEKV
                     FEEVKPTLVYHCAAYTAVDAAEDEGRELDFAINVTGTKNVAKASEKHGATLVYISTDYV
                     FDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKNFVF
                     TMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDTTWYD
                     FAVEILKGTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQEFYKQE
                     VR"
     misc_feature    19120..19968
                     /gene="rmlD"
                     /locus_tag="SPC23A_0021"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 1.6e-147"
     misc_feature    19123..19764
                     /gene="rmlD"
                     /locus_tag="SPC23A_0021"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 9.3e-05"
     misc_feature    19123..19752
                     /gene="rmlD"
                     /locus_tag="SPC23A_0021"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 1.4e-19"
     misc_feature    19126..19854
                     /gene="rmlD"
                     /locus_tag="SPC23A_0021"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 1.4e-08"
     misc_feature    20053..20496
                     /gene="tnp"
                     /locus_tag="SPC23A_0022"
                     /note="HMMPfam hit to PF03050, Transposase IS66 family,
                     score 7.1e-05"
                     /pseudo=""
ORIGIN
        1 tgtccaatga agagcaagac ttgacagtag aaggaaaagt caaatctgtc ttgattgaaa
       61 acactgcggc taaagaagta cttgaaaaac aggtcttggc tccatgggat gctttctgtg
      121 tggaattact ataaatattt tttgcagaaa aatttaaaat tgaaatcgta taaaaacaag
      181 ggaagactgt ataaaaggca gaaatccttt gttttttata accaaggttt ataaaccttc
      241 attctcgaaa ttcaattaac tttacaaatt cccactatta aggagaaata agacgaacat
      301 aaagaagcgt atccttagtg caggcctgac ttttacatct gatttgcttt tagctgcttg
      361 cggccaatca ggttcagata caaaaactta ctcatcaacc tttagtggaa atccaactac
      421 atttaactat ctattagact attacgctga taatatagtc aattgaaaca agaacaggac
      481 aaaagagcct cataaaaggt attgcaactt ggtaatacct ttttgaggtg ctttttgata
      541 tgagcccatg ttttctcaat aggattgtac tcaggtgagt agggaggaag aggtaaaagt
      601 ttatgcccaa actcttcaca caagagttct aacttaccca ttctatggaa tcttgcatta
      661 tccataataa taaccgatgg tgtggttaat gttggtaaga aaaacttctg aaaccatact
      721 tcaaaaaagt cgctcgtcat cgtctcttcg taagtcattg gagcgattaa ttcaccattt
      781 gttagacctg caaccaaaga aatcctctga tatcttcttc cagatacttt gcctcttctt
      841 aactgacctt ttaatgagcg accatattct cgataaaaat aagtatcgaa tcctgtttca
      901 tcaatctaaa caggtgctag gtgctttaaa ctattaaaat tcttaagaaa taaggctact
      961 ttttctgggt cttgttcata attagattga aactagaata gtacacatct gcttctaaaa
     1021 cattgttaga aaacgatttg actgtcctga acaatttgtc atgttcttgt ttcattttac
     1081 tatatttttg gttcgcggga agtctactaa gatacttaaa gatgcagata gtgaaaaaaa
     1141 ggtgtagaca ttaccgtaaa aaagtgatat aatcgtatga tgttcaatgt ataggtgtta
     1201 atcatgagta gacgttttaa aaaatcaggt tcacagaaag tgaagcgaag tgttaatata
     1261 gttttgttga ctatttattt attgttagtt tgttttttat tgttcttaat ctttaagtac
     1321 aatatccttg cttttagata tcttaatcta gtggtaactg cgttagtcct actagttgcc
     1381 ttggtagggc tacttctgat tatctataaa aaagctgaaa aatttactat ttttctgttg
     1441 gtgttctcta tccttgtcag ctctgtgtcg ctctttgcag tacagcagtt tgttggactg
     1501 accaatcgtt taaatgcgac ttctaattac tcagaatatt caatcagtgt cgctgtttta
     1561 gcagatagtg atatcgaaaa tgttacgcaa ctgacgagtg tgacagcacc gactgggact
     1621 gataatgaaa atattcaaaa actactagct gatatcaagt caagtcagaa taccgatttg
     1681 acggtcaacc agagttcgtc ttacttggca gcttacaaga gtttgattgc aggggagact
     1741 aaggccattg tcctaaatag tgtctttgaa aatatcatcg agtcagagta tccagactat
     1801 gcatcgaaga taaaaaagat ttataccaag ggattcacta aaaaagtaga agctcctaag
     1861 acgtctaaga atcagtcttt caatatctat gttagtggaa ttgacaccta tggccctatt
     1921 agttcggtgt cgcgatcaga tgtcaatatc ctgatgactg tcaatcgaga taccaagaaa
     1981 atcctcttga ccacaacgcc acgtgatgcc tatgtaccaa tcgcagatgg tggaaataat
     2041 caaaaagata aattaaccca tgcgggcatt tatggagttg attcgtccat tcacacctta
     2101 gaaaatctct atggagtgga tatcaattac tatgtgcgat tgaacttcac ttcgtttttg
     2161 aaattgattg atttgttggg tggaattgat gtttataatg atcaagaatt tactgcccat
     2221 acgaatggaa agtattaccc tgcaggcaat gttcatcttg attcagaaca ggctctcggt
     2281 tttgttcgtg agcgctactc actagcagat ggcgatcgtg accgcgggcg caatcaacaa
     2341 aaggtgattg tggctatcct tcaaaaatta acgtcaaccg aagcactgaa aaattatagc
     2401 acgatcatta atagcttgca agattctatc caaacaaata tgccacttga gactatgata
     2461 aatttggtca atgctcagtt agaaagtgga gggaattata aagtaaattc tcaagattta
     2521 aaaggtacag gtcggacgga tcttccttct tatgcaatgc cagacagtaa cctctatgtg
     2581 atggaaatag atgatagtag tttagctgta gttaaagcag ctatacagga tgtgatggag
     2641 ggtagataaa atgatagaca tccattcgca tatcgttttt gatgtagatg acggtcccaa
     2701 gtcaagagag gaaagcaagg ctctcttgac agaatcctac aggcaggggg tgcgaaccat
     2761 tgtctctacc tctcaccgtc gcaagggcat gtttgaaact ccggaagaga agatagcaga
     2821 aaactttctt caggttcggg aaattgcaaa agaagtagca gatgatttag tcattgctta
     2881 tggcgcagag atatactata ctctggatgc tctagaaaag ctagaaaaaa aagaaattcc
     2941 taccctcaat gatagtcgtt atgccttgat agagtttagt atgaacactc cttatcgcga
     3001 tatccatagc gccttgagca agatcttgat gttgggaatt actccagtca ttgcccacat
     3061 tgagcgctat gatgctcttg aaaataacgg aaaacgtgtt cgtgaactga ttgatatggg
     3121 gtgctatact cagataaata gttatcatgt ttcaaaacct aagttctttg gtgaaaaata
     3181 taaattcatg aaaaagagag ctcggtattt tttggaacgt gatttagttc atgtagttgc
     3241 aagtgatatg cacaatttag acagtagacc tccatatatg caacaggcat atgatatcat
     3301 tgctaagaaa tatggagcga aaaaagcgaa agaacttttt gtagataatc ccagaaaaat
     3361 tataatggat caattaattt aggagaaaat atgaaggaac aaaacacttt ggaaatcgat
     3421 gtattgcaac tattcagagc tttatggaaa agaaagttgg tcattttatt agtggcaatt
     3481 ataacttctt cggttgcttt tacctacagt acttttgtta tcaaacctga gtttactagt
     3541 acgactcgga tttatgtagt taaccgtaat cagggagaga agtctggttt aaccaatcaa
     3601 gacttgcagg caggaacata cttggttaaa gactatcgtg aaattatcct atcgcaggat
     3661 gttttggagg aagttgtttc tgatttgaaa ctagatttga cgccaaaagg tttggctaat
     3721 aaaattaaag taacagtacc agttgatacc cgtattgtct ctgtttcagt taatgatcga
     3781 gttcctgaag aggcaagccg tatcgctaac tctttgagag aagtagctgc tcaaaaaatt
     3841 atcagtatta ctcgtgtttc tgatgtgaca acactggagg aggcaagacc ggcgatatcc
     3901 ccgtcttcgc caaatattaa acgcaatata ctaattggtt ttttggcagg ggtgattgga
     3961 actagtgtta tagttcttct tcttgaactt ttagacactc gtgtgaaacg tccggaagat
     4021 atcgaagata cactgcagat gacacttttg ggagttgtac caaacttgaa taagttgaaa
     4081 taggagagag agatgccgac attagaaata gcacaaaaaa aactggagtt cattaagaag
     4141 gcagaagaat attacaatgc cttgtgtaca aatatacagt tgagcggaga taaactaaaa
     4201 gtaatttccg ttacttctgt tagccctggg gaaggaaaaa caactacttc cgtaaatata
     4261 gcatggtcgt ttgcgcgtgc aggctataaa actcttttga tcgatggcga tactcgaaat
     4321 tcagttatat caggattttt taaatctcgt gaaaaaatta cagggctaac agaattttta
     4381 tctgggacag ctgatttatc tcacggttta tgtgatacaa atattgaaaa tttatttgta
     4441 gttcaatcgg gatctgtatc accaaaccct acagccttgt tacaaagtaa aaattttaat
     4501 gatatgattg aaacattgcg taaatatttt gattatatca ttgttgatac agcacctatt
     4561 ggaattgtta ttgatgcggc aattatcact caaaagtgtg atgcgtccat cttggtaaca
     4621 gcaacaggtg aggcgaataa acgtgatgtc caaaaagcga aacaacaatt aaaacaaaca
     4681 ggaaaactgt tcctaggggt tgttttaaat aaattagata tctcggttga taagtatgga
     4741 gtttacggtt tctatggaaa ttatggtaaa aaataattta ggaaagattc tatggatgaa
     4801 aaaggattga aaatttttat ggcagtatta cagagtatta ttgtcatttt attggtttat
     4861 tttcttagct ttgttagaga gacagaactt gaacgttctt cgatggttat actatacctt
     4921 ctccactttt ttgtattcta tgttagttcc tatggtaaca atttttttaa aagagggtac
     4981 ctagttgagt ttaatagtac tataagatat atttttttct ttgcaatagc tataagtgta
     5041 ttaaactttt ttatagcgga acggtttagt atctctagaa gaggaatggt atacttctta
     5101 actttagaag gaatatcctt atacttgtta aatttcttag taaagaaata ttggaaacat
     5161 gtgtttttta atctaaaaaa tagcaagaaa attttactgt taacagtaac gaaaaatatg
     5221 gaaaaagttc ttgataaatt gctagaatct gatgaacttt catggaagtt ggtagcagta
     5281 agtgttttga ataaatctga ttttcaacat gataaaatac ctgtaattga aaaggaaaaa
     5341 attattgaat ttgcaacgca tgaagttgtg gatgaggtgt ttgtcaatct tccaggagag
     5401 agctacgata ttggagaaat tatctctagg tttgagacaa tggggataga tgtaactgta
     5461 aatcttaaag catttgataa gaatttgggt cgcaataaac aaattcatga gatggtagga
     5521 ttgaatgtag tcactttctc tacaaatttt tataaaacta gtcatgtgat ttcaaagaga
     5581 attctcgata tttgtggtgc cactattggc cttattcttt ttgctatagc tagtctagtt
     5641 ttagttccat tgattcgtaa agatggcgga ccagctattt ttgctcaaac tcgtataggg
     5701 aaaaatggtc gacattttac cttttataaa ttccgttcga tgaggatcga tgctgaagct
     5761 atcaaagaac agttgatgga tcaaaatacg atgcaaggtg gtatgtttaa gatagacaat
     5821 gatcctcgtg ttacaaaaat tggtcgcttt attcgtaaaa ccagtttaga tgaattgccg
     5881 cagttttgga atgtctttat aggagatatg agtttggtgg gaacacgtcc acctacagta
     5941 gacgagtatg atcagtatac tccagaacaa aaacgtcgac tcagctttaa acctggtatt
     6001 acaggtttat ggcaggttag cggccgtagt aaaataaccg attttgacga tgttgtaaaa
     6061 ttagatgtgt cttatattga taattggaca atctggaaag atattgaaat tttgcttaaa
     6121 actgttaaag ttgtatttat gagagatgga gcgaagtaat ttctgtatat ccatcatatt
     6181 aggagagaaa tgaaaaagtc agtttatatc attggttcaa aaggaattcc tgctaagtat
     6241 ggaggatttg aaacttttgt tgaaaaatta acagccttcc aacaagataa ggctatccaa
     6301 tattatgtgg cttgtatgcg tgaaaactct gcaaaatcag ggactactga ggatgttttt
     6361 gaacataatg gtgctatctg ttataacgtc gatgttccta atattggtcc agcgcgagcc
     6421 atagtatatg atatcgcggc aattaacaga gctattgaaa ttgccaaaga aaataaggat
     6481 gaagatccaa tcttctatat tttagcttgt cgaatcggtc cgttcatcca tggaattaag
     6541 aaaaaaatcc aggcgatagg tgggactctt ctagttaatc cagatggtca cgagtggtta
     6601 cgagctaagt ggagcactcc agttcgtcgt tattggaaaa tttccgaagg tcttatggtc
     6661 aaacatgcag atttattggt ttgtgacagt aaaaatatcg aacagtatat ccaagaagat
     6721 tataaacagt tccaacctaa gaccacctat atcgcttatg ggaccgatac aacacgctcc
     6781 atattaaaga gtagtgatga aaaagtacgt tcttggttca aagagaagaa tgtttctgag
     6841 aacgagtatt atctagttgt aggacgattt gttccagaga ataactatga atctatgatt
     6901 cttggcttct tggcttctaa ctctaagaag gactttgttt taattacaaa tgtagaacag
     6961 aataaatttt ataatcagtt gttggcaaaa actggttttg ataaagatcc acgagtaaaa
     7021 tttgtaggga cagtctacaa ccaagagctt ctaaagtata ttcgagaaaa tgcttttgct
     7081 tacttccacg ggcatgaagt tggtggaaca aatccttcgt tacttgaagc attagcatcc
     7141 acaaagttaa acttactact cgatgttggc tttaaccgag aagtagctga ggatggtgct
     7201 gattactggg aaaaagataa tcttcataag gttattgaag cgagtgaaca aaaaacacaa
     7261 gaagagataa atgaaaaaaa tatactgtca acaaagcaag tgacggagcg cttctcttgg
     7321 gatttgatag ttaatgagta tgagaaactt tttacgagaa aaaactagaa actcataagg
     7381 gattatttga ataaataagt ttttgctttt tctcattgat agaacaataa gattgcttta
     7441 gtaaataata attagaaaac tgtatataaa atttcataat atggaaaatg agtttcgaag
     7501 agaagagtac atatgtcatg aatgtagtaa ttgataacag aaaattaggg gggataagtt
     7561 gaaagtagat atgatttttg aggtacggaa taatgagaat tagttttagt aaaaaaacta
     7621 tgctgtgtgg tttattgtat attggtttaa ttttatccgt agtaacaata cctacaattg
     7681 taacattttt atattctttg ctattcatcg ggattgtaac agtcttaaat tataattcta
     7741 ttctagcaag tgacgaagat gcgaactctt tttttgttgc attacctatt attttatctt
     7801 cttttcaaaa tgtatatttg ggatttggag cggatcgatt aaattctgtc acactacaag
     7861 ttctgctatc tattagcatt gctattatta caattacagt ttttctaggt attatcttaa
     7921 atagattcaa atcaaaagaa tttagttggt tagttttaag tattcttgta attataattc
     7981 aatcagtaat tcttttaata ttctttccca ctaccttgcc agcatattta tcatctatga
     8041 gaaatatact agccccacta ctgatttttt atttttctat ctatgggttt aaaaatatta
     8101 atttacaaaa attttataaa tatatgttca taattatatt agttgttcta atttttggat
     8161 ttattgagta tatatacgga aatagtttat ggacaagatt gaatattaaa aagctttggg
     8221 ctttgaaggg gctggcgatt gagaataggg ttgttcctgg gaattggcac tcttctgaat
     8281 taattggcgg taaacaatta aggcgtatgg tttcaacatt tgccgatccc gtaaatctag
     8341 gttcgtatct ctttgcggca tttatgttag cttggtacaa aaataagaaa ctacttcaag
     8401 ttttattgct cgcttctttt gtactcagtg taagtaaagc agcgttttta agcatgttgg
     8461 tatatataat aatttatacc tgggttgtgg ataaaaataa aattttatcg atttttggaa
     8521 taataatttc aactgtattg gggttgtatt tttataattt tagtcaagtt agcagttatg
     8581 gtagtataaa tgcacatatc gatggttttt ttagtgcgtt aagtactccc ctccattacc
     8641 catttggtat gggagtaggg agtgtgggag ttctagcttc aaaattaggt tcacaaacag
     8701 cactttcttc agaggtttta gaaacaggaa ttggaatgat aattgctcaa ttaggattcg
     8761 tgggtgtgat aatatatttg attttctttg taaaactctc cgtaatagga aagaatatta
     8821 ataataaaag agataaaatt ttatggttta ctttaattta tagctttttg gctaatgcct
     8881 tttttaacga ggttgcactt tctcctaact catgcacctt atatttttta attttaggac
     8941 tgctttataa taaaaataaa attagaagca cagagtttag ttaatggaaa aattagttag
     9001 tattattctg cccgtctaca atgtcgaaca gtatataaaa aattgtttag aatcaattca
     9061 acaacaaact tatccaaatt tggaagtaat cattgttaat gacggttcaa ccgataaaag
     9121 cgttgaatat tgtgagcaaa tttgtaagat agattctagg ttttctatca ctcacaaaga
     9181 aaatggtgga ctttccgatg caagaaatgt cggtatagat aaagccaagg gagattacct
     9241 catttttgtt gacagtgatg attttgtttc tcaagatatg gtatcttatt tagtatcttg
     9301 tatggagaac aatgaggcag acattgctat ttgcgatcct gttcattatt atagtgatcg
     9361 tcaaaacaat gatcttaata ttttttctcc agcatcaagc gttaaggttt acgaaacaac
     9421 ggaggctcta tgtgagatgt tttatcaaaa atcttttttg gtgtctgcct gggccaagat
     9481 atttaaaaga gagttgtttg atgatataag atttcctgta ggtaagctat ttgaagatag
     9541 tgcgattatg tatttgctcc tcgaaaagtg tgaaacaatt gcatactctg atgcgaaatt
     9601 atatgcttat gtacacaggg ataatagtat cacaacaaag aaattttcgg atagagactt
     9661 agatattttg gagattacga acacaattat taatcactat ggtgataatt tacgcgtgta
     9721 tactgcagcg gtgtcttata aggtatctgc atgtttcaga attctattaa actcaccttc
     9781 tgaagaaaag tataaaaaag tacaaaaaga atgtttgagt tatattttac aaaattggag
     9841 aaacatatta tttaataata atgttcgatt gaagaacaag cttgccttaa tttctataac
     9901 tattttcaat ccttttgtta aattgatcta tagtaaagta aacagatggg aatgatagca
     9961 aatgaacaaa tatgaagaaa gatatcaaga aaatttatct aagaatgatt tttataaatt
    10021 aattaataag agttacttat cagataaaga acttcaagta caacaagtaa aagctgggat
    10081 agtcttacca ccaaaggcat ttgaaacaaa attatcaaat aaacttggcc tacaaaaatc
    10141 tttgcatgga aagggtggag ttgtagactc aaatggaaat tacattgaac tatctgcaca
    10201 aaaagcagtc gggatgagaa atagagtcta tggtccgtat aaaattaatt acgataatct
    10261 gccaattaga aatgaaaaag taatctattt gaactatttc atcaaacaat ggggacattt
    10321 tttactggat gttgttggaa ggttatggta tccattgctg caggataatg atactaagtt
    10381 agtctatacc tgctatgctg gaacagaaac aaagattgag ggaaactatt tagagttttt
    10441 gaagcttctc ggcatagatc aatcacgttt aatcatgata aactgtccca ctcagttctc
    10501 agaagtcatt attcctgaaa gctccatttt accgggggga tattatacaa aagagtataa
    10561 acaactattc agttcggtag tagaaaatat taaattggac aagtatgatg tgaatgctaa
    10621 aatgatttat tgttcgaggt ctaaattagg gattgctaaa agtaaagaat ttggcgaaga
    10681 cggtattgag gggattttta aacaaaatgg ctatacatct gtttacatgg aaacaatgtc
    10741 tttggaagag caaataaaaa ccttattatc ggctaagaca atagtattaa cgagtggttc
    10801 gttagcacat aatcttttat ttgtaaataa agatattgat gtttttattt tgaataaaac
    10861 ctatagagta aatctccatc aatttttaat aaacgagatc tcagatgcta cagtaagatt
    10921 tgtagatatc tatcgatcac ctttaccgat tttatacgga tatggaccat ttttaatgga
    10981 tcttacaaaa cctttggcta atttcttgga cgataatgaa tttgtatatg aaaaaggtac
    11041 tgttttaagt aaaaaagatt attttaaata ctatttgaaa tggttgtgga gttatagatt
    11101 ctttttattt aggttaaatg gtattaaaga aggaaatagt gaattcgaga agagttttaa
    11161 gataattagg agatactata aaacaggacg atagaatgag taaatataag gaattagcaa
    11221 aaaatacagg tatttttgct ttggctaact tttcatcaaa gattttaatt tttttgttag
    11281 tacctatata tacacgggta cttaccacta cggaatatgg tttttatgac ttagtctata
    11341 caactattca gctttttgta ccaatcttga cattaaatat atctgaagcc gttatgaggt
    11401 tcctaatgaa agatggtgtt tctaaaaaat cagtcttttc aattgctgtt ttagatatat
    11461 ttattggatc aattgctttt gctttattgt tgttagtaaa taacctgttt tctttatcag
    11521 atttaatttc tcaatacagt atttacatat ttgtaatctt tgttttctat accctaaata
    11581 attttttgat acaattttct aagggaattg ataaaattgg tgttacagct atctctgggg
    11641 tcataagtac agcagttatg cttgccatga atgtcattct tctagtagta tttgattggg
    11701 gattgttagg tttctttatt gctaatgttt gtggatatgt tataccttgt atttatatag
    11761 tttctagatt aagattgtgg gaattatttg aaattaagat tgataaaaaa ttacaatggg
    11821 aaatggttta ctatgctttg ccattagttt taaatatatt aagctggtgg gtaaataata
    11881 cttcagatag atatattgtg actgcaatag taggtataca agctagtgca attatttcag
    11941 tcgcttataa aattccacag attttgtcta cgattagtgc aatttttatt caatcatggc
    12001 aaatctctgc aattaaaata caagaagata agagcggtac tacatttgta tcaaacatgc
    12061 tcctatacta taatgcactt ctattgatta tagcgagtgg tatcatatta tttgtcaaac
    12121 ctatttctaa tatattgttt ggtatttcct tctattctgc gtgggagctg gtaccatttt
    12181 taataattag cagtctattc aatgcaattt caggttgtat aggagcaatt atgggagcta
    12241 aaatggatac tcataacatt gcaaagtcgg ctttagttgg gatgattgca aatattattt
    12301 taaatatagt gttaacattc ttaatgggtc cacagggaat tacaatttct accctgatag
    12361 ctagttttct tattttttat atgcgaaaag atagtgtaaa agaaattaat tcagaaacat
    12421 atagagcaat ttatttatcg tggatactat tagttgtaga ggcctgtctg ctaatttata
    12481 tggattttat tattggtgct ttaatagcaa tggtaataaa cttattttta ctaaaagatg
    12541 ttatcaaacc tttatattta aaaattttca aaagaaatta ggtacaaaat gattgtttta
    12601 caatacttta agattttagc tagattcgtt tttatgtttt tgataagtgc ggtgttactg
    12661 cctttcaaaa taaaacctaa taagattgtt tttattaatt tcaatgggaa aggatatggt
    12721 gataatccga aaagtatttg tgagtatctt agaactactt acccagattt agatttggtt
    12781 tggcttgcaa gagataacga aggttttcca gatggggtta gggttgttaa atatgggact
    12841 ttccaagctt tttatgagca agcgagttcg aaggtttggg tatataatgt aagagctttt
    12901 gcaagaatac taaaaaaacg aggacagatt tatattcaaa cttggcatgg tgcttctagt
    12961 tttaagttga tagaaaaaca agctgattta ccaataaatt atgttttaga agctaagtat
    13021 gatgcaagag tcacagatat aatgatttca gatagcagaa aacaaactga agaatttcaa
    13081 aagtattttt ggtattcagg agaaattttt gaggtgggga tgccgagaaa tgatgccttg
    13141 tttcactata aggaagacta cgacaagtta aataatatca gaaaagaact aagcattcat
    13201 tcagatgatt atgttatttt atatgcccct actttcagag atgatgggga tgcatcttat
    13261 ttagatataa attttgaacg gcttttgcaa tgtgttgaac acggaattaa aaagaaatgt
    13321 aaattcttaa ttaggttaca ccctaatcac tcccatttgt gtaataatat ttcatttaat
    13381 aagaatataa tcaatgctac gttttattca gatatgcaag agcttacttt gttggcagat
    13441 gttttagtca cagattattc ttcctcgata tttgatttta tgcttttaaa caagccttat
    13501 gtcagatatg tgaatgattt agaaaaatat gctgagctta ggggggtatc agatacatat
    13561 tacgaattgc cggattcgat tattaaaact gctgaagaat tgtatgactt actgcctaaa
    13621 aaaatagaaa attttgatta tgattctata aaaaaatata gaaatgaaat actgtgtcca
    13681 atctttaatg gaaccgctag tgaaaatgta ggaaggagaa taattcaaga gttgtgaagt
    13741 aaaacattgg gttattttta aggtaacgag atttgaaaaa taatgattta aagataggaa
    13801 gtggagctat tcatcaaatt tccgctacac tttctcaaaa tagtatttcg ggaaagattt
    13861 tatattgtgc tgatccagtt gtcgatgact tgtacggttc gatagtacgt tcacaaatag
    13921 aggaaattgg tcgggtaaag gaagaaagtt gcaattataa tactattgct tatgcgatga
    13981 atatagcaga acgggctatt gccacagata ttgactgtat tgtgggaatg ggaggaggtc
    14041 gtgttttaga tgtctgcaag tatgcatctt ttatttcgaa acgtccttac ctatcgattc
    14101 cgacaacagc agcaaatgat ggcattgctt ccccagttgc tgttttgaaa aggcaggatg
    14161 atagaccaaa aagcttaggg gcggctatcc cctcaatgac actaattgat attgatgtta
    14221 ttgcatcagg acctatacaa aatataaaag ctggtatcgg tgatacaata tccaattaca
    14281 ctgcattgaa agattgggag ttggcagttg agcgagggaa agatgagatg catggttttg
    14341 catatctaat gtcgcaaaat tctttagatg ctttaatgaa aacgaagtat aattctatta
    14401 cccctgattt tattgaagtt ttggtaaact ctttagtttt atcaggcatt gcaatggatt
    14461 ttgcgggaag tagtagacct gtcagtgggt cagagcactt atttagtcat gcattagatt
    14521 actatggttc tacaaggaat cttcatggaa ttcaggttgc attaggtaca gtcgcagttt
    14581 tgaaattaat tgaaaattct gttgatactg tagtggatta cttgcaaaga tttgaggttc
    14641 atattaaccc gaaacttttg gggatagatg aagagttgtt tatttattgt atgcaacatg
    14701 ctacaaaaat gagaagtaat cgctatacct atctgcatga agttgatctt agcacagata
    14761 gattgaaaca aatatataag gaactcataa gcgagttgta gagaagagag gaaaaaatga
    14821 aagcacttat tttagcagca gggttaggaa cacgtctagc tccaattacc aatgaggtac
    14881 caaaatcttt ggtaccagtc aatggtaagc caattttgat gaaacaaatt gaaaatttat
    14941 atcaaaataa tattacagat attacgatta ttgctggata taagtcatct gtattaacag
    15001 atgcagttac tgaaaagtat ccagaaatta atattattga taatgttgat tttaaaacga
    15061 ctaataatat gtattcagcc tatctaggaa aagctgcaat gggtgatagt gacttcttaa
    15121 tgatgaatgc agatgtattt tatgatgctt ctgttattaa aagtctgttg cttcataaag
    15181 ctccaaatgc aattgtaact gatttaggta tttatattga agagtctatg aaagtcgtag
    15241 aaaaaaatgg tcgtttagta gaaatttcta aacagatttc acctgaggaa actttaggag
    15301 cttctattga tgtttataaa ttctcttatg aagcaggtgc tcgattcttt gaaaagtgta
    15361 aggaatttat tgaagataaa cgagaacttc aaatgtggag tgaggttgct cttaatgcaa
    15421 ttctttctga agttgaattt gtagcatgtc cattagaggg tcgttggtta gaaattgata
    15481 atcatgaaga cttagttgct gcagaaaaac tatttgcttg aaccgaatac ggagaatgaa
    15541 attgacaaat agagttgatt attttggtgc tgatattagt gaacttcaga ataaaaaatt
    15601 attcttattt gatatggatg gtaccattta tgaagaagat aggttgtttg agggtactct
    15661 cgaattatta gactatattc ataatattgg cggtgagtat atttttatta caaacaattc
    15721 atctaagtct gttgttgact atgttgaaaa agttaacaga ttaggtatta aagctgaacg
    15781 agataatttt tttacctctg ctcaagccac aattgtttat attaaagaaa attatcctaa
    15841 atctaaagtt tattgccaag gaacaaaatc tttgataaaa gaactatctg acgcaggaat
    15901 tgatgtaact gagcaagtta gtgctgatat agatgttgtt cttgttggtt ttgatacaga
    15961 attaaccagt gataaaattc gcaatacctg cgagattcta tcaacaaagg acgtaccttt
    16021 catagctact aaccctgata ttcgctgccc agtatcgttt ggattcatcc cggattgtgg
    16081 ttctatttgt gatatgatta gtaaatcagt cgataggaaa cctgtttaca taggtaaacc
    16141 tgaacctacg atggttgata ttgttcgaaa aaaattaaat tattctctat ttgaaacagt
    16201 tgtgattgga gatcgcttgt atacggatat catgactggt ataaatgcag gagtaacttc
    16261 agtttgtgtg ctgacaggag aagcaacggt gaatgatatt caacaagata gtataaaacc
    16321 gacttataca tttaaaaacg tgaaagaaat gtggaaagga attgtctgat tttttcattc
    16381 tgaatagtga attcatgaat actgtcaaaa tactcgtatg tatttaaatt gattttatta
    16441 ttttaataat ggacaaatta aaattatttt tctccccaaa tcgttcgtga acgtaaagta
    16501 ctcatcaaca aagaaaggta ccccttttat gaaaggtatt attctagcag gtggttcggg
    16561 aactcgcttg tatcctttga ctcgcgctgc atcaaaacaa cttatgccgg tttatgataa
    16621 accgatgatt tactacccac tttcaacatt aatgttggct gggattaggg atattttgat
    16681 tatctcaact cctcaagatt tgcctcgttt taaagagctt cttcaagatg gttctgagtt
    16741 tggtattaaa ctttcttatg ctgagcaacc aagtccagat ggtttggcac aagcctttat
    16801 cattggggaa gagtttatcg gtgacgatag cgttgccttg attttaggtg acaatatcta
    16861 ccatggtcct ggtctgagca caatgcttca aaaagcagcc aagaaagaga aaggtgcgac
    16921 tgtttttggc taccatgtca aggatccaga acgctttggt gttgtagaat ttgatgaaaa
    16981 tatgaatgct atctccatcg aagaaaagcc agaataccct cgttcaaact atgcagtgac
    17041 aggactctat ttctatgata atgatgtagt agagattgcc aaaagtatta aaccaagtcc
    17101 tcgtggtgaa ttggaaatta cagatgtcaa caaggcttac ttggatcgtg gtgatttgtc
    17161 tgttgagctc atgggacgtg gttttgcttg gttggatact ggcactcatg aaagtttact
    17221 agaggcttcg cagtacatcg aaacagtcca acggatgcaa aatgttcagg tagcaaactt
    17281 agaagaaatt gcttaccgta ggggctatat cagtcgagaa gatgtattgg ccttagccca
    17341 atcacttaag aaaaatgaat acggacagta tctgctccgt ttgattggag aagcatagat
    17401 gacagataat tttttcggta agacgcttgc ggcacgcaag gttgaagcta ttccaggcat
    17461 gttggagttt gatatccccg ttcatggaga taatcgtggc tggtttaaag aaaatttcca
    17521 aaaggaaaaa atgcttccac ttggatttcc agagtctttc tttgcagaag gaaaattgca
    17581 aaacaatgta tccttctcac gtaaaaatgt ccttcgaggc ctccacgcag agccttggga
    17641 taagtacatc tctgtagcag atggagggaa agttctgggt tcttgggttg atctacgcga
    17701 gggtgaaacc tttgggaata cctatcagac agtgattgat gcgagtaagg gaatctttgt
    17761 tcctcgaggc gtagctaatg gcttccaagt tttatcagat acagtgtcat atagctatct
    17821 ggtcaatgat tactgggctc ttgaactcaa acccaagtat gcctttgtga actacgctga
    17881 tccaagcctt ggtattgaat gggaaaatat tgcagaagca gaggtttcag aagcagataa
    17941 aaatcatcca ctacttaagg atgtaaaacc tttgaaaaaa gaagatttgt aaaaaggaaa
    18001 gaatatgact gaatacaaaa atattatcgt gacaggtgga gctggcttta tcggttctaa
    18061 ctttgtccat tatgtttacg agaactttcc agatgttcat gtgacagtcc tagataagtt
    18121 gacttatgct ggaaaccgcg cgaatattga ggaaatttta ggtaatcgtg ttgagttagt
    18181 tgttggtgac attgctgatg cggagttggt agacaagttg gctgctcaag cagatgctat
    18241 cgttcattat gcagcggaaa gccacaatga taattcgctc aatgatccat cgccatttat
    18301 tcatactaac ttcatcggaa cctatactct tttagaagct gctcgtaagt atgatattcg
    18361 cttccaccat gtatcgacag atgaagttta tggggatctc cctttacgcg aagatttgcc
    18421 aggtcatggt gaaggaccag gtgagaaatt tactgctgaa acaaaataca acccaagctc
    18481 tccgtactca tcaaccaagg cagcctcaga tttgattgtc aaagcctggg tgcgttcttt
    18541 tggagtcaag gcaacgattt ccaactgttc aaataactac ggtccttatc aacatatcga
    18601 aaaattcatc ccacgtcaga ttactaacat cctaagtgga attaagccaa aactttacgg
    18661 tgaaggtaag aatgttcgtg actggattca taccaatgac cattcttcag gagtttggac
    18721 aatcttgaca aaagggcaaa tcggtgaaac ctacttgatt ggggctgatg gtgagaagaa
    18781 caataaggaa gttttggaac ttatccttaa ggaaatggga caagctgtgg atgcctatga
    18841 tcatgtgact gaccgtgcag gacatgacct tcgctatgcg attgatgcta gcaagctccg
    18901 tgatgagttg gggtggaaac ctgaatttac caactttgaa gctgggctca aggcaacaat
    18961 caagtggtat acagataacc aagaatggtg gaaagcagaa aaagaagctg ttgaagccaa
    19021 ttatgctaag actcaggaga ttattacagt ataaaaagca ggaaatagct gctttttatt
    19081 gctatattgg gaagagttac atattagaaa ggtctagaga tgattttaat tacaggggca
    19141 aatggccaat taggaacgga acttcgctat ttattggatg aacgtaatga agaatacgtg
    19201 gcagtagatg tggctgagat ggacattacc gatgcagaaa tggttgagaa agtttttgaa
    19261 gaggtgaaac cgactttagt ctaccactgt gcagcctaca ccgctgttga tgcagcagag
    19321 gatgaaggaa gagagttgga cttcgccatc aatgtgacgg ggacaaaaaa tgtcgcaaaa
    19381 gcatctgaaa agcatggtgc aactctagtt tatatttcta cggactatgt ctttgatggt
    19441 aagaaaccag ttggacaaga gtgggaagtt gatgaccgac cagatccaca gacagaatat
    19501 ggccgtacta agcgtatggg ggaagagtta gttgagaagc atgtgtctaa tttctatatt
    19561 atccgtactg cctgggtatt tggaaattat ggcaaaaact tcgtttttac catgcaaaat
    19621 cttgcgaaaa ctcataagac tttaacagtt gtaaatgacc agtacggtcg tccgacttgg
    19681 actcgtacct tggctgagtt catgacctac ctagctgaaa atcgtaagga atttggttat
    19741 tatcatttgt caaatgatgc gacagaagac acaacatggt atgattttgc agttgaaatt
    19801 ttgaaaggta cagatgtcga agtcaagcca gtagattcca gtcaatttcc agccaaagct
    19861 aaacgtccgc taaactcaac gatgagcctg gccaaagcca aagctactgg atttgttatt
    19921 ccaacttggc aagatgcatt gcaagaattt tacaaacaag aagtgagata agtagtagaa
    19981 tgattttcta gtctaataaa agaggcagat aatgaactcc aaaggagctt aagatgtacg
    20041 attatcttgt tgttggtgct gatctctttg gcgcatagct ttggctcagt ttctattatc
    20101 gctcacacca tccatcagaa gtttaatctg aaggtaccca attatcgcca agaagaagat
    20161 tgggctagga tgggtttacc aatcacacgt aaggaaatct ctaattggca tatcaaggca
    20221 agtcaatact atttagagtc cctttataac cttttacgag aaaagttgtt agaacaacct
    20281 cttcttcatg cggatgaaac ttcttatagg gtgctagaga gtgatagtca gctgacttac
    20341 tattggacct ttttgtctgg gaaagctgag aatcaagcaa tcacgctgta ccaccatgat
    20401 cagcgtcgga gtggtttagt agtacaagaa ttcctaggag attattctgg ctatgttcat
    20461 tgtgacatgt tgcggcagta acttaggact ttagtcctct agttctgcct atgcgatagc
    20521 agtccaaggt ttaggagcaa ggcgacgcta agcttggtaa actgcgaacc gctagaagct
    20581 tatcgtcaac tggaagaagc tgaacttgtt ggatgttggg cgcatgtgag aaggaagttt
    20641 tttgaagcga cccccaagca agcggataaa tcatcgttag gagctaaagg tttagcttat
    20701 tgtaatcagt tattttcctt ggaaagagac tgggaggctt tgccagctga tgaacgacta
    20761 cagaaacgtc aagaagagct ccaaccccta atggaagact tctttgcttg atgccggcgt
    20821 cagtcagttt tatcgggttc aaaactagga agggcaattg aatacagcct caagtataaa
    20881 gaaaccttta agactatttt gaaagacgga catctggtcc tttccaataa tctagctgaa
    20941 tgcgccatta aatcattggt tatgggacgg agtaaaagag tccagtggac tcttttagcc
    21001 taagctcagt ttaaaaaagc gagggtggtt attttctcaa aattttgaag gagctaaagc
    21061 aagagctatt attatgagtt tgttggaaac agctaaacgt catcaattaa atagcgagaa
    21121 atatctatcc tatcttctag aatgtcttcc aaacgaggaa actctcgtaa acaaagaggt
    21181 tttagaggcc tatttaccgt ggactaaagt tgtacaagaa aagtgtaaat aagaaatctc
    21241 cagattagga actatccgtg agttctctag tctggagatt tttcaatata cttcgttatt
    21301 ggacggttac gatattcata ttttttgcaa agatgttgtt tgaaaaataa ttttcaaaaa
    21361 ttctgaaaat tctgttgaca actttctgaa aagagtctat aatggagaga aagttttaaa
    21421 ggagaaaatg atgaaaagtt caaaactact tgcccttgcg ggcgtgacat tattg
//
