CAZyme Information
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Sequence: WP_002915629.1
Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
Signalp annotations |
TMHMM annotations |
PSSpred annotations |
LipoP annotations
Basic Information help
| Species | Klebsiella pneumoniae 30660/NJST258_1 | |||||||||||||
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| CAZyme ID | WP_002915629.1 | |||||||||||||
| CAZy Family | CE4; | |||||||||||||
| CAZyme Description | cobalt-precorrin-3B C(17)-methyltransferase | |||||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 1012080; End: 1012805 Strand: + | |||||||||||||
| View CDS | CDS sequence | |||||||||||||
| UniProt ID | A0A1C1RLB7; A0A0E1C9F4; A0A0H3H278; A0A0J2GJV0; W8UFN9; | |||||||||||||
| InterPro Annotation | A0A1C1RLB7; A0A0E1C9F4; A0A0H3H278; A0A0J2GJV0; W8UFN9; | |||||||||||||
Genomic Context If it does not show, please wait or refresh. help
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | Start | End | Domain Description |
|---|---|---|---|---|---|
| PRK15478 | cbiH | 8.44e-180 | 1 | 241 |
cobalt-precorrin-3B C(17)-methyltransferase; Provisional
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| cd11646 | Precorrin_3B_C17_MT | 8.76e-145 | 2 | 239 |
Precorrin-3B C(17)-methyltransferase (CobJ/CbiH). Precorrin-3B C(17)-methyltransferase participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. This model includes CobJ of the aerobic pathway and CbiH of the anaerobic pathway, both as stand-alone enzymes and when CobJ forms part of a bifunctional enzyme. In the aerobic pathway, once CobG has generated precorrin-3b, CobJ catalyzes the methylation of precorrin-3b at C-17 to form precorrin-4 (the extruded methylated C-20 fragment is left attached as an acyl group at C-1). In the corresponding anaerobic pathway, CbiH carries out this ring contraction, using cobalt-precorrin-3b as a substrate to generate a tetramethylated delta-lactone.
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| TIGR01466 | cobJ_cbiH | 2.44e-138 | 2 | 240 |
precorrin-3B C17-methyltransferase. This model represents precorrin-3B C17-methyltransferase, one of two methyltransferases commonly referred to as precorrin-3 methylase (the other is precorrin-4 C11-methyltransferase, EC 2.1.1.133). This enzyme participates in the pathway toward the biosynthesis of cobalamin and related products. Members of this family may appear as fusion proteins with other enzymes of cobalamin biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
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| COG1010 | CobJ | 6.23e-134 | 1 | 241 |
Precorrin-3B methylase [Coenzyme transport and metabolism].
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| PRK05765 | PRK05765 | 9.38e-84 | 2 | 239 |
precorrin-3B C17-methyltransferase; Provisional
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PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2ZVB_A | 6.4e-56 | 2 | 241 | 4 | 263 |
Chain A, Crystal Structure Of Tt0207 From Thermus Thermophilus Hb8
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| 3NUT_A | 5.3e-34 | 2 | 240 | 11 | 250 |
Chain A, Crystal Structure Of The Methyltransferase Cobj
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Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
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| sp|Q05590|CBIH_SALTY | 1.8e-125 | 1 | 241 | 1 | 241 |
Probable cobalt-factor III C(17)-methyltransferase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=cbiH PE=1 SV=1
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| sp|O87689|CBIH_BACME | 2.3e-61 | 2 | 239 | 5 | 246 |
Cobalt-factor III methyltransferase OS=Bacillus megaterium GN=cbiH60 PE=1 SV=1
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| sp|O29534|CBIHC_ARCFU | 8.4e-51 | 2 | 240 | 10 | 244 |
Cobalamin biosynthesis protein CbiHC OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) GN=cbiHC PE=3 SV=1
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| sp|Q58223|CBIH_METJA | 1.8e-45 | 1 | 239 | 1 | 243 |
Probable cobalt-factor III C(17)-methyltransferase OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) GN=cbiH PE=3 SV=1
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| sp|O27454|CBIH_METTH | 7.6e-44 | 1 | 241 | 1 | 237 |
Probable cobalt-factor III C(17)-methyltransferase OS=Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) GN=cbiH PE=3 SV=1
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