LOCUS       CR931685               22330 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain Dr. Melchior (serotype 23f).
ACCESSION   CR931685
VERSION     CR931685.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 22330)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 22330)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..22330
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="Dr. Melchior"
                     /db_xref="taxon:1313"
     misc_feature    complement(723..1223)
                     /gene="tnp"
                     /locus_tag="SPC23F_0002"
                     /note="HMMPfam hit to PF00665, Integrase core domain, score
                     1.8e-21"
                     /pseudo=""
     gene            1882..3327
                     /gene="wzg"
                     /locus_tag="SPC23F_0003"
     CDS             1882..3327
                     /gene="wzg"
                     /locus_tag="SPC23F_0003"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI33856.1"
                     /db_xref="GOA:Q9R928"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q9R928"
                     /translation="MSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAFR
                     YLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNRLN
                     ATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLTVDQ
                     SSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAPKTSK
                     NQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADGGNNQK
                     DKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALH
                     GKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNYS
                     TIIDSLQDSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRTDLPSYAMPDSNLY
                     VMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1882..1998
                     /gene="wzg"
                     /locus_tag="SPC23F_0003"
                     /note="Signal peptide predicted for SPC1208 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.540 between residues 39 and 40"
     misc_feature    2086..2433
                     /gene="wzg"
                     /locus_tag="SPC23F_0003"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 6.7e-65"
     misc_feature    2611..3054
                     /gene="wzg"
                     /locus_tag="SPC23F_0003"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 5.7e-70"
     gene            3329..4060
                     /gene="wzh"
                     /locus_tag="SPC23F_0004"
     CDS             3329..4060
                     /gene="wzh"
                     /locus_tag="SPC23F_0004"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI33857.1"
                     /db_xref="GOA:O54645"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:O54645"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLTESYRQGVRTIVSTSHRRK
                     GMFETPEEKIAENFLQVREIAKEVADDLVIAYGAEIYYTLDALEKLEKKEIPTLNDSRY
                     ALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELIDMGCYTQVN
                     SSHVLKPKLFGERYKFMKKRAQYFLEQDLVHVIASDMHNLDGRPPHMAEAYDLVTQKYG
                     EAKAQELFIDNPRKIVMDQLI"
     misc_feature    3332..3940
                     /gene="wzh"
                     /locus_tag="SPC23F_0004"
                     /note="HMMPfam hit to PF02811, PHP domain, score 6.7e-38"
     gene            4066..4761
                     /gene="wzd"
                     /locus_tag="SPC23F_0005"
     CDS             4066..4761
                     /gene="wzd"
                     /locus_tag="SPC23F_0005"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q93E03|8.A.3.2.3"
                     /protein_id="CAI33858.1"
                     /db_xref="GOA:Q4K0G3"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4K0G3"
                     /translation="MMKEQNTIEIDVFQLFKTLWKRKLMILIVALVTGTGAFAYSTFIV
                     KPEYTSTTRIYVVNRNQGDKPGLTNQDLQAGTYLVKDYREIILSQDALEKVATNLKLDM
                     PAKTLASKVQVAVPADTRIVSISVKDKQPEEASRIANSLREVAAEKIVAVTRVSDVTTL
                     EEARPATTPSSPNVRRNSLFGFLGGAVVTVIAVLLIELLDTRVKRPEDVEDVLKIPLLG
                     LVPDFDKIK"
     misc_feature    4087..4503
                     /gene="wzd"
                     /locus_tag="SPC23F_0005"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 6.4e-55"
     misc_feature    4609..4686
                     /gene="wzd"
                     /locus_tag="SPC23F_0005"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            4771..5460
                     /gene="wze"
                     /locus_tag="SPC23F_0006"
     CDS             4771..5460
                     /gene="wze"
                     /locus_tag="SPC23F_0006"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q93NW3|8.A.3.2.2"
                     /protein_id="CAI33859.1"
                     /db_xref="GOA:O84996"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:O84996"
                     /translation="MPTLEISQAKLDSVKKAEEYYNALCTNLQLSGDGLKVFSITSVKI
                     GEGKSTTSANIAWAFARAGYKTLLIDGDIRNSVMLGVFKARNKITGLTEFLSGTTDLSQ
                     GLCDTNIENLFVIQAGSVSPNPTALLQSKNFTTMLETLRKYFDYIIVDTAPVGVVIDAA
                     IITRNCDASILVTEAGEINRRDIQKAKEQLEHTGKPFLGIVLNKFDTSVDKYGSYGNYG
                     NYGKNKK"
     gene            5475..6842
                     /gene="wchA"
                     /locus_tag="SPC23F_0007"
     CDS             5475..6842
                     /gene="wchA"
                     /locus_tag="SPC23F_0007"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|H8E4X1|9.B.18.1.2"
                     /protein_id="CAI33860.1"
                     /db_xref="GOA:Q4K0G1"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4K0G1"
                     /translation="MNEKILRSSLAIIQSFLVILLTYLLSAVRETEIVSTTAIALCILH
                     YFVFYISDYGQDFFKRRYLIELVQTLKYILFFALAIGISNFFLEDRFSISRRGMIYFLT
                     LHALLVYVLNLFIKWYWKRAYPNFKGSKKILLLTATSRVEKVLDRLIESNEVVGKLVAV
                     SVLDKPDFQHDCLKVVAEGGIVNFATHEVVDEVFINLPSEKYNIGELVSQFETMGIDVI
                     VNLNAFDRSLARNKQIREMAGLNVVTFSTTFYKTSHVIAKRIIDIVGALVGLILCGLVS
                     IVLVPLIRKDGGSAIFAQTRIGKNGRQFTFYKFRSMCVDAEAKKRELMEQNTMQGGMFK
                     VDDDPRITKIGCFIRKTSLDELPQFYNVLKGDMSLVGTRPPTVDEYEHYTPEQKRRLSF
                     KPGITGLWQVSGRSEIKNFDEVVKLDVAYIDGWTIWKDIEILLKTVKVVFMRDGAK"
     misc_feature    5475..5561
                     /gene="wchA"
                     /locus_tag="SPC23F_0007"
                     /note="Signal peptide predicted for SPC1212 by SignalP 2.0
                     HMM (Signal peptide probability 0.670) with cleavage site
                     probability 0.344 between residues 29 and 30"
     misc_feature    6258..6839
                     /gene="wchA"
                     /locus_tag="SPC23F_0007"
                     /note="HMMPfam hit to PF02397, Bacterial sugar transferase,
                     score 1.7e-161"
     gene            6873..8051
                     /gene="wchF"
                     /locus_tag="SPC23F_0008"
     CDS             6873..8051
                     /gene="wchF"
                     /locus_tag="SPC23F_0008"
                     /note="member of homology group 15"
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="CAI33861.1"
                     /db_xref="GOA:Q4K0G0"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="InterPro:IPR015393"
                     /db_xref="UniProtKB/TrEMBL:Q4K0G0"
                     /translation="MKKSVYIIGSKGIPAKYGGFETFVEKLTAFQQDKAIQYYVACMRE
                     NSAKSGTTEDVFEHNGAICYNVDVPNFGPARAIAYDIAAINRAIEIAKENKDEDPIFYI
                     LACRIGPFIHGIKKKIQEIGGTLLVNPDGHEWLRAKWSAPVRRYWKISEGLMVKHADLL
                     VCDSKNIEKYIQEDYKQYQPKTTYIAYGTDTTRSVLKSSDEKVRSWFKEKNVSENEYYL
                     VVGRFVPENNYESMIRGFLASNSKKDFVLITNVEQNKFYNQLLAKTGFDKDPRVKFVGT
                     VYEQELLKYIRENAFAYFHGHEVGGTNPSLLEALASTKLNLLLDVGFNREVAEDGAIYW
                     KKDNLHEIIETSEQKTQKEIDEKDILSIKQVTERFSWELIVNEYEKLFLCEK"
     misc_feature    7488..7994
                     /gene="wchF"
                     /locus_tag="SPC23F_0008"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases group,
                     score 0.0029"
     gene            8351..9544
                     /gene="wzy"
                     /locus_tag="SPC23F_0009"
     CDS             8351..9544
                     /gene="wzy"
                     /locus_tag="SPC23F_0009"
                     /note="member of homology group 168"
                     /codon_start=1
                     /transl_table=11
                     /product="oligosaccharide repeat unit polymerase Wzy"
                     /protein_id="CAI33862.1"
                     /db_xref="UniProtKB/TrEMBL:Q9R925"
                     /translation="MTIKINNLFFVCLSFFGIVLSSSQVIVNLGLSSIIQYISYFMLML
                     CVFLTLIKNTLNVFANRIIYFLIISFLFIIGINLQNLPLSRKIYLSFSMLIISSLSTLP
                     IKLINNLSDLRRISYYLLHSIFLSVFLGLVFKISLVTVAVEGIGFSYGFNGGLTHKNFY
                     AITILVSYILLYVSRKYDAKHQIDSFVLWLDLFLLLISNTRTVYIILVVFWIIINRNFI
                     NNIKKEHRLVVTATTIVISLLALTFFFKHIINNSESYSHRVLGVVNFFKYYESDRFHLF
                     FGDAELAFGNTTKGYGHNIRSVLGWDGTVEMPLLSVMIKNGYVGLVGYIIVLFKFISSI
                     ISVKNSTKKNIGLSIFIPLLLSATVENYIVNISFVFMPVCFCILCSIKNIKLVNNRK"
     misc_feature    8351..8461
                     /gene="wzy"
                     /locus_tag="SPC23F_0009"
                     /note="Signal peptide predicted for SPC1214 by SignalP 2.0
                     HMM (Signal peptide probability 0.975) with cleavage site
                     probability 0.241 between residues 37 and 38"
     gene            9548..10519
                     /gene="wchV"
                     /locus_tag="SPC23F_0010"
     CDS             9548..10519
                     /gene="wchV"
                     /locus_tag="SPC23F_0010"
                     /note="member of homology group 109"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|P75905|4.D.1.1.3"
                     /protein_id="CAI33863.1"
                     /db_xref="GOA:O85000"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:O85000"
                     /translation="MEKLVSIILPVYNVEQYIKNCLESIQQQTYSNLEVIIVNDGSTDK
                     SVEYCEQICKIDSRFSITHKENGGLSDARNVGIDKSKGDYLIFVDSDDFVSQDMVSYLV
                     SCMENNEADIAICDPVHYYSDRQNNDLNIFSPASNVKVYETTEALCEMFYQKSFLVSAW
                     AKIFKRELFDDIRFPVGKLFEDSAIMYLLFEKCETIAYSDAELYAYVHRDNSITTKKFS
                     DRDLDILEITNTIINHYGDNLRVYTAAVSYKVSACFRILLNSPSGEKYKKVQKECLSYI
                     LQNWRNILFNNNVRLKNKLALISITIFNPFVKFIYSKVNRWE"
     misc_feature    9563..10075
                     /gene="wchV"
                     /locus_tag="SPC23F_0010"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase family,
                     score 9.1e-49"
     gene            10526..11758
                     /gene="wchW"
                     /locus_tag="SPC23F_0011"
     CDS             10526..11758
                     /gene="wchW"
                     /locus_tag="SPC23F_0011"
                     /note="member of homology group 110"
                     /codon_start=1
                     /transl_table=11
                     /product="putative transferase"
                     /protein_id="CAI33864.1"
                     /db_xref="GOA:Q9R924"
                     /db_xref="UniProtKB/TrEMBL:Q9R924"
                     /translation="MNKYEERYQENLSKNDFYKLINKSYLSDKELQVQQVKAGIVLPPK
                     AFETKLSNKLGLQKSLHGKGGVVDSNGNYIELSAQKAVGMRNRVYGPYKINYDNLPIRN
                     EKVIYLNYFIKQWGHFLLDVVGRLWYPLLQDNDTKLVYTCYAGTETKIEGNYLEFLKLL
                     GIDQSRLIMINCPTQFSEVIIPESSILPGGYYTKEYKQLFSSVVENIKLDKYDVNAKMI
                     YCSRSKLGIAKSKEFGEDGIEGIFKQNGYTSVYMETMSLEEQIKTLLSAKTIVLTSGSL
                     AHNLLFVNKDIDVFILNKTYRVNLHQFLINEISDATVRFVDIYRSPLPILYGYGPFLMD
                     LTKPLANFLDDNEFVYEKGTVLSKKDYFKYYLKWLWSYRFFLFRLNGIKEGNSEFEKSF
                     KIIRRYYKTGR"
     gene            11760..13145
                     /gene="wzx"
                     /locus_tag="SPC23F_0012"
     CDS             11760..13145
                     /gene="wzx"
                     /locus_tag="SPC23F_0012"
                     /note="member of homology group 111"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase Wzx"
                     /protein_id="CAI33865.1"
                     /db_xref="GOA:Q9R923"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q9R923"
                     /translation="MSKYKELAKNTGIFALANFSSKILIFLLVPIYTRVLTTTEYGFYD
                     LVYTTIQLFVPILTLNISEAVMRFLMKDGVSKKSVFSIAVLDIFIGSIAFALLLLVNNL
                     FSLSDLISQYSIYIFVIFVFYTLNNFLIQFSKGIDKIGVTAISGVISTAVMLAMNVILL
                     VVFDWGLLGFFIANVCGYVIPCIYIVSRLRLWELFEIKIDKKLQWEMVYYALPLVLNIL
                     SWWVNNTSDRYIVTAIVGIQASAIISVAYKIPQILSTISAIFIQSWQISAIKIQEDKSD
                     TTFVSNMLLYYNALLLIIASGIILFVKPISNILFGISFYSAWELVPFLIISSLFNAISG
                     CIGAIMGAKMDTHNIAKSALVGMIANIILNIVLTFLMGPQGITISTLIASFLIFYMRKD
                     SVKEINSETYRAIYLSWILLVVEACLLIYMDFIIGALIAMVINLFLLKDVIKPLYLKIF
                     KRN"
     misc_feature    11778..12587
                     /gene="wzx"
                     /locus_tag="SPC23F_0012"
                     /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis
                     protein, score 6.3e-67"
     gene            13153..14301
                     /gene="wchX"
                     /locus_tag="SPC23F_0013"
     CDS             13153..14301
                     /gene="wchX"
                     /locus_tag="SPC23F_0013"
                     /note="member of homology group 53"
                     /codon_start=1
                     /transl_table=11
                     /product="putative glycerol phosphotransferase"
                     /protein_id="CAI33866.1"
                     /db_xref="GOA:Q9R922"
                     /db_xref="InterPro:IPR007554"
                     /db_xref="UniProtKB/TrEMBL:Q9R922"
                     /translation="MIVLQYFKILARFVFMFLISAVLLPFKIKPNKIVFINFNGKGYGD
                     NPKSICEYLRTTYPDLDLVWLARDNEGFPDGVRVVKYGTFQAFYEQASSKVWVYNVRAF
                     ARILKKRGQIYIQTWHGASSFKLIEKQADLPINYVLEAKYDARVTDIMISDSRKQTEEF
                     QKYFWYSGEIFEVGMPRNDALFHYKEDYDKLNNIRKELSIHSDDYVILYAPTFRDDGDA
                     SYLDINFERLLQCVEHGIKKKCKFLIRLHPNHSHLCNNISFNKNIINATFYSDMQELTL
                     LADVLVTDYSSSIFDFMLLNKPYVRYVNDLEKYAELRGVSDTYYELPDSIIKTAEELYD
                     LLPKKIENFDYDSIKKYRNEILCPIFNGTASENVGRRIIQEL"
     misc_feature    13741..14292
                     /gene="wchX"
                     /locus_tag="SPC23F_0013"
                     /note="HMMPfam hit to PF04464,
                     CDP-Glycerol:Poly(glycerophosphate) gl, score 4.3e-73"
     gene            14337..15365
                     /gene="gtp1"
                     /locus_tag="SPC23F_0014"
     CDS             14337..15365
                     /gene="gtp1"
                     /locus_tag="SPC23F_0014"
                     /note="member of homology group 40"
                     /codon_start=1
                     /transl_table=11
                     /product="putative glycerol-2-phosphate dehydrogenase"
                     /protein_id="CAI33867.1"
                     /db_xref="GOA:Q9R921"
                     /db_xref="InterPro:IPR002658"
                     /db_xref="InterPro:IPR016205"
                     /db_xref="UniProtKB/TrEMBL:Q9R921"
                     /translation="MKNNDLKIGSGAIHQISATLSQNSISGKILYCADPVVDDLYGSIV
                     RSQIEEIGRVKEESCNYNTIAYAMNIAERAIATDIDCIVGMGGGRVLDVCKYASFISKR
                     PYLSIPTTAANDGIASPVAVLKRQDDRPKSLGAAIPSMTLIDIDVIASGPIQNIKAGIG
                     DTISNYTALKDWELAVERGKDEMHGFAYLMSQNSLDALMKTKYNSITPDFIEVLVNSLV
                     LSGIAMDFAGSSRPVSGSEHLFSHALDYYGSTRNLHGIQVALGTVAVLKLIENSVDTVV
                     DYLQRFEVHINPKLLGIDEELFIYCMQHATKMRSNRYTYLHEVDLSTDRLKQIYKELIS
                     EL"
     misc_feature    14358..15278
                     /gene="gtp1"
                     /locus_tag="SPC23F_0014"
                     /note="HMMPfam hit to PF01761, 3-dehydroquinate synthase,
                     score 2.9e-70"
     gene            15381..16085
                     /gene="gtp2"
                     /locus_tag="SPC23F_0015"
     CDS             15381..16085
                     /gene="gtp2"
                     /locus_tag="SPC23F_0015"
                     /note="member of homology group 41"
                     /codon_start=1
                     /transl_table=11
                     /product="putative nucleotidyl transferase"
                     /protein_id="CAI33868.1"
                     /db_xref="GOA:O85005"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="UniProtKB/TrEMBL:O85005"
                     /translation="MKALILAAGLGTRLAPITNEVPKSLVPVNGKPILMKQIENLYQNN
                     ITDITIIAGYKSSVLTDAVTEKYPEINIIDNVDFKTTNNMYSAYLGKAAMGDSDFLMMN
                     ADVFYDASVIKSLLLHKAPNAIVTDLGIYIEESMKVVEKNGRLVEISKQISPEETLGAS
                     IDVYKFSYEAGARFFEKCKEFIEDKRELQMWSEVALNAILSEVEFVACPLEGRWLEIDN
                     HEDLVAAEKLFA"
     misc_feature    15384..16082
                     /gene="gtp2"
                     /locus_tag="SPC23F_0015"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 1e-07"
     gene            16100..16933
                     /gene="gtp3"
                     /locus_tag="SPC23F_0016"
     CDS             16100..16933
                     /gene="gtp3"
                     /locus_tag="SPC23F_0016"
                     /note="member of homology group 42"
                     /codon_start=1
                     /transl_table=11
                     /product="putative phosphotransferase"
                     /protein_id="CAI33869.1"
                     /db_xref="GOA:Q4K0F2"
                     /db_xref="InterPro:IPR005834"
                     /db_xref="InterPro:IPR006357"
                     /db_xref="UniProtKB/TrEMBL:Q4K0F2"
                     /translation="MKLTNRVDYFGADISELQNKKLFLFDMDGTIYEEDRLFEGTLELL
                     DYIHNIGGEYIFITNNSSKSVVDYVEKVNRLGIKAERDNFFTSAQATIVYIKENYPKSK
                     VYCQGTKSLIKELSDAGIDVTEQVSADIDVVLVGFDTELTSDKIRNTCEILSTKDVPFI
                     ATNPDIRCPVSFGFIPDCGSICDMISKSVDRKPVYIGKPEPTMVDIVRKKLNYSLFETV
                     VIGDRLYTDIMTGINAGVTSVCVLTGEATVNDIQQDSIKPTYTFKNVKEMWKGIV"
     misc_feature    16157..16843
                     /gene="gtp3"
                     /locus_tag="SPC23F_0016"
                     /note="HMMPfam hit to PF00702, haloacid dehalogenase-like
                     hydrolase, score 5.9e-25"
     gene            17093..17962
                     /gene="rmlA"
                     /locus_tag="SPC23F_0017"
     CDS             17093..17962
                     /gene="rmlA"
                     /locus_tag="SPC23F_0017"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI33870.1"
                     /db_xref="GOA:Q4K0F1"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:Q4K0F1"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLAG
                     IRDILIISTPQDLPRFKELLQDGSEFGIKLSYAEQPSPDGLAQAFIIGEEFIGDDSVAL
                     ILGDNIYHGPGLSTMLQKAAKKEKGATVFGYHVKDPERFGVVEFDENMNAISIEEKPEY
                     PRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRGFAWL
                     DTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRRGYISREDVLALAQSLKKNEYGQY
                     LLRLIGEA"
     misc_feature    17096..17812
                     /gene="rmlA"
                     /locus_tag="SPC23F_0017"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 3.7e-121"
     gene            17963..18556
                     /gene="rmlC"
                     /locus_tag="SPC23F_0018"
     CDS             17963..18556
                     /gene="rmlC"
                     /locus_tag="SPC23F_0018"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase RmlC"
                     /protein_id="CAI33871.1"
                     /db_xref="GOA:Q9AHA9"
                     /db_xref="HSSP:1NXM"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q9AHA9"
                     /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEKM
                     LPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREGET
                     FGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYADPS
                     LGIEWENIAEAEVSEADKNHPLLKDVKPLKKEDL"
     misc_feature    17999..18529
                     /gene="rmlC"
                     /locus_tag="SPC23F_0018"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 4.5e-16"
     gene            18569..19618
                     /gene="rmlB"
                     /locus_tag="SPC23F_0019"
     CDS             18569..19618
                     /gene="rmlB"
                     /locus_tag="SPC23F_0019"
                     /EC_number="4.2.1.46"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI33872.1"
                     /db_xref="GOA:Q9AHA8"
                     /db_xref="HSSP:1KEP"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q9AHA8"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNR
                     ANIEEILGNRVELVVGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTNFI
                     GTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSPYSS
                     TKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGK
                     NVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQAVDAYDHV
                     TDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKEAVEANY
                     AKTQEIITV"
     misc_feature    18584..19540
                     /gene="rmlB"
                     /locus_tag="SPC23F_0019"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 9.7e-05"
     misc_feature    18587..19327
                     /gene="rmlB"
                     /locus_tag="SPC23F_0019"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 5.4e-77"
     misc_feature    18590..19402
                     /gene="rmlB"
                     /locus_tag="SPC23F_0019"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 1.6e-05"
     gene            19684..20535
                     /gene="rmlD"
                     /locus_tag="SPC23F_0020"
     CDS             19684..20535
                     /gene="rmlD"
                     /locus_tag="SPC23F_0020"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI33873.1"
                     /db_xref="GOA:Q4K0E8"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K0E8"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDITDAEMVEKV
                     FEEVKPTLVYHCAAYTAVDAAEDEGRELDFAINVTGTKNVAKASEKHGATLVYISTDYV
                     FDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKNFVF
                     TMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDTTWYD
                     FAVEILKGTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQEFYKQE
                     VR"
     misc_feature    19684..20532
                     /gene="rmlD"
                     /locus_tag="SPC23F_0020"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 1.6e-147"
     misc_feature    19687..20328
                     /gene="rmlD"
                     /locus_tag="SPC23F_0020"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 9.3e-05"
     misc_feature    19687..20316
                     /gene="rmlD"
                     /locus_tag="SPC23F_0020"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 1.4e-19"
     misc_feature    19690..20418
                     /gene="rmlD"
                     /locus_tag="SPC23F_0020"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 1.4e-08"
ORIGIN
        1 cgaccgtcgc ttcctagttg tggctaactt gtccaatgaa gagcaagact tgacagtaga
       61 aggaaaagtc aaatctgtct tgattgaaaa caccctagct caagaagtct ttgaaaaaca
      121 aatcttagtt ccatgggatg ctttctgtgt ggaaatgact gactagaatg agcaaacctc
      181 aagtttttga agcttgaggt tttttactat agtggattga aactagaata gtgcacctct
      241 gcttctaaaa cattgttaga aatcgatttg actgtcccga tcgattcgtc ctattcttat
      301 ttcattttgc tatacttgta gttgaggaga attaagctcc tcactagtaa actcttcata
      361 atccttttta tttttatgaa gatattgttt gaaagatgtg agtttccacg gatgggtttg
      421 tggagggata tacttgcgtc tttctttttt tgttctggtt cttgttcaaa gtttttcgaa
      481 tagagttcat gatttagtag ctcctttgtg tgatagattt tgtcagcgat attgaggtag
      541 atgtctccgt caaatgcttt tataactaat gctttcgtct ttctgatgaa atagacttct
      601 tttccttgtt cggtagggat atagtaacga ttttggaatc ggatatggtg tccactatcg
      661 acgactctct ccgccagtct agccagaatg agattccttt cagaggggtt aggaacctcc
      721 tcgaagacag agagttttgt cttgtttcca aactgttcat taaaggtttg aatgtaggaa
      781 agcaggaagg tattggcttc ttccaaggta tgaatattgt tttgttccag ttcgataggc
      841 aggcgagatt gtagtgtctg attgagtctt tcgactctcc ctttagcttg agggatagag
      901 gttgtctcaa ggagaatccc tagttggtga caggcgtatc caaactgtgt atgggtatcg
      961 tcctccattt tcttagagtt ggaggcttga taggtaaaga ccgttctctt atctgtttta
     1021 atttgaaggg gaatgccgtg attggctaag atttgttcga ggacatgata gtaagcattc
     1081 aagttctctt gtttatcaaa ataagcgcct aggatattgc cagaagcatc atcaatggct
     1141 aagtgtaagt tagatgtttg ggctccaaac taggcatgag gactggcatc catttgaatg
     1201 agttcaccag caaatttctt tctgggtcta ctaggatgta cttttttagg gtcttcaagg
     1261 aagttttcag ccgtcggtaa gattggattg tctaggggtt gattcaggtt cagtttagct
     1321 tgttttctta ctctcttctt tgtctttcta tgggacttag gcgacaggat atttttctta
     1381 tagagtattt ttctaacagt agtatcagag agctgaattc cttcttcttc agctagcaat
     1441 tcacagaaat gaaggacatt tggtttatat gtttcatagg agaggtattt ttttaggaga
     1501 cgttctttga tttcatcagg gattgcatgt tttggttttc gatttctgtt tccgtgtctg
     1561 aaggcttctt tgtcctttca gttgataggc tagtagcaga cgattgattt gtctttcaga
     1621 aagattgagc tcgacacagg ctcgtttctt tgttttcttt ccttgggcta tagcttttat
     1681 cacaagatat tttttcgttt cattcatatt cagttggatc cttttcatat gactattcta
     1741 ccaaatggga cattttcacg ttcgatttac taaagacatt atcacattcg aattacacaa
     1801 gatgcagata gtaaaaaaaa tgtagacatt accgtaaaaa agtgatataa tcgtatgatg
     1861 ttcaaggtat aggtgttaat catgagtaga cgttttaaaa aatcacgttc acagaaagtg
     1921 aagcgaagtg ttaatatcgt tttgctgact atttatttat tgttagtttg ttttttattg
     1981 ttcttaatct ttaagtacaa tatccttgct tttagatatc ttaacctagt ggtaactgcg
     2041 ttagtcctac tagttgcctt ggtagggcta ctcttgatta tctataaaaa agctgaaaag
     2101 tttactattt ttctgttggt gttctctatc cttgtcagct ctgtgtcgct ctttgcagta
     2161 cagcagtttg ttggactgac caatcgttta aatgcgactt ctaattactc agaatattca
     2221 atcagtgtcg ctgttttagc agatagtgat atcgaaaatg ttacgcaact gacgagtgtg
     2281 acagcaccga ctgggactga taatgaaaat attcaaaaac tactagctga tattaagtca
     2341 agtcagaata ccgatttgac ggtcgaccag agttcgtctt acttggcagc ttacaagagt
     2401 ttgattgcag gggagactaa ggccattgtc ttaaatagtg tctttgaaaa tatcatcgag
     2461 tcagagtatc cagactacgc atcgaagata aaaaagattt ataccaaggg attcactaaa
     2521 aaagtagaag ctcctaagac gtctaagaat cagtctttta atatctatgt tagtggaatt
     2581 gacacctatg gtcctattag ttcggtgtcg cgatcagatg tcaatatcct gatgactgtc
     2641 aatcgagata ccaagaaaat cctcttgacc acaacgccac gtgatgccta tgtaccaata
     2701 gcagatggtg gaaataatca aaaagataaa ttaacccatg cgggcattta tggagttgat
     2761 tcgtccattc acaccttaga aaatctctat ggagtggata tcaattacta tgtgcgattg
     2821 aacttcactt ctttcttgaa aatgattgac ttattgggag gggtagatgt tcataatgat
     2881 caagagtttt cagctctaca tgggaagttc catttcccag tagggaatgt ccatctagac
     2941 tctgagcagg ctctaggttt tgtacgtgaa cgctactcac tagccgatgg agaccgtgac
     3001 cgtggtcgca accaacaaaa ggttattgta gctatccttc aaaaattaac gtcaaccgaa
     3061 gcactgaaaa attatagtac gatcattgat agcttgcaag attctatcca aacaaatatg
     3121 ccacttgaga ctatgataaa tttggtcaat gctcagttag aaagtggagg gaattataaa
     3181 gtaaattctc aagatttaaa aggtacaggt cggacggatc ttccttctta tgcaatgcca
     3241 gacagtaacc tctatgtgat ggaaatagat gatagtagtt tagctgtagt taaagcagct
     3301 atacaggatg tgatggaggg tagatgaaat gatagacatc cattcgcata tcgtttttga
     3361 tgtagatgac ggtcccaagt caagagagga aagcaaggct ctcttgacag aatcctacag
     3421 gcagggggtg cgaaccattg tctctacctc tcaccgtcgc aagggcatgt ttgaaactcc
     3481 ggaagagaag atagcagaaa actttcttca ggttcgggaa attgcaaaag aagtagcaga
     3541 tgatttagtc attgcttatg gcgcagagat atactatact ctggatgctc tagaaaagct
     3601 agaaaaaaaa gaaattccta ccctcaatga tagtcgttat gccttgatag agtttagtat
     3661 gaacactcct tatcgcgata ttcatagcgc cttgagcaag atcttgatgt tgggaattac
     3721 tccagtcatt gcccacattg agcgctatga tgctcttgaa aataacgaaa aacgtgttcg
     3781 tgaactgatt gatatgggct gttacacgca agtaaatagt tcacatgtcc tcaaacccaa
     3841 actttttggc gaacgttata aattcatgaa aaaaagagct cagtattttt tagagcagga
     3901 tttggtccat gtcattgcaa gtgatatgca caatctagac ggtagacctc ctcatatggc
     3961 agaagcatat gaccttgtta cccaaaaata cggagaagcg aaggctcagg aactttttat
     4021 agacaatcct cgaaaaattg taatggatca actaatttag gagaaatgat gaaagaacaa
     4081 aacacgatag aaatcgatgt atttcaatta tttaaaacct tgtggaaacg caagctaatg
     4141 attttaatag tggcacttgt gacaggtacg ggggcttttg catatagcac ttttattgtt
     4201 aagccagaat atacgagtac cacgcgaatt tatgtagtga atcgcaatca aggagacaag
     4261 ccggggttga caaatcagga tttgcaggca ggaacttatc tggtaaaaga ctaccgtgag
     4321 attatccttt cgcaggatgc attggaaaaa gtagcgacaa atttgaagtt ggatatgcca
     4381 gcaaaaacgt tagccagcaa agttcaagtg gctgtgccag ctgacactcg tatcgtctca
     4441 atctctgtca aggataaaca gccagaggaa gccagtcgta tcgctaattc tctacgagaa
     4501 gttgctgcag aaaagatcgt cgctgtaacg cgagtatctg atgtaacgac acttgaagaa
     4561 gcgcgaccag ctacgactcc ctcttctcca aatgttcgac gcaattcctt gtttggtttt
     4621 cttggaggag cagtcgtaac agtaattgct gttcttttga ttgagttgct cgacacccgt
     4681 gtgaaacgtc ctgaagatgt tgaagatgta ctgaaaattc cacttttagg gctcgttcca
     4741 gattttgaca aaataaaata ggaggaagtt atgccaacat tagaaatctc acaggcaaaa
     4801 ttggattctg taaaaaaggc agaggaatat tataacgctt tgtgcacgaa cctacagtta
     4861 agtggagatg gtttgaaagt attttctatc acttctgtga aaataggaga aggaaaatca
     4921 acgacttccg ccaatatcgc ttgggctttt gcgcgtgcag gttacaaaac gctgctgatt
     4981 gatggagata ttcgcaattc tgttatgtta ggtgtcttta aagcaaggaa taagattaca
     5041 ggcctgacag aatttttatc aggaactaca gacctatcac aagggctttg tgataccaat
     5101 atcgaaaatc tctttgtaat tcaggctggc tctgtgtcac cgaatccgac agctcttctt
     5161 caaagtaaga atttcactac aatgcttgaa accttgcgta aatattttga ctacatcatt
     5221 gtagatactg ctcctgttgg tgtcgtgatt gatgcggcta ttattacgcg aaactgcgat
     5281 gcttctattt tagtgacgga ggcaggtgaa ataaatcgac gggatattca aaaagcaaaa
     5341 gaacagttgg aacacacagg aaagccgttt ttgggaattg tgttgaataa attcgatact
     5401 tcagtagaca aatacggttc ttatggaaat tatggaaatt acgggaaaaa taaaaaatag
     5461 gtcaggggat agagatgaat gaaaaaatat taagatcttc attggccata attcagagtt
     5521 ttcttgttat tttattgact tatctactta gtgctgtgag agaaacggag attgtttcaa
     5581 caacagctat tgcactttgt atcctccatt attttgtctt ttatatcagt gattatggac
     5641 aggatttctt taaaaggaga tatttgattg aacttgtcca gacattgaaa tatatcctat
     5701 tctttgcact agcgattggt atttctaatt ttttcttaga ggatcgattt agtatttcca
     5761 gacgaggcat gatttacttc ctcacattac atgctctctt agtctatgtg ctaaacctat
     5821 ttatcaagtg gtattggaag cgggcttatc ccaactttaa aggaagtaag aagattctct
     5881 tacttacagc aacttctcgt gtcgaaaagg tactggatag attaatagaa tcaaatgagg
     5941 ttgttgggaa gttggtagcc gtcagtgtct tagataaacc agattttcag catgattgtt
     6001 taaaggtagt agcagagggg gggatagtaa actttgcgac tcacgaggtg gtcgatgaag
     6061 tctttatcaa tcttccaagt gaaaaataca atattggaga gcttgtctct cagtttgaaa
     6121 cgatgggaat tgatgtaata gtcaatctaa atgcttttga tcgtagtttg gcacgtaaca
     6181 agcaaattcg tgagatggca gggttaaacg ttgtgacttt ttctacaaca ttttataaga
     6241 ctagtcatgt aattgctaag cggattattg atatcgtggg tgcattggta gggctgatac
     6301 tatgtggttt agtcagtatt gtactggttc ctttgattcg aaaggatggg ggatctgcta
     6361 tttttgctca gacgcgtata ggaaaaaatg gtcgtcagtt cactttttat aagtttcgct
     6421 ctatgtgtgt agatgccgag gcgaaaaaaa gagaactcat ggaacaaaat accatgcaag
     6481 gtggaatgtt taaggtggac gatgatcctc gtatcacgaa aattggttgt tttatacgga
     6541 agactagctt ggacgagcta ccacagtttt ataatgttct aaagggagat atgagtttgg
     6601 ttggcacacg gccaccaaca gtggacgagt atgagcacta taccccagaa caaaaacgcc
     6661 gactaagttt taaacctggc ataacaggtt tatggcaggt cagcggacga agtgagatca
     6721 agaatttcga tgaagttgtc aaattagatg tggcctatat tgatggttgg acaatctgga
     6781 aagatattga aattttattg aagacagtta aagtagtatt tatgagagat ggagcgaagt
     6841 aatttctgta tatccatcat attaggagag aaatgaaaaa gtcagtttat atcattggtt
     6901 caaaaggaat tcctgctaag tatggaggat ttgaaacttt tgttgagaaa ttaacagcct
     6961 tccaacaaga taaggctatc caatattatg tggcttgtat gcgtgaaaac tctgcaaaat
     7021 cagggactac tgaggatgtt tttgaacata atggtgctat ctgttataac gtcgatgttc
     7081 ctaattttgg tccagcgcga gctatagcgt atgatatcgc tgcaattaac agagctattg
     7141 agattgccaa agaaaataag gatgaagatc caatcttcta tattttagct tgtcgaattg
     7201 gtccgttcat ccatggaatt aagaaaaaaa tccaggagat aggtgggact cttctagtta
     7261 atccagatgg ccacgagtgg ttgcgagcta agtggagtgc tcctgttcgt cgctactgga
     7321 aaatttctga aggtcttatg gtcaaacatg cagatctttt agtgtgtgat agtaaaaata
     7381 ttgaaaaata tatccaagaa gattataaac agtatcaacc taagacaacc tatatcgctt
     7441 atgggactga tacaacacgc tccgtattaa agagtagtga tgaaaaagta cgttcttggt
     7501 tcaaagagaa gaatgtttct gagaacgagt attatctagt tgtaggacgt tttgtaccag
     7561 aaaacaacta tgaatctatg attcgtggct ttttggcgtc taactctaag aaggactttg
     7621 tcttaatcac aaatgtagaa cagaataaat tttataatca gttgttggca aaaactggtt
     7681 ttgataagga cccacgagta aaatttgtag gtacagtcta tgagcaagag cttcttaaat
     7741 atattcgtga aaacgccttt gcttacttcc acgggcatga agttggtgga accaatcctt
     7801 cgcttttaga agctctggca tcaactaaac tgaatttatt gctagatgtt ggctttaacc
     7861 gagaagttgc tgaagatggt gccatttact ggaagaaaga taatcttcat gagattattg
     7921 aaacgagtga acaaaaaaca caaaaagaga ttgatgagaa agatatactt tcaataaaac
     7981 aagtgacgga gcggttctct tgggaattga tagttaatga gtatgagaaa ctttttttat
     8041 gtgagaaata atttacagtt tcatagaaat gttataaaaa attaactctg aagaataatt
     8101 acatattgga tttagaatgt tttttgctga ttcttgttgt ttatggattt gaaaaaataa
     8161 gagaagatgc ctcctttttg tcaggatatc tatgcaatgt atacagaaat aatgactatt
     8221 agctgattgt attattctcg aaattgtaat taaatataat tgtattttgt ttttactata
     8281 ttcgaaaata caagtgactt tatacaatca aatcaaaatc tttcttgtta tttaataaaa
     8341 ggaatcaagt gtgactataa aaattaataa tttgtttttt gtttgtctat ccttttttgg
     8401 gatagtttta agtagttcac aagtgatagt gaacttggga ttgtctagta ttattcagta
     8461 catttcttat tttatgttga tgttgtgtgt atttttaaca ttaattaaga atactctcaa
     8521 cgtgtttgca aatagaatca tatatttttt gattatttca tttttgttta ttattgggat
     8581 taatttacaa aatcttccat tatcaagaaa gatttattta tcattctcta tgttaattat
     8641 ttctagctta tccaccttac cgataaagct aataaataat ctcagtgatt taagaaggat
     8701 atcatattac ttattgcaca gcatattttt atctgtattt ttaggtttgg tttttaaaat
     8761 atctttagta acagttgctg tagagggaat tggcttttca tatggtttta atggaggttt
     8821 gactcataaa aatttttatg caattacaat tttagtttcc tatattctac tatatgtcag
     8881 cagaaaatat gacgctaaac atcagattga tagttttgta ttatggttag atcttttttt
     8941 acttttaata tctaatacgc gaacagttta tataatacta gttgtttttt ggattattat
     9001 taatagaaat tttataaata atattaaaaa agagcataga ctggtagtga cagcaacgac
     9061 aatagtcatc tctttactgg cgttaacatt ttttttcaaa catataatta ataatagtga
     9121 atcatatagc catcgagtgt taggtgttgt gaattttttt aaatattatg aatcagatag
     9181 gtttcatttg ttttttgggg atgctgaatt agcctttgga aatacgacga agggttatgg
     9241 acacaatatt agaagtgtgt taggttggga tggaacggta gagatgcctt tactcagtgt
     9301 aatgattaaa aatggttatg ttgggttagt tggttacatt atagtgctgt ttaagtttat
     9361 atcttcaata atctcagtta aaaatagcac aaaaaaaaat attggattat caatctttat
     9421 tccgttactt ctatctgcaa cagttgaaaa ttatatcgtc aacattagct ttgtattcat
     9481 gcctgtctgc ttttgtattt tatgttcaat taaaaatata aaattagtaa ataacagaaa
     9541 gtaatatatg gaaaaattag ttagtattat tctgcccgtc tacaatgtcg aacagtatat
     9601 aaaaaattgt ttagaatcaa ttcaacaaca aacttattca aatttggaag taatcattgt
     9661 taatgacggt tcaaccgata aaagcgttga atattgtgag caaatttgca agatagattc
     9721 taggttttct atcactcaca aagaaaatgg tggactttcc gatgcaagaa atgtcggtat
     9781 agataaatcc aagggagatt acctcatttt tgttgacagt gatgattttg tctctcaaga
     9841 tatggtatct tatttagtat cttgtatgga gaacaatgag gcagacattg ctatttgcga
     9901 tcctgttcat tattacagtg atcgtcaaaa caatgatctt aatatttttt ctccggcatc
     9961 aaacgttaag gtttacgaaa caacggaggc tctatgtgag atgttttatc aaaaatcttt
    10021 tttggtgtct gcctgggcca agatatttaa aagagagttg tttgatgata taagatttcc
    10081 tgtaggtaag ctatttgaag atagtgcgat tatgtatttg ctcttcgaaa aatgtgaaac
    10141 aattgcatac tctgatgcgg aattatatgc ttatgtacac agggataata gcatcacaac
    10201 aaagaaattt tcggatagag acttagatat tttggagatt acgaacacaa ttattaatca
    10261 ctatggtgat aatttacgcg tgtatactgc agcggtgtct tataaggtat ctgcatgttt
    10321 cagaattcta ttaaactcac cttctggaga aaagtataaa aaagtacaaa aagaatgtct
    10381 gagttatatt ttacaaaatt ggagaaacat attatttaat aataatgttc gattgaagaa
    10441 caagcttgcc ttaatttcta taactatttt caatcctttt gttaaattta tctatagtaa
    10501 agtaaacaga tgggaatgat agcaaatgaa caaatatgaa gaaagatatc aagaaaattt
    10561 atctaagaat gatttttata aattaattaa taagagttac ttatcagata aagaacttca
    10621 agtacaacaa gtaaaagctg ggatagtctt accaccaaag gcatttgaaa caaaattatc
    10681 aaataaactt ggcctacaaa aatctttgca tggaaagggt ggagttgtag actcaaatgg
    10741 aaattacatt gaactatctg cacaaaaagc agtcgggatg agaaatagag tctatggtcc
    10801 gtataaaatt aattacgata atctgccaat tagaaatgaa aaagtaatct atttgaacta
    10861 tttcatcaaa caatggggac attttttact ggatgttgtt ggaaggttat ggtatccatt
    10921 gctgcaggat aatgatacta agttagtcta tacctgctat gctggaacag aaacaaagat
    10981 tgagggaaac tatttagagt ttttgaagct tctcggcata gatcaatcac gtttaatcat
    11041 gataaactgt cccactcagt tctcagaagt cattattcct gaaagctcca ttttaccggg
    11101 gggatattat acaaaagagt ataaacaact attcagttcg gtagtagaaa atattaaatt
    11161 ggacaagtat gatgtgaatg ctaaaatgat ttattgttcg aggtctaaat tagggattgc
    11221 taaaagtaaa gaatttggcg aagacggtat tgaggggatt tttaaacaaa atggctacac
    11281 atctgtttac atggaaacaa tgtctttgga agagcaaata aaaaccttat tatcggctaa
    11341 gacaatagta ttaacgagtg gttcgttagc acataatctt ttatttgtaa ataaagatat
    11401 tgatgttttt attttgaata aaacctatag agtaaatctc catcaatttt taataaacga
    11461 gatctcagat gctacagtaa gatttgtaga tatctatcga tcacctttac cgattttata
    11521 cggatatgga ccatttttaa tggatcttac aaaacctttg gctaatttct tggacgataa
    11581 tgaatttgta tatgaaaaag gtactgtttt aagtaaaaaa gattatttta aatactattt
    11641 gaaatggttg tggagttata gattcttttt atttaggtta aatggtatta aagaaggaaa
    11701 tagtgaattc gagaagagtt ttaagataat taggagatac tataaaacag gacgatagaa
    11761 tgagtaaata taaggaatta gcaaaaaata caggtatttt tgctttggct aacttttcat
    11821 caaagatttt aatttttttg ttagtaccta tatatacacg ggtacttacc actacggaat
    11881 atggttttta tgacttagtc tatacaacta ttcagctttt tgtaccaatc ttgacattaa
    11941 atatatctga agccgttatg aggttcctaa tgaaagatgg tgtttctaaa aaatcagtct
    12001 tttcaattgc tgttttagat atatttattg gatcaattgc ttttgcttta ttgttgttag
    12061 taaataacct gttttcttta tcagatttaa tttctcaata cagtatttac atatttgtaa
    12121 tctttgtttt ctatacccta aataattttt tgatacaatt ttctaaggga attgataaaa
    12181 ttggtgttac agctatctct ggggtcataa gtacagcagt tatgcttgcc atgaatgtca
    12241 ttcttctagt agtatttgat tggggattgt taggtttctt tattgctaat gtttgtggat
    12301 atgttatacc ttgtatttat atagtttcta gattaagatt gtgggaatta tttgaaatta
    12361 agattgataa aaaattacaa tgggaaatgg tttactatgc tttgccatta gttttaaata
    12421 tattaagctg gtgggtaaat aatacttcag atagatatat tgtgactgca atagtaggta
    12481 tacaagctag tgcaattatt tcagtcgctt ataaaattcc acagattttg tctacgatta
    12541 gtgcaatttt tattcaatca tggcaaatct ctgcaattaa aatacaagaa gataagagcg
    12601 atactacatt tgtatcaaac atgctcctat actataatgc acttctattg attatagcga
    12661 gtggtatcat attatttgtc aaacctattt ctaatatatt gtttggtatt tccttctatt
    12721 ctgcgtggga gctggtacca tttttaataa ttagcagtct attcaatgca atttcaggtt
    12781 gtataggagc aattatggga gctaaaatgg atactcataa cattgcaaag tcggctttag
    12841 ttgggatgat tgcaaatatt attttaaata tagtgttaac attcttaatg ggtccacagg
    12901 gaattacaat ttctaccctg atagctagtt ttcttatttt ttatatgcga aaagatagtg
    12961 taaaagaaat taattcagaa acatatagag caatttattt atcgtggata ctattagttg
    13021 tagaggcctg tctgctaatt tatatggatt ttattattgg tgctttaata gcaatggtaa
    13081 taaacttatt tttactaaaa gatgttatca aacctttata tttaaaaatt ttcaaaagaa
    13141 attaggtaca aaatgattgt tttacaatac tttaagattt tagctagatt cgtttttatg
    13201 tttttgataa gtgcggtgtt actgcctttc aaaataaaac ctaataagat tgtttttatt
    13261 aatttcaatg ggaaaggata tggtgataat ccgaaaagta tttgtgagta tcttagaact
    13321 acttacccag atttagattt ggtttggctt gcaagagata acgaaggttt tccagatggg
    13381 gttagggttg ttaaatatgg gactttccaa gctttttatg agcaagcgag ttcgaaggtt
    13441 tgggtatata atgtaagagc ttttgcaaga atactaaaaa aacgaggaca gatttatatt
    13501 caaacttggc atggtgcttc tagttttaag ttgatagaaa aacaagctga tttaccaata
    13561 aattatgttt tagaagctaa gtatgatgca agagtcacag atataatgat ttcagatagc
    13621 agaaaacaaa ctgaagaatt tcaaaagtat ttttggtatt caggagaaat ttttgaggtg
    13681 gggatgccga gaaatgatgc cttgtttcac tataaggaag actacgacaa gttaaataat
    13741 atcagaaaag aactaagcat tcattcagat gattatgtta ttttatatgc ccctactttc
    13801 agagatgatg gggatgcatc ttatttagat ataaattttg aacggctttt gcaatgtgtt
    13861 gaacacggaa ttaaaaagaa atgtaaattc ttaattaggt tacaccctaa tcactcccat
    13921 ttgtgtaata atatttcatt taataagaat ataatcaatg ctacgtttta ttcagatatg
    13981 caagagctta ctttgttggc agatgtttta gtcacagatt attcttcctc gatatttgat
    14041 tttatgcttt taaacaagcc ttatgtcaga tatgtgaatg atttagaaaa atatgctgag
    14101 cttagggggg tatcagatac atattacgaa ttgccggatt cgattattaa aactgctgaa
    14161 gaattgtatg acttactgcc taaaaaaata gaaaattttg attatgattc tataaaaaaa
    14221 tatagaaatg aaatactgtg tccaatcttt aatggaaccg ctagtgaaaa tgtaggaagg
    14281 agaataattc aagagttgtg aagtaaaaca ttgggttatt tttaaggtaa cgagatttga
    14341 aaaataatga tttaaagata ggaagtggag ctattcatca aatttccgct acactttctc
    14401 aaaatagtat ttcgggaaag attttatatt gtgctgatcc agttgtcgat gacttgtacg
    14461 gttcgatagt acgttcacaa atagaggaaa ttggtcgggt aaaggaagaa agttgcaatt
    14521 ataatactat tgcttatgcg atgaatatag cagaacgggc tattgccaca gatattgact
    14581 gtattgtggg aatgggagga ggtcgtgttt tagatgtctg caagtatgca tcttttattt
    14641 cgaaacgtcc ttacctatcg attccgacaa cagcagcaaa tgatggcatt gcttccccag
    14701 ttgctgtttt gaaaaggcag gatgatagac caaaaagctt aggggcggct atcccctcaa
    14761 tgacactaat tgatattgat gttattgcat caggacctat acaaaatata aaagctggta
    14821 tcggtgatac aatatccaat tacactgcat tgaaagattg ggagttggca gttgagcgag
    14881 ggaaagatga gatgcatggt tttgcatatc taatgtcgca aaattcttta gatgctttaa
    14941 tgaaaacgaa gtataattct attacccctg attttattga agttttggta aactctttag
    15001 ttttatcagg cattgcaatg gattttgcgg gaagtagtag acctgtcagt gggtcagagc
    15061 acttatttag tcatgcatta gattactatg gttctacaag gaatcttcat ggaattcagg
    15121 ttgcattagg tacagtcgca gttttgaaat taattgaaaa ttctgttgat actgtagtgg
    15181 attacttgca aagatttgag gttcatatta acccgaaact tttggggata gatgaagagt
    15241 tgtttattta ttgtatgcaa catgctacaa aaatgagaag taatcgctat acctatctgc
    15301 atgaagttga tcttagcaca gatagattga aacaaatata taaggaactc ataagcgagt
    15361 tgtagagaag agaggaaaaa atgaaagcac ttattttagc agcagggtta ggaacacgtc
    15421 tagctccaat taccaatgag gtaccaaaat ctttggtacc agtcaatggt aagccaattt
    15481 tgatgaaaca aattgaaaat ttatatcaaa ataatattac agatattacg attattgctg
    15541 gatataagtc atctgtatta acagatgcag ttactgaaaa gtatccagaa attaatatta
    15601 ttgataatgt tgattttaaa acgactaata atatgtattc agcctatcta ggaaaagctg
    15661 caatgggtga tagtgacttc ttaatgatga atgcagatgt attttatgat gcttctgtta
    15721 ttaaaagtct gttgcttcat aaagctccaa atgcaattgt aactgattta ggtatttata
    15781 ttgaagagtc tatgaaagtc gtagaaaaaa atggtcgttt agtagaaatt tctaaacaga
    15841 tttcacctga ggaaacttta ggagcttcta ttgatgttta taaattctct tatgaagcag
    15901 gtgctcgatt ctttgaaaag tgtaaggaat ttattgaaga taaacgagaa cttcaaatgt
    15961 ggagtgaggt tgctcttaat gcaattcttt ctgaagttga atttgtagca tgtccattag
    16021 agggtcgttg gttagaaatt gataatcatg aagacttagt tgctgcagaa aaactatttg
    16081 cttgaaccga atacggagaa tgaaattgac aaatagagtt gattattttg gtgctgatat
    16141 tagtgaactt cagaataaaa aattattctt atttgatatg gatggtacca tttatgaaga
    16201 agataggttg tttgagggta ctctcgaatt attagactat attcataata ttggcggtga
    16261 gtatattttt attacaaaca attcatctaa gtctgttgtt gactatgttg aaaaagttaa
    16321 cagattaggt attaaagctg aacgagataa tttttttacc tctgctcaag ccacaattgt
    16381 ttatattaaa gaaaattatc ctaaatctaa agtttattgc caaggaacaa aatctttgat
    16441 aaaagaacta tctgacgcag gaattgatgt aactgagcaa gttagtgctg atatagatgt
    16501 tgttcttgtt ggttttgata cagaattaac cagtgataaa attcgcaata cctgcgagat
    16561 tctatcaaca aaggacgtac ctttcatagc tactaaccct gatattcgct gcccagtatc
    16621 gtttggattc atcccggatt gtggttctat ttgtgatatg attagtaaat cagtcgatag
    16681 gaaacctgtt tacataggta aacctgaacc tacgatggtt gatattgttc gaaaaaaatt
    16741 aaattattct ctatttgaaa cagttgtgat tggagatcgc ttgtatacgg atatcatgac
    16801 tggtataaat gcaggagtaa cttcagtttg tgtgctgaca ggagaagcaa cggtgaatga
    16861 tattcaacaa gatagtataa aaccgactta tacatttaaa aacgtgaaag aaatgtggaa
    16921 aggaattgtc tgattttttc attctgaata gtgaattcat gaatactgtc aaaatactcg
    16981 tatgtattta aattgatttt attattttaa taatggacaa attaaaatta tttttctccc
    17041 caaatcgttc gtgaacgtaa agtactcatc aacaaagaaa ggtacccctt ttatgaaagg
    17101 tattattcta gcaggtggtt cgggaactcg cttgtatcct ttgactcgcg ctgcatcaaa
    17161 acaacttatg ccggtttatg ataaaccgat gatttactac ccactttcaa cattaatgtt
    17221 ggctgggatt agggatattt tgattatctc aactcctcaa gatttgcctc gttttaaaga
    17281 gcttcttcaa gatggttctg agtttggtat taaactttct tatgctgagc aaccaagtcc
    17341 agatggtttg gcacaagcct ttatcattgg ggaagagttt atcggtgacg atagcgttgc
    17401 cttgatttta ggtgacaata tctaccatgg tcctggtctg agcacaatgc ttcaaaaagc
    17461 agccaagaaa gagaaaggtg cgactgtttt tggctaccat gtcaaggatc cagaacgctt
    17521 tggtgttgta gaatttgatg aaaatatgaa tgctatctcc atcgaagaaa agccagaata
    17581 ccctcgttca aactatgcag tgacaggact ctatttctat gataatgatg tagtagagat
    17641 tgccaaaagt attaaaccaa gtcctcgtgg tgaattggaa attacagatg tcaacaaggc
    17701 ttacttggat cgtggtgatt tgtctgttga gctcatggga cgtggttttg cttggttgga
    17761 tactggcact catgaaagtt tactagaggc ttcgcagtac atcgaaacag tccaacggat
    17821 gcaaaatgtt caggtagcaa acttagaaga aattgcttac cgtaggggct atatcagtcg
    17881 agaagatgta ttggccttag cccaatcact taagaaaaat gaatacggac agtatctgct
    17941 ccgtttgatt ggagaagcat agatgacaga taattttttc ggtaagacgc ttgcggcacg
    18001 caaggttgaa gctattccag gcatgttgga gtttgatatc cccgttcatg gagataatcg
    18061 tggctggttt aaagaaaatt tccaaaagga aaaaatgctt ccacttggat ttccagagtc
    18121 tttctttgca gaaggaaaat tgcaaaacaa tgtatccttc tcacgtaaaa atgtccttcg
    18181 aggcctccac gcagagcctt gggataagta catctctgta gcagatggag ggaaagttct
    18241 gggttcttgg gttgatctac gcgagggtga aacctttggg aatacctatc agacagtgat
    18301 tgatgcgagt aagggaatct ttgttcctcg aggcgtagct aatggcttcc aagttttatc
    18361 agatacagtg tcatatagct atctggtcaa tgattactgg gctcttgaac tcaaacccaa
    18421 gtatgccttt gtgaactacg ctgatccaag ccttggtatt gaatgggaaa atattgcaga
    18481 agcagaggtt tcagaagcag ataaaaatca tccactactt aaggatgtaa aacctttgaa
    18541 aaaagaagat ttgtaaaaag gaaagaatat gactgaatac aaaaatatta tcgtgacagg
    18601 tggagctggc tttatcggtt ctaactttgt ccattatgtt tacgagaact ttccagatgt
    18661 tcatgtgaca gtcctagata agttgactta tgctggaaac cgcgcgaata ttgaggaaat
    18721 tttaggtaat cgtgttgagt tagttgttgg tgacattgct gatgcggagt tggtagacaa
    18781 gttggctgct caagcagatg ctatcgttca ttatgcagcg gaaagccaca atgataattc
    18841 gctcaatgat ccatcgccat ttattcatac taacttcatc ggaacctata ctcttttaga
    18901 agctgctcgt aagtatgata ttcgcttcca ccatgtatcg acagatgaag tttatgggga
    18961 tctcccttta cgcgaagatt tgccaggtca tggtgaagga ccaggtgaga aatttactgc
    19021 tgaaacaaaa tacaacccaa gctctccgta ctcatcaacc aaggcagcct cagatttgat
    19081 tgtcaaagcc tgggtgcgtt cttttggagt caaggcaacg atttccaact gttcaaataa
    19141 ctacggtcct tatcaacata tcgaaaaatt catcccacgt cagattacta acatcctaag
    19201 tggaattaag ccaaaacttt acggtgaagg taagaatgtt cgtgactgga ttcataccaa
    19261 tgaccattct tcaggagttt ggacaatctt gacaaaaggg caaatcggtg aaacctactt
    19321 gattggggct gatggtgaga agaacaataa ggaagttttg gaacttatcc ttaaggaaat
    19381 gggacaagct gtggatgcct atgatcatgt gactgaccgt gcaggacatg accttcgcta
    19441 tgcgattgat gctagcaagc tccgtgatga gttggggtgg aaacctgaat ttaccaactt
    19501 tgaagctggg ctcaaggcaa caatcaagtg gtatacagat aaccaagaat ggtggaaagc
    19561 agaaaaagaa gctgttgaag ccaattatgc taagactcag gagattatta cagtataaaa
    19621 agcaggaaat agctgctttt tattgctata ttgggaagag ttacatatta gaaaggtcta
    19681 gagatgattt taattacagg ggcaaatggc caattaggaa cggaacttcg ctatttattg
    19741 gatgaacgta atgaagaata cgtggcagta gatgtggctg agatggacat taccgatgca
    19801 gaaatggttg agaaagtttt tgaagaggtg aaaccgactt tagtctacca ctgtgcagcc
    19861 tacaccgctg ttgatgcagc agaggatgaa ggaagagagt tggacttcgc catcaatgtg
    19921 acggggacaa aaaatgtcgc aaaagcatct gaaaagcatg gtgcaactct agtttatatt
    19981 tctacagact atgtctttga tggtaagaaa ccagttggac aagagtggga agttgatgac
    20041 cgaccagatc cacagacaga atatggccgt actaagcgta tgggggaaga gttagttgag
    20101 aagcatgtgt ctaatttcta tattatccgt actgcctggg tatttggaaa ttatggcaaa
    20161 aacttcgttt ttaccatgca aaatcttgcg aaaactcata agactttaac agttgtaaat
    20221 gaccagtacg gtcgtccgac ttggactcgt accttggctg agttcatgac ctacctagct
    20281 gaaaatcgta aggaatttgg ttattatcat ttgtcaaatg atgcgacaga agacacaaca
    20341 tggtatgatt ttgcagttga aattttgaaa ggtacagatg tcgaagtcaa gccagtagat
    20401 tccagtcaat ttccagccaa agctaaacgt ccgctaaact caacgatgag cctggccaaa
    20461 gccaaagcta ctggatttgt tattccaact tggcaagatg cattgcaaga attttacaaa
    20521 caagaagtga gataagtagt agaatgattt tctagtctaa taaaagaggc agataatgaa
    20581 ctccaaagga gcttaagatg tacgattatc ttgttgttgg tgctgatctc tttggcgcat
    20641 agctttggct cagtttctat tatcgctcac accatccatc agaagtttaa tctgaaggta
    20701 cccaattatc gccaagaaga agattgggct aggatgggtt taccaatcac acgtaaggaa
    20761 atctctaatt ggcatatcaa ggcaagtcaa tactatttag agtcccttta taacctttta
    20821 cgagaaaagt tgttagaaca acctcttctt catgcggatg aaacctctta tcgggtgcta
    20881 gagagtgata gccatctgac ctactattgg acctttttgt ctgggaaagc tgagaatcaa
    20941 gcaatcacgc tgtaccatca tgatcagcgt cggagtggtt tagtagtaca agaattccta
    21001 ggagattatt ctggctatgt gcattgtgat atgttgcggc agtaacttag gactttagtc
    21061 ctctagttct gcctatgcga tagcagtcca aggtttagga gcaaggcgac gctaagcttg
    21121 gtaaactaag cttatcgtca actggaagaa gctgaacttg ttggatgttg ggcacatgtg
    21181 agaaggaagt tttttgaagc gacccccaag caagcagata aatcatcctt aggagctaaa
    21241 ggtttagctt attgtgatca gttattttcc ctggaaagag actgggaggc tttgccagct
    21301 gatgaacgac tacagaaacg tcaagaacat ctccagccct taatggaaga cttctttgct
    21361 tagtgccggc gtcagtcagt tttagcaggt tcaaaactag gaagggcaat tgaatacagc
    21421 ctcaagtatg aagaaacctt taagactatt ttgaaagacg gacatctggt cctttccaat
    21481 aatctagctg aacgcgccat taaatcattg gttatgggac ggagtaaaag aattcagtgg
    21541 actcttttag cctaagctaa attttaaaaa gcgagggtgg ttattttctc aaagttttga
    21601 aggagctaaa gcaacagcta ttattatgag tttgttggaa acagctaaac gtcatcaatt
    21661 aaatagcgag aaatatctat tctatcttct agaatgtctt ccaaacgagg aaactctcgt
    21721 aaacaaagag gttttagagg cttatttacc atggactaaa gttgtacaag aaaagtgcaa
    21781 ataagaaatc tccagattag gaactatccg tgagttctct agtctggaga tttttcaata
    21841 tacttcgtta ttggacggtt acgatattca tattttttgc aaagatgttg tttgaaaaat
    21901 aattttcaaa aattctgaaa attctgttga caactttctg aaaagagtct ataatggaga
    21961 gaaagtttta aaggagaaaa tgatgaaaag ttcaaaacta tttgcccttg cgggcgtgac
    22021 attattggcg gcgactactt tagctgcatg ctctggatca ggttcaagca ctaaaggtga
    22081 gaagacattc tcatacattt atgagacaga ccctgataac ctcaactatt tgacaactgc
    22141 taaggctgcg acagcaaata ttaccagtaa cgtggttgat ggtttgctag aaaatgatcg
    22201 ctacgggaac tttgtgccgt ctatggctga ggattggtct gtatccaagg atggattgac
    22261 ttacacttat actatccgta aggatgcaaa atggtatact tctgaaggtg aagaatacgc
    22321 ggcagtcaaa
//
