LOCUS       CP012801               15993 bp    DNA     linear   BCT 16-OCT-2015
DEFINITION  Bacteroides cellulosilyticus strain WH2, complete genome.
ACCESSION   CP012801
VERSION     CP012801.1
DBLINK      BioProject: PRJNA289334
            BioSample: SAMN03852682
KEYWORDS    .
SOURCE      Bacteroides cellulosilyticus
  ORGANISM  Bacteroides cellulosilyticus
            Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
            Bacteroides.
REFERENCE   1  (bases 1 to 15993)
  AUTHORS   Wu,M., McNulty,N.P., Rodionov,D.A., Khoroshkin,M.S., Griffin,N.W.,
            Cheng,J., Latreille,P., Kerstetter,R.A., Terrapon,N., Henrissat,B.,
            Osterman,A.L. and Gordon,J.I.
  TITLE     Genetic determinants of in vivo fitness and diet responsiveness in
            multiple human gut Bacteroides
  JOURNAL   Science 350 (6256), AAC5992 (2015)
   PUBMED   26430127
REFERENCE   2  (bases 1 to 15993)
  AUTHORS   McNulty,N.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2015) Center for Genome Sciences and Systems
            Biology, Washington University School of Medicine, 4444 Forest Park
            Ave., Saint Louis, MO 63108, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method       :: HGAP 2.0 and Celera v. AUG-2014
            Assembly Name         :: B_cell_WH2_2.0
            Long Assembly Name    :: Bacteroides cellulosilyticus WH2 2.0
            Genome Coverage       :: 209x
            Sequencing Technology :: PacBio; Illumina MiSeq
            ##Genome-Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..15993
                     /organism="Bacteroides cellulosilyticus"
                     /mol_type="genomic DNA"
                     /strain="WH2"
                     /isolation_source="stool sample"
                     /host="Homo sapiens"
                     /db_xref="taxon:246787"
     gene            1..909
                     /gene="rbsK_2"
                     /locus_tag="BcellWH2_02691"
     CDS             1..909
                     /gene="rbsK_2"
                     /locus_tag="BcellWH2_02691"
                     /EC_number="2.7.1.15"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P0A9J6"
                     /codon_start=1
                     /transl_table=11
                     /product="STP|PfkB"
                     /protein_id="ALJ59930.1"
                     /translation="MSKNIIVIGSCNTDMVIKADRLPVPGETIIGGSFMMNPGGKGANQ
                     AVAAARLKGNVHFIAKTGNDLFGKRSIEQYEDEGIHVENIYSDLTLPSGVALIMVDMNG
                     ENSIAIASGANGSLSPEDIRKAQPTIEKGDILLMQLEIPIETVEYAAQIASEQGIKVIL
                     NPAPARALSNKLLQNLYMIIPNETEAEILSGIKVTDWESARRAADIISAKGVDIVVITL
                     GSKGALIKEKDTFHEVPVPKVKAVDTTAAGDTFCGALCVALSEDVDVLNAVKFANKCAS
                     ITVTRMGAQPSLPYRKEIDVL"
     gene            934..1938
                     /locus_tag="BcellWH2_02692"
     CDS             934..1938
                     /locus_tag="BcellWH2_02692"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="protein motif:Pfam:PF07168.5"
                     /codon_start=1
                     /transl_table=11
                     /product="Fatty acid elongase 3-ketoacyl-CoA synthase 1"
                     /protein_id="ALJ59931.1"
                     /translation="MFIVDSYSLAVIFCVVTMLCWGSWGNTQKLAGKTWRYELFYWDYV
                     IGILAFSLLLGFTLGSTGDAGRGFVEDLKQISMENYASAFAGGVIFNLSNILLSASVSM
                     AGLTVAFPLGVGIALVLGVFVNYFGEPKGDAVILFSGVALVVLAIIFNAIAAGKMNQKG
                     SSINKKGIIIAIIAGVLMSFFYRFVAAAMDLNNFESPTPTMATPYSAFFIFAIGIFISN
                     FIINTIVMKKPFVGTPVSYKEYFQGKFSTHMVGVLGGAIWGLGTALSYIAAGKAGAAIS
                     YALGQGAPMIAALWGIFIWKEFKGSSRAVNILLACMFVLFISGLGAIIISGAN"
     gene            2057..3517
                     /locus_tag="BcellWH2_02693"
     CDS             2057..3517
                     /locus_tag="BcellWH2_02693"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="ALJ59932.1"
                     /translation="MRVINILLYCFLLTILACSNTNEPERPPAVHPQKLIVEGKPFLML
                     GAQLRTDYFLQLDKKTLNELEPYFELAANMNILVIQVPVGWRDIEVQKDIYNTELVEKY
                     IELCDKYQMKLEILWFGSYMCGYSVEGYIPEYIVNDPVTYPDLKPDAAFDGWLGKHYYL
                     KPNTPALVERESKALGKMMEAIYNYDNIHNQKHTVIGIQIENEPDMLATRHNEAHGYTP
                     EQIWPDLIIMLDKLGQVVKSSPYDCYTRVNQTTTYPEYLTKSTAIAITEGIDYVGVDPY
                     ENSIQAIDGKLRQLRKIEGNYAHIAENGGEYANNDLLALKAFSLGCGYEIFEVITTPHP
                     FLTEWTLRGIYNPDFTPKAHTQQIVDAFKIFKEAWVDLANANYLDIAGFNLKSNDGMEQ
                     TSESKNTTHAGIKWSTKSRGVAFAIEYNDHLTVASTKSDEMVFRNIQIKSIEKGHYDID
                     GNWVSEEKAEAPDNRLAMEPCIVYRIKF"
     gene            3536..4762
                     /locus_tag="BcellWH2_02694"
     CDS             3536..4762
                     /locus_tag="BcellWH2_02694"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="protein motif:Pfam:PF13004.1"
                     /note="Bacteroidetes-Associated Carbohydrate-binding Often
                     N-terminal"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="ALJ59933.1"
                     /translation="MKRNLFITGIACTILFLTGCKDDDSPNLRIEAESNIQVECKKDTI
                     NIPVFCNMPSKATITYDSPDKSGWIFLLPSVLNGDGIFTLWIDEYSNVLEDRTATFLVT
                     AGDETKEIHITQLAKPSLATEPANIAPISNNAGDYQVKVLCKGTWQATVNREAASWCTL
                     KNDTGEGVGNITIHLSEVSDNEMRMATITVSSGNLSSDITIQQGFGIEINGLIWAKSDV
                     AQPGYFTASPDTKGLLYQYDSAIGYPNTSPKEDNNKPNGFRTGAYDDGIPSWRAEKNPC
                     PEGWRIPEYEEIQRLTGNSGNPYFIWAEPTNSHFLVPGAIVGIPREEAALANKDNMRGA
                     IFWPQSGFRDRDSGAQIIWWPANITSITRPGQTWDRYICWIGADNSISNNEFAGNAAAY
                     PVRCVANKK"
     gene            4812..8075
                     /locus_tag="BcellWH2_02695"
     CDS             4812..8075
                     /locus_tag="BcellWH2_02695"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="protein motif:Pfam:PF00593.18"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q45780|1.B.14.6.1"
                     /protein_id="ALJ59934.1"
                     /translation="MKDYSKHYFRLLQGMALSVSDYIRNQKPIVIIVFLLVHSISIYAQ
                     DNTISGLVKDNEGEPLPGVSVAVKAGESISGVVTDINGKYQLKASPNATIEFSFIGFKS
                     IQQQVGNRKVINVTLEIDNQMLEEVVVVGYGTQKKVNLTGSVSVIDSKAFESVPVANAV
                     QALQGQVPGLNIYSNKGGGLNQKQSINVRGIGTIGEGSTGDALILIDGMEADIFSVNPQ
                     DIESISVLKDAAASSIYGSRAPFGVVLVTTKKGKAGKAQINYNNSFRLSSPINMPSSLD
                     SYTYALFFNDAGYNSGWGSYNWVSQTRLQRIKDYMDGKISYTTIPLNGSNTWADGYQEG
                     NDNIDYYNLFFKKNVFAHEHNFSVNGGTDKIQYYLSANYLDQDGTLRMGEDYSKRYTMS
                     AKISAQLSRAVSLSSNTRFVRNDFVQPTHMNDSFFSDIGRQCWPVKPLYDPNGNLFDDH
                     VQQMKNGGRKTERNTWLYQQFNLTIEPIKGWRLIGDLSYRYNTQYAHEDLLTISQIGVD
                     GVTKVRSWDENSSVSESSFASDYFNVNLYTDFEKTFAKSHHLKALAGFQAEANNYRNIW
                     AQKIGITYPGKPTINTSTGIDKDGKVIAPNVSGGHNRWSTAGFFGRVNYDFQEKYLVEA
                     NLRYDGSSRFRSDDRWGFFPSASLGWNIAREEFFQPATRIMNTLKLRASYGSLGNQNTT
                     ALYPTYTVMGTGTSDKWLMNGVKPNIAWAPALVSYDLTWEKIRTWNVGIDIGLFNNRLT
                     GSFDYFIRNTNDMVGPSEKLPATLGIAVPPSNNTDLRTAGWELELMWKDRLQNGLNYSL
                     RFTLADSRTKITRYSNPSGLIDSFYEGKYCGEIWGYETIGIARTDDEMAEHVGSLVNGG
                     QSALGQDWQAGDIMYSDLNEDGKIDAGARTLDNHGDLKRIGNSTPRYNVGIDLSADWKG
                     FDFRMFWQGTLKRDYFQGSYYFWGANGSQGYWFSTALKGHEDYFRNDESSPLGVNLDSY
                     YPRPLLNTNKNQQCQTKYLQNAAYMRLKNLQIGYTLPRKIVQKMGVQNLRFFASGENLL
                     TITDLVKFFDPETIESGSFAHGYAYPLSRTYAFGLNITF"
     gene            8124..10130
                     /locus_tag="BcellWH2_02696"
     CDS             8124..10130
                     /locus_tag="BcellWH2_02696"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="protein motif:Pfam:PF07980.5"
                     /codon_start=1
                     /transl_table=11
                     /product="SusD family protein"
                     /protein_id="ALJ59935.1"
                     /translation="MKNHLIYTLSGMLFLLTSCDAFLNQEPLDQLAPDEYMTTETNVAS
                     YANDQYQMLPTHGTYGYGTFESDQHTDNMAAMQPSTLYAPGYWRVGQSDGTWYFGNIYR
                     CNYFLENVLPAYEANTITGNRENIRHYIGEIYFFRAFDYFERLRTVGDFPIITKTYPNE
                     SGILTEISKRSPRNEVARFILSDLNTAIEMLKEQSPDGTKNRVTRDCAILLKSRVALYE
                     ASWLKNFKGTAFVPGGPGWAGANKEYNAGYTFPSGSIDNEINFFFDEAIAASQIIADKH
                     TLTTNTGYFAQNPEDTENPYFSMFCSTDMDKYDEVLLWKRYDWAQGVANEVCEYACTGN
                     HGVGTTKSMVDAFILKNGEPIYASPMWADENNSYWGDNNMEHITKNRDTRADIFIKKPG
                     QRNLHTPPQGTVAAGREYETKPDITAATVTDKYNTGYAIRKGLNPDGKYTANTQSNVGS
                     IVFRAAEAYLNYIEAYYERYGTLNDVAEEYWRTIRRRAGVNEDFQKTIRLTDMAKEAET
                     DWGAYSAGQVIDATRYNIRRERRCELMAEGLRSMDLHRWRAMDQMITKPYHILGMNLWQ
                     EMYNWDWYKDGSGNSILKEGENVSSRNFSTYLAPYHITANNIAYNGYRWHMAHYLDPIA
                     IEHFLVTSQGGDLNSSPIYQNPEWPMIGGGTPE"
     gene            10184..11806
                     /locus_tag="BcellWH2_02697"
     CDS             10184..11806
                     /locus_tag="BcellWH2_02697"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="protein motif:Pfam:PF01301.13"
                     /codon_start=1
                     /transl_table=11
                     /product="Glycosyl hydrolases family 35"
                     /protein_id="ALJ59936.1"
                     /translation="MYKKAILLAYTLACFSFLAIACADSEVDETGKEPILPQIEVSKVA
                     TENGKTYLEVDGKPFPLLGAQIRLDALLNCDKMSINEVENYFKKAQELGVNCVQIPISW
                     NMIEAKEEKYDFNIVNSILQFANKYDLKIELLWFSTNMVGDSFTYLTPQYVLQNYHKRF
                     GRNDEGSFWNYYGYQYTMILDDSWVLERETKAITALFNHIRYWDSQNGDKHPVITAQIH
                     NEPDALMRWRIEQKDLKYRDGTPLSKEKAWNMTTNALNAVGNAVKNSSYKVATRVNLIY
                     GDGINPFPEANNACPKDVFDLQGIDFIGVDAYKDNIKQLKEQVSSYASINGNYALVAEN
                     KGSYSNTPSLILTALALGGGYDIYDLATSNFFINNTSEPDQIDHGIYTWDLQEKDFTNP
                     TRMIIKGLTDANVDVATVKPENFAAFNISDNHPIAVKQQQIRTTNVEITFSTNNASLAF
                     ALDKGSYLLVYSTGDSEFHFGNGTFEKVIYGKYNDKGTFVEEGNTVLNNQTLHAKGGVL
                     YKVTYSSQQPLISNTIENIGNNL"
     gene            11811..14915
                     /gene="lacZ_14"
                     /locus_tag="BcellWH2_02698"
     CDS             11811..14915
                     /gene="lacZ_14"
                     /locus_tag="BcellWH2_02698"
                     /EC_number="3.2.1.23"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P81650"
                     /codon_start=1
                     /transl_table=11
                     /product="GH2"
                     /protein_id="ALJ59937.1"
                     /translation="MKRRLITGLLTVLAMTGNAQSFKEWTDPEVNAVNRAPMHANYFAY
                     ESADAAMQGRKECSSNFMTMNGTWKFFWVRNADSRPTDFWRYDFNDKGWNDLQIPAVWE
                     LNGYGDPIYVNIGYAWRNQYQNNPPQVPTENNHVGSYRREFIIPASWQGKDIIAHFGSV
                     TSNIYLWVNGKYVGYSEDSKLEAEFDLTSYLKPGQKNLIAFQVFRWCDGTYLEDQDFFR
                     FSGVGRDCYLYARSKKRIQDIRITPDLDENYKNGSLNVSLSVKGSGNVDLKLLDATGKQ
                     VAMSTIKGSGNVVIHVENPYKWSAEIPYLYTLQATLQGSNEVIPIKTGFRKIEQKNGQI
                     LVNGQPILFKGVNRHEMDPDGGYVVSPERMLQDIQIMKRFNINAVRTCHYPDDNLWYDL
                     CDKYGIYVVAEANIESHGMGYDVKTLAKRDDYKEAHMERNQRNVQRNFNHPSIIFWSLG
                     NEAGFGPNFEAAYRWVKSEDISRPVQYEQAHGNDFTDVDCPMYADYNQMEKYAQRNDIQ
                     KPLIQCEYAHAMGNSLGGFKEYWDLIRKYPHLQGGFIWDFVDQSVRWKGKNGATIYAYG
                     GDFNRFDASDKNFCDNGLISPDRIPNPHMYEVGYFYQNIWTTPGDLIQGEINVYNEYFF
                     RDLSGYYLEWEVLADGEPVRTGRVTELNVAPQQTAKLKLNIGKICSDKECLLNITYRLK
                     NQENMLPAGYTVAKDQLILSPYKTPSMELKNAKTTNTVTVIPQIQDNDSHYLIVNGEAF
                     CLEFNKHTGYLNRYNVAGIEMMNQDTQLVPNFWRAPTDNDFGAGLQQKFAVWRNPGLKL
                     TSFKWETVNEQVILYAEYEMQHVSAKLNLTYIINNEGAIKVTQKMVTNPQAKIPPMFRF
                     GMQVQMPKAFETIEYYGRGPIENYSDRNHSTTIGLYRQSVNEQFYPYIRPQETGTKTDI
                     RWWKLLNAAGHGLQIVADAPFSASALHYTIKSLDDGIDKAQRHSPEVKQSDLTNLCIDK
                     IQMGLGCINSWGAWPLPQYQIPYGDYEFSFILSPVYHSYFNSTLQ"
     gene            14935..15993
                     /locus_tag="BcellWH2_02699"
     CDS             14935..15993
                     /locus_tag="BcellWH2_02699"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="protein motif:Pfam:PF01156.13"
                     /codon_start=1
                     /transl_table=11
                     /product="Inosine-uridine preferring nucleoside hydrolase"
                     /protein_id="ALJ59938.1"
                     /translation="MIKSKIYLLSAFLIALSSCTSSKKQQEVEITSNVDRIILETDIGN
                     DVDDALALDMLYKYLDTDKINLLGIMINKEGVYPAEFVDIMNTWYGYPKIPIGIIHNGI
                     DCENDAINYAKAVCLMQKENGEPTFKRSLQNYDELSEAPVMYRKILAQQPDSSVTIISV
                     GFSTNLARLLDTPADNISPLTGKELVAQKVKLLCTMGGCFDNSNPLEYNVVKDIPAAQK
                     VFAEWPTRLVTSPFEVGIKINYPASSIEKDFQWATTHPMVEAYKSYQKMPYDRPTWDLT
                     SVLYAVEGPSYFNISAPGHIVVTDEGATQFTSDDKGKQYYLTVDSIQADKIKKHFVELL
                     SRQPIHFNNKEE"
ORIGIN
        1 atgagcaaaa atattattgt aataggtagt tgtaatacag atatggtcat caaagctgac
       61 cgtcttcccg taccgggaga aacaatcata ggtggtagtt tcatgatgaa tcccggaggc
      121 aaaggagcca accaagctgt agctgctgcc agactaaagg ggaatgtaca cttcattgcc
      181 aaaaccggaa acgacctgtt cggcaaacgt tccatagaac aatatgaaga cgaaggaatc
      241 catgttgaaa atatctattc agatctcaca cttccttcag gtgtagcgct aattatggtg
      301 gatatgaatg gagaaaacag catcgccatc gcttccggag ccaatggttc attgagtccc
      361 gaagacatcc ggaaggcaca gcctaccatt gaaaaaggtg acatcttgtt gatgcaactg
      421 gaaattccca tagaaacagt ggaatatgcc gctcagatag ccagcgaaca gggtatcaaa
      481 gtaatcctga atccggcacc cgcccgggca ctctccaaca aattattgca gaacctgtat
      541 atgatcattc ccaatgaaac ggaagctgaa atactctcgg gaatcaaagt gaccgattgg
      601 gaaagcgccc gtagagccgc ggatattatc agtgccaaag gagtggatat cgtggttatc
      661 actcttggtt ccaaaggagc actgattaaa gagaaagata cattccatga agtgcccgta
      721 cccaaagtta aagccgtaga cactacagca gcgggagaca ctttctgcgg tgcattgtgc
      781 gtcgctttat ccgaagatgt agatgtgttg aatgcagtta aattcgcaaa taaatgtgca
      841 tccatcactg tgacccgaat gggagcccag ccctccctac cctatcgtaa agaaattgat
      901 gttttataaa tagtaattta aaaatctaat accatgttta tagtcgacag ttattcatta
      961 gcagttattt tctgcgttgt cacgatgctt tgttggggtt cgtggggtaa tacacagaaa
     1021 cttgccggga aaacctggcg ttacgaattg ttctactggg attacgtaat cggtatcctt
     1081 gccttctctc tcctcttagg tttcaccctg ggcagtacgg gagatgccgg acgcggtttt
     1141 gttgaagatt tgaagcagat cagtatggag aactatgcaa gcgcttttgc aggaggcgtc
     1201 atattcaatc tgtccaacat cctcttatca gcttccgttt ctatggcagg gcttacggta
     1261 gcattcccct taggagtcgg catagccttg gtattaggtg ttttcgtcaa ttatttcggt
     1321 gagcctaaag gtgatgcagt aattctgttc agtggtgtgg cactcgttgt attagccata
     1381 atctttaatg ccatagctgc cggaaaaatg aatcagaaag gaagcagcat caataagaaa
     1441 gggattatca ttgccattat agccggtgta ctgatgtctt tcttctatcg gtttgttgct
     1501 gccgccatgg acttgaacaa ttttgagtca cctaccccca caatggctac tccatattca
     1561 gcattcttta tattcgcaat aggtatcttc ataagcaatt tcattatcaa taccatcgtg
     1621 atgaaaaagc cgtttgtagg tactcccgtg agctataagg agtatttcca aggcaagttc
     1681 agcacacaca tggtcggagt gctgggagga gctatttggg gattgggtac ggctctcagt
     1741 tatattgcag caggaaaagc cggtgcagct atttcttacg cactaggaca aggagcaccc
     1801 atgattgcag ccttgtgggg catatttatc tggaaagaat tcaaaggctc ttcccgtgcg
     1861 gtaaatattc ttctggcctg catgttcgtt ctgtttatat ccggtttagg agcaattatt
     1921 atctccggag ctaattaaaa aagaactccc gcccctctcc tttatgcttt ctttttctat
     1981 tatctcaaag ataagagggg aggagaaata aaagctttaa aaccaaaaat cttgtatcaa
     2041 caaaaaacgt aaaattatga gagttatcaa catcttgtta tactgcttcc tacttaccat
     2101 actagcatgc agtaatacta atgagcctga acgacctcct gccgtccatc ctcaaaaact
     2161 aatagtggaa ggaaagccat tcttaatgtt aggagcccaa ctgcgcacag actatttcct
     2221 gcaattagat aaaaaaactc taaatgaact ggaaccgtat tttgaactgg cagctaatat
     2281 gaacatatta gtcatacaag ttcctgttgg ttggagggat atagaagtgc aaaaagacat
     2341 ctataacaca gaactggtag aaaagtacat cgaactgtgc gacaaatacc agatgaaact
     2401 ggaaatctta tggtttggta gttatatgtg tggatattct gtagaggggt atataccgga
     2461 gtatatagta aatgatcctg tgacttatcc cgatctcaaa ccagatgctg cttttgacgg
     2521 atggttagga aagcactatt acttgaaacc taatacacct gctttggtag aacgtgaatc
     2581 aaaggcattg ggaaaaatga tggaagccat ctacaactat gacaatatac ataaccaaaa
     2641 acacacggtc ataggtattc aaattgaaaa tgaaccggat atgctggcaa cccggcataa
     2701 cgaagcacac gggtatacac cggagcaaat atggcccgac ctaataatca tgctggacaa
     2761 gttaggacaa gtagtcaaaa gttctccata cgattgctac acacgggtaa atcagacaac
     2821 aacctatcct gaatatctaa ctaaaagtac agctattgca attactgaag gtatcgatta
     2881 tgtaggagta gatccttacg aaaatagcat ccaagctata gacggaaaac tcagacaatt
     2941 gagaaagatt gaaggtaatt atgcacacat tgcagagaat ggaggtgaat atgcaaataa
     3001 tgaccttctc gctttaaaag cattcagtct gggttgtgga tatgagatat tcgaagtcat
     3061 cactacccct cacccattcc tcacagaatg gacactgcga gggatctaca atcccgactt
     3121 tactcctaag gcacatacac agcaaatagt ggatgccttt aaaatcttta aagaagcatg
     3181 ggtagacctc gctaatgcaa attatttgga tatagcggga ttcaacttaa agagtaatga
     3241 cggaatggaa caaacctccg agagtaaaaa cactactcac gcaggtatca aatggagtac
     3301 caaatctcgt ggagtggcct ttgcgataga gtataatgac cacctgactg ttgcttccac
     3361 caaaagtgat gagatggtat tcagaaacat acaaataaaa agcatagaaa aagggcatta
     3421 tgatattgac ggaaactggg tatctgaaga gaaagcagaa gctcccgata accggcttgc
     3481 catggagcct tgtatagtct atagaataaa gttttaacct actaaagaaa atacaatgaa
     3541 aagaaattta tttatcacag gaatagcatg cacaatacta ttcctgacag gatgcaaaga
     3601 tgacgattct cccaacttga gaatagaagc agaatctaat attcaagttg aatgtaagaa
     3661 agatacaatc aacatacccg tattctgcaa tatgccgtcc aaagcaacca ttacctacga
     3721 ctcaccggac aaatccgggt ggatatttct tttaccttcg gtgctaaacg gagatgggat
     3781 attcactttg tggattgacg aatacagtaa tgtactggaa gatcgtactg ccactttcct
     3841 tgtaactgcc ggtgacgaaa caaaagaaat tcatattacc caactagcta agccctcact
     3901 ggcaacagaa cctgcaaaca tcgcccctat tagtaataat gcaggagact atcaggtaaa
     3961 agtattatgt aaaggaacct ggcaagcaac agtcaatcga gaagcagcct cctggtgtac
     4021 tttaaaaaat gatacaggag aaggcgtagg aaatattacc attcacttgt cagaagtatc
     4081 tgataatgaa atgcgaatgg ctactattac ggtcagttca ggtaacctgt cttcagacat
     4141 aaccatacaa caaggattcg gaattgaaat taatggtctg atctgggcga aaagcgatgt
     4201 tgctcaacct ggatatttta cagcatctcc cgacaccaaa ggattgttgt atcaatatga
     4261 ctcagctatc ggctatccca acaccagtcc gaaagaagac aataataaac ctaatggttt
     4321 cagaacggga gcatacgacg acggaattcc aagctggaga gctgaaaaga atccttgtcc
     4381 ggaaggctgg agaattcccg aatatgaaga aatacaaaga ttgactggaa actccgggaa
     4441 tccttatttc atttgggcag aaccaacaaa cagtcatttc ctcgtacccg gagccattgt
     4501 aggtatcccg agagaagaag ctgctcttgc aaacaaagac aatatgagag gtgctatttt
     4561 ctggccgcag tctggtttcc gtgacagaga ttccggtgca caaatcatct ggtggccggc
     4621 caatatcaca agtatcacac gccccggaca gacctgggac cgatacattt gttggatagg
     4681 cgcagacaac agtataagca acaacgaatt tgccggaaat gcagcagctt acccagtacg
     4741 ctgcgtagca aataaaaaat aaaacgaaaa catgagaaaa ttctaattta tacatattaa
     4801 atcgataaat tatgaaagac tattcaaaac attatttcag acttttgcaa ggaatggctt
     4861 tgtcggtatc tgattacatc agaaatcaga agccaatcgt aatcatagtt ttcttgctag
     4921 tgcattctat cagtatatat gcacaagaca atacaatctc cggacttgta aaagacaacg
     4981 aaggagaacc attgccagga gtttctgttg ccgtaaaagc aggagaatca atatccggag
     5041 tagtgacaga tataaatggt aaatatcagc taaaagcttc tcctaatgct accatagaat
     5101 ttagctttat cggcttcaaa tctatacagc aacaggttgg caatagaaaa gtgataaatg
     5161 taaccttgga aatagataac caaatgcttg aagaagtggt cgttgtaggt tacggtactc
     5221 aaaaaaaggt aaatcttaca ggttccgtaa gtgtaataga ctcaaaagct ttcgaatctg
     5281 tacctgtagc caacgctgta caagcactgc aagggcaggt tcccggcctg aatatttaca
     5341 gtaacaaagg tggagggctt aatcaaaaac aaagtatcaa tgtacgtggt ataggtacca
     5401 ttggtgaagg ttccacgggt gatgccctca ttctgataga tggcatggaa gctgatattt
     5461 tctccgtaaa tccacaggat atagagtcta tttcagtatt gaaagatgcc gcagcctctt
     5521 ctatatacgg atcaagagca cctttcggag ttgtattggt aaccaccaaa aaaggaaaag
     5581 ctggtaaagc ccaaataaac tataataaca gtttccgcct aagcagcccc attaatatgc
     5641 cttcatcctt agattcttac acgtatgctt tatttttcaa tgatgctggc tacaattctg
     5701 gctggggatc ttataactgg gtgtcccaaa cacgtttgca acgtatcaaa gattacatgg
     5761 atggaaaaat ctcttatact actatccctc tgaatggaag caacacctgg gccgacggtt
     5821 accaagaagg aaatgacaat atagactact acaacttgtt tttcaagaag aatgtttttg
     5881 cacatgaaca taatttcagt gtaaacggtg gtacggacaa gatacaatat tacttgtcag
     5941 ccaattatct cgatcaggat ggaactctcc gcatgggcga ggattactct aagcgatata
     6001 cgatgtcagc caagattagc gcccaattat ccagagctgt atcattatct tcaaacaccc
     6061 gttttgtacg taatgatttt gtacaaccta cccacatgaa tgattccttc ttttctgata
     6121 tcggccgtca atgctggcct gtgaaacctc tgtacgaccc gaacggtaac ttatttgacg
     6181 atcatgtaca acaaatgaaa aatggcggtc gtaaaaccga acgcaacact tggctgtacc
     6241 agcaattcaa tcttaccata gagcccatta aaggatggcg tctgattggt gacctaagtt
     6301 atcggtataa tactcaatat gcacatgagg acttacttac tatcagtcaa attggtgtag
     6361 atggagtaac caaagtaaga agttgggatg agaattcttc tgtatctgaa agtagcttcg
     6421 ccagtgatta cttcaatgta aatctctata ccgattttga gaagacattt gctaaatctc
     6481 atcatctgaa agcactggcc ggatttcagg ctgaagctaa caactaccgt aatatatggg
     6541 cacagaagat tggtatcact tatcctggta aaccaaccat aaacacctct acaggtatag
     6601 acaaagatgg aaaagttatt gctcccaatg tatccggagg acacaatcgc tggagcactg
     6661 ccggattctt cggcagagtg aactatgatt ttcaggaaaa atacttagtc gaagccaatc
     6721 ttcgttacga tggttcttca cgttttcgca gtgatgaccg ttggggattc tttccctctg
     6781 catcattggg ttggaacatt gcaagagagg aattcttcca accagctacg cgtataatga
     6841 ataccttgaa actaagagcc tcttatggta gcttaggtaa tcaaaacact acagcacttt
     6901 accccactta tactgttatg ggaacaggta caagcgacaa gtggctcatg aatggtgtaa
     6961 aacccaacat agcttgggca cctgcattgg tcagctacga tcttacatgg gaaaagatac
     7021 gtacttggaa tgtcggtata gatattggac tgtttaacaa tcgtttgaca ggctcttttg
     7081 actactttat ccgaaacacc aacgatatgg taggtccgtc agaaaagtta cctgctacat
     7141 taggtattgc cgtaccaccc tccaacaata ccgatctgcg aacagccggt tgggaactgg
     7201 aattaatgtg gaaagaccgt ctgcaaaacg ggttaaatta cagcctgcgc ttcacactag
     7261 cagacagtcg tactaaaatt acccgttatt caaatccatc aggcctgata gacagtttct
     7321 atgaaggtaa atattgcggt gaaatctggg gatatgaaac catcggaata gccagaaccg
     7381 atgatgagat ggccgagcat gtaggcagtt tagtaaatgg tggacaaagc gcattgggtc
     7441 aagattggca agccggcgac atcatgtaca gtgatctcaa tgaagatggt aaaatagatg
     7501 ccggtgcacg taccttagat aaccatggcg acttgaaacg cattggtaat tctacaccac
     7561 gctataatgt aggaattgat ctgtcagctg actggaaggg attcgacttc cgtatgttct
     7621 ggcaaggaac gctgaaacgg gactattttc aaggaagtta ctatttttgg ggagcaaatg
     7681 gctcacaagg atattggttc tctactgctc tcaaaggcca tgaagattat ttccgtaatg
     7741 acgaaagcag cccgttggga gtcaatctgg attcctatta tcccagaccg ttactcaata
     7801 caaacaagaa ccagcaatgc cagaccaaat acttacagaa tgctgcatat atgcgcctga
     7861 aaaacctaca aatcggttat acgttaccgc gtaagatagt acaaaaaatg ggagtacaga
     7921 acctgcgttt cttcgcttcc ggtgagaatt tgttaacgat taccgatctg gtcaagtttt
     7981 tcgatcccga aacaatagaa agtggtagtt ttgcacatgg ttatgcttac ccactctcca
     8041 gaacctatgc tttcgggctg aacattacgt tctaatcggt aaaccaaatg aaaatcttaa
     8101 tgctcaaatt taaaaaaaca cttatgaaaa atcatctcat atatacgcta tcaggaatgt
     8161 tattcctcct gacaagttgc gatgctttcc tcaatcagga accgcttgac caactcgcac
     8221 ccgacgagta catgactacg gagacgaatg tagcctctta cgccaatgac caatatcaaa
     8281 tgttgcctac acatggtact tatggttacg gtactttcga atcagatcag cataccgaca
     8341 atatggctgc catgcaaccc agtactctct acgctcctgg ttattggaga gtaggacaaa
     8401 gtgacggtac ctggtatttc ggaaatattt accgttgtaa ctatttcctg gaaaatgtgt
     8461 tacctgccta tgaagctaat actataaccg gcaaccggga aaacatccgt cactatattg
     8521 gtgaaatcta ctttttccgt gcttttgact actttgaacg gctaaggact gtaggagatt
     8581 tccccatcat tacaaaaact tatcccaatg aaagcggaat actaacggaa atcagtaaaa
     8641 gatctcctcg taatgaagtt gcacgtttca ttctgtccga cctcaataca gccattgaaa
     8701 tgctgaagga acaatcacca gacggtacta aaaaccgtgt cacccgagat tgcgccatcc
     8761 tactcaaatc cagagtggca ttgtatgaag catcatggct gaaaaacttc aaaggaacag
     8821 cttttgttcc tggcggtccg ggatgggctg gagcaaataa agaatacaat gccggctata
     8881 ctttcccatc cggaagtatt gacaacgaaa tcaatttctt ctttgacgaa gctattgcag
     8941 catctcagat tattgccgac aaacacactc tgactaccaa tacaggttac ttcgcacaga
     9001 atccagaaga cacagaaaat ccttatttca gtatgttctg tagcacagac atggataaat
     9061 atgacgaagt attattgtgg aagcgctatg actgggcaca aggtgtggct aatgaagtat
     9121 gcgaatatgc ttgtacggga aatcatggtg tgggaacaac caaaagtatg gtagatgctt
     9181 ttatcttgaa aaacggcgaa ccaatatacg cttcacccat gtgggctgac gagaataatt
     9241 cctattgggg agacaacaat atggaacata ttaccaaaaa tcgtgataca cgcgctgata
     9301 tctttatcaa gaagccagga caacgcaatc tgcatactcc tccacaaggc actgtagcag
     9361 ccggcagaga atatgaaacc aaacctgaca tcacagctgc caccgttact gataaataca
     9421 ataccggcta cgccatacgt aaaggtttaa atccggatgg caaatataca gcaaatacgc
     9481 aaagtaacgt tggctccatt gtattccgtg cagcagaggc ctatctcaat tatatagaag
     9541 cctactacga acgctacggt acacttaatg acgttgcaga agaatactgg cgcaccatac
     9601 gtcgtcgagc cggcgtgaat gaagatttcc aaaaaaccat ccgcctaacg gatatggcca
     9661 aagaagctga aactgactgg ggagcctatt ccgccggaca agttattgat gccacccgct
     9721 acaacatccg ccgtgaacgc cgatgtgagc tgatggccga agggcttcgt tcaatggatc
     9781 tgcaccgctg gcgcgctatg gatcagatga tcactaagcc ttaccatata ctgggaatga
     9841 atctatggca agagatgtac aattgggact ggtataaaga cggttccgga aactcaatat
     9901 tgaaagaagg agaaaatgta tcatcccgta atttcagtac ctatttagct ccataccaca
     9961 tcactgccaa taacatcgcc tacaatggct atcgatggca catggcgcac tatcttgatc
    10021 ctattgccat agaacatttt ctggtgactt cacaaggagg agacctgaat agctccccca
    10081 tctaccagaa tcccgaatgg cctatgatcg gaggaggtac tcccgaatag tagccggaca
    10141 aagttcataa aatagattca ttaacagata aatggaaaat atgatgtata aaaaagcaat
    10201 attattagcc tatactttgg cctgtttttc tttccttgcc atagcttgcg cagacagtga
    10261 agttgacgaa acaggaaagg aaccgatact acctcagata gaagtaagta aagttgcaac
    10321 agaaaatggt aaaacttatc ttgaggtgga tggtaagccc ttcccactcc tcggggcaca
    10381 aatacgcctt gatgccctgc tcaactgtga caaaatgagt ataaacgagg tagagaatta
    10441 tttcaaaaaa gctcaagaac taggagtgaa ctgtgtgcag attcctattt cctggaatat
    10501 gatagaagca aaggaagaga agtatgattt caatatcgta aattcaatct tacaatttgc
    10561 gaataaatat gatctgaaaa tagaacttct ctggttcagt actaacatgg taggtgattc
    10621 tttcacctac ctaacccccc aatacgtcct tcagaattat cataaacgat tcggtaggaa
    10681 cgacgaaggc agcttttgga attattacgg ttaccaatat actatgattc ttgatgacag
    10741 ttgggtgttg gagagagaaa caaaagctat cacggcactt ttcaatcata tacgatactg
    10801 ggattcgcaa aatggtgata aacatccggt tatcactgca caaatacaca atgaaccgga
    10861 tgcactgatg cgttggagaa ttgaacaaaa agatcttaaa tatcgtgatg gaaccccact
    10921 ttccaaagaa aaagcatgga acatgacaac aaatgccctc aacgccgttg ggaatgccgt
    10981 aaagaacagt tcctataaag ttgcaacccg agtgaaccta atatacggtg atggaatcaa
    11041 tcctttcccg gaagccaata atgcatgtcc caaagatgtt tttgacttgc aaggtattga
    11101 tttcatcgga gtagacgctt ataaagacaa tatcaagcag ctaaaagagc aagtatcatc
    11161 ttatgcttcc ataaacggca actatgcatt ggtagctgaa aacaaaggca gctactccaa
    11221 tacaccaagc cttatactga cggcattggc attaggagga ggatatgata tttacgacct
    11281 ggcaacaagt aacttcttta tcaacaatac aagcgaaccg gaccaaattg accatggcat
    11341 ctatacgtgg gatttacaag aaaaagattt cacaaacccc acgagaatga ttattaaagg
    11401 gctgactgac gctaatgtag acgttgctac agtgaaacca gaaaactttg ctgcattcaa
    11461 catcagcgac aaccacccca tagcagtaaa acagcaacaa atacgcacca caaacgtgga
    11521 aataactttc tcaaccaaca atgcctcttt ggcatttgca ctcgataaag gcagttattt
    11581 gcttgtttac tctactggtg attcggaatt ccattttggc aatggtacat ttgaaaaagt
    11641 gatttacgga aagtataacg ataaaggtac ctttgttgaa gaaggaaaca cagttttaaa
    11701 taaccagaca ctccatgcga aaggtggcgt gctctataaa gtgacatact cttctcaaca
    11761 acctttaatt agcaatacga ttgaaaatat cggaaataat ttataatatc atgaaaagac
    11821 gactcattac cggactgctc acagtcttgg ccatgacagg aaatgcacaa tccttcaaag
    11881 aatggaccga cccggaagtg aatgctgtaa atcgtgctcc tatgcatgcg aactactttg
    11941 cttatgaatc agcagatgcc gctatgcagg gtagaaaaga atgttcatct aatttcatga
    12001 ccatgaatgg tacttggaaa ttcttctggg tgagaaatgc cgactctcgt cctacagact
    12061 tttggagata cgatttcaac gataaaggtt ggaatgatct gcaaatacct gccgtatggg
    12121 aattaaacgg atatggtgat cctatctatg tcaatatcgg ttatgcatgg cgtaaccaat
    12181 atcagaacaa tcctcctcag gtaccaacag aaaacaatca tgtaggttct taccgccggg
    12241 aatttataat tcccgcttcc tggcaaggta aagatatcat tgcacacttc ggatctgtga
    12301 cttccaatat ctacctgtgg gtaaatggaa agtatgtagg ttatagtgaa gatagtaaat
    12361 tggaagcaga attcgatctg acttcttatt taaaaccagg acaaaagaat ctgattgcct
    12421 ttcaggtatt ccgttggtgc gatggtacct atttggaaga ccaagacttt ttccgtttca
    12481 gtggtgtagg tcgtgattgt tatttatatg cccgcagtaa aaaacgtatt caggatatcc
    12541 gcattacacc tgatttggat gagaattaca agaatggctc gttgaatgta agcctgagcg
    12601 taaaaggtag cggtaatgtt gatttgaaat tactggatgc cacaggaaaa caagtggcca
    12661 tgtcaacaat caaaggtagc ggaaatgtcg tgatacatgt ggagaatccg tataagtggt
    12721 cagctgaaat tccatatctc tatacgttgc aggctacatt gcaaggcagt aatgaagtaa
    12781 ttcccataaa aacaggtttc cgcaaaatag agcagaagaa cgggcagatt ttagtaaacg
    12841 gacaacccat actcttcaaa ggagtcaatc gtcatgagat ggatccggat ggtggctatg
    12901 tggtatctcc tgaacgaatg ttacaggata ttcagatcat gaagagattt aatataaatg
    12961 ccgtgcgcac ctgccactat ccagatgata acctttggta tgacttgtgc gataaatatg
    13021 gcatctacgt agtagccgaa gcaaatatag aatcacatgg catgggctat gatgtaaaaa
    13081 cacttgccaa acgggatgat tacaaagaag cacacatgga acgcaaccaa cgtaatgtac
    13141 agagaaactt caatcacccc agtatcatct tctggtcatt aggcaacgaa gctggttttg
    13201 gcccaaattt tgaagcagct tatcgttggg taaagtccga ggacatcagt cgccctgttc
    13261 agtatgaaca ggcacatggc aatgatttta cagacgtaga ctgtcctatg tacgctgatt
    13321 ataaccaaat ggaaaaatat gctcaacgta atgacatcca gaagccattg attcaatgcg
    13381 aatatgctca tgctatgggt aattctctag gaggatttaa agaatattgg gatttaattc
    13441 gtaaatatcc tcatttgcaa ggtggcttta tttgggactt cgtagatcag tctgtccgtt
    13501 ggaaaggcaa aaatggtgcg accatctacg cttacggtgg cgactttaac cgattcgatg
    13561 cttcagataa gaacttttgc gacaatggcc ttatcagtcc cgaccgtatc cccaacccac
    13621 atatgtatga agttggctat ttctatcaaa acatctggac cacaccaggc gatctgatac
    13681 aaggtgaaat aaacgtgtac aatgaatact tcttccgcga cctctccggt tactacctgg
    13741 aatgggaagt gcttgccgat ggagagcctg tacgtacagg tagggtaact gaattgaatg
    13801 tggctccaca acagacagcc aaactcaagc tcaatatagg caagatctgc tcagacaaag
    13861 aatgtctact aaatataact tatcgtctga agaatcaaga aaacatgctt cctgcgggat
    13921 acaccgtagc caaggatcag cttatactga gcccttacaa aactccttcc atggaattga
    13981 aaaatgcaaa gacaaccaac actgttactg ttattccaca aatacaagac aacgattcac
    14041 actatttaat tgttaatggt gaagctttct gtctggaatt taataaacac accggttact
    14101 tgaaccgcta taatgtggca ggtatagaaa tgatgaatca agacactcaa ctggtgccca
    14161 acttctggcg tgccccaaca gacaatgact ttggagcagg tttacaacaa aagtttgccg
    14221 tttggaggaa tcctggtctg aaactgactt cattcaaatg ggagactgtc aatgaacagg
    14281 taatattata tgctgaatat gaaatgcaac acgtttcagc aaagttgaat ctcacttata
    14341 ttatcaataa cgaaggtgct attaaagtaa cacagaaaat ggtaaccaat ccacaagcaa
    14401 agatacctcc catgttccgt ttcggtatgc aagtacaaat gcctaaagca tttgaaacca
    14461 tagaatatta tggccgtggt ccgatagaaa actacagtga tcgtaatcat tctacaacca
    14521 ttggattgta ccgtcagagt gttaacgaac agttctaccc atacattcgc ccgcaagaaa
    14581 ccggaaccaa aacagatatt cgatggtgga agctattgaa tgcagccggt cacggactac
    14641 aaatcgtagc agatgctccc ttctccgctt ctgccttgca ctacaccatt aaatcattgg
    14701 acgatggcat tgataaggcg caacgccact ctcccgaagt gaaacaatct gatctaacca
    14761 atctttgcat tgataagata caaatgggat taggttgtat taacagttgg ggggcatggc
    14821 cattacctca ataccagatt ccttatggag actatgaatt ctcattcata ttaagccctg
    14881 tatatcatag ttatttcaat tcaaccttac aataactcat aaaaatacat cattatgatc
    14941 aaaagcaaaa tttatctctt aagtgcattt ttaatagctt tgtcaagctg cacttcttct
    15001 aagaaacaac aggaagtaga aatcacttca aatgtagaca gaattatcct ggagacagat
    15061 attgggaatg atgtcgacga tgctctggcg ttggatatgc tctacaaata cttggataca
    15121 gacaagatta atttattagg tattatgatc aataaggaag gtgtataccc tgcagagttc
    15181 gtcgatatta tgaatacctg gtatggctac cccaaaattc ccattggtat tatacacaat
    15241 ggcatagatt gtgaaaatga tgctataaac tatgcaaagg ctgtatgtct catgcaaaaa
    15301 gagaacggtg agcccacatt taaacgttca ttgcaaaact atgatgaatt atcagaagct
    15361 cctgtaatgt atcgcaagat attggcacaa caaccagata gttctgtcac aatcatttcc
    15421 gtaggcttct ctaccaacct cgctcgttta ctggacactc ccgctgataa catatcacca
    15481 cttacaggca aagaactggt tgcccaaaaa gtgaaactgc tatgtaccat gggaggatgc
    15541 tttgacaact ccaatcctct tgaatacaat gttgtgaaag atattcctgc agcacagaaa
    15601 gtttttgctg aatggccaac acgtttagtt acttctccat tcgaagtagg cattaaaatc
    15661 aattatccgg ccagtagtat tgagaaagat tttcaatggg caaccacaca tccgatggtg
    15721 gaggcttaca aaagttatca aaaaatgccc tacgatcgtc caacatggga tttaacatcc
    15781 gtattatatg cagttgaagg tccctcctac ttcaatattt ctgcacccgg acatattgtc
    15841 gtaacagatg aaggagccac acagtttaca tctgatgaca aaggaaagca atattatctc
    15901 actgtagatt caattcaggc agataagatt aaaaaacatt ttgtggaatt actgtctaga
    15961 caacctatcc atttcaataa taaagaagaa taa
//
