Basic Information | |
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Species | Malus domestica |
Cazyme ID | MDP0000214280 |
Family | AA3 |
Protein Properties | Length: 338 Molecular Weight: 36847.8 Isoelectric Point: 7.2303 |
Chromosome | Chromosome/Scaffold: 018720434 Start: 7546 End: 9331 |
Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
AA3 | 105 | 338 | 1.3e-29 |
XKYDYIVVGGGTSGCPLAATLSAKYSVLVLERGXLPTAYPNXLNQDGFLYXLXQEDDGNTPVQRIMSEDXIPTVRGRILGGTSMINAGVXARANISFYNE SGIEWDMDLVNKTYKWVENTIVGRPNNSVGGWQSVAQKAFLEAGGYDPNNGFVLDHIEGTRFTGDELLNKGDPNNLRVAVHATVEKIIFSTLSKKSTXLS ATGVIYRDSNGRSHRALVHDKGEIILSSGTIASP |
Full Sequence |
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Protein Sequence Length: 338 Download |
MSLCELFSPL MSLSHHRPTS IYRGGLVVHP RCTPNPTVYG VVVISAYFQM HVGSVFLNYG 60 CSFTYAGIIN VSYTTGVTPL WSSSSIRDFG YLKFVYNATD LPLGXKYDYI VVGGGTSGCP 120 LAATLSAKYS VLVLERGXLP TAYPNXLNQD GFLYXLXQED DGNTPVQRIM SEDXIPTVRG 180 RILGGTSMIN AGVXARANIS FYNESGIEWD MDLVNKTYKW VENTIVGRPN NSVGGWQSVA 240 QKAFLEAGGY DPNNGFVLDH IEGTRFTGDE LLNKGDPNNL RVAVHATVEK IIFSTLSKKS 300 TXLSATGVIY RDSNGRSHRA LVHDKGEIIL SSGTIASP |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam00732 | GMC_oxred_N | 1.0e-8 | 162 | 338 | 199 | + GMC oxidoreductase. This family of proteins bind FAD as a cofactor. | ||
TIGR01810 | betA | 6.0e-10 | 108 | 338 | 280 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
PRK02106 | PRK02106 | 4.0e-15 | 106 | 338 | 283 | + choline dehydrogenase; Validated | ||
COG2303 | BetA | 1.0e-19 | 106 | 338 | 276 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
PLN02785 | PLN02785 | 2.0e-64 | 107 | 338 | 246 | + Protein HOTHEAD |
Gene Ontology | |
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GO Term | Description |
GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
GO:0050660 | flavin adenine dinucleotide binding |
GO:0055114 | oxidation-reduction process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAL11514.1 | 0 | 82 | 338 | 29 | 290 | AF412329_1 R-oxynitrile lyase isoenzyme 1 precursor [Prunus dulcis] |
GenBank | ACY69987.1 | 0 | 82 | 338 | 23 | 284 | mandelonitrile lyase 1 [Eriobotrya japonica] |
GenBank | ACY69988.1 | 0 | 82 | 338 | 23 | 284 | mandelonitrile lyase 2 [Eriobotrya japonica] |
EMBL | CAT02462.2 | 0 | 82 | 338 | 27 | 290 | (R)-(+)-mandelonitrile lyase precursor [Eriobotrya japonica] |
Swiss-Prot | P52706 | 0 | 82 | 338 | 29 | 290 | MDL1_PRUSE RecName: Full=(R)-mandelonitrile lyase 1; AltName: Full=Hydroxynitrile lyase 1; Short=(R)-oxynitrilase 1; Flags: Precursor |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3gdp_B | 0 | 82 | 338 | 2 | 263 | A Chain A, Crystal Structure Of E. Coli Phenylalanine-Trna Synthetase Complexed With Phenylalanine And Amp |
PDB | 3gdp_A | 0 | 82 | 338 | 2 | 263 | A Chain A, Crystal Structure Of E. Coli Phenylalanine-Trna Synthetase Complexed With Phenylalanine And Amp |
PDB | 3gdn_B | 0 | 82 | 338 | 2 | 263 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
PDB | 3gdn_A | 0 | 82 | 338 | 2 | 263 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
PDB | 1ju2_B | 0 | 82 | 338 | 2 | 263 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
DT000299 | 209 | 85 | 281 | 0 |
DR989821 | 207 | 85 | 279 | 0 |
DW341090 | 218 | 88 | 293 | 0 |
AM726975 | 285 | 61 | 327 | 0 |
DT001380 | 193 | 76 | 268 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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