| Basic Information | |
|---|---|
| Species | Arabidopsis lyrata |
| Cazyme ID | 488189 |
| Family | GH89 |
| Protein Properties | Length: 807 Molecular Weight: 93085.7 Isoelectric Point: 8.1301 |
| Chromosome | Chromosome/Scaffold: 6 Start: 5526261 End: 5530901 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 93 | 801 | 0 |
| PEIRIKGTTGVEIASGLHWYLKYKCNAHVSWDKTGGIQIASVPQPGHLPRLDSKRILIRRPIPWNYYQNVVTSSYSYVWWGWERWEREIDWMALQGINLP LAFTGQEAIWQKVFKRFNITKEDLDDYFGGPAFLAWARMGNLHTWGGPLSKNWLNDQLILQKQILSQMLKLGMTPVLPSFSGNVPSALRKIYPGANITRL DNWNTVDGDSRWCCTYLLNPSDPLFIDIGEAFIKQQPEEYGEITNIYNCDTFNENTPPTSEPEYISSLGAAVYKAMSKGNKNAVWLMQGWLFSSDSKFWK PPQMKVLLHSVPFGKMIVLDLYAEVKPIWNTSAQFYGTPYIWCMLHNFGGNIEMYGALDSISSGPVDARVSKNSTMVGVGMCMEGIEQNPVVYELISEMA FRDEKVDVQKWLKSYARRRYMKENHQIEAAWEILYHTVYNCTDGIADHNTDFIVKLPDWDPSSSVQDESKHTDSYMISTGPYETKRRVLFQDKSSDLPKA HLWYSTKEVIQALKLFLEAGDELSRSLTYRYDMVDLTRQVLSKLANQVYIEAVTAFVKKDIGSLGQLSEKFLELIKDIDVLLASDDNFLLGTWLESAKKL ARNGDERKQYEWNARTQVTMWYDSKDVNQSKLHDYANKLWSGLLEDYYLPRARLYFNEMLKSLRDKKKFKVEKWQREWIMMSHKWQQSSSEVYPVKAKGD ALAISKHLL | |||
| Full Sequence |
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| Protein Sequence Length: 807 Download |
| MHSIKLVLLV LLVLSFHSQS LSKHHPTIDR LLNRLDSLLP TSSVQESAAK GLLQRLLPTH 60 FHSFEFRIFS KDVCGGTSCF LIENYDDPRR IGPEIRIKGT TGVEIASGLH WYLKYKCNAH 120 VSWDKTGGIQ IASVPQPGHL PRLDSKRILI RRPIPWNYYQ NVVTSSYSYV WWGWERWERE 180 IDWMALQGIN LPLAFTGQEA IWQKVFKRFN ITKEDLDDYF GGPAFLAWAR MGNLHTWGGP 240 LSKNWLNDQL ILQKQILSQM LKLGMTPVLP SFSGNVPSAL RKIYPGANIT RLDNWNTVDG 300 DSRWCCTYLL NPSDPLFIDI GEAFIKQQPE EYGEITNIYN CDTFNENTPP TSEPEYISSL 360 GAAVYKAMSK GNKNAVWLMQ GWLFSSDSKF WKPPQMKVLL HSVPFGKMIV LDLYAEVKPI 420 WNTSAQFYGT PYIWCMLHNF GGNIEMYGAL DSISSGPVDA RVSKNSTMVG VGMCMEGIEQ 480 NPVVYELISE MAFRDEKVDV QKWLKSYARR RYMKENHQIE AAWEILYHTV YNCTDGIADH 540 NTDFIVKLPD WDPSSSVQDE SKHTDSYMIS TGPYETKRRV LFQDKSSDLP KAHLWYSTKE 600 VIQALKLFLE AGDELSRSLT YRYDMVDLTR QVLSKLANQV YIEAVTAFVK KDIGSLGQLS 660 EKFLELIKDI DVLLASDDNF LLGTWLESAK KLARNGDERK QYEWNARTQV TMWYDSKDVN 720 QSKLHDYANK LWSGLLEDYY LPRARLYFNE MLKSLRDKKK FKVEKWQREW IMMSHKWQQS 780 SSEVYPVKAK GDALAISKHL LLKYFP* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 8.0e-24 | 45 | 143 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 2.0e-112 | 502 | 804 | 303 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 158 | 497 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 5 | 805 | 68 | 867 | unnamed protein product [Vitis vinifera] |
| GenBank | EEE59081.1 | 0 | 45 | 805 | 56 | 811 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | NP_196873.1 | 0 | 1 | 806 | 1 | 806 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 5 | 805 | 3 | 802 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 27 | 805 | 28 | 805 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 50 | 795 | 175 | 867 | A Chain A, Crystal Structure Of The Putative Acetylxylan Esterase From Clostridium Acetobutylicum, Northeast Structural Genomics Target Car6 |
| PDB | 2vcb_A | 0 | 50 | 795 | 175 | 867 | A Chain A, Crystal Structure Of The Putative Acetylxylan Esterase From Clostridium Acetobutylicum, Northeast Structural Genomics Target Car6 |
| PDB | 2vca_A | 0 | 50 | 795 | 175 | 867 | A Chain A, Crystal Structure Of The Putative Acetylxylan Esterase From Clostridium Acetobutylicum, Northeast Structural Genomics Target Car6 |
| PDB | 2vc9_A | 0 | 50 | 795 | 175 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 50 | 795 | 198 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
