dbAPIS serves as a comprehensive data repository for experimentally validated viral anti-prokaryotic immune system (APIS) proteins and their associated protein families. APIS proteins, typically encoded by phages, prophages, and other mobile genetic elements like plasmids, play a key role in inhibiting prokaryotic immune or defense mechanisms. Notably, our database does not include anti-CRISPR proteins due to their extensive coverage in existing databases such as Anti-CRISPRdb, AcrDB , CRISPRminer, AcrCatalog , etc.
The key features of dbAPIS include:
dbAPIS aims to routinely curate literature and collect all experimentally characterized APIS genes, and to facilitate the research in phage anti-prokaryotic immune mechanisms and aid in the discovery of novel APIS proteins by providing a comprehensive web resource.
Enterobacterales (48) | Unknown (29) | Bacillales (8) |
Pseudomonadales (3) | Burkholderiales (3) | Bacillales_D (1) |
Bacteroidales (1) | Peptostreptococcales (1) | Mycobacteriales (1) |