Basic Information | |
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Species | Ricinus communis |
Cazyme ID | 30109.m000167 |
Family | GT65 |
Protein Properties | Length: 446 Molecular Weight: 51205 Isoelectric Point: 8.7566 |
Chromosome | Chromosome/Scaffold: 30109 Start: 71234 End: 72894 |
Description | O-fucosyltransferase family protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT65 | 83 | 394 | 0 |
GLNNQKIAFARACLTARMLNRTLLMPKLSASLFYKEIDRLQPISFDKIFQFERFNSLCNGFVQLGQYSDVRNHSGVYELQKGSGRRWTVERDLDQLRQFI QDPYNGHEVIRIVGKNPFLWHDHWPVKDYARVFECLVLVEEIEKEAAKVISKIREVGREVRSNIENPSNSSDSDGSSLQAVPYVAVHMRIEIDWMIHCKK LERRSNISQICSSKEEIMERVGNIVGMKTPSVVYLAVADSLLEDPSILTGWKHGLLPFEKKKLGVDGIYKKYPYLIQSAIDYEVCLRADIFFGNSFSTFS SLIALERTQKMI |
Full Sequence |
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Protein Sequence Length: 446 Download |
MDLNSNYKHP RLFGRNLNSV TCKCLSLVVI LLVLRVVLLS SFSDYGRINQ KDIDLIPSRS 60 LSLDSDYGVR KDKFLEVPQI VWGLNNQKIA FARACLTARM LNRTLLMPKL SASLFYKEID 120 RLQPISFDKI FQFERFNSLC NGFVQLGQYS DVRNHSGVYE LQKGSGRRWT VERDLDQLRQ 180 FIQDPYNGHE VIRIVGKNPF LWHDHWPVKD YARVFECLVL VEEIEKEAAK VISKIREVGR 240 EVRSNIENPS NSSDSDGSSL QAVPYVAVHM RIEIDWMIHC KKLERRSNIS QICSSKEEIM 300 ERVGNIVGMK TPSVVYLAVA DSLLEDPSIL TGWKHGLLPF EKKKLGVDGI YKKYPYLIQS 360 AIDYEVCLRA DIFFGNSFST FSSLIALERT QKMIRMGVTN TCGMDVRWPS YAYNILGESN 420 GPQRWMTNMS DARLQAISYG TNTIYC |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd11296 | O-FucT_like | 0.0002 | 74 | 122 | 49 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
cd11302 | O-FucT-1 | 5.0e-5 | 264 | 389 | 146 | + GDP-fucose protein O-fucosyltransferase 1. The protein O-fucosyltransferase 1 (Ofut1 or O-FucT-1) adds O-fucose to EGF (epidermal growth factor-like) repeats. The O-fucsosylation of the Notch receptor signaling protein is dependent on this enzyme, which requires GDP-fucose as a substrate. O-fucose residues added to the target of O-FucT-1 may be further elongated by other glycosyltransferases. On top of O-fucosylation, O-FucT-1 may have other functions such as the regulation of the Notch receptor exit from the ER. Six highly conserved cysteines are present in O-FucT-1, which is a soluble ER protein, as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The membrane-bound pre-protein is released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. O-FucT-1 is similar to family 1 glycosyltransferases (GT1). | ||
cd11299 | O-FucT_plant | 1.0e-15 | 83 | 390 | 343 | + GDP-fucose protein O-fucosyltransferase, plant specific subfamily. Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
cd11296 | O-FucT_like | 5.0e-22 | 204 | 390 | 191 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
pfam10250 | O-FucT | 1.0e-42 | 83 | 390 | 344 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3zy6_A | 0.00008 | 262 | 389 | 210 | 344 | B Chain B, Crystal Structure Of The Complex Between Pectin Methylesterase And Its Inhibitor Protein |
PDB | 3zy5_A | 0.00008 | 262 | 389 | 210 | 344 | B Chain B, Crystal Structure Of The Complex Between Pectin Methylesterase And Its Inhibitor Protein |
PDB | 3zy4_A | 0.00008 | 262 | 389 | 210 | 344 | B Chain B, Crystal Structure Of The Complex Between Pectin Methylesterase And Its Inhibitor Protein |
PDB | 3zy3_B | 0.00008 | 262 | 389 | 210 | 344 | B Chain B, Crystal Structure Of The Complex Between Pectin Methylesterase And Its Inhibitor Protein |
PDB | 3zy3_A | 0.00008 | 262 | 389 | 210 | 344 | B Chain B, Crystal Structure Of The Complex Between Pectin Methylesterase And Its Inhibitor Protein |