LOCUS       NC_006347              13875 bp    DNA     linear   CON 04-APR-2020
DEFINITION  Bacteroides fragilis YCH46, complete genome.
ACCESSION   NC_006347
VERSION     NC_006347.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMD00061068
            Assembly: GCF_000009925.1
KEYWORDS    RefSeq.
SOURCE      Bacteroides fragilis YCH46
  ORGANISM  Bacteroides fragilis YCH46
            Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
            Bacteroides.
REFERENCE   1
  AUTHORS   Kuwahara,T., Yamashita,A., Hirakawa,H., Nakayama,H., Toh,H.,
            Okada,N., Kuhara,S., Hattori,M., Hayashi,T. and Ohnishi,Y.
  TITLE     Genomic analysis of Bacteroides fragilis reveals extensive DNA
            inversions regulating cell surface adaptation
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (41), 14919-14924 (2004)
   PUBMED   15466707
REFERENCE   2  (bases 1 to 13875)
  AUTHORS   Hattori,M., Yamashita,A., Toh,H., Oshima,K. and Shiba,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2004) Contact:Masahira Hattori Graduate School of
            Frontier Sciences, University of Tokyo; 5-1-5 Kashiwanoha, Kashiwa,
            Chiba 277-8561, Japan
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 04/04/2020 09:42:13
            Annotation Pipeline               :: NCBI Prokaryotic Genome
            Annotation Method                 :: Best-placed reference protein
            Annotation Software revision      :: 4.11
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
            Genes (total)                     :: 4,454
            CDSs (total)                      :: 4,360
            Genes (coding)                    :: 4,278
            CDSs (with protein)               :: 4,278
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 82
            CDSs (without protein)            :: 82
            Pseudo Genes (ambiguous residues) :: 0 of 82
            Pseudo Genes (frameshifted)       :: 42 of 82
            Pseudo Genes (incomplete)         :: 34 of 82
            Pseudo Genes (internal stop)      :: 28 of 82
            Pseudo Genes (multiple problems)  :: 17 of 82
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence was derived from
            AP006841.
            This work was done in collaboration with Tomomi Kuwahara, Haruyuki
            Nakayama, Natsumi Okada, Yoshinari Ohnishi (University of
            Tokushima), Hideki Hirakawa, Satoru Kuhara (Kyushu University),
            Tetsuya Hayashi (Miyazaki Medical College), and supported by the
            Research for the Future Program of the Japan Society for the
            Promotion of Science.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotation Pipeline (PGAP)
            set; GeneMarkS-2+
            repeat_region
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..13875
                     /organism="Bacteroides fragilis YCH46"
                     /mol_type="genomic DNA"
                     /strain="YCH46"
                     /db_xref="taxon:295405"
     gene            1..300
                     /locus_tag="BF_RS13895"
                     /old_locus_tag="BF2921"
     CDS             1..300
                     /locus_tag="BF_RS13895"
                     /old_locus_tag="BF2921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008777440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_008777440.1"
                     /translation="MSLQQVAWLCMQGFTTKYYLCEAERGDFVVNLQVTTLHTIKTWQI
                     PLRHNSHRADRKLICEHVGVCSVRMCVKGGYEVKEYRSEKRKEARAYLLFWLYG"
     gene            <726..1220
                     /locus_tag="BF_RS13900"
                     /old_locus_tag="BF2922"
                     /pseudo=""
     CDS             <726..1220
                     /locus_tag="BF_RS13900"
                     /old_locus_tag="BF2922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014299082.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /protein_id="WP_014299082.1"
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-1,2-fucosyltransferase"
     gene            1227..2345
                     /locus_tag="BF_RS13905"
                     /old_locus_tag="BF2923"
     CDS             1227..2345
                     /locus_tag="BF_RS13905"
                     /old_locus_tag="BF2923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011203057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="WP_011203057.1"
                     /translation="MKKKLLIFHSALAPYRINFFNKLSEEFSATIVFLSDNLRNQNFNR
                     ANLLAQITFTPHYLKHKIVINDRDINFGYSSYIFKVQPDIIIGGEYGLPTVIPFLIKKI
                     FRKKYKIYTICDDSVQMSVNCGKIRSIFRHFLAPRLDGIIVVSPNTADWYRSHFTLKSN
                     PIIFPILQEEITFRKKLHLALPLSKQFIKKWQLNNKKAWLFVGRLVEIKGLDRVLKAFA
                     SAKIDTDTVLILVGEGELLETLKSQAKNLKISDRVLFVGRYEDIELLAWYNIGSNLILA
                     SHQEAFGAVVNEALISGCQVLCSSRAGACCLIQDDVNGYIFDTYNHDDFSEKISIMSRK
                     MPPINESNTEIKPSLMIEDFNMNIENLIHQLY"
     gene            2351..3439
                     /locus_tag="BF_RS13910"
                     /old_locus_tag="BF2924"
     CDS             2351..3439
                     /locus_tag="BF_RS13910"
                     /old_locus_tag="BF2924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014299083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="WP_011203058.1"
                     /translation="MIVFQVISSFDLGGAERVAINITKSPNPNFKFHLFEVVKGHSDFS
                     TSLKKEFKENGIPYHCSPFKNRKIAICLFWIWFIWYYIKYSPNIIHAHTETPDLSLWIF
                     RKIAWLCFWISPSYIRTIHNTKLWNEWEKIGNIVEKYYIKHQSNIAISTSTRDCYTRCY
                     GGEQPPIIYNGIDEIPQKKFQVIKPTQINILFAGRFEYQKGVDQMIAVVSALKDDSRFY
                     FHVVGSGSMEPKVITAFKGLTNVTVYQKVFGLAQYIGSFDYLFMPSNHEGLALMPIEAS
                     LAYTPTIINNCPGLKDTLPEDWPLSVNNNSIPDFIELISKKLNKQNYGELAKNAHRFAI
                     ERFSLNMMQKKYEELYRNRQKK"
     gene            3453..4526
                     /locus_tag="BF_RS13915"
                     /old_locus_tag="BF2925"
     CDS             3453..4526
                     /locus_tag="BF_RS13915"
                     /old_locus_tag="BF2925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005788649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="WP_164927417.1"
                     /translation="MHMPPPVHGASMMGKYIHDSKLIDQTFDCRYINLTLAKDLSDIGK
                     GGFSKLWSFLKQMNHIASTIHMEKPQLCYVTPNTKGGAFYKDFIVVMLLKAMGQNVIAH
                     YHNKGVATRQDRVLDNFLYNHFFKNQKVILLAKALYKDIEKYVARKDVYICPNGIPESY
                     SLPKPPSKKQESFKILFLSNMMIEKGVWDLLEACRILKEKEKAFHCDFVGKWSDVSFQT
                     FHDRIREYGLEDYITAHGSKYGTEKEKYLREADLFVFPTYYNNECFPLVLLEAMEYSLP
                     CISTNEGGITDIIEESKTGYIVEKQNPKILAQQIEYLLDHPELRKQMGQAGKNKFQKEF
                     TLEKFEERMKTILEEVI"
     gene            4696..5415
                     /locus_tag="BF_RS13920"
                     /old_locus_tag="BF2926"
     CDS             4696..5415
                     /locus_tag="BF_RS13920"
                     /old_locus_tag="BF2926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005788650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT26"
                     /protein_id="WP_011203060.1"
                     /translation="MLKLKTVSLLKHRSDLSILPEGKLLINTINAHSYNTALKDAGFAE
                     ALLKGGALIPDGASMVLAFRWLRKESIERTAGWDLFEYEMERLNRKGGICYFLGSSKNT
                     LKLIKEKAKTVYPNIRIETYSPPYKPEFTEEENQMMIDAINAVKPDLLWIGMTAPKQEK
                     WAYTHLDALEVNGHIGTIGAVFDFFAGTVERAPVQWQEHGLEWLYRLIKEPRRMWRRYI
                     IGNALFLWNITKEKFSI"
     gene            5425..6129
                     /locus_tag="BF_RS13925"
                     /old_locus_tag="BF2927"
     CDS             5425..6129
                     /locus_tag="BF_RS13925"
                     /old_locus_tag="BF2927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008769761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_011203061.1"
                     /translation="MRLKKAVLTVCVMMITSGIKAQYTMGTTGMMNIPTAEMQQTGTFM
                     IGGNYLPEELNPFKYNSGNYFVNITFFSFLELNYRCILLKSDYMAKKPKFNQQDRSLSV
                     RLRPLKEGKYWPAIVIGSNDPFKDKGYNYFASVYGVATKSFMIGEHRLAATAGYYYPLS
                     KDKYTLQDGIFGGLSYTPSFCKPLSIMVEYDSDGFNVGAAAKLWKHLSLNVFTREFKCI
                     SGGIRYECVLIH"
     gene            6135..7376
                     /locus_tag="BF_RS13930"
                     /old_locus_tag="BF2928"
     CDS             6135..7376
                     /locus_tag="BF_RS13930"
                     /old_locus_tag="BF2928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010993141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_005788655.1"
                     /translation="MKKQLTIIIGLLLSSSITVHAQVAQKLRELGMENIRTIETGGTTV
                     AAFEDNVYRGTYRGVGKAIIAGMEGMGNGNLELVALDGNGIPQLSISLPDTLIAGYKSG
                     EISLKEVYERMEMSYDTDRPMGLLKGSTGVINRSAWKADIVLYPEVSLENSTFDKLYSY
                     RVNLSPAVEMDLWKGAKATAQVVFPIATNMKGEYKKIRPGVMTISQEIRFRNNFLARIV
                     AGNFTDHRIGAQAEVKYRTGNGRVELGAQIGTTGYSTITDDGWYIGTRQRINAAVKGSL
                     YVPQFNTQLDLQAGRYLYGDYGLRGDCTRHFGEYAVGVYAMYVEGEVNGGFHFAIPLPG
                     KKWNRNHAVRMKPAEFFAAEYSMVSWGEYADRKMGYTYQTRPAENRSNGFFQPEYIRHF
                     LIKSIEKERNKKQF"
     gene            7402..8688
                     /locus_tag="BF_RS13935"
                     /old_locus_tag="BF2929"
     CDS             7402..8688
                     /locus_tag="BF_RS13935"
                     /old_locus_tag="BF2929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008769759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxypeptidase regulatory-like
                     domain-containing protein"
                     /protein_id="WP_008660805.1"
                     /translation="MKKSDLFKIGVLLMATTLGTTGCSFGEDEKKPEIVVDPAEKTIEY
                     YIAGKVTEGTTALSGVEVKAGEVTATTDAEGAYKLTVDSKKVYTVTFSKEGYMSIDNAT
                     ATIADNAANRSMVSLSVKLSKKAPEKEVKADAEEEVVVTDKGDSNISQAEAAVIIPPKA
                     IETTTTVSVTPYEEPAAVTTTVTPGNNVETPVAIANIEVETAKEVTLAKPVTLAIINKA
                     SEHTTFENVEVYNQKTTTRAGENWNKVADAIYDSETNSYKFTLPAGASLSGKYSMRVKS
                     SKTTGKELVGETNKEEKKSNEGNMTAIPEYKINFEATAGWEYTVSPEKALMNAGVDAAD
                     AQGMATTINSAIEAQEGTTGTYKVAHELIAGISGNHILYYLNQAKYCEKTYTFKISGGR
                     TVTITLKFYTGMQITYTNVEASQHSGGKI"
     gene            8728..9303
                     /locus_tag="BF_RS13940"
                     /old_locus_tag="BF2930"
     CDS             8728..9303
                     /locus_tag="BF_RS13940"
                     /old_locus_tag="BF2930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005788659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_005815284.1"
                     /translation="MKLNNIKTGLLLAGLLLLFGNVKAQDNPFKPEWFVSGGINGVTAL
                     NGSANNILGGKVSGGVWLNKIIGLRVDAEAGNVWLKGGYNAVTVGAGVDILVNLMKNYT
                     DEDRKFRLNAIFGLGYNYYSFGDDYPRLSKTNTMSGNFSLQAAFRLNSHLSIFAEPGIK
                     ISTKFYDIENKDDVFAGGMMTVGVIYKF"
     gene            9409..9921
                     /gene="gldL"
                     /locus_tag="BF_RS13945"
                     /old_locus_tag="BF2931"
     CDS             9409..9921
                     /gene="gldL"
                     /locus_tag="BF_RS13945"
                     /old_locus_tag="BF2931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005820742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gliding motility protein GldL"
                     /protein_id="WP_005788660.1"
                     /translation="MKLSKFLSSRTGKRFYNLCYCWGACLVILGAVFKIAHMPYDNLFL
                     MIGLFTEVFIFFISGFDEPAREYKWERVFPLLNDKNANINPHTGVSDTLMTEKYIQQLK
                     RLENNVCKLNETYEAQIKGMTEHAKSLNEMNSEELKKETEKMAAYIELLNKQYSQMLNA
                     MNVKTGK"
     gene            9933..11249
                     /locus_tag="BF_RS13950"
                     /old_locus_tag="BF2932"
     CDS             9933..11249
                     /locus_tag="BF_RS13950"
                     /old_locus_tag="BF2932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005803170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q5EGM3|9.A.25.1.1"
                     /protein_id="WP_011203062.1"
                     /translation="MAKYTLPPRQKMINLLYVVLIAMLAINISSDVLEGYGQMNNDYLP
                     QIKKLEEYNRTLLERINSRNDKAALSAQNIDATAGKLMDTLEELKEDIARKADKEKYEA
                     GKLKAKDDLNAVPEVFLSVTGGKGKALRLSLDTFKEDALSLIKNDAHRQLVGTYLNTES
                     PGTGISWEKETFSYLPAIGGVTFINKMQEEVLLCVNEVYRSLLYEEAEDGKSGAFVFIN
                     EDQMIVNKDGTVDLPVVQITPALTSILYTDYENPLNILTAGIPFNEVTFRMTNGKILKR
                     GNHCIAVPDEKAQTATVTATQIKNGVARQLAEYRYTVKALPDPTPYILCTDENGRTVQY
                     RGNVPINKRLVSNMTQLGASISDGPKANYEISSFEMVLIKGSSKAVTSIPNTGNKFSAR
                     QMELIRQLEKGDKFYITSIVVTGPGNKKKQIASINVVLI"
     gene            11257..12354
                     /locus_tag="BF_RS13955"
                     /old_locus_tag="BF2933"
     CDS             11257..12354
                     /locus_tag="BF_RS13955"
                     /old_locus_tag="BF2933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008660808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OmpA family protein"
                     /protein_id="WP_011203063.1"
                     /translation="MTNILGLKQNRWIVGAVLLLTTCNLQAQEQPNAREKFEKGNWFVS
                     GALNGEWLTKTIGNVYAGGKISGGVYLTPLSGFRATAEIGKNRIGNDTEATQLSANLDY
                     MLTLIGNNGFKKFNLAAILGAGFNYYDFGDNDPKYTRVNTISGNFSIQASYNVNRKFSV
                     FIEPGLKVLPKYYSKELNNKIYMQSNLTIGLAYTFRDKYRKSVDNSIHPLYLPEADLLE
                     IKEKIGMLCEEVMQMKQELKERRKITDGQNLMIVPPKDALSIDIMFDEFSSFVSEEQGQ
                     KIDGIGEWMKNNNASIRIIAFSDNLTDKKADQELRKRRSEAIRKILIEKYHISPERISE
                     STPEAMGYENKTGCNAMIVYIPENK"
     gene            12382..12810
                     /locus_tag="BF_RS13960"
                     /old_locus_tag="BF2934"
     CDS             12382..12810
                     /locus_tag="BF_RS13960"
                     /old_locus_tag="BF2934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009293222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_005788667.1"
                     /translation="MTIAVDFDGTIVEHRYPKIGEEIPFATETLKILAQERHKLILWTV
                     REGELLEEAIEWCRQRGVFFYSVNKDYPEEEKSHNGFSRKLKADLFIDDRNLGGLPDWG
                     TIYQMIHEQKPYEPVLCDRQKPTGDLSWIEKLLGKRNK"
     gene            12826..13875
                     /locus_tag="BF_RS13965"
                     /old_locus_tag="BF2935"
     CDS             12826..13875
                     /locus_tag="BF_RS13965"
                     /old_locus_tag="BF2935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009293221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-1-phosphate guanylyltransferase"
                     /protein_id="WP_011203064.1"
                     /translation="MNNHVVIMAGGIGSRFWPMSTPECPKQFIDILGCGKTLIQLTVER
                     FGNVCPQENMWVVTSEKYIDTIREQLPGIPESNILAEPCPRNTAPCIAYACWKIKKKYP
                     EANIVVTPSDQVVIDTTEFRRVIEKALLFTDKSSAIITLGIKPARPETGYGYIAAGEPI
                     TRDKEIFHVEAFKEKPDKETAEKYLAAGNYFWNAGIFVWNVRTITAVMRVYAPGIAQIF
                     DRIYPDFYTEREEESVKKLFPTAESISIDYAVMEKAEEIYVLPAQMGWSDLGTWGALHT
                     LLPKDKEGNATVGPDIRMYESQNCMVHASQEKRVVIQGLNDYIIAEKDNILLICQLSEE
                     QRIKDFSKE"
ORIGIN
        1 atgtcgcttc aacaggtggc atggctatgt atgcagggtt tcactacaaa atactacctc
       61 tgcgaagcgg agcgtggaga ttttgtagtg aaccttcagg ttacaacctt gcatacaata
      121 aagacatggc aaataccttt gcgacacaat tcccatcggg cagaccgaaa gttgatatgc
      181 gagcatgtgg gagtttgctc ggtacggatg tgtgtaaaag gtggctatga agtaaaagag
      241 tatcgcagcg aaaagagaaa agaggcaaga gcttatcttc tcttttggct gtatgggtag
      301 aatgggaaaa tcacaaaaag taacatgaaa atccagtttg gtttagtttg ttagccttat
      361 atatgctaaa ctaaattaaa ctaaatatag gcaggcattt ttggctgcct gtacaaaaaa
      421 gattatcttt gctacaagca atacaacttc aagagataat aatttgtatt ctctttatga
      481 gctgcaaata atttgttagt taaagttagg agcaaattct tcgaatgatg agagcagata
      541 aaattgctcg gaatgcactc tgaaagcaaa caaacgaaaa gaaagaaaca gagtgcaaat
      601 agaaaaatga gaaatcactt taattcctat ttttgttcct tatttgtttc tccactaaaa
      661 tcacctttct tataacatat tgattataaa atatttaagt gtatattttt aagatgatta
      721 agaatattgc caagtatccc cctaacacaa aactttgttc cgtacacttc agaaacgcat
      781 tagattatcg tataaaagga tatatgcttg caaaacacta ttggaataat gctgctcaac
      841 aattattaca agaggaaaat gccaacattg tttttctcgt tttttacgac aagaagaccc
      901 gactagttaa atcatttata aaaaatcatc aaagcgaaac attacactat tctctattta
      961 aagattttag tttaatttca aaatgcgatt ttcatattgt atgtaacagt tcatttagtg
     1021 taatggctgc actaatggac gaaagatcca ataagacttt ttgtccatct atatggccaa
     1081 ctcccaaagg atattttccg atggactctt atccccaaga atggattaga atttcgacta
     1141 aacgaaatcc agtgtctcac ataatgggat atattgctcc cattctatct cccctaaaac
     1201 atcttataaa aaagaagtaa ttttctatga aaaagaaatt attaattttc cattcagcat
     1261 tagcacctta tagaatcaat tttttcaata aattaagtga agaatttagt gctaccattg
     1321 ttttcttaag cgataattta cgcaatcaga acttcaatag agcgaaccta ttagcacaaa
     1381 ttactttcac tccacattac ttaaaacata aaatagttat aaatgataga gacattaatt
     1441 tcggatatag ttcatacatt tttaaagtac agcctgatat aattatagga ggcgaatatg
     1501 gtctacctac ggtcatacct tttttgatta aaaagatatt ccgaaaaaag tacaaaattt
     1561 atactatttg cgatgatagt gtacaaatgt ctgttaactg tgggaaaatt cgatcgattt
     1621 ttcgccattt tctggcacct agattagacg ggattatagt agttagccca aatacggcgg
     1681 actggtatag atcacatttc acattaaaaa gtaatccaat aattttccca atcctacaag
     1741 aagaaatcac atttagaaag aaattgcatt tagctctccc attatcaaaa caatttataa
     1801 agaaatggca actaaacaac aaaaaagcat ggctttttgt tgggcgatta gttgaaataa
     1861 aaggactgga tcgtgtttta aaagcatttg cttcagctaa aattgatact gatacagttt
     1921 tgattcttgt aggagaagga gagctattag aaacattaaa aagccaagct aaaaatttaa
     1981 aaatatcaga tagagtacta tttgtaggac gatatgaaga tatagaacta ttggcttggt
     2041 acaatatagg tagcaactta atattagcaa gccatcagga ggcttttgga gctgttgtca
     2101 atgaggctct tatttctgga tgtcaagtac tttgttcttc ccgagctggt gcatgttgtt
     2161 taatacaaga tgatgtaaac ggatatatat ttgatacata taaccatgat gatttttcag
     2221 aaaaaatctc tataatgtct cgcaaaatgc ctcctataaa tgaatccaat acagaaataa
     2281 aaccatctct tatgattgaa gatttcaaca tgaatataga aaatttaatc catcagttat
     2341 attaaataaa atgattgtat ttcaagttat ttcatctttt gatctcggag gtgccgaaag
     2401 agtagcaatc aatattacaa aatccccaaa tccaaacttt aaattccacc tgtttgaagt
     2461 tgtaaaagga cactccgatt tctctacctc tcttaaaaaa gagtttaaag aaaatggtat
     2521 accatatcat tgctctcctt tcaaaaacag aaaaatagca atctgtctct tttggatatg
     2581 gttcatctgg tactatataa aatactctcc aaacatcata cacgcacaca cggaaacacc
     2641 ggatctctca ctttggatat ttaggaaaat agcatggctt tgcttttgga ttagccccag
     2701 ctacataaga acaatacaca atacaaagct atggaatgaa tgggaaaaaa ttgggaatat
     2761 agtagaaaaa tattatataa agcaccagag taatattgca atctctactt ccacgagaga
     2821 ctgctatact cgctgttacg ggggagaaca accaccaatc atttataatg gtatagatga
     2881 aatacctcaa aaaaagtttc aagtaatcaa accaactcag attaatattt tatttgccgg
     2941 aagatttgaa taccaaaagg gagtagacca aatgattgca gtagtcagtg cactcaagga
     3001 tgattcaaga ttttactttc atgtggtagg aagtggatct atggaaccta aagtaataac
     3061 agcttttaaa ggattaacca atgtaacagt atatcaaaaa gtattcggac tagctcagta
     3121 catcggttca tttgattact tatttatgcc ttctaaccac gaaggtctag ctcttatgcc
     3181 tatagaagcc agcctagcat atacccccac aatcataaat aactgccctg gactaaaaga
     3241 tacactaccg gaagattggc cattaagtgt aaataataac tccattccag actttattga
     3301 acttatctcc aaaaaactga ataaacaaaa ttacggggaa ctggcaaaaa atgcccatag
     3361 atttgctatc gaacgttttt ctttaaatat gatgcaaaag aaatatgaag aactctacag
     3421 aaaccggcaa aagaaataaa atacttttca tcatgcacat gcctcccccg gtccatggtg
     3481 catcaatgat gggaaaatat atccatgaca gcaaactgat cgaccaaaca tttgactgcc
     3541 gatatatcaa tctgacattg gcaaaagatt tatcggatat tgggaaagga ggtttctcta
     3601 aattatggag ttttctgaaa cagatgaatc atatagcatc tacaattcac atggaaaaac
     3661 cccaactatg ctacgtaacc cccaatacca aaggaggtgc tttctacaaa gattttatag
     3721 tggtgatgtt actcaaagct atgggacaaa acgtaattgc gcattatcat aataaaggag
     3781 tagcgacacg gcaagacagg gtattggata actttttata caaccatttt tttaagaatc
     3841 aaaaagttat attgctggca aaagctttat acaaagatat agagaaatat gtagcccgaa
     3901 aagatgtgta tatatgtccg aatggaatcc cggaaagtta ttctctaccg aaaccaccct
     3961 ctaagaaaca agagtctttc aagatactct tcttatcgaa tatgatgata gaaaaaggag
     4021 tatgggactt actggaggcg tgcagaatac ttaaagaaaa agaaaaggca tttcattgtg
     4081 acttcgtcgg gaaatggagt gatgtcagtt ttcaaacatt tcatgacaga atacgggaat
     4141 atggactaga agattacata acagcccatg gttcaaaata tggaactgaa aaagagaagt
     4201 atctacgaga agcagattta tttgttttcc cgacttacta caataatgaa tgttttcctc
     4261 ttgtcctgct tgaagcaatg gaatatagtt taccatgtat cagtaccaac gaaggaggaa
     4321 tcactgacat catagaagaa agtaaaactg gctatattgt tgagaaacaa aatcccaaaa
     4381 ttttggctca acaaatagaa tatttattag atcatccgga attgcgaaaa caaatggggc
     4441 aagccggaaa aaataagttt caaaaagagt tcacactaga aaaatttgaa gaaagaatga
     4501 aaactatttt agaagaagta atttagattc aataataaga cattatatcc gaatatcttt
     4561 tttaataaat actttcctct ttatcggaaa aagcatacct ttgcaaagaa attcttaccc
     4621 cataattcca aagcctgctc ttcgtgacag gtagcagcgt agcgtactta taactaccca
     4681 ttccatctca gaaacatgtt gaagctcaaa acagtttcac tcctgaagca caggagcgac
     4741 ttatctatat tgcccgaagg taaattattg ataaacacaa ttaacgccca ttcatataat
     4801 acagccttga aagatgccgg gtttgcagag gctctgctca aaggcggagc actgattcct
     4861 gacggagcaa gcatggtatt ggcgtttaga tggctccgaa aagagagcat agaacgtact
     4921 gccggatggg atctctttga atatgaaatg gaacggctga accggaaagg aggtatttgc
     4981 tactttctgg gaagcagcaa aaatacactt aaactgatca aagaaaaagc taaaaccgta
     5041 tatccaaata ttcgaataga gacttactcc ccaccctaca aaccggaatt tacagaagaa
     5101 gaaaatcaaa tgatgataga tgccataaat gcggtaaagc cggacttatt atggataggt
     5161 atgacggctc ccaaacaaga aaaatgggcg tatacgcatc tggatgcact ggaggtgaac
     5221 ggacatatag gaaccatcgg agcggtattc gacttctttg cgggtacggt ggaacgtgct
     5281 ccggtccagt ggcaagagca cggactggaa tggctgtatc gcttgatcaa agagcctagg
     5341 cgcatgtggc gccggtatat catcgggaat gccttgttcc tgtggaacat caccaaagaa
     5401 aaattctcta tataacatca atcaatgagg ctaaaaaaag cagtattaac ggtctgtgta
     5461 atgatgataa catcaggaat caaggcacag tataccatgg ggacaacagg aatgatgaac
     5521 attccgaccg ccgagatgca acagacaggt accttcatga tcggcggtaa ctatttgcct
     5581 gaagaactga atccttttaa atacaactcc ggaaactatt tcgtgaacat caccttcttt
     5641 tcattcctgg aattgaatta ccgttgcatc ttgctgaaaa gtgactacat ggctaaaaag
     5701 cctaaattca atcagcaaga cagatcgcta tctgtaaggc tccgcccgct gaaagagggt
     5761 aaatactggc cggcaattgt cattggcagt aacgatccgt tcaaagataa aggatacaat
     5821 tatttcgcat ccgtatatgg agtggccaca aaaagtttca tgataggcga acaccggctg
     5881 gcagcaaccg caggatatta ttatccatta agtaaagaca agtatacctt gcaagacggc
     5941 atattcggcg gcctcagcta tactccctct ttttgcaagc cactgtccat catggtcgaa
     6001 tatgactccg acggattcaa tgtaggagca gccgcaaagt tgtggaaaca tctctcactg
     6061 aacgtgttta cccgcgaatt taaatgtatc tccggaggaa tacgatatga atgtgtctta
     6121 atccattaag ctgtatgaag aaacaattga caataataat cggcctgctc ctctcctcct
     6181 ctatcactgt ccatgcacag gtcgcccaaa agctcaggga gctgggtatg gaaaatatcc
     6241 ggaccattga aacgggagga acgactgttg ccgcctttga ggacaatgta tacagaggaa
     6301 cctaccgcgg agtgggaaaa gcaatcatcg caggaatgga aggaatgggc aacggcaacc
     6361 tggaactggt ggcactggac ggaaacggta ttccgcaact cagcatcagc ctgccggata
     6421 cgttgatagc gggctataaa tccggtgaga tttcattgaa agaggtgtac gaacggatgg
     6481 agatgagtta tgataccgac cgccctatgg gactattgaa aggaagcaca ggggtgatca
     6541 accgctcggc atggaaagcg gacatcgtcc tgtatccgga agtgtcactg gaaaactcca
     6601 ctttcgataa actgtattcg tacagagtca atctgtcgcc ggctgtagaa atggacttgt
     6661 ggaaaggagc gaaagcaacg gcacaggtgg tcttccccat cgcaaccaat atgaagggcg
     6721 aatacaaaaa gatacgtccg ggggtaatga cgatttcaca ggaaataagg ttccggaata
     6781 attttctggc ccgcatcgtg gcaggcaact tcaccgatca tcggatcgga gcacaggctg
     6841 aagtgaaata tcgtaccggc aacggacggg tggagctggg agcgcagata ggcacaaccg
     6901 gatactcgac catcacggac gacggatggt atatcggtac ccgtcaacga atcaatgcag
     6961 ccgtgaaagg ctcgctctat gtaccgcaat tcaatactca actcgaccta caggccggaa
     7021 gatatttgta tggagactat gggctgagag gagactgcac acgccacttc ggagagtatg
     7081 ccgtaggagt gtatgccatg tatgtggaag gagaagttaa cggaggattt cattttgcca
     7141 tccccctgcc cggaaagaaa tggaaccgga atcatgctgt caggatgaag ccggctgagt
     7201 tttttgccgc cgaatatagc atggtgtcgt ggggcgagta tgccgatagg aaaatgggat
     7261 atacctatca gacacgaccg gcagaaaacc ggagcaacgg attctttcag ccggaatata
     7321 tacggcattt cctgataaaa agtatcgaaa aagagagaaa caaaaaacag ttttaatatt
     7381 ttcttaatga caaaaatgat tatgaaaaag agtgacttat ttaagatagg tgtgttgctg
     7441 atggcaacga ccttgggaac aaccggatgc tctttcggag aagacgagaa gaaaccggaa
     7501 attgtagtgg atcctgccga aaaaacaata gaatactaca ttgcaggtaa agtgacggaa
     7561 ggaacgaccg cgctgtccgg tgtagaagtg aaagccggtg aagtaacggc tacgacggat
     7621 gcggaagggg cttataaact gacagtggac agcaagaagg tgtacaccgt gacattcagc
     7681 aaagaagggt atatgagcat agacaatgca acggcaacca tcgcagacaa tgcggcaaac
     7741 cgcagtatgg tgagtctgag tgtgaaatta agcaagaaag ctccggaaaa agaagtgaag
     7801 gccgatgcgg aagaagaagt ggtggtaacc gataaaggag acagcaatat ctctcaggca
     7861 gaagcagctg taattattcc tcccaaagcc atagaaacaa ctacaaccgt aagcgtgacc
     7921 ccgtatgaag aaccggctgc cgtgacaaca accgtgacac cgggaaataa tgtggagact
     7981 ccggtagcga tcgcaaacat cgaagtggaa acagccaaag aggtcactct ggccaaaccg
     8041 gtaacactgg caatcataaa caaagcttcg gaacatacaa cgttcgaaaa tgtggaagtg
     8101 tacaatcaga aaacaaccac aagggccgga gaaaactgga acaaagtggc agatgccatt
     8161 tatgactcgg aaacgaacag ctataagttc acattgcccg caggcgcatc actgtccgga
     8221 aaatattcga tgcgtgtcaa gagtagcaag accacaggaa aagaactggt aggcgagaca
     8281 aacaaggaag agaaaaaaag caatgaaggc aatatgactg ccattccgga atacaaaatc
     8341 aactttgagg ctacggccgg atgggaatat actgtcagtc cggaaaaggc gctgatgaat
     8401 gcaggcgtag acgctgcgga tgcccaaggc atggccacga cgatcaacag tgccattgaa
     8461 gcgcaggaag gaacgacggg aacttataaa gtggctcacg aactgatagc gggtatcagc
     8521 ggtaaccata tcctttatta cctgaatcag gctaaatatt gcgaaaagac atatacattc
     8581 aaaatcagtg gcggaagaac agtgaccatc accctgaaat tctatacagg aatgcagatt
     8641 acttacacca acgtggaagc aagccagcac tcgggaggta agatttaaaa gttgtccgat
     8701 aaacactaac taaaaaataa ataaatcatg aagctgaata atataaaaac aggattgctg
     8761 ttggccggat tgctgctgct attcggaaat gtaaaggcac aggataatcc attcaaaccg
     8821 gaatggtttg tatcgggagg tattaacggg gtcacagctt taaatggttc ggcaaacaac
     8881 atattgggag ggaaagtctc cggcggcgtg tggttaaata agatcatcgg tctgcgcgtc
     8941 gatgcagaag ccggcaacgt atggctgaaa ggcggataca atgccgtgac agttggtgcc
     9001 ggagtggata tcctggtgaa cctgatgaag aattataccg acgaagacag aaaattccgg
     9061 ttgaacgcca ttttcggatt agggtacaac tactattcgt ttggtgatga ttatcccaga
     9121 ctgtcaaaga cgaataccat gagcggtaac ttctctctgc aagctgcttt caggctgaat
     9181 tcgcatctga gcatctttgc tgaaccggga atcaaaatca gtaccaagtt ctatgacatc
     9241 gaaaacaaag atgatgtgtt tgccggcgga atgatgaccg taggtgtgat atacaaattc
     9301 taatagcata aaattgacca cagattagca cagatcattc cacgagacta atccgtgaaa
     9361 cgatctgtgt aaactccgtg gtgaaatcaa aaaaacggat tgactacaat gaaattaagt
     9421 aaattcttat cgagcagaac aggaaaacgt ttctataacc tctgttattg ctggggagcc
     9481 tgtctggtta ttttgggagc cgtattcaaa atcgctcaca tgccttatga taatttgttt
     9541 ttaatgatcg gattatttac ggaggtattc atcttcttca tctccggatt tgacgaaccg
     9601 gcaagagagt acaaatggga aagggtgttt ccgctattga atgataaaaa cgcaaacata
     9661 aatccccata caggagtatc ggatacactg atgacagaaa agtacataca gcagctgaaa
     9721 agactggaaa acaacgtgtg taaactcaat gaaacgtacg aagcgcaaat aaagggaatg
     9781 acggaacacg ctaagtcgtt gaacgagatg aattcggagg aactgaaaaa ggagacagaa
     9841 aaaatggcag catacataga attactgaac aagcaatata gtcagatgct gaatgccatg
     9901 aatgtaaaaa ccgggaaata agacgaagag acatggctaa atatacattg ccgccaaggc
     9961 aaaagatgat taacctgctg tacgtggtat tgattgctat gctggccatc aatatatcgt
    10021 cggatgtctt agaggggtat ggacaaatga acaacgacta ccttccacaa ataaaaaagc
    10081 tggaagaata taaccggact ttactggaaa gaattaacag ccgaaatgat aaagcggctt
    10141 tatctgcaca gaacatagat gcgacggcag gaaaactaat ggatacactg gaggaactga
    10201 aagaagatat cgcccggaaa gcggacaaag agaaatatga agccggcaag ctaaaagcaa
    10261 aagatgactt gaacgctgtg ccggaggtat ttctgtcggt caccgggggg aaagggaaag
    10321 cactcaggct ctcactggat acattcaaag aagacgcttt atcgctgatc aagaatgatg
    10381 cacacagaca actggtaggc acttacctca atacggaaag tccgggtacc ggaatatcct
    10441 gggaaaagga aaccttttct tatcttcctg ccatcggtgg agtgacattt atcaataaaa
    10501 tgcaggaaga ggtgttgctg tgcgtgaatg aagtatatcg gtcactgctg tacgaagagg
    10561 cagaagatgg aaaaagcgga gcttttgtat tcatcaatga agaccagatg atagtaaata
    10621 aagatggaac ggtagacctg cctgtagtac agatcacacc cgccttaaca agtatcttgt
    10681 ataccgacta tgaaaacccg ctaaatatac tgactgcggg aataccgttc aacgaggtga
    10741 cattccggat gacgaacgga aagatactca aaagaggaaa ccattgcata gccgttcccg
    10801 acgaaaaagc acagacagcg acagttaccg ccacacagat aaaaaacggg gtggcaaggc
    10861 aactggccga ataccggtat accgtaaagg cactgcccga tccgacacct tatatactct
    10921 gcacggatga aaacgggaga acggtgcaat accggggaaa tgtgcccatt aacaaacggc
    10981 tggtatccaa catgacacag ctgggagctt caatcagcga tggtccgaaa gccaactacg
    11041 agatcagcag ctttgaaatg gtattgatca aaggaagcag taaagcggta acttcaatac
    11101 ccaacaccgg gaacaaattc tcggccaggc aaatggaact gatcagacaa ctggagaaag
    11161 gagataaatt ctatatcact tcgattgttg tgaccggtcc gggaaacaaa aagaaacaga
    11221 ttgcatcaat caatgtcgta ttaatataac acaaccatga caaatatatt gggattgaaa
    11281 caaaacagat ggatcgttgg ggcagtactg ctgctgacaa cctgtaactt acaggcacag
    11341 gaacagccaa acgccaggga aaagtttgaa aaaggaaatt ggtttgtatc cggtgccctg
    11401 aatggagaat ggctgaccaa gacaatcggt aacgtatatg caggcggtaa aatctccgga
    11461 ggtgtatatc tgacgcctct ttcgggattc agagccactg cggagatcgg taagaaccgg
    11521 atagggaatg acacagaagc cacgcaactc agcgcaaacc tggattatat gttgactctg
    11581 ataggaaaca atggattcaa aaaatttaat ctggcggcta ttctgggtgc cggtttcaac
    11641 tattatgact ttggggacaa tgatccgaaa tatacaagag tcaacaccat ttcgggtaac
    11701 ttctcgattc aggcttcgta caatgtaaac agaaaattca gcgtatttat agaaccggga
    11761 ttaaaggttt tacccaaata ctacagcaaa gaactgaaca acaaaattta tatgcaaagc
    11821 aacctcacaa taggacttgc atatactttc agagataaat atcggaagag cgtggacaac
    11881 agcatccacc ccctctatct accggaagcg gatctactgg agataaagga gaaaataggg
    11941 atgctctgtg aagaggtaat gcaaatgaag caggaattaa aggaacgccg gaaaataaca
    12001 gacgggcaaa acctgatgat tgttccgcca aaggatgcac tctccatcga tattatgttc
    12061 gacgaattca gttcgttcgt tagcgaagag cagggacaga aaatagacgg aattggcgaa
    12121 tggatgaaga ataataacgc aagtatccgg atcattgctt tcagtgataa cctgaccgac
    12181 aaaaaagcgg atcaggagct gcgtaaacgt cgttcggaag ccatccggaa gatattgata
    12241 gagaaatatc acatctctcc cgaacgcatt tcggaatcga caccggaagc gatgggatat
    12301 gaaaacaaaa cgggatgtaa tgcaatgatt gtatacattc ctgaaaacaa ataataatca
    12361 caattcacac acactaatca catgacgatt gctgttgatt ttgatggtac catcgtagaa
    12421 caccgctatc cgaagatcgg agaagaaatt ccattcgcaa cagaaaccct gaaaatattg
    12481 gctcaggagc gacataagct tatcttatgg accgtacgcg aaggagaatt gcttgaagaa
    12541 gcgattgaat ggtgccgcca acggggagtc tttttctatt ctgtcaacaa ggactatccg
    12601 gaagaagaaa agagtcataa cggattctcc cgtaaactga aagcagacct gtttattgat
    12661 gaccggaacc tgggaggttt gcctgactgg ggaaccatct accagatgat ccatgaacaa
    12721 aagccatacg aacctgttct atgtgacagg cagaaaccga ccggcgattt aagctggata
    12781 gagaaactgc tcggcaaacg taacaaataa agaaagaggt taacaatgaa caatcatgta
    12841 gtaattatgg ccggtggcat aggaagtcga ttttggccca tgagtacacc ggaatgtccc
    12901 aaacaattca tagatatatt gggatgtgga aaaacactga ttcagctaac tgtagagaga
    12961 ttcggtaatg tttgtccaca ggagaacatg tgggtggtca cttcggaaaa gtatatagat
    13021 actattcggg agcaactgcc gggtatcccg gaaagtaata tactggcaga accctgtccc
    13081 agaaatacag ctccctgcat tgcgtatgcc tgctggaaaa taaaaaagaa atatccggaa
    13141 gccaacattg tcgtgactcc ttccgatcaa gtggtaatcg ataccactga atttcgcagg
    13201 gtgattgaga aagcgctttt gttcactgat aaaagcagtg ccatcatcac attgggaata
    13261 aaacccgccc gtccggaaac cggatatgga tatatcgccg caggtgaacc gataacgaga
    13321 gacaaagaaa tattccacgt agaagcattc aaagaaaagc ctgataaaga aactgctgaa
    13381 aaatatctgg cagcaggcaa ctacttctgg aatgcaggaa tattcgtttg gaatgtgaga
    13441 acgatcacag ccgtaatgcg ggtatatgca ccggggatag ctcagatttt cgaccggata
    13501 tatcccgact tttatacaga acgcgaggaa gaaagcgtga agaagctatt ccccactgcc
    13561 gaaagtatct cgatagatta tgcagtgatg gaaaaagcgg aagagattta tgtattacct
    13621 gcccaaatgg ggtggtcgga cttaggtacc tggggagcac tacacacctt gttgccaaaa
    13681 gataaagaag gaaatgcaac agtaggaccg gatatccgga tgtatgaaag tcaaaactgc
    13741 atggtgcacg cctcacagga aaaacgagta gtcatacaag ggctgaacga ttacatcata
    13801 gccgaaaaag acaatatatt attaatatgc cagttatcag aagagcaacg aattaaagat
    13861 ttctcaaaag aataa
//
