| Basic Information | |
|---|---|
| Species | Selaginella moellendorffii |
| Cazyme ID | 102402 |
| Family | GH89 |
| Protein Properties | Length: 762 Molecular Weight: 86199.7 Isoelectric Point: 6.9469 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH89 | 53 | 754 | 0 |
| RKISIHGTSGVELCAGLYWYLKNWCGAHISWDLTGGSQLDTIPEPQALPALPPGGVKIQRSVPWSYYQNVVTSSYSYAWWNWKRWRKEIDWMALQGINLP LAFTGQETIWQKVFESKFNMTKHELDDYFGGPSFLAWARMGNLHGWGGPLPEKWLELQLILQKKILHHMRSLGMIAVLPAFSGNVPRALKILYPSANITR LPDWNTVDGNPQWCCTYLLQPMDPLFIQIGKAFIEQQVKEYGSTQHVYNCDTFNENLPPTDDPSYISALAASVYGAMIVADKQAIWLMQGWLFSSDAQFW KPPQMKALLHAVPFGKMIVLDLFAEVRPIWSKSSHFYGVPYIWCMLHNFGGNHEMYGRLDVVSSGPVDAKTSANSTMIGVGMCMEGIEQNPVVYELMAEM AFRSTRNALKDWVNDYSTRRYGKAVPEALEAWQILSHTLYNCSDGLQDHNTDVIVKFPDLNASSLTTLSRYLAEEAGTQTRRLLTEGLTSFGHLWYRPTE AKVALSYMLNASSSLSNVATYRYDLVDLTRQVLMKLANQIHLQALVSFVKGDLEELTKNCDILIGIIKDSELLLRSNNGFLLGPWLESAKKLGTNSDEKH LYEWNARTQVTMWFDNTRSLPSALHDYANKMWSGLFEDYYLPRASLYTKLLVKALHDKEPFPYGSWRSSWILLTNTFQNGTKNYPLEAAGDSIEIAKSLF SK | |||
| Full Sequence |
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| Protein Sequence Length: 762 Download |
| MPPARDQLRA AASVLRRLIP GHASAFQLQI ITLEDCGGKS CFQLSSLMDE GSRKISIHGT 60 SGVELCAGLY WYLKNWCGAH ISWDLTGGSQ LDTIPEPQAL PALPPGGVKI QRSVPWSYYQ 120 NVVTSSYSYA WWNWKRWRKE IDWMALQGIN LPLAFTGQET IWQKVFESKF NMTKHELDDY 180 FGGPSFLAWA RMGNLHGWGG PLPEKWLELQ LILQKKILHH MRSLGMIAVL PAFSGNVPRA 240 LKILYPSANI TRLPDWNTVD GNPQWCCTYL LQPMDPLFIQ IGKAFIEQQV KEYGSTQHVY 300 NCDTFNENLP PTDDPSYISA LAASVYGAMI VADKQAIWLM QGWLFSSDAQ FWKPPQMKAL 360 LHAVPFGKMI VLDLFAEVRP IWSKSSHFYG VPYIWCMLHN FGGNHEMYGR LDVVSSGPVD 420 AKTSANSTMI GVGMCMEGIE QNPVVYELMA EMAFRSTRNA LKDWVNDYST RRYGKAVPEA 480 LEAWQILSHT LYNCSDGLQD HNTDVIVKFP DLNASSLTTL SRYLAEEAGT QTRRLLTEGL 540 TSFGHLWYRP TEAKVALSYM LNASSSLSNV ATYRYDLVDL TRQVLMKLAN QIHLQALVSF 600 VKGDLEELTK NCDILIGIIK DSELLLRSNN GFLLGPWLES AKKLGTNSDE KHLYEWNART 660 QVTMWFDNTR SLPSALHDYA NKMWSGLFED YYLPRASLYT KLLVKALHDK EPFPYGSWRS 720 SWILLTNTFQ NGTKNYPLEA AGDSIEIAKS LFSKYDSLVH D* 780 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 2.0e-21 | 7 | 103 | 97 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 8.0e-87 | 463 | 755 | 293 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 1.0e-173 | 118 | 458 | 341 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 38 | 755 | 200 | 877 | A Chain A, Crystal Structure Of Hyperthermophilic Beta-Glucosidase From Pyrococcus Furiosus |
| PDB | 2vcb_A | 0 | 38 | 755 | 200 | 877 | A Chain A, Crystal Structure Of Hyperthermophilic Beta-Glucosidase From Pyrococcus Furiosus |
| PDB | 2vca_A | 0 | 38 | 755 | 200 | 877 | A Chain A, Crystal Structure Of Hyperthermophilic Beta-Glucosidase From Pyrococcus Furiosus |
| PDB | 2vc9_A | 0 | 38 | 755 | 200 | 877 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 38 | 755 | 223 | 900 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| Hydropathy |
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| Sequence Alignments (This image is cropped. Click for full image.) |
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