CAZyme Information: MGYG000002433_00031

Basic Information

• Species: Campylobacter_A concisus_P
• Lineage: Bacteria; Campylobacterota; Campylobacteria; Campylobacterales; Campylobacteraceae; Campylobacter_A; Campylobacter_A concisus_P
• CAZyme ID: MGYG000002433_00031
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1F

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
642		72198.28	6.534

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002433	1923750	Isolate	Denmark	Europe

• Gene Location: Start: 29945; End: 31873 Strand: +

Full Sequence      

MKYILAFIFIVAISLGGAFLYFYSQVRFDAYAIIDYKPKLTTQIFDRNNELIANIFEENR
IYVKYNDIPPRVIEALVAIEDTSYFEHGGINVEAMARAAIKDIKARKLVEGASTLTQQLI
KNLALSREKKFTRKIKEIVLAMKLESELSKEDIIERYLNHVYFGHGYYGIKTAAEGYFRK
ELNELSIKEVAMLVGLPKAPSTYDPTKHLDLSLSRANRVLERMYSIGWINEDEYRKGVLE
EPAVFDDTLTRNKAPYVVDEIIKEASKKFDDIKTGGYKIQSTVDLNVQKIAQEALVYGYN
EILKRDKKANAEILNGAIVVTHPQSGQILALIGGIDYAKSSYNRATQSKRQPGSSFKPFI
YQIALDSGYSVVSQVADIARTFDMGNGKEWTPKNYSGGFQGYITIKSAITQSRNLATINL
LNDLGLSSVRKQLTDMGFNDIPENLSIALGSFGISPLDFAKFYSMFPNEGEMVEPTLIKH
IENSFGASMDYEPQRKQVLKPEQAFLMTTLLQNVVNNGTGRNAKINGIQIAGKTGTTNNN
IDAWFCGYSPDIEAIIWYGNDDNSPMKKIEGGGRTAAPVFKKFMEGYIKLYPTLRRAFEQ
PDGVYKGYYGGSDEYYTNDSPLPQNIPANDIIQDQENDGLLF

Enzyme Prediction     

No EC number prediction in MGYG000002433_00031.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	49	224	2.1e-66	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG5009	MrcA	0.0	4	604	11	733	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	0.0	59	589	1	530	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	0.0	4	629	19	641	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	2.51e-101	1	585	4	782	penicillin-binding protein 1a; Provisional
COG4953	PbpC	4.16e-100	1	585	1	559	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QPH86550.1	0.0	1	642	1	642
QPI03226.1	0.0	1	642	1	642
QPH84709.1	0.0	1	642	1	642
QPH88279.1	0.0	1	642	1	642
ALF47903.1	0.0	1	642	1	642

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	1.41e-97	32	604	11	737	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	2.95e-94	43	584	22	712	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
5FGZ_A	1.21e-75	38	584	142	690	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	1.76e-75	38	584	163	711	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]
3FWL_A	1.77e-73	38	584	146	694	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O66874	1.62e-103	38	601	41	679	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
O87626	3.50e-101	36	604	44	719	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1
O87579	7.20e-100	36	616	44	728	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1
P38050	7.90e-100	23	601	27	616	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
P0A0Z6	3.86e-99	36	616	44	728	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup B (strain MC58) OX=122586 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.973343	0.018964	0.006246	0.000156	0.000081	0.001229

TMHMM  Annotations     

start	end
5	24