| Basic Information | |
|---|---|
| Species | Ricinus communis |
| Cazyme ID | 29737.m001236 |
| Family | GH18 |
| Protein Properties | Length: 445 Molecular Weight: 49804.7 Isoelectric Point: 7.1639 |
| Chromosome | Chromosome/Scaffold: 29737 Start: 251986 End: 254189 |
| Description | cysteine-rich RLK (RECEPTOR-like protein kinase) 10 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH18 | 1 | 222 | 5.5e-31 |
| MVSNSTYRRSFIDSSIRRARLYGFQGLDLSWGSANTSDNMANLDTLFQEWRAAVASEMRNSSMSELILTASVHYSPELNSISLPADSIQRNLNWFTHAHA ALYDPRSTVNTDFGVGAWMNKGLIASTLVLSWPFYGYAWTLANSNNNSIGAPATGPAITETGAMRCNDIKNFIQQSVNYCANGSTWICFHDVEAVRTKVS YAKEKKLLGYVVWHVSNDDNWE | |||
| Full Sequence |
|---|
| Protein Sequence Length: 445 Download |
| MVSNSTYRRS FIDSSIRRAR LYGFQGLDLS WGSANTSDNM ANLDTLFQEW RAAVASEMRN 60 SSMSELILTA SVHYSPELNS ISLPADSIQR NLNWFTHAHA ALYDPRSTVN TDFGVGAWMN 120 KGLIASTLVL SWPFYGYAWT LANSNNNSIG APATGPAITE TGAMRCNDIK NFIQQSVNYC 180 ANGSTWICFH DVEAVRTKVS YAKEKKLLGY VVWHVSNDDN WELSQAAQLE DVQGQEKQPP 240 SLVIILTTTA AAVLLLIGFM LYIRRKRTLR SKVSKLETDE AATAGYFGSN GVLVGGEEIA 300 VKKLSNTSAQ GSEEFKNEVM LTAKLQHVFL ARVLGFCIDR EEQMLIYEYM PNKSLDYYLF 360 DPIRRCTLDW TKRVEISEGV TQGLLYLQEY SRMTVIHRDL KASKILFDND LKAKISNIGM 420 TRIFTKEGPE ANTDRIVGTL GVVPP 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| smart00219 | TyrKc | 4.0e-24 | 285 | 422 | 146 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
| cd02872 | GH18_chitolectin_chitotriosidase | 2.0e-35 | 1 | 219 | 258 | + This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens. | ||
| smart00636 | Glyco_18 | 5.0e-37 | 1 | 218 | 253 | + Glyco_18 domain. | ||
| pfam00704 | Glyco_hydro_18 | 2.0e-40 | 1 | 218 | 242 | + Glycosyl hydrolases family 18. | ||
| cd02879 | GH18_plant_chitinase_class_V | 3.0e-69 | 1 | 224 | 243 | + The class V plant chitinases have a glycosyl hydrolase family 18 (GH18) domain, but lack the chitin-binding domain present in other GH18 enzymes. The GH18 domain of the class V chitinases has endochitinase activity in some cases and no catalytic activity in others. Included in this family is a lectin found in black locust (Robinia pseudoacacia) bark, which binds chitin but lacks chitinase activity. Also included is a chitinase-related receptor-like kinase (CHRK1) from tobacco (Nicotiana tabacum), with an N-terminal GH18 domain and a C-terminal kinase domain, which is thought to be part of a plant signaling pathway. The GH18 domain of CHRK1 is expressed extracellularly where it binds chitin but lacks chitinase activity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
| GO:0004672 | protein kinase activity |
| GO:0005975 | carbohydrate metabolic process |
| GO:0006468 | protein phosphorylation |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3alg_A | 0 | 1 | 238 | 85 | 353 | A Chain A, Crystal Structure Of Class V Chitinase (E115q Mutant) From Nicotiana Tobaccum In Complex With Nag4 |
| PDB | 3alf_A | 0 | 1 | 238 | 85 | 353 | A Chain A, Crystal Structure Of Class V Chitinase From Nicotiana Tobaccum |
| PDB | 3aqu_D | 0 | 1 | 227 | 86 | 339 | A Chain A, Crystal Structure Of A Class V Chitinase From Arabidopsis Thaliana |
| PDB | 3aqu_C | 0 | 1 | 227 | 86 | 339 | A Chain A, Crystal Structure Of A Class V Chitinase From Arabidopsis Thaliana |
| PDB | 3aqu_B | 0 | 1 | 227 | 86 | 339 | A Chain A, Crystal Structure Of A Class V Chitinase From Arabidopsis Thaliana |
