y
Basic Information | |
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Species | Ricinus communis |
Cazyme ID | 29720.m000137 |
Family | GH79 |
Protein Properties | Length: 551 Molecular Weight: 61192.1 Isoelectric Point: 7.1636 |
Chromosome | Chromosome/Scaffold: 29720 Start: 49696 End: 53131 |
Description | glucuronidase 3 |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 53 | 544 | 0 |
DEDFICATLDWWPPEKCDYGTCSWDHASLINLDLNNNILLNAVKAFSPLKIRLGGTLQDKVIYDTDDNHEPCKQFVRNTTEMFGFTQGCLPMYRWDELNA FFKKSGAKIIFGLNALTGRSIQSDGSAAGAWNYANAQSFISYTVNKNYTIHGWELGNELCGSGVGTRVSANQYALDTISLHNIVQEIYSGIEPKPLIISP GGFFDENWFKEFVDKTGNSVDAITHHIYNLGPGVDQHLVEKILDPSYLDGEANTFSRLKSTLKNSATSATAWVGESGGAYNSGHNLVSNAFVYSFWYLDQ LGMSAVYDTKTYCRQTLIGGNYGLLNTTTFVPNPDYYSALLWHRLMGRNVLSTNFSGMKKIRAYAHCAKESKGVTLLLINLDNSTTVQVHVTLNTTATLH DKYRHHSHRSFKSHRSHRTRTILLPKGSADSTREEYHLTAKDGNLHSQTMLLNGNILDVNSSGDIPTLEPLRVNSSQPITVTPFSIVFVHLP |
Full Sequence |
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Protein Sequence Length: 551 Download |
MGFQFLLKGF CFLLCVFCYS SFYASSQTVV SGGGSSVQGT VFIDGKSFIG KIDEDFICAT 60 LDWWPPEKCD YGTCSWDHAS LINLDLNNNI LLNAVKAFSP LKIRLGGTLQ DKVIYDTDDN 120 HEPCKQFVRN TTEMFGFTQG CLPMYRWDEL NAFFKKSGAK IIFGLNALTG RSIQSDGSAA 180 GAWNYANAQS FISYTVNKNY TIHGWELGNE LCGSGVGTRV SANQYALDTI SLHNIVQEIY 240 SGIEPKPLII SPGGFFDENW FKEFVDKTGN SVDAITHHIY NLGPGVDQHL VEKILDPSYL 300 DGEANTFSRL KSTLKNSATS ATAWVGESGG AYNSGHNLVS NAFVYSFWYL DQLGMSAVYD 360 TKTYCRQTLI GGNYGLLNTT TFVPNPDYYS ALLWHRLMGR NVLSTNFSGM KKIRAYAHCA 420 KESKGVTLLL INLDNSTTVQ VHVTLNTTAT LHDKYRHHSH RSFKSHRSHR TRTILLPKGS 480 ADSTREEYHL TAKDGNLHSQ TMLLNGNILD VNSSGDIPTL EPLRVNSSQP ITVTPFSIVF 540 VHLPYDLPAC R 600 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 42 | 354 | 314 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAN81917.1 | 0 | 1 | 551 | 1 | 555 | hypothetical protein [Vitis vinifera] |
RefSeq | XP_002263173.1 | 0 | 1 | 551 | 5 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002324603.1 | 0 | 39 | 550 | 1 | 505 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002331013.1 | 0 | 9 | 550 | 2 | 546 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002533671.1 | 0 | 1 | 551 | 1 | 551 | heparanase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.00000003 | 148 | 451 | 122 | 418 | A Chain A, Structure Of The Amylomaltase From Thermus Thermophilus Hb8 In Space Group P21212 |
PDB | 3vnz_A | 0.00000003 | 148 | 451 | 122 | 418 | A Chain A, Structure Of The Amylomaltase From Thermus Thermophilus Hb8 In Space Group P21212 |
PDB | 3vny_A | 0.00000003 | 148 | 451 | 122 | 418 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |