Basic Information | |
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Species | Ricinus communis |
Cazyme ID | 29848.m004590 |
Family | GH79 |
Protein Properties | Length: 527 Molecular Weight: 57334.9 Isoelectric Point: 7.4922 |
Chromosome | Chromosome/Scaffold: 29848 Start: 856726 End: 859214 |
Description | glucuronidase 3 |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 29 | 516 | 0 |
DNDFICATLDWWPTDKCDYGTCSWGRASFLNLDLRNPILLNAIKAFSPLKIRMGGTLQDKVVYEIKGEPCPLFIKNSSEMFGFSQGCLPMTRWDDLNNFF KQAGATVIFGLNALRGRTIASDGSAFGAWDSSNAESLIQYTVNKGYKIHGWELGNELSGNGVGTRVAADQYASDANTLQYIVQTIYAGLEDKPLVIAPGG FFDAQWFSEFINKTPKSLQVVTQHIYNLGPGVDGHLISKILNPSYLDGGSQPFSSLQRILKSSGTQAVAWVGEAGGAYNSGHNLVTNAFVFSFWYLDQLG MASSFNTKTYCRQTLIGGNYGLLNTNTFVPNPDYYSALLWHRLMGTNALATSFSGTKKMRAYAHCSKATQGITLLLINLDGNTSFEVRISTENVGSNVTW TMQDHSNRGEKFARMSRGSVSKLYEITRDEYHLTAKDGDLHSQTVLLNGKILTPDSSGAIPSLEPIKASLLNPIAVAPFSIVFAQIAN |
Full Sequence |
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Protein Sequence Length: 527 Download |
MGKSSVFVAS QSVEGTVFIN GTASIGTTDN DFICATLDWW PTDKCDYGTC SWGRASFLNL 60 DLRNPILLNA IKAFSPLKIR MGGTLQDKVV YEIKGEPCPL FIKNSSEMFG FSQGCLPMTR 120 WDDLNNFFKQ AGATVIFGLN ALRGRTIASD GSAFGAWDSS NAESLIQYTV NKGYKIHGWE 180 LGNELSGNGV GTRVAADQYA SDANTLQYIV QTIYAGLEDK PLVIAPGGFF DAQWFSEFIN 240 KTPKSLQVVT QHIYNLGPGV DGHLISKILN PSYLDGGSQP FSSLQRILKS SGTQAVAWVG 300 EAGGAYNSGH NLVTNAFVFS FWYLDQLGMA SSFNTKTYCR QTLIGGNYGL LNTNTFVPNP 360 DYYSALLWHR LMGTNALATS FSGTKKMRAY AHCSKATQGI TLLLINLDGN TSFEVRISTE 420 NVGSNVTWTM QDHSNRGEKF ARMSRGSVSK LYEITRDEYH LTAKDGDLHS QTVLLNGKIL 480 TPDSSGAIPS LEPIKASLLN PIAVAPFSIV FAQIANITVP ACVQVSK |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 13 | 328 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI25561.1 | 0 | 12 | 522 | 27 | 532 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002283254.1 | 0 | 1 | 527 | 17 | 541 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002283260.1 | 0 | 1 | 522 | 17 | 545 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002324878.1 | 0 | 15 | 522 | 1 | 504 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002515478.1 | 0 | 1 | 527 | 1 | 527 | heparanase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000003 | 122 | 418 | 122 | 409 | A Chain A, Crystal Structure Of Class V Chitinase From Nicotiana Tobaccum |
PDB | 3vnz_A | 0.000003 | 122 | 418 | 122 | 409 | A Chain A, Crystal Structure Of Class V Chitinase From Nicotiana Tobaccum |
PDB | 3vny_A | 0.000003 | 122 | 418 | 122 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
DT548485 | 284 | 70 | 351 | 0 |
DT569595 | 278 | 76 | 351 | 0 |
GO873156 | 332 | 172 | 501 | 0 |
CO091102 | 279 | 83 | 359 | 0 |
HO806132 | 325 | 1 | 322 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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