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CAZyme Information: MGYG000002131_00686
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | CAG-882 sp900545455 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; CAG-882; CAG-882 sp900545455 | |||||||||||
| CAZyme ID | MGYG000002131_00686 | |||||||||||
| CAZy Family | CE12 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 6572; End: 15640 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| PL11 | 1016 | 1641 | 3.3e-206 | 0.9605488850771869 |
| CE12 | 251 | 487 | 3.5e-62 | 0.9952380952380953 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd10318 | RGL11 | 0.0 | 985 | 1632 | 3 | 564 | Rhamnogalacturonan lyase of the polysaccharide lyase family 11. The rhamnogalacturonan lyase of the polysaccharide lyase family 11 (RGL11) cleaves glycoside bonds in polygalacturonan as well as RG (rhamnogalacturonan) type-I through a beta-elimination reaction. Functionally characterized members of this family, YesW and YesX from Bacillus subtilis, cleave glycoside bonds between rhamnose and galacturonic acid residues in the RG-I region of plant cell wall pectin. YesW and YesX work synergistically, with YesW cleaving the glycoside bond of the RG chain endolytically, and YesX converting the resultant oligosaccharides through an exotype reaction. This domain is sometimes found in architectures with non-catalytic carbohydrate-binding modules (CBMs). There are two types of RG lyases, which both cleave the alpha-1,4 bonds of the RG-I main chain through a beta-elimination reaction, but belong to two structurally unrelated polysaccharide lyase (PL) families, 4 and 11. |
| cd01821 | Rhamnogalacturan_acetylesterase_like | 2.54e-62 | 250 | 487 | 1 | 198 | Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are highly branched regions in pectic polysaccharides, consisting of repeating -(1,2)-L-Rha-(1,4)-D-GalUA disaccharide units, with many rhamnose residues substituted by neutral oligosaccharides such as arabinans, galactans and arabinogalactans. Extracellular enzymes participating in the degradation of plant cell wall polymers, such as Rhamnogalacturonan acetylesterase, would typically be found in saprophytic and plant pathogenic fungi and bacteria. |
| COG3401 | FN3 | 1.75e-18 | 632 | 963 | 45 | 332 | Fibronectin type 3 domain [General function prediction only]. |
| COG2755 | TesA | 3.18e-11 | 250 | 428 | 9 | 171 | Lysophospholipase L1 or related esterase [Amino acid transport and metabolism]. |
| pfam18370 | RGI_lyase | 4.78e-09 | 987 | 1072 | 7 | 69 | Rhamnogalacturonan I lyases beta-sheet domain. This is the beta-sheet domain found in rhamnogalacturonan (RG) lyases, which are responsible for an initial cleavage of the RG type I (RG-I) region of plant cell wall pectin. Polysaccharide lyase family 11 carrying this domain, such as YesW (EC:4.2.2.23) and YesX (EC:4.2.2.24), cleave glycoside bonds between rhamnose and galacturonic acid residues in RG-I through a beta-elimination reaction. Other family members carrying this domain are hemagglutinin A, lysine gingipain (Kgp) and Chitinase C (EC:3.2.1.14). |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| ADL33943.1 | 0.0 | 66 | 2696 | 168 | 2451 |
| BCJ93926.1 | 0.0 | 68 | 1686 | 54 | 1638 |
| QYR24106.1 | 4.98e-280 | 154 | 1640 | 62 | 1388 |
| AWB46910.1 | 1.20e-278 | 71 | 1634 | 61 | 1421 |
| QNF30995.1 | 1.16e-276 | 107 | 1638 | 22 | 1415 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2Z8R_A | 1.23e-153 | 1018 | 1638 | 20 | 572 | Crystalstructure of rhamnogalacturonan lyase YesW at 1.40 A resolution [Bacillus subtilis],2Z8R_B Crystal structure of rhamnogalacturonan lyase YesW at 1.40 A resolution [Bacillus subtilis],2Z8S_A Crystal structure of rhamnogalacturonan lyase YesW complexed with digalacturonic acid [Bacillus subtilis],2Z8S_B Crystal structure of rhamnogalacturonan lyase YesW complexed with digalacturonic acid [Bacillus subtilis],2ZUX_A Crystal structure of rhamnogalacturonan lyase YesW complexed with rhamnose [Bacillus subtilis],2ZUX_B Crystal structure of rhamnogalacturonan lyase YesW complexed with rhamnose [Bacillus subtilis] |
| 2ZUY_A | 1.71e-153 | 1017 | 1638 | 22 | 593 | Crystalstructure of exotype rhamnogalacturonan lyase YesX [Bacillus subtilis] |
| 4CAG_A | 5.88e-150 | 1010 | 1642 | 22 | 583 | Bacilluslicheniformis Rhamnogalacturonan Lyase PL11 [Bacillus licheniformis] |
| 2O14_A | 8.16e-14 | 127 | 448 | 57 | 335 | X-RayCrystal Structure of Protein YXIM_BACsu from Bacillus subtilis. Northeast Structural Genomics Consortium Target SR595 [Bacillus subtilis] |
| 3C1U_A | 1.66e-07 | 251 | 460 | 2 | 201 | ChainA, Rhamnogalacturonan acetylesterase [Aspergillus aculeatus] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| O31527 | 7.23e-153 | 1017 | 1638 | 22 | 593 | Rhamnogalacturonan exolyase YesX OS=Bacillus subtilis (strain 168) OX=224308 GN=yesX PE=1 SV=1 |
| O31526 | 1.73e-152 | 1018 | 1638 | 57 | 609 | Rhamnogalacturonan endolyase YesW OS=Bacillus subtilis (strain 168) OX=224308 GN=yesW PE=1 SV=1 |
| O31528 | 1.54e-37 | 252 | 487 | 5 | 202 | Probable rhamnogalacturonan acetylesterase YesY OS=Bacillus subtilis (strain 168) OX=224308 GN=yesY PE=1 SV=1 |
| O31523 | 3.33e-33 | 252 | 487 | 8 | 212 | Rhamnogalacturonan acetylesterase RhgT OS=Bacillus subtilis (strain 168) OX=224308 GN=rhgT PE=1 SV=1 |
| P42304 | 1.49e-14 | 127 | 449 | 72 | 351 | Uncharacterized esterase YxiM OS=Bacillus subtilis (strain 168) OX=224308 GN=yxiM PE=1 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.002473 | 0.996474 | 0.000286 | 0.000336 | 0.000219 | 0.000199 |
