| AD families | AD genes | Defense system | CLAN ID | Phages/MGEs | References | Description |
|---|---|---|---|---|---|---|
| APIS024 | Tad1 | Thoeris | CLAN031 | SBSphiJ7 of B. subtilis | PMID:36174646 | Tad1 proteins are not an enzymes, but are 'sponges' that bind and sequester the immune signaling molecule (cyclic ADP-ribose or gcADPR) produced by TIR-domain proteins, thus decoupling phage sensing from immune effector activation and rendering Thoeris inactive. |
| APIS029 | Tad2 | Thoeris | CLAN031 | Bacillus phage SPO1 | Yirmiya et al., 2023 | Tad2 is a "sponge" that sequesters the immune signaling molecules produced by Thoeris TIR-domain proteins in response to phage. |
| APIS043 | CLAN031 | Pasteurella phage Pm86 | ||||
| APIS045 | CLAN031 | |||||
| APIS052 | CLAN031 | |||||
| APIS061 | CLAN031 | |||||
| APIS070 | CLAN031 | |||||
| APIS079 | CLAN031 | Pseudomonas phage Skulduggery |