Basic Information | |
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Species | Medicago truncatula |
Cazyme ID | Medtr2g031110.1 |
Family | GH31 |
Protein Properties | Length: 1730 Molecular Weight: 194792 Isoelectric Point: 6.5996 |
Chromosome | Chromosome/Scaffold: 2 Start: 10739203 End: 10749605 |
Description | Glycosyl hydrolases family 31 protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH31 | 69 | 543 | 0 |
AGSSPELVLDQYTQFIGRPAPMPYWSFGSGLESTFYQGFHQCRWGYKNVNDVQGVVTNYAKAGIPLEVMWTDIDYMDAYKDFTLDPVNFPKDKMRNFVDT LHKNGQKYVLILDPGISVNNTYATYVRGLQADVYLKRNGVNYLGEVWPGPVYYPDFLNPHSQEFWGEEIKLFRELLPFDGIWLDMNELSNFITSNDTPHS NLDSPPYKINSTGVQRPINNKTVPATSLHYGNITEYDSHNLYGLLESKTTNRALVEITSKRPFILSRSTFVSSGKYTAHWTGDNAATWNDLAYSIPSILN FGIFGVPMVGADICGFSADTTEELCRRWIQLGAFYPFARDHSDKSSIRQELYLWDSVAASARKVLALRYRLLPYFYTLMYESNTKGTPIARPLFFSFPED ITTYEINSQFLLGNGVLVSPVLQSGAVTVDAYFPKGNWFDLFNPSNSVSAESGKYVTLDAPSDHINVHVGEGNIL | |||
GH31 | 1081 | 1404 | 0 |
YFFSGSSPELVLDQYTQFIGRPAPMPYWSFGFHQCRYGYKNVSDVEGVVTNYAKAGIPLEVMWTDIDYMDAYKDFTLDPVNFPQDKMINFVDTLHKNGQK YVLILDPGISINTTYATYVRGLQADVYIKRNGVNYQGEVWPGQVYYPDFLNPHSQQFWAEEIKLFKDVLAFDGLWLDMNELSNFITSPNTPHSNLDNPPY KINSSGVQRPINEKTVPATSLHYGNITEYDSHNLYGLLESKATNKALVDITGKRPFILSRSTFVSSGKYTAHWTGDNAATWNDLAYSIPSILNFGIFGVP MVGADICGFSADTTEELCRRWIQV | |||
GH31 | 1431 | 1575 | 0 |
LGAFYPFARDHSDKNSIRQELYLWDSVAASARKVLGLRYRLLPYFYTLMYESNTKGTPIARPLFFSFPEDITTYEINSQFLLGKGVLVSPVLQSGAVTVD AYFPRGNWFDLFNPSNSVNAKSGKYVTLDAPSDHINVHVGEGNIL |
Full Sequence |
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Protein Sequence Length: 1730 Download |
MYSLNRKSFK RKLKDIDDDA CKPEDVIGES TKGGXXXXXX XXXXXXXXXX XXXXXXXXXX 60 XXXXXXXXAG SSPELVLDQY TQFIGRPAPM PYWSFGSGLE STFYQGFHQC RWGYKNVNDV 120 QGVVTNYAKA GIPLEVMWTD IDYMDAYKDF TLDPVNFPKD KMRNFVDTLH KNGQKYVLIL 180 DPGISVNNTY ATYVRGLQAD VYLKRNGVNY LGEVWPGPVY YPDFLNPHSQ EFWGEEIKLF 240 RELLPFDGIW LDMNELSNFI TSNDTPHSNL DSPPYKINST GVQRPINNKT VPATSLHYGN 300 ITEYDSHNLY GLLESKTTNR ALVEITSKRP FILSRSTFVS SGKYTAHWTG DNAATWNDLA 360 YSIPSILNFG IFGVPMVGAD ICGFSADTTE ELCRRWIQLG AFYPFARDHS DKSSIRQELY 420 LWDSVAASAR KVLALRYRLL PYFYTLMYES NTKGTPIARP LFFSFPEDIT TYEINSQFLL 480 GNGVLVSPVL QSGAVTVDAY FPKGNWFDLF NPSNSVSAES GKYVTLDAPS DHINVHVGEG 540 NILALQGEAM TTKAARNTAF ELLVVFSGNG NSYGQVYLDD GEALDLEGEK DQWTLVRFYG 600 ALYNNDSVSV TSNVTNGKFA LDQKWTIEKV TFLGIPNYGR LNGNDLAESE LNVVSGMNST 660 RKRVLITKFD RSSKFVTVEV SNLKQLIGEQ FELKTKISRV NNMADPIAGS NRRKQRMSHV 720 DMRGTHEENT HTHYSMVSLG DVSAKCLQTI NTSTQTKWLQ VQELKPAXXX XXXXXXXXXX 780 XXXXXXXXXX XXXXXXXXXX XILLPLLAFC FNVFVILSQT VADSPSKETQ VGYGYTIISV 840 KSDPTGKSLS ANLKLIKSSS VFGPDIPLLN LSASFEAKDK LRVRITDSNN QRWEVPEELI 900 PRDSSSSSLS HHFRQQNSQN SKYIITHPNS DLIFTLHNTT PFGFTITRKS NKDILFNTLP 960 EDPLNPETFL VFKEQYLQIS TSLPSKRASL YGFGEHTKSS FKLKPNQTFT LWNEDIGSSN 1020 VDVNLYGSHP FYLDVRKGSS DGRVKSGTTH GVLLLNSNGM DVVYSGDRLT YKVIGGVFDL 1080 YFFSGSSPEL VLDQYTQFIG RPAPMPYWSF GFHQCRYGYK NVSDVEGVVT NYAKAGIPLE 1140 VMWTDIDYMD AYKDFTLDPV NFPQDKMINF VDTLHKNGQK YVLILDPGIS INTTYATYVR 1200 GLQADVYIKR NGVNYQGEVW PGQVYYPDFL NPHSQQFWAE EIKLFKDVLA FDGLWLDMNE 1260 LSNFITSPNT PHSNLDNPPY KINSSGVQRP INEKTVPATS LHYGNITEYD SHNLYGLLES 1320 KATNKALVDI TGKRPFILSR STFVSSGKYT AHWTGDNAAT WNDLAYSIPS ILNFGIFGVP 1380 MVGADICGFS ADTTEELCRR WIQVKKGFKL QIRCNSYISE NRGDKAAIAV LGAFYPFARD 1440 HSDKNSIRQE LYLWDSVAAS ARKVLGLRYR LLPYFYTLMY ESNTKGTPIA RPLFFSFPED 1500 ITTYEINSQF LLGKGVLVSP VLQSGAVTVD AYFPRGNWFD LFNPSNSVNA KSGKYVTLDA 1560 PSDHINVHVG EGNILALQGE AMTTKAARNT TFELLVVFSG NGNSYGQVYL DDGEALDIEG 1620 EKDQWTLVRF YGALYNDSVS VTSNVTNGKF SLDQKWIIEK VTFLGIPNYG RLNGNDLAES 1680 ELNVVSVKNS MRKRVLITKF DRSSKFVTVE VSNLKQLIGE QFELKTKIR* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
COG1501 | COG1501 | 2.0e-121 | 918 | 1614 | 710 | + Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism] | ||
cd06602 | GH31_MGAM_SI_GAA | 0 | 85 | 472 | 393 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
cd06602 | GH31_MGAM_SI_GAA | 0 | 1100 | 1504 | 410 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
pfam01055 | Glyco_hydro_31 | 0 | 69 | 543 | 479 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. | ||
pfam01055 | Glyco_hydro_31 | 0 | 1081 | 1575 | 499 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. |
Gene Ontology | |
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GO Term | Description |
GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
GO:0005975 | carbohydrate metabolic process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | XP_002298949.1 | 0 | 807 | 1666 | 23 | 856 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002317678.1 | 0 | 69 | 697 | 301 | 912 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002317678.1 | 0 | 827 | 1728 | 43 | 912 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002317679.1 | 0 | 69 | 698 | 293 | 905 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002317679.1 | 0 | 808 | 1727 | 21 | 903 | predicted protein [Populus trichocarpa] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3w38_A | 0 | 802 | 1725 | 16 | 905 | A Chain A, Arabidopsis Thaliana Peroxidase A2 |
PDB | 3w38_A | 0 | 69 | 694 | 296 | 905 | A Chain A, Arabidopsis Thaliana Peroxidase A2 |
PDB | 3w37_A | 0 | 802 | 1725 | 16 | 905 | A Chain A, Arabidopsis Thaliana Peroxidase A2 |
PDB | 3w37_A | 0 | 69 | 694 | 296 | 905 | A Chain A, Arabidopsis Thaliana Peroxidase A2 |
PDB | 3l4z_A | 0 | 845 | 1622 | 61 | 782 | A Chain A, Arabidopsis Thaliana Peroxidase A2 |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
HO795307 | 693 | 1064 | 1728 | 0 |
HO795307 | 657 | 69 | 697 | 0 |
DY272797 | 332 | 77 | 407 | 0 |
DY272797 | 318 | 1092 | 1408 | 0 |
ES793134 | 288 | 253 | 540 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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