| APIS006 |
abc1 |
RecBCD |
CLAN005 |
Salmonella phage S149 |
Silas et al., 2023 |
Trigger programmed cell death (PCD) by P4 prophage. |
| APIS020 |
Abc2 |
RecBCD |
CLAN019 |
Salmonella phage P22 |
PMID:10669596 36533901 |
Bacteriophage P22 Abc2 protein binds to the RecBCD enzyme from E. coli to promote phage growth and recombination; the RecBCD-Abc2 structure shows that Abc2 binds to the Chi-recognition domains of the RecC subunit in a position that might enable it to mediate the loading of phage recombinases onto its single-stranded DNA products. |
| APIS023 |
gp5.9 |
RecBCD |
CLAN022 |
T7 of E. coli |
PMID:36533901 |
Gp5.9 completely inhibits RecBCD by preventing it from binding to DNA. The RecBCD-gp5.9 structure shows that gp5.9 acts by substrate mimicry, binding predominantly to the RecB arm domain and competing sterically for the DNA binding site. |
| APIS049 |
|
|
CLAN005 |
|
|
|
| APIS092 |
Gam |
RecBCD |
CLAN036 |
Lambda of E. coli |
PMID:24086157 |
The protein Gam inhibits the host RecBCD exonuclease activity thus allowing efficient rolling-circle replication. |
