| Basic Information | |
|---|---|
| Species | Ricinus communis |
| Cazyme ID | 29737.m001238 |
| Family | GH18 |
| Protein Properties | Length: 721 Molecular Weight: 81532.2 Isoelectric Point: 8.7952 |
| Chromosome | Chromosome/Scaffold: 29737 Start: 259351 End: 262170 |
| Description | receptor kinase 1 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH18 | 10 | 337 | 0 |
| YYDSSGNLPASSVNSALFTHIYYGFAGIDNSTYQLSYPFSNEQDVSTFTATLKRKNPSIITLLSIGLAYRNYSTFSTMVSQPSYRKAFIRSSIKIARRYG FHGLDLAWLWPNTSFDMKNVGVLLEEWRAAVNSESRNSSEPQIILTMMTYRLPVIGNLTFPVESIERNLNWVNILTFDYHLPLKERATGNHAALYDPSGH VNTDFCVRAWLERGLPPSKLVLGLPYHGYAWTLVNPNDNSVGAPSSGPDLTMDGSIGYKMIQSVISGYGYGVASTYNATYAVNYFTIRTTWINFDDVEAI RTKISYAVTKGLLGYFVFQLANDDDWKL | |||
| Full Sequence |
|---|
| Protein Sequence Length: 721 Download |
| MAKPWIKAAY YDSSGNLPAS SVNSALFTHI YYGFAGIDNS TYQLSYPFSN EQDVSTFTAT 60 LKRKNPSIIT LLSIGLAYRN YSTFSTMVSQ PSYRKAFIRS SIKIARRYGF HGLDLAWLWP 120 NTSFDMKNVG VLLEEWRAAV NSESRNSSEP QIILTMMTYR LPVIGNLTFP VESIERNLNW 180 VNILTFDYHL PLKERATGNH AALYDPSGHV NTDFCVRAWL ERGLPPSKLV LGLPYHGYAW 240 TLVNPNDNSV GAPSSGPDLT MDGSIGYKMI QSVISGYGYG VASTYNATYA VNYFTIRTTW 300 INFDDVEAIR TKISYAVTKG LLGYFVFQLA NDDDWKLSRA AYGVGNDEKK KKSQIIIVLV 360 PIVVVILLLF APASYYIRCR TLKSRGNTEF GEVPSFELGQ PITVVNEYPD QNAPNLQGKL 420 PRGQEIAVKR LSKTSNQGLK EFKNELKLTA KLQHVNLVRL LGYCTERKEK MLIYEYMPNK 480 SLDFYLFDQK RRLELNWEKR VHIIEGIAQG LLYLQEYSNL TIIHKDIKSS NILLDSNMKP 540 KISDFGMARI FQKENHEANT CQIVGTYGYV PPEYVKRGVY STKYDVYSFG VLLLQIISGK 600 KNTCYYGSHV NLNLLEYAYE FWETGNGKEF LDPVLDDSHS TCKLLRCLQV GLLCVQESPI 660 DRPSILQICS MLKNENDIIV SPKRPAFSVT SNDEIEKNVS KSTSQDVGSV NSASLSELLP 720 R 780 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| smart00219 | TyrKc | 3.0e-43 | 423 | 672 | 253 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
| cd02872 | GH18_chitolectin_chitotriosidase | 2.0e-56 | 22 | 333 | 332 | + This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens. | ||
| pfam00704 | Glyco_hydro_18 | 5.0e-65 | 8 | 332 | 335 | + Glycosyl hydrolases family 18. | ||
| smart00636 | Glyco_18 | 3.0e-71 | 7 | 332 | 343 | + Glyco_18 domain. | ||
| cd02879 | GH18_plant_chitinase_class_V | 2.0e-124 | 4 | 338 | 340 | + The class V plant chitinases have a glycosyl hydrolase family 18 (GH18) domain, but lack the chitin-binding domain present in other GH18 enzymes. The GH18 domain of the class V chitinases has endochitinase activity in some cases and no catalytic activity in others. Included in this family is a lectin found in black locust (Robinia pseudoacacia) bark, which binds chitin but lacks chitinase activity. Also included is a chitinase-related receptor-like kinase (CHRK1) from tobacco (Nicotiana tabacum), with an N-terminal GH18 domain and a C-terminal kinase domain, which is thought to be part of a plant signaling pathway. The GH18 domain of CHRK1 is expressed extracellularly where it binds chitin but lacks chitinase activity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
| GO:0004672 | protein kinase activity |
| GO:0004674 | protein serine/threonine kinase activity |
| GO:0005524 | ATP binding |
| GO:0005975 | carbohydrate metabolic process |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3aqu_D | 0 | 6 | 341 | 5 | 339 | A Chain A, Crystal Structure Of A Class V Chitinase From Arabidopsis Thaliana |
| PDB | 3aqu_C | 0 | 6 | 341 | 5 | 339 | A Chain A, Crystal Structure Of A Class V Chitinase From Arabidopsis Thaliana |
| PDB | 3aqu_B | 0 | 6 | 341 | 5 | 339 | A Chain A, Crystal Structure Of A Class V Chitinase From Arabidopsis Thaliana |
| PDB | 3aqu_A | 0 | 6 | 341 | 5 | 339 | A Chain A, Crystal Structure Of A Class V Chitinase From Arabidopsis Thaliana |
| PDB | 3alg_A | 0 | 6 | 350 | 4 | 353 | A Chain A, Crystal Structure Of Class V Chitinase (E115q Mutant) From Nicotiana Tobaccum In Complex With Nag4 |
