LOCUS       NC_006347              10144 bp    DNA     linear   CON 04-APR-2020
DEFINITION  Bacteroides fragilis YCH46, complete genome.
ACCESSION   NC_006347
VERSION     NC_006347.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMD00061068
            Assembly: GCF_000009925.1
KEYWORDS    RefSeq.
SOURCE      Bacteroides fragilis YCH46
  ORGANISM  Bacteroides fragilis YCH46
            Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
            Bacteroides.
REFERENCE   1
  AUTHORS   Kuwahara,T., Yamashita,A., Hirakawa,H., Nakayama,H., Toh,H.,
            Okada,N., Kuhara,S., Hattori,M., Hayashi,T. and Ohnishi,Y.
  TITLE     Genomic analysis of Bacteroides fragilis reveals extensive DNA
            inversions regulating cell surface adaptation
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (41), 14919-14924 (2004)
   PUBMED   15466707
REFERENCE   2  (bases 1 to 10144)
  AUTHORS   Hattori,M., Yamashita,A., Toh,H., Oshima,K. and Shiba,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2004) Contact:Masahira Hattori Graduate School of
            Frontier Sciences, University of Tokyo; 5-1-5 Kashiwanoha, Kashiwa,
            Chiba 277-8561, Japan
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 04/04/2020 09:42:13
            Annotation Pipeline               :: NCBI Prokaryotic Genome
            Annotation Method                 :: Best-placed reference protein
            Annotation Software revision      :: 4.11
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
            Genes (total)                     :: 4,454
            CDSs (total)                      :: 4,360
            Genes (coding)                    :: 4,278
            CDSs (with protein)               :: 4,278
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 82
            CDSs (without protein)            :: 82
            Pseudo Genes (ambiguous residues) :: 0 of 82
            Pseudo Genes (frameshifted)       :: 42 of 82
            Pseudo Genes (incomplete)         :: 34 of 82
            Pseudo Genes (internal stop)      :: 28 of 82
            Pseudo Genes (multiple problems)  :: 17 of 82
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence was derived from
            AP006841.
            This work was done in collaboration with Tomomi Kuwahara, Haruyuki
            Nakayama, Natsumi Okada, Yoshinari Ohnishi (University of
            Tokushima), Hideki Hirakawa, Satoru Kuhara (Kyushu University),
            Tetsuya Hayashi (Miyazaki Medical College), and supported by the
            Research for the Future Program of the Japan Society for the
            Promotion of Science.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotation Pipeline (PGAP)
            set; GeneMarkS-2+
            repeat_region
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..10144
                     /organism="Bacteroides fragilis YCH46"
                     /mol_type="genomic DNA"
                     /strain="YCH46"
                     /db_xref="taxon:295405"
     gene            1..1446
                     /locus_tag="BF_RS21505"
                     /old_locus_tag="BF4504"
     CDS             1..1446
                     /locus_tag="BF_RS21505"
                     /old_locus_tag="BF4504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005803862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipopolysaccharide biosynthesis protein"
                     /protein_id="WP_005814097.1"
                     /translation="MAEQSLKEKTAKGLFWGGFSNGIQQLLNLLFGIIITRMLDSTDYG
                     MIGMLAIFTAVANSIQESGFTAALANKQTFRHEDYNAVFWFSFLMGASLYLLLFFCAPF
                     IAAFYKTPQLIPLSRFLFLGFLISSCGTAHNAVLFKKLMVKEKAKATITALLCSGTIGI
                     VMAYNGMAFWGLAVQQITYIFIANALLWYFSPWRPTFSFNFKPIREMLPFSSKLLITNV
                     FHYINDNIFSVLLGRFYTSQDVGYYTQANKWTNMGFSLISNMINGVSQPVLVETSSDAM
                     RQKNIFRKMLRFTAFISFPAMFGLALIANEFIVIAVTAKWQACVPIMQILCIWGAFVPI
                     TYMYSNLLISKGKSNLFMWNTIAQSLVQLTMLLCTISQGILVMAVIYTVINIGWLLIWH
                     YFVNKQIHITLWEVMKDITPYLLISGGVIGTSYFLTIGFHNLYVLLILKIGIAVSLYVF
                     IMWIGKSVIFFESVQFIRKKLLK"
     gene            2647..3657
                     /locus_tag="BF_RS21515"
                     /old_locus_tag="BF4506"
     CDS             2647..3657
                     /locus_tag="BF_RS21515"
                     /old_locus_tag="BF4506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005797203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT0|GT94"
                     /protein_id="WP_011203721.1"
                     /translation="MKVTIYPYSINKGDICVNPYISDFIHALQQNGITIANPPHKNPLF
                     SLIPRKADSDAYIFHWPENVPDYKYGMLQTLAAIWLLFKIKCHHKKIIWFLHNKQPHVM
                     KHRWSKKLLIHLLLRKADLIVTHATEGIKVVQNQYPKAVAKTVFLHHPTKNRIEEYIPQ
                     PPETDLLIWGNISRYKGVPEFVRFATQHSLKLKTKIIGKCSSQELLEELRKESNEMISI
                     EDRSIPFEELKQEIRRSRFVLVPYAAESILSSGILMDSLSFGAKVIGPAVGSFRDYATE
                     PLLNVYTFHTFDDIQELVDKANEATDIAGYNRFLNAHSWNEFGKKFQNLLQKIIQ"
     gene            3657..4856
                     /locus_tag="BF_RS21520"
                     /old_locus_tag="BF4507"
     CDS             3657..4856
                     /locus_tag="BF_RS21520"
                     /old_locus_tag="BF4507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005811820.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="WP_005814093.1"
                     /translation="MKVLYTFGGMPHYLNAMLNKLHNKGVEITVITPQKGNATIGKGVK
                     MVEGGTYRHLTAIEKKAFYGKSAYPSLPEIVREEKPDILIMGWPYFLQVFFQPRLRKAM
                     KECRTRLVIREIPFQTPPYGKIKEYFHENPMYDENMRLVSTGTGFYLKQWLTAKIRKYC
                     YARITGTLNYSTAAYDILPSYGVKQEQIHVTYNSTDTDALLKEKEAVLTSPPLLPPSSK
                     RALHIGRLVKWKRVDLLIDAFTKVIASHPDAELVVVGDGPELDNLKKQAADLNLTEQVR
                     FIGAVYSPKELGAYMNESTVYVLAGMGGLSINDAMTYGLPVVCSVCDSTERDLVTDGVN
                     GLFFKEGNADSLSDKLNKLFASPERCASMGRESERIIREKINIETVSERYLQAFRTFMQ
                     "
     gene            4925..5572
                     /locus_tag="BF_RS21525"
                     /old_locus_tag="BF4508"
     CDS             4925..5572
                     /locus_tag="BF_RS21525"
                     /old_locus_tag="BF4508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005797199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_005791920.1"
                     /translation="MTDLTILIAVIALALWPIVFLISRILHERNKRAKPSGDTASAETE
                     EVTEEMTTSALIMSILQQLGCQPEVNEENHISFKYQGDDFLVAAEDGLRLIIVWNPWWA
                     SISIDNQALPYLKEIINAVNMNSLVTTVYALDEDEKTFGIHSKCHMLFAPEEEEPEKSF
                     TDLLDSFFTTHNTIKENLKQLGNGMPDMEKKERVRIKGFAAYKDNSTELKGE"
     gene            complement(5624..6754)
                     /gene="wecB"
                     /locus_tag="BF_RS21530"
                     /old_locus_tag="BF4509"
     CDS             complement(5624..6754)
                     /gene="wecB"
                     /locus_tag="BF_RS21530"
                     /old_locus_tag="BF4509"
                     /EC_number="5.1.3.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005791919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine 2-epimerase
                     (non-hydrolyzing)"
                     /protein_id="WP_005791919.1"
                     /translation="MKKILLVFGTRPEAIKMAPLVKALQRDTEHFETKVCVTAQHRQML
                     DQVLEVFDIIPDYDLNIMAPNQDLYDITTKVLLGLRDVLKDFCPDTVLVHGDTTTSMAA
                     SLAAFYRQVAVGHVEAGLRTYDMLSPWPEEMNRQVTDRICTYYFAPTGKSKQNLLQENI
                     DAKKIFVTGNTVIDALLMAVDIISKKPGIKEKLHQELRDKGYEVGQREYILVTGHRREN
                     FGEGFLHICKAIRELAALHPEMDIVYPVHLNPNVQKPVYELLSGVDNVYLISPLDYLPF
                     IYAMQHSTLLLTDSGGVQEEAPSLGKPVLVMRNTTERPEAVEAGTVKLVGTDAEAIVSN
                     VTELLRNKELYRRMSETHNPYGDGHACERILSALTR"
     gene            complement(6809..8011)
                     /gene="wecC"
                     /locus_tag="BF_RS21535"
                     /old_locus_tag="BF4510"
     CDS             complement(6809..8011)
                     /gene="wecC"
                     /locus_tag="BF_RS21535"
                     /old_locus_tag="BF4510"
                     /EC_number="1.1.1.336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005791918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetyl-D-mannosamine dehydrogenase"
                     /protein_id="WP_005791918.1"
                     /translation="MKKVVFLGLGYIGLPTAAVAAGHGYEVVGVDVNPSVVETINQGKI
                     HIVEPELDQIVKEVVRTGNLRAVSKPEQADAFFVVVPTPFKQNHRADITYVESATRSVI
                     PYLREGNLFVIESTSPVFTTERMAEVIYKERPELKDKIYIAYCPERVLPGNTLYELVHN
                     DRVIGGVNPESTAKAIEFYSAFVQGKLHPTNARTAEMCKLTENSSRDSQIAFANELSMI
                     CDKAGINVWELIELANKHPRVNILQPGCGVGGHCIAVDPWFIVSDYPEQAQIIKRARET
                     NDYKADWCANKVMEACQQFVEKNDREPVVACMGLAFKPNIDDLRESPAKYIASRIVSES
                     RAEVLIVEPNVASHASFHLTDYREAYQKADIVVWLVRHTPFVELPREESKLELDFCGVR
                     K"
     gene            8113..9378
                     /locus_tag="BF_RS21540"
                     /old_locus_tag="BF4511"
     CDS             8113..9378
                     /locus_tag="BF_RS21540"
                     /old_locus_tag="BF4511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008662500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT4"
                     /protein_id="WP_011203722.1"
                     /translation="MRVLIINTSERLGGAAVAASRLMESLKNNGIKAKMLVRDKQTDQI
                     SVVGLQRNWWQVWRFVWERIVIWKANRFKKNNLFAVDIANTGTDITSLPEFQQADVIHL
                     HWVNQGMLSLNDIRKILKSGKPVVWTMHDMWPCTGICHYARECTNYHQECNHCPYLYGG
                     GSKKDLSNRIFRKKQQLYKEAPITFVTCSQWLKGQAEKSALLTGETVISIPNPINTNLF
                     KPRNKKEARSKCHLPQNGKLILFGSVKITDKRKGIDYLIESCKLLAEKHPELKDSLSVV
                     VFGKQSEQLKPLLPFKVYPLNYVSNEHELVDVYNAVDLFVTPSLEDNLPNTIMEAMACG
                     VPCIGFNVGGIPEMIDHLHNGYVAQYKSSEDFANGIYWALTDPDYPSLSEQANRKVIAN
                     YSEGIIAKRYIDVYNKITGRYA"
     gene            9371..10144
                     /locus_tag="BF_RS21545"
                     /old_locus_tag="BF4512"
     CDS             9371..10144
                     /locus_tag="BF_RS21545"
                     /old_locus_tag="BF4512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010993801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT2_Glycos_transf_2|GT2"
                     /protein_id="WP_011203723.1"
                     /translation="MHSHPSPKFSVITVTYNAEKVLEDTVQSVISQTYHHVEYIIIDGA
                     SKDGTLEIVNRYRDRINQLVSEPDKGLYDAMNKGIALATGDYLCFLNAGDSFHEDDTLQ
                     KIVHSINGNELPDILYGETALVDAERHFLRMRRLSAPETLNWKSFKQGMLVCHQAFFPR
                     HTLIEPYDLQYRFSADFDWCIRIMKKARTFHNTHLILIDYLAEGMTTQNHKASLLERFR
                     IMTRHYGLLSTLAHHAWFVVRSFSRNSATPSDAPF"
     gene            complement(10078..>10144)
                     /locus_tag="BF_RS21550"
                     /old_locus_tag="BF4513"
     CDS             complement(10078..>10144)
                     /locus_tag="BF_RS21550"
                     /old_locus_tag="BF4513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005814086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="NAD-dependent deacylase"
                     /protein_id="WP_005791915.1"
                     /translation="MKNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARD
                     PELVTHFYNERRKQLLEVEPNRGHELLAELEKDFQVTIVTQNIDNLHERAGSSHIIHLH
                     GELTKVCSSRDPNNPHYIKELKPEEFEVKIGDLAGDGSQLRPFIVWFGESVPEIETAID
                     WVEKADVFVIIGTSMNVYPAAGLLNYVPRNAEIYLIDPKPVDVHSSRPIHVIQKGASEG
                     VAELREKLLTTNHA"
ORIGIN
        1 atggcagaac agtcgctaaa agaaaaaaca gccaaaggat tattctgggg tggattcagc
       61 aatggcatcc agcaattact gaacctgctg ttcggaatta tcatcacccg tatgctggat
      121 tcgacagact acggtatgat tggtatgctg gctatattta ccgccgtagc caactctata
      181 caagagagcg gatttacggc cgctttggcc aataagcaga cgttccgtca tgaagactac
      241 aatgcggtgt tctggttcag ttttctaatg ggtgcatcgc tttacctgct gctctttttt
      301 tgtgccccgt ttatcgcagc attctataag actccacagc ttattcctct atcccgcttc
      361 cttttcctgg gttttctgat ttcaagttgc ggaactgccc ataatgcggt attatttaaa
      421 aaactaatgg tgaaagaaaa agcgaaagca accattaccg cactattgtg ttcaggcacc
      481 ataggaattg tcatggcata caatggaatg gctttctggg ggctggccgt acagcaaatc
      541 acctatattt tcatcgctaa tgcgctgtta tggtactttt ctccgtggcg tcctactttt
      601 tcgttcaatt tcaaacctat cagggagatg cttccgttca gcagtaaact gcttatcacc
      661 aatgtatttc attacatcaa tgataacata ttttctgttc tgctggggcg cttttatacc
      721 agtcaggatg taggttacta tactcaggcc aataaatgga ccaatatggg cttctcactg
      781 atcagtaaca tgatcaacgg agtatctcag cctgtcctgg tcgaaacctc ttccgacgcc
      841 atgcgacaga aaaatatatt tcggaagatg ttgcgcttca ccgcctttat ctctttcccg
      901 gccatgttcg gactggcatt gatagccaac gagttcatcg taattgccgt caccgccaaa
      961 tggcaggcat gtgtacccat catgcagatt ctttgcatct ggggagcatt tgtccccatt
     1021 acttatatgt actccaatct cctgatcagt aaaggaaagt cgaatctttt tatgtggaat
     1081 accattgcac agagcctggt tcaactcaca atgcttcttt gtactatctc acaaggcata
     1141 ctcgtcatgg ccgtgattta tacggttatc aacatcggtt ggctgctgat atggcattat
     1201 ttcgtaaaca agcagattca catcacccta tgggaagtca tgaaagatat cactccgtac
     1261 ctactgatct ccggaggagt cataggaacc agctatttcc tcacgatcgg cttccataac
     1321 ctatatgtat tgctgattct taaaatagga atagccgtaa gcctttatgt gttcatcatg
     1381 tggatcggca aatcggtgat cttttttgaa agtgtacaat ttatccggaa aaaactcttg
     1441 aaataagtca tgaacatcct gatccaacaa accaaagcat ttcctcatcg tgccaatagc
     1501 ttttattggt tctatgcgca actgaccgaa tggctgactg cacacggagt ggacagtaag
     1561 ctttactttt cgtacctgga actggctgac agcgaatttg agaacggcct cctgttgccc
     1621 gatcattatt ctcaattcta tactccccgc aacatcgaag caatctgtcg cttcattatc
     1681 gacaaacaga tagacgtgat tctcgattac tcccatgtca tcaccggaga tacacgcaaa
     1741 tattacctcg aaatcaaaaa aagaaatccc ggaatcaaaa tatgcacgat gatccacaac
     1801 tgtcccagcc atacgacaca gttaaaacaa tacgagttat ctacactccg gttcaaagac
     1861 gtgcatggac ccaagaaact ttttcagtgg atgctaccac aactctacat cagcttatta
     1921 aaaaaagtgg tcagccatca aaaccgttcg gcatacgaca cgctcgacga agtggtactg
     1981 ctgtcacccg cttatatacc cgaattcaag aaacttatag gcaaaaaaga cgcatggaag
     2041 ttatctgcca tccctaatgc cataaaacct gtgcatagta acatcccgat tgaggagaag
     2101 gacaaagaaa tcatctttgt tggcagaatg gcaaccgaaa aggcattacc caaattacta
     2161 aagatatggg gtatggttca ggataaactg ccggactgga aactcaccct tgtaggagat
     2221 ggtccccaat tcggcacgtg ccggcaaatt attgccgaga aaaaattgaa acgggtctgc
     2281 ctgaccggcc atcagatgtc gatcccctat atagaccgtg cccggattct ttgtctgact
     2341 tccgtcatag aaggactacc caccgtattt acagaagcaa tgtcactggg ggtgattcct
     2401 atcggattcg attctttcaa tgcgatctat gacatgatag atgacggcat agacggattc
     2461 attattcccg acaacaatta tgaacaatat gcagaaacca ttctacggtt ggcacaagat
     2521 gacacactcc gctgccagat agcctacaaa gcttaaaagc ggaaaaacag atatgacata
     2581 gaacaggtag gaccactgtg gatggaaact ttccgtaaac atggattaat taaataggag
     2641 aacacaatga aggtcacgat atatccatac tctatcaaca aaggtgatat atgcgttaat
     2701 ccgtatatca gcgatttcat ccatgcactg caacagaacg gaatcacaat agccaatccc
     2761 ccacacaaga atccgttatt cagcctcatc ccaagaaaag cagatagcga tgcttatatc
     2821 tttcattggc cggagaatgt acccgactac aaatatggaa tgttgcagac tcttgctgct
     2881 atctggcttc ttttcaaaat taaatgccac cataagaaga tcatctggtt cttgcacaat
     2941 aagcagcccc atgtgatgaa acaccgatgg tcgaaaaagt tattgataca tctgctcctc
     3001 cgcaaagccg atttgatagt gacacatgct acagaaggta tcaaagtggt tcagaatcaa
     3061 tatccgaagg ctgtagccaa aacggtattc ttgcatcacc ctactaaaaa ccggatagaa
     3121 gaatacatcc cccaaccacc ggaaaccgac ctgctgatct ggggaaatat ctcccgatac
     3181 aaaggggtac cggaattcgt acgttttgct actcagcatt cattaaaact gaagactaaa
     3241 atcatcggga aatgcagttc gcaggaactc ctggaagaac tacgcaaaga aagtaatgag
     3301 atgatcagca tagaggaccg tagtattcct ttcgaagagc taaaacaaga gatccgcaga
     3361 tcacgtttcg tactggtacc ttatgctgcc gagtctatct taagttccgg catactgatg
     3421 gactctctct cattcggagc caaagtcatc ggaccggctg taggctcttt cagggactac
     3481 gccaccgaac ccttgcttaa cgtatatact ttccatacgt tcgatgatat acaggaactc
     3541 gttgacaagg caaacgaagc aacagatata gccggttaca accggttcct caatgcacat
     3601 agctggaacg aattcggcaa aaagtttcaa aatttacttc agaaaataat acagtaatga
     3661 aagtactcta tacattcggc ggcatgcccc attatctgaa tgccatgctc aacaaacttc
     3721 ataacaaagg agtggaaatc accgttatca ctcctcaaaa aggaaatgcc actatcggta
     3781 aaggtgtaaa aatggtagag ggaggaacat acaggcacct caccgccatt gagaagaaag
     3841 cattctacgg aaaaagcgcc tatccctccc taccggaaat agtacgtgaa gagaaaccgg
     3901 atattctgat aatgggatgg ccctatttcc tgcaagtgtt ctttcaaccc cgattgagaa
     3961 aggctatgaa agagtgccgg acacggttgg ttatccgtga aattcccttc cagacccctc
     4021 cctacgggaa aataaaagaa tatttccatg aaaacccgat gtatgatgaa aacatgcgac
     4081 tggtcagtac cggaaccggc ttttatctta aacaatggct gacagcgaaa atacgtaaat
     4141 actgctacgc acgcattacc ggaacgctga attactcgac cgctgcatac gatattcttc
     4201 cttcctatgg agtgaagcag gagcaaatac atgtcactta caactctacg gacacagatg
     4261 ccttactgaa ggagaaagaa gccgtactca cctcgccccc gcttcttcct ccttcctcca
     4321 aaagagcgct acacatcggc cgattagtga aatggaaaag ggtggatctg ctgatcgatg
     4381 catttacaaa ggttattgcc agtcatccgg acgcggaact ggtagtggta ggcgatggac
     4441 cggagctgga taatctgaaa aaacaggcag ccgacctgaa tctgacagaa caggttcgat
     4501 tcatcggtgc agtatacagt cccaaagaac tgggagccta tatgaatgaa tcgactgtct
     4561 atgtactcgc gggcatggga ggattatcca tcaatgatgc catgacctac ggactgcccg
     4621 tggtttgttc ggtatgtgac agcaccgaac gtgacctggt gacggacgga gtgaacggac
     4681 ttttcttcaa agaaggcaat gccgacagct tgagtgacaa gctcaacaaa ctgtttgcct
     4741 ctcccgaacg ttgtgcctct atgggacgtg agtcggaacg aatcatccgc gagaaaatca
     4801 acattgaaac ggtcagcgaa cgttatttgc aagctttccg aacttttatg cagtaaaaat
     4861 ggagtacgac caaaaagaat gattatcttt aggcagacat taatcattta atagctctac
     4921 tactatgacc gatcttacca ttctcatcgc agtcatcgca ttggcgttat ggccaattgt
     4981 attcctgata tcacgtatcc tgcacgagcg gaacaaacgt gcgaagccat cgggtgacac
     5041 tgcctctgcc gaaacggaag aagtgacaga ggaaatgact acctccgcac tgatcatgag
     5101 catccttcaa cagctcggtt gccaaccgga agtgaatgaa gaaaatcata tcagcttcaa
     5161 gtatcaggga gacgatttcc ttgtcgcagc cgaagacggt ctccggttaa tcattgtatg
     5221 gaatccttgg tgggcgtcca tcagtatcga caatcaggca ttaccctatc tgaaagaaat
     5281 tatcaatgca gtcaatatga actcattagt gaccactgtc tatgcgctgg acgaggatga
     5341 aaaaacattt ggtatccaca gtaaatgcca tatgctcttt gctcccgaag aagaggagcc
     5401 ggaaaaaagt ttcaccgacc tgctggacag ttttttcact acccacaata ctattaaaga
     5461 aaacctgaaa caattgggta acggaatgcc ggatatggaa aagaaagaac gagtaagaat
     5521 caaaggattt gctgcctaca aggacaacag cacggaactg aaaggggaat gaacttcccc
     5581 tcttcctctt gcccgtacag cctataaacg aatcatgtga gctttaacgg gttaatgccg
     5641 acaggatgcg ttcacaagca tgcccgtcac cataaggatt atgtgtttcg gacatacgac
     5701 ggtataactc cttattacgg agcagctcag tcacattact gacaatcgcc tcagcatccg
     5761 tccccaccag ttttacagtt cccgcctcta ctgcttcagg acgttccgtg gtatttcgca
     5821 tcaccaacac cggcttgcca agtgaaggag cctcctcttg tactccaccg ctatcggtca
     5881 gcagcaaagt ggagtgctgc atagcgtaaa taaacggcag ataatccaac ggcgaaataa
     5941 gatatacatt gtctactcct gacagaagtt cgtatacggg tttctgtaca ttcgggttca
     6001 gatgtaccgg atatacaata tccatctcgg gatgcaacgc ggctaattct ctaatcgctt
     6061 tacaaatatg taaaaatcct tccccaaagt tctcacgacg atgcccggta accagaatat
     6121 attcacgttg tcccacttcg taacctttgt cacgaagttc ctgatgcaac ttttctttga
     6181 ttcccggctt cttcgaaata atgtcaacag ccatcaacaa agcatcgata accgtattac
     6241 cggtaacaaa tatcttcttt gcgtcgatgt tttcctgtaa cagattctgt ttcgatttcc
     6301 cggtaggagc aaaatagtag gtacaaatac ggtcggtcac ctgacgattc atctcttccg
     6361 gccagggaga cagcatatca taggtacgca aaccggcctc aacatgtccc acggcaacct
     6421 gccgatagaa tgcagccagt gaagcggcca tcgacgtagt ggtatctccg tgtaccagca
     6481 ccgtatccgg acagaaatct ttcagcacat cgcgcaggcc cagaagaact ttagtggtga
     6541 tgtcgtacaa gtcctggttg ggtgccataa tattcagatc gtagtcagga atgatgtcga
     6601 acacttcaag tacctggtcc aacatctgac gatgttgtgc cgtcacacac actttcgttt
     6661 caaagtgttc agtatctctt tgcaaggctt tcaccaacgg ggccatctta atggcctcag
     6721 gacgggtacc gaaaacaagt aatatctttt tcattatacg atcagactat ttacgatggt
     6781 tcattaagac gatatgccag ttctctttct actttcttac tccgcagaag tccaactcca
     6841 atttactttc ttcacggggc aactccacaa acggagtgtg acgtaccagc cataccacga
     6901 tatccgcttt ctgataagcc tcccgatagt cagtcagatg gaaactggca tgtgaagcga
     6961 cattgggttc tacaatcagc acctctgcac gcgactcaga tacaatgcgg gaagcaatat
     7021 atttagcagg agattcacgc aaatcatcaa tattgggttt aaaggcaagt cccatgcaag
     7081 ccactaccgg ttcacgatcg ttcttctcga caaattgctg acaagcttcc attactttgt
     7141 tggcacacca atcagcttta taatcgttcg tctcacgggc acgtttgatg atttgtgcct
     7201 gttcgggata gtccgaaaca ataaaccagg gatctacggc tatacagtgt cctcccactc
     7261 cgcagccggg ttgcaggatg ttcacacgcg gatgtttgtt agccaattct atcagttccc
     7321 agacgttgat acccgctttg tcacaaatca tggacaattc gttggcaaac gcaatctgag
     7381 agtcgcgcga agagttctcg gtcaacttac acatttctgc cgtacgagca ttcgtcgggt
     7441 ggagtttacc ctgtacaaag gcagaataaa actctatggc tttagcggtc gactcgggat
     7501 tgacgccacc gatcacccga tcgttatgaa ctagttcata aagcgtatta cccggcaata
     7561 cacgttcggg acaataggct atgtatattt tgtctttcag ttccgggcgc tctttataaa
     7621 tgacttcagc catacgttcg gtcgtaaata ccggtgaagt ggactcgata acaaacaggt
     7681 ttccttctct cagataagga attacggagc gggtagccga ttccacatag gtgatatctg
     7741 cacggtggtt ttgtttgaaa ggggtaggta ctaccacaaa aaaagcatct gcctgctcag
     7801 gtttcgaaac ggcacggaga ttacctgttc gcaccacctc ttttacaatc tgatccagtt
     7861 ccggctccac aatatgtatt ttaccctgat tgatggtttc tacgaccgaa ggattaacat
     7921 ccacacctac aacttcataa ccatgtccgg cggccacggc agcagtagga agtccgatat
     7981 agcctaatcc taaaaaaaca acctttttca tacgtatatc tccttaataa gtgccgcaaa
     8041 agtacaaata atatgtgact ttgtacggtt tctcaccgaa aaccactact tttgccaaaa
     8101 catttcgatc gaatgagagt tttaataatc aatacttccg aacgtttggg cggagcggcc
     8161 gtcgcagcaa gccgcttgat ggaatcgttg aaaaacaacg gtatcaaagc caaaatgttg
     8221 gtgcgcgaca agcaaaccga ccagatcagc gtagtaggtc tgcaacgtaa ctggtggcaa
     8281 gtatggaggt ttgtgtggga acgcattgtc atctggaaag ccaaccgctt taagaagaac
     8341 aatcttttcg cagtcgatat agctaataca ggcacagaca ttacaagcct gccggagttt
     8401 cagcaggcag atgtcatcca cctgcattgg gtgaatcagg gaatgttgtc actgaacgat
     8461 atccggaaga ttctgaaatc cggtaaaccg gtagtgtgga ccatgcacga tatgtggcct
     8521 tgcacaggca tctgccatta cgcccgtgag tgtaccaact accatcagga gtgtaaccac
     8581 tgtccatacc tgtatggagg gggaagcaag aaagatctgt ccaaccgtat cttccgtaaa
     8641 aaacaacaac tctacaaaga agcacccatt accttcgtca cttgtagcca atggctgaag
     8701 ggacaagccg aaaagagtgc tttgctgaca ggagaaacgg taatcagtat acccaacccc
     8761 attaacacca atctatttaa acccagaaac aagaaagaag cacgcagcaa atgccattta
     8821 ccccaaaacg gaaaactgat tcttttcggt tcagtcaaaa tcacggataa gcggaaaggc
     8881 atcgattatc tgattgaatc gtgtaaatta ctggctgaga agcatcctga actgaaagat
     8941 tctctaagtg tagtcgtttt tggcaagcaa tcggaacaac tcaagccgtt gcttcctttt
     9001 aaagtatatc ctctcaacta cgtgagtaac gagcatgaac tggtagatgt ttacaatgcg
     9061 gtcgaccttt tcgttactcc ctcactggaa gataacctgc ccaataccat catggaagct
     9121 atggcatgcg gagtgccttg tatcggcttc aatgtcggcg gcatcccgga aatgatagac
     9181 catctgcaca acgggtatgt ggcacaatac aaatcatccg aagattttgc caacggcatc
     9241 tattgggcac tgaccgaccc ggattatccg tctctctcgg aacaggccaa ccgaaaagta
     9301 atcgccaact actcggaagg cattattgcc aaaagataca ttgatgtcta caataaaata
     9361 acaggaagat atgcatagcc accccagtcc caaattctcc gtgatcacag tgacctacaa
     9421 tgccgaaaag gtattggaag atactgtgca aagcgtaatt tcgcagacct atcatcatgt
     9481 agagtatatc atcatcgacg gtgcatcgaa agacgggact ttagagattg tcaaccgata
     9541 ccgcgaccgc atcaaccaat tggtgagcga accggacaaa ggactttatg acgcaatgaa
     9601 caaaggaatc gccctggcaa cgggcgacta tctctgcttt ctgaatgccg gagacagttt
     9661 ccacgaagac gacactttgc aaaagatagt tcactccatc aatggaaatg agttgcccga
     9721 catactgtat ggcgaaacag ccttagtgga tgccgagagg catttcctcc gtatgcgtcg
     9781 gttatcggca ccggagacac tgaactggaa aagtttcaag cagggaatgc ttgtgtgcca
     9841 tcaggctttt ttcccccgcc atacacttat cgagccttat gatctgcaat atcgtttctc
     9901 ggcggatttc gattggtgta tccgcatcat gaaaaaagca cgtacttttc acaatactca
     9961 ccttatcctg attgattatc tggcagaagg catgacgaca caaaatcata aggcatcgct
    10021 tttggaacga ttccgcatca tgacccgcca ctatggcctg ctaagtaccc tcgcacatca
    10081 cgcatggttt gtggtaagaa gtttctcccg caactcagct actccttccg atgcaccctt
    10141 ctga
//
