| Basic Information | |
|---|---|
| Species | Aquilegia coerulea |
| Cazyme ID | Aquca_039_00072.1 |
| Family | GH89 |
| Protein Properties | Length: 753 Molecular Weight: 85682.7 Isoelectric Point: 6.3737 |
| Chromosome | Chromosome/Scaffold: 39 Start: 853239 End: 861075 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
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| Family | Start | End | Evalue |
| GH89 | 43 | 748 | 0 |
| GKEIIIKGTTAVEIASALHWYLKYSCGAHISWDKTGGAQLSSVPNPGSLPPVKDKGVIIQHSYVWWDWERWEKELDWMALQGINLPLAFTGQEAIWEKVF KNFNTSKKDLDGFFGGPAFLAWARMGNLHAWGGPLQQSWLDQQLALQKLILTRIVELGMTPVLPSFSGNVPESLKRIFPSANITRLGDWNTVNGDPRWCC TYLLDPSDPLFVEIGDAFIRQQMEEYGDITDIYNCDTFNENSPPTNDLAYISLLGAAVYKAMSKTDKDAVWLMQGWLFSSDSAFWKPPQMKALLHSVPLG KMIVLDLFADVKPIWETSSQFYETPYVCQNYSLFLLHNFGGNIEMYGILDVISSGPVDARISQNSTMVGVGMCIEGIEQNPVVYELMSEMAFRSEKVPLK EWLKSYSYRRYGKKDPQIDSAWEILHQTIYNCTDGIADHNKDFIVQFPDWDPSDYFHTNMSKETHVHNLFAHNNTKRFFLRETTTDLPRAHLWHSTEEVI IALQLFLDAGSHLAGSLTYSSDVLNFLLQNSIDDNSILSKLANQVYLDAMTAFQQKNAKALTLQSLKFVELIKDIDTLLASDDNLLLGTWIESAKNLAAS PREMRQYEWNARTQVTMWYDTTKTNQSKLHDYANKFWSGLLEKYYLPRASTYFTYLLASLVQKEGFKLEEWRREWISFSNKRQSGTELYPVRAQGDALAI SKALSK | |||
| Full Sequence |
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| Protein Sequence Length: 753 Download |
| IGVLKRLLPN HLSSFEFKVV PKDVCGGYSC FWIKNAKTGN AKGKEIIIKG TTAVEIASAL 60 HWYLKYSCGA HISWDKTGGA QLSSVPNPGS LPPVKDKGVI IQHSYVWWDW ERWEKELDWM 120 ALQGINLPLA FTGQEAIWEK VFKNFNTSKK DLDGFFGGPA FLAWARMGNL HAWGGPLQQS 180 WLDQQLALQK LILTRIVELG MTPVLPSFSG NVPESLKRIF PSANITRLGD WNTVNGDPRW 240 CCTYLLDPSD PLFVEIGDAF IRQQMEEYGD ITDIYNCDTF NENSPPTNDL AYISLLGAAV 300 YKAMSKTDKD AVWLMQGWLF SSDSAFWKPP QMKALLHSVP LGKMIVLDLF ADVKPIWETS 360 SQFYETPYVC QNYSLFLLHN FGGNIEMYGI LDVISSGPVD ARISQNSTMV GVGMCIEGIE 420 QNPVVYELMS EMAFRSEKVP LKEWLKSYSY RRYGKKDPQI DSAWEILHQT IYNCTDGIAD 480 HNKDFIVQFP DWDPSDYFHT NMSKETHVHN LFAHNNTKRF FLRETTTDLP RAHLWHSTEE 540 VIIALQLFLD AGSHLAGSLT YSSDVLNFLL QNSIDDNSIL SKLANQVYLD AMTAFQQKNA 600 KALTLQSLKF VELIKDIDTL LASDDNLLLG TWIESAKNLA ASPREMRQYE WNARTQVTMW 660 YDTTKTNQSK LHDYANKFWS GLLEKYYLPR ASTYFTYLLA SLVQKEGFKL EEWRREWISF 720 SNKRQSGTEL YPVRAQGDAL AISKALSKKY LG* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 4.0e-20 | 2 | 94 | 93 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 6.0e-91 | 443 | 750 | 308 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 1.0e-168 | 104 | 438 | 336 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 2 | 751 | 114 | 867 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC75285.1 | 0 | 2 | 751 | 62 | 811 | hypothetical protein OsI_11626 [Oryza sativa Indica Group] |
| GenBank | EEE59081.1 | 0 | 2 | 751 | 62 | 811 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | XP_002273084.1 | 0 | 2 | 751 | 49 | 802 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 2 | 752 | 52 | 806 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 22 | 741 | 195 | 867 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
| PDB | 2vcb_A | 0 | 22 | 741 | 195 | 867 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
| PDB | 2vca_A | 0 | 22 | 741 | 195 | 867 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
| PDB | 2vc9_A | 0 | 22 | 741 | 195 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 22 | 741 | 218 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| HO783455 | 329 | 239 | 566 | 0 |
| HO783455 | 154 | 576 | 729 | 0 |
| GT627657 | 277 | 141 | 416 | 0 |
| GT622356 | 278 | 215 | 491 | 0 |
| EY072797 | 262 | 173 | 433 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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