| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_011268m |
| Family | GT47 |
| Protein Properties | Length: 340 Molecular Weight: 39090.1 Isoelectric Point: 8.8098 |
| Chromosome | Chromosome/Scaffold: 00784 Start: 63166 End: 66772 |
| Description | Exostosin family protein |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT47 | 87 | 215 | 5.4e-24 |
| LKIYIYEEYEIDGLKELLRGREGKISPDACLKGQWGTQVKIHRLFLKSRFRTRKKEEADLFFVPAYVKCVRMMGGLNDKEINQTYVKVLSQMPYFRRSGG RDHVFVFPSGAGAHLFRSWATYINRSIIL | |||
| Full Sequence |
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| Protein Sequence Length: 340 Download |
| MGSLNNRAKI FTAHHQAPPC TRTHQIGAIL LVAATFFLTR LFDESFPACI PSSFDHHITP 60 QSQSLVHVTD GGSLSWPQRG YGTYLSLKIY IYEEYEIDGL KELLRGREGK ISPDACLKGQ 120 WGTQVKIHRL FLKSRFRTRK KEEADLFFVP AYVKCVRMMG GLNDKEINQT YVKVLSQMPY 180 FRRSGGRDHV FVFPSGAGAH LFRSWATYIN RSIILTPEEC VPVILSDQVE LPFQNVIDYT 240 HVSIKWPSTR IGPELLDYLE AIPDEDVERM IARGRLIRCL WVYAPESELC SAMQGLMWEL 300 QRKVRQFHQS AETFWLHNRT IVNRNLVEFS SWKPPMPLP* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 3.0e-7 | 220 | 262 | 43 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| pfam03016 | Exostosin | 1.0e-15 | 87 | 213 | 127 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ABK93189.1 | 0 | 1 | 218 | 1 | 218 | unknown [Populus trichocarpa] |
| RefSeq | XP_002300942.1 | 0 | 1 | 218 | 1 | 218 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002300942.1 | 0 | 219 | 339 | 340 | 460 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002307477.1 | 0 | 1 | 218 | 1 | 218 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002307477.1 | 0 | 219 | 339 | 340 | 460 | predicted protein [Populus trichocarpa] |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
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| Hit | Length | Start | End | EValue |
| JG006160 | 219 | 1 | 218 | 0 |
| DT493440 | 220 | 1 | 218 | 0 |
| GW879378 | 197 | 1 | 196 | 0 |
| CF231349 | 220 | 1 | 218 | 0 |
| DB892644 | 192 | 27 | 218 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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