Basic Information | |
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Species | Ricinus communis |
Cazyme ID | 30174.m009143 |
Family | GH79 |
Protein Properties | Length: 206 Molecular Weight: 23309.5 Isoelectric Point: 8.7395 |
Chromosome | Chromosome/Scaffold: 30174 Start: 3272761 End: 3273752 |
Description | glucuronidase 1 |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 71 | 203 | 4.06377e-44 |
DPTLSNKIQDPFFLDQIAQMYSKVSTTIKEFGAWVGDAGEAYNNGSKSVSHTFAHGFWYLDQLGMTSTFNHKVFCRQTLIGGNYGLLNTTTFIPNPDNYG ALLWHRLMGKNVLATSYVGSPYLRAYSHCPKAT |
Full Sequence |
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Protein Sequence Length: 206 Download |
MKYTISKGYE IDSYEFGNEL CSNGVTARVE AEQYGKTSLC LKNWCKNYTQ IRRHSQRCWV 60 QVVSLMINGL DPTLSNKIQD PFFLDQIAQM YSKVSTTIKE FGAWVGDAGE AYNNGSKSVS 120 HTFAHGFWYL DQLGMTSTFN HKVFCRQTLI GGNYGLLNTT TFIPNPDNYG ALLWHRLMGK 180 NVLATSYVGS PYLRAYSHCP KATFSI |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 5.0e-44 | 1 | 134 | 164 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 1 | 206 | 186 | 421 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 1 | 206 | 184 | 419 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 1 | 201 | 180 | 408 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 1 | 206 | 189 | 424 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512115.1 | 0 | 1 | 206 | 1 | 206 | conserved hypothetical protein [Ricinus communis] |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
AJ802651 | 224 | 3 | 196 | 0 |
AJ805815 | 217 | 20 | 206 | 0 |
GR196104 | 142 | 69 | 206 | 0 |
GR072627 | 142 | 69 | 206 | 0 |
GR196104 | 19 | 169 | 187 | 2.2 |
Sequence Alignments (This image is cropped. Click for full image.) |
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