| APIS family ID | APIS024 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Inhibited defense system | Thoeris | |||||||||||||
| CLAN ID | CLAN031 | |||||||||||||
| Seed protein property |
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| Phage property |
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| PMID/References | PMID:36174646 | |||||||||||||
| PDB structures | 7UAV; | |||||||||||||
| Pfam domains | ||||||||||||||
| Phrog | phrog_2428 | |||||||||||||
| Host taxa | d__Bacteria;p__Firmicutes;c__Bacilli;o__Bacillales;f__Bacillaceae;g__Bacillus;s__Bacillus subtilis | |||||||||||||
| Gene Location | Start: ; End: ; Strand: | |||||||||||||
| Description | Tad1 proteins are not an enzymes, but are 'sponges' that bind and sequester the immune signaling molecule (cyclic ADP-ribose or gcADPR) produced by TIR-domain proteins, thus decoupling phage sensing from immune effector activation and rendering Thoeris inactive. | |||||||||||||
| Fam ID | Seed protein | Member count | Model | Alignment | APIS024 | UPI13470.1 | 229 | HMM model | Member alignment |
|---|
| Hit APIS family | E-Value | Query Start | Query End | Hit Start | Hit End | Immune system | Seed protein |
|---|---|---|---|---|---|---|---|
| APIS061 | 1.16E-66 | 3 | 123 | 71 | 197 | IMGVR_UViG_3300024337_000617|3300024337|Ga0255060_100056963 | |
| APIS070 | 3.98E-65 | 4 | 123 | 81 | 199 | IMGVR_UViG_3300037297_000240|3300037297|Ga0394146_0000041_21955_22497 |
| APIS | Contig | Range |
|---|---|---|
| APIS024 | OM982674.1 | - |